pegylation peg derivatives drug delivery click chemistry pegylated proteins liposomes cancer diagnosis biochempeg dxd sn-38 topoisomerase i inhibitors gene drugs ga drugs dry eye drugs amd drugs ophthalmic drug influenza oseltamivir baloxavir marboxil safer azide tco spaac peptides pegylation reagents limitations of pegylation peg lipids target delivery pharmaceutical biochemistry chemistry polyethylene glycols surface modification adc conjugation peg linkers fda approved pegylated drugs pegylated drgs
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