GKA deel 2 college 5

Deel 2: 70-140 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],HIV 2008 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

In search of AIDS-resistance genes O’Brien & Dean, Scientific American 277, 1997, 28-35 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],HIV 2008

Search for genes O’Brien & Dean ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],HIV 2008

Binding of HIV to receptor O’Brien & Dean HIV 2008

32 nucleotides deletion prevents expression of CCR5 O’Brien & Dean ,[object Object],HIV 2008

Adaptation to CXCR4 receptor of T-cell O’Brien & Dean ,[object Object],[object Object],HIV 2008

Prevalence of mutant CCR5  32 allele O’Brien & Dean ,[object Object],[object Object],[object Object],[object Object],HIV 2008

Delayed AIDS progression in heterozygotes O’Brien & Dean ,[object Object],[object Object],HIV 2008

Where does the allele come from? O’Brien & Dean ,[object Object],[object Object],[object Object],[object Object],HIV 2008

Worldwide distribution of allele O’Brien & Dean HIV 2008

Co-receptors O’Brien & Dean ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],HIV 2008

Vaccin virus? Nolan, Cell HIV 2008

Resistentie in LTNP O’Brien & Dean ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],HIV 2008 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

MHC-allele factor in set-point ,[object Object],[object Object],HIV 2008 ,[object Object],[object Object],[object Object],[object Object],Added 091007

Follow-up: a microbicide as drug? ,[object Object],[object Object],[object Object],[object Object],HIV 2008 =============

GKA deel 2 college 5

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