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Complex Regional Pain
 www.bodyinmind.com.au
Copyright GL Moseley 2009


                                              Syndrome

                                          CRPS Rehabilitation
                                        (or training the brain)


                     Lorimer Moseley
                     NHMRC Senior Research Fellow
                     Prince of Wales Medical Research Institute & Faculty of Medicine, University of NSW, Sydney,
                     Australia
www.bodyinmind.com.au
Copyright GL Moseley 2009
                            Why train the brain?



      CRPS as an extreme protective response.
www.bodyinmind.com.au
Copyright GL Moseley 2009
                                          Why train the brain?



                        Our approach to treating CRPS
     Cognitive               Behavioural          Brain changes
 Understanding the             Function &         S1 reorganisation
 problem                       movement
                                hierarchy          Reorganisation
 Other threatening                                  elsewhere?
 cues are relevant          ‘training the brain
                                   part 1’        ‘training the brain
 Educate & explain                                       part 2’
www.bodyinmind.com.au
Copyright GL Moseley 2009
                                          Why train the brain?



      CRPS as an extreme protective response.
     Cognitive               Behavioural          Brain changes
 Understanding the             Function &         S1 reorganisation
 problem                       movement
                                hierarchy          Reorganisation
 Other threatening                                  elsewhere?
 cues are relevant          ‘training the brain
                                   part 1’
 Educate & explain
www.bodyinmind.com.au
Copyright GL Moseley 2009
                                          Why train the brain?



      CRPS as an extreme protective response.
     Cognitive               Behavioural          Brain changes
 Understanding the             Function &         S1 reorganisation
 problem                       movement
                                hierarchy          Reorganisation
 Other threatening                                  elsewhere?
 cues are relevant          ‘training the brain
                                   part 1’
 Educate & explain
resources




                                      DAVID BUTLER
                                      |
                                      LORIMER MOSELEY
                                      |
                                      ART SUNYATA
                     www.noigroup.com
                     www.physiouk.co.uk
                        www.OPTP.com

www.noigroup.com
www.OPTP.com
www.physiouk.co.uk



                      www.amazon.com
                      CA$35 & post.
www.bodyinmind.com.au

         The motor/behavioural heirarchy
Copyright GL Moseley 2009




      Most              Functional tasks
  threatening

                             Movements
                            Reduce speed, range,
                             duration, frequency


                      Explicit motor imagery

                     Implicit motor imagery
     Least
  threatening                Motor empathy
www.bodyinmind.com.au

         The motor/behavioural heirarchy
Copyright GL Moseley 2009




      Most              Functional tasks           Pain
  threatening

                             Movements
                            Reduce speed, range,
                             duration, frequency


                      Explicit motor imagery

                     Implicit motor imagery
     Least
  threatening                Motor empathy
www.bodyinmind.com.au

         The motor/behavioural heirarchy
Copyright GL Moseley 2009




      Most              Functional tasks
  threatening

                              Movements            Pain
                            Reduce speed, range,
                             duration, frequency




     Least
  threatening
www.bodyinmind.com.au

         The motor/behavioural heirarchy
Copyright GL Moseley 2009




      Most              Functional tasks
  threatening

                              Movements            Pain
                            Reduce speed, range,
                             duration, frequency




     Least
  threatening
www.bodyinmind.com.au

         The motor/behavioural heirarchy
Copyright GL Moseley 2009




      Most              Functional tasks
  threatening

                             Movements
                            Reduce speed, range,
                             duration, frequency


                      Explicit motor imagery



     Least
  threatening
www.bodyinmind.com.au

         The motor/behavioural heirarchy
Copyright GL Moseley 2009




      Most              Functional tasks
  threatening

                             Movements
                            Reduce speed, range,
                             duration, frequency


                      Explicit motor imagery

                     Implicit motor imagery
     Least
  threatening
www.bodyinmind.com.au

         The motor/behavioural heirarchy
Copyright GL Moseley 2009




      Most              Functional tasks
  threatening

                             Movements
                            Reduce speed, range,
                             duration, frequency


                      Explicit motor imagery

                     Implicit motor imagery
     Least
  threatening                Motor empathy
www.bodyinmind.com.au

         The motor/behavioural heirarchy
Copyright GL Moseley 2009




      Most              Functional tasks
  threatening

                             Movements
                            Reduce speed, range,
                             duration, frequency


                      Explicit motor imagery

                     Implicit motor imagery
                                                   ‘Training
                                                   the brain’
     Least
  threatening                Motor empathy
www.bodyinmind.com.au
Copyright GL Moseley 2009

      Do imagined movements activate the
      protective response?

      Most        Functional tasks
  threatening

                       Movements


                 Reduce speed, range,


                 Explicit motor imagery


                 Implicit motor imagery

     Least
  threatening       Motor empathy




Moseley 2004 Neurology 62: 1644
Moseley et al 2008 Arth Care & Res 59, 623-31
www.bodyinmind.com.au
Copyright GL Moseley 2009
                             Imagined movements

                                                    extensors
                                                    flexors
                                                    hyperthenar

                                                    thenar


                                                5 sec
                        New picture

Moseley 2004 Neurology 62: 1644
Moseley et al 2008 Arth Care & Res 59, 623-31
www.bodyinmind.com.au
                                       CRPS        Non CRPS
Copyright GL Moseley 2009
                           8
                Pain

                           4



                           0
                        125
                Size
                Ratio
                (%)
                     110



                            95
Moseley 2004 Neurology 62: 1644  Pre Post 60 min
Moseley et al 2008 Arth Care & Res 59, 623-31
www.bodyinmind.com.au
Copyright GL Moseley 2009


       Experiment: Can visual input
       alone activate CRPS neurotag?




                            Acerra
&
Moseley
2005
Neurology
65:
751‐3
www.bodyinmind.com.au
Copyright GL Moseley 2009




                            Acerra
&
Moseley
2005
Neurology
65:
751‐3
www.bodyinmind.com.au
Copyright GL Moseley 2009




                            Acerra
&
Moseley
2005
Neurology
65:
751‐3
www.bodyinmind.com.au
Copyright GL Moseley 2009




                            Acerra
&
Moseley
2005
Neurology
65:
751‐3
www.bodyinmind.com.au
Copyright GL Moseley 2009




                            Acerra
&
Moseley
2005
Neurology
65:
751‐3
www.bodyinmind.com.au
Copyright GL Moseley 2009




              experience

  normal                    stimulus




                                       Acerra
&
Moseley
2005
Neurology
65:
751‐3
www.bodyinmind.com.au
Copyright GL Moseley 2009




              experience

  normal                    stimulus




                                       Acerra
&
Moseley
2005
Neurology
65:
751‐3
www.bodyinmind.com.au
Copyright GL Moseley 2009




              experience

  normal                    stimulus




                                       Acerra
&
Moseley
2005
Neurology
65:
751‐3
www.bodyinmind.com.au
Copyright GL Moseley 2009




              experience
                            stimulus
     CRPS1




                                           “dysynchiria”
                                       Acerra
&
Moseley
2005
Neurology
65:
751‐3
www.bodyinmind.com.au
Copyright GL Moseley 2009




              experience
                            stimulus
     CRPS1




                                           “dysynchiria”
                                       Acerra
&
Moseley
2005
Neurology
65:
751‐3
www.bodyinmind.com.au
Copyright GL Moseley 2009




            pain

              experience
                            stimulus
     CRPS1




                                           “dysynchiria”
                                       Acerra
&
Moseley
2005
Neurology
65:
751‐3
www.bodyinmind.com.au
Copyright GL Moseley 2009

                                         Parasthaesia
                                         Allodynia


                                         Response to light
                                         touch on opposite
                                         hand while looking
                          x x x          in mirror
     x x x
   x                      x x x x
  x x x x                 x x x x        p = pain
  x xx x                   x x    x
  x x xx              op x x x
                               x         x = ‘odd sensation’
  p pp p p
      p                 p       x
  pppp                    pp x           0 =nothing (normal
 o pp                     p p            response)
o o o                   o o o
                                      Acerra
&
Moseley
2005
Neurology
65:
751‐3
www.bodyinmind.com.au
Copyright GL Moseley 2009

      Do imagined movements activate the
      protective response?

      Most        Functional tasks
  threatening

                       Movements


                 Reduce speed, range,


                 Explicit motor imagery


                 Implicit motor imagery

     Least
  threatening       Motor empathy




Moseley 2004 Neurology 62: 1644
Moseley et al 2008 Arth Care & Res 59, 623-31
www.bodyinmind.com.au
Copyright GL Moseley 2009

      Do imagined movements activate the
      protective response?

      Most        Functional tasks
  threatening

                       Movements


                 Reduce speed, range,


                 Explicit motor imagery         Reducing the
                                                   threat of
                 Implicit motor imagery           imagined
                                                movements.
     Least
  threatening       Motor empathy




Moseley 2004 Neurology 62: 1644
Moseley et al 2008 Arth Care & Res 59, 623-31
www.bodyinmind.com.au
Copyright GL Moseley 2009



      Graded motor imagery
      1. Implicit motor imagery (left/right judgement task)




Moseley (2004) Pain; 108: 192-8;
Moseley (2005) Pain 114;54-61
Moseley (2006) Neurology 67 2129-34
www.bodyinmind.com.au

 Is this a left or a right hand?
Copyright GL Moseley 2009




 One image is shown at a time
 Software is online and via CD
 “Recognise” www.noigroup.com
 Objectives:
 - Equal reaction times for left & right
 - >80% accuracy
www.bodyinmind.com.au
Copyright GL Moseley 2009



      Graded motor imagery
      1. Implicit motor imagery (left/right judgement task)

      2. Explicit motor imagery (imagined movements)




Moseley (2004) Pain; 108: 192-8;
Moseley (2005) Pain 114;54-61
Moseley (2006) Neurology 67 2129-34
www.bodyinmind.com.au
 Imagined limb movements
Copyright GL Moseley 2009




 One image is shown at a time
 Software is online and via CD
 “Recognise” www.noigroup.com

 “Imagine adopting this posture with your
 own hand and then returning it to where
 it is. Imagine a pain-free, smooth
 movement”.

 Objectives:
 - Little or no symptom provocation
 - Task is easy or boring
www.bodyinmind.com.au
Copyright GL Moseley 2009



      Graded motor imagery
      1. Implicit motor imagery (left/right judgement task)

      2. Explicit motor imagery (imagined movements)

      3. Mirror movements




Moseley (2004) Pain; 108: 192-8;
Moseley (2005) Pain 114;54-61
Moseley (2006) Neurology 67 2129-34
www.bodyinmind.com.au
 Mirror movements
Copyright GL Moseley 2009




 “Gently adopt the posture shown with
 both hands, while watching the mirror
 image of your good hand”.

 Objectives:
 -Little or no symptom provocation
 -Movement is not dystonic
 -Movement L & R similar in range and
 speed
 - Task is easy or boring
www.bodyinmind.com.au                                                           Single




                                   n
Copyright GL Moseley 2009




                               itio
                                                                                 blind




                                            d
                                          ine
                             gn
                                                                                  RCT




                                                   or
                                        ag
                           co




                                                  irr
                                       Im
                          Re




                                                 M
                                       MIP                       MIP


            50




Neuropathic
 pain scale
                                                                  Crossed over




           20
                      0           2          4          6   12         18   24

Moseley(2004) Pain; 108: 192-8;             Time (weeks)
www.bodyinmind.com.au
Copyright GL Moseley 2009
                                                      Single
                                                      blind
         • CRPS of arm or leg                          RCT
         • 18-75 years old
         • No other diagnoses   Moseley (2006) Neurology 67 2129-34

         • English-proficient
         • Presented to GP,
         physiotherapy, pain
         management or
         neurology
www.bodyinmind.com.au                Single
Copyright GL Moseley 2009
                                      blind
                                       RCT




Moseley (2006) Neurology 67 2129-34
www.bodyinmind.com.au                Single
Copyright GL Moseley 2009
                                      blind
                                       RCT




Moseley (2006) Neurology 67 2129-34
www.bodyinmind.com.au                                     Single
Copyright GL Moseley 2009
                                                           blind
                                                            RCT


                                      NNT to get a 50%
                                      reduction in pain

                                      Post-MIP = 3 (2-6)

                                      6 months = 2 (1-5)


                                      NNT to get a 4/10 point
                                      increase in function

                                      Post-MIP = 4 (2-11)

                                      6 months = 3 (2-4)
Moseley (2006) Neurology 67 2129-34
www.bodyinmind.com.au
Copyright GL Moseley 2009
                                  Why train the brain?



                        Our approach to treating CRPS

 Go to the                               Brain changes

 next set of                             S1 reorganisation

 slides:                                  Reorganisation
                                           elsewhere?

                                         ‘training the brain
                                                part 2’

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Training The Brain 2 Behavioural

  • 1. Complex Regional Pain www.bodyinmind.com.au Copyright GL Moseley 2009 Syndrome CRPS Rehabilitation (or training the brain) Lorimer Moseley NHMRC Senior Research Fellow Prince of Wales Medical Research Institute & Faculty of Medicine, University of NSW, Sydney, Australia
  • 2. www.bodyinmind.com.au Copyright GL Moseley 2009 Why train the brain? CRPS as an extreme protective response.
  • 3. www.bodyinmind.com.au Copyright GL Moseley 2009 Why train the brain? Our approach to treating CRPS Cognitive Behavioural Brain changes Understanding the Function & S1 reorganisation problem movement hierarchy Reorganisation Other threatening elsewhere? cues are relevant ‘training the brain part 1’ ‘training the brain Educate & explain part 2’
  • 4. www.bodyinmind.com.au Copyright GL Moseley 2009 Why train the brain? CRPS as an extreme protective response. Cognitive Behavioural Brain changes Understanding the Function & S1 reorganisation problem movement hierarchy Reorganisation Other threatening elsewhere? cues are relevant ‘training the brain part 1’ Educate & explain
  • 5. www.bodyinmind.com.au Copyright GL Moseley 2009 Why train the brain? CRPS as an extreme protective response. Cognitive Behavioural Brain changes Understanding the Function & S1 reorganisation problem movement hierarchy Reorganisation Other threatening elsewhere? cues are relevant ‘training the brain part 1’ Educate & explain
  • 6. resources DAVID BUTLER | LORIMER MOSELEY | ART SUNYATA www.noigroup.com www.physiouk.co.uk www.OPTP.com www.noigroup.com www.OPTP.com www.physiouk.co.uk www.amazon.com CA$35 & post.
  • 7. www.bodyinmind.com.au The motor/behavioural heirarchy Copyright GL Moseley 2009 Most Functional tasks threatening Movements Reduce speed, range, duration, frequency Explicit motor imagery Implicit motor imagery Least threatening Motor empathy
  • 8. www.bodyinmind.com.au The motor/behavioural heirarchy Copyright GL Moseley 2009 Most Functional tasks Pain threatening Movements Reduce speed, range, duration, frequency Explicit motor imagery Implicit motor imagery Least threatening Motor empathy
  • 9. www.bodyinmind.com.au The motor/behavioural heirarchy Copyright GL Moseley 2009 Most Functional tasks threatening Movements Pain Reduce speed, range, duration, frequency Least threatening
  • 10. www.bodyinmind.com.au The motor/behavioural heirarchy Copyright GL Moseley 2009 Most Functional tasks threatening Movements Pain Reduce speed, range, duration, frequency Least threatening
  • 11. www.bodyinmind.com.au The motor/behavioural heirarchy Copyright GL Moseley 2009 Most Functional tasks threatening Movements Reduce speed, range, duration, frequency Explicit motor imagery Least threatening
  • 12. www.bodyinmind.com.au The motor/behavioural heirarchy Copyright GL Moseley 2009 Most Functional tasks threatening Movements Reduce speed, range, duration, frequency Explicit motor imagery Implicit motor imagery Least threatening
  • 13. www.bodyinmind.com.au The motor/behavioural heirarchy Copyright GL Moseley 2009 Most Functional tasks threatening Movements Reduce speed, range, duration, frequency Explicit motor imagery Implicit motor imagery Least threatening Motor empathy
  • 14. www.bodyinmind.com.au The motor/behavioural heirarchy Copyright GL Moseley 2009 Most Functional tasks threatening Movements Reduce speed, range, duration, frequency Explicit motor imagery Implicit motor imagery ‘Training the brain’ Least threatening Motor empathy
  • 15. www.bodyinmind.com.au Copyright GL Moseley 2009 Do imagined movements activate the protective response? Most Functional tasks threatening Movements Reduce speed, range, Explicit motor imagery Implicit motor imagery Least threatening Motor empathy Moseley 2004 Neurology 62: 1644 Moseley et al 2008 Arth Care & Res 59, 623-31
  • 16. www.bodyinmind.com.au Copyright GL Moseley 2009 Imagined movements extensors flexors hyperthenar thenar 5 sec New picture Moseley 2004 Neurology 62: 1644 Moseley et al 2008 Arth Care & Res 59, 623-31
  • 17. www.bodyinmind.com.au CRPS Non CRPS Copyright GL Moseley 2009 8 Pain 4 0 125 Size Ratio (%) 110 95 Moseley 2004 Neurology 62: 1644 Pre Post 60 min Moseley et al 2008 Arth Care & Res 59, 623-31
  • 18. www.bodyinmind.com.au Copyright GL Moseley 2009 Experiment: Can visual input alone activate CRPS neurotag? Acerra
&
Moseley
2005
Neurology
65:
751‐3
  • 19. www.bodyinmind.com.au Copyright GL Moseley 2009 Acerra
&
Moseley
2005
Neurology
65:
751‐3
  • 20. www.bodyinmind.com.au Copyright GL Moseley 2009 Acerra
&
Moseley
2005
Neurology
65:
751‐3
  • 21. www.bodyinmind.com.au Copyright GL Moseley 2009 Acerra
&
Moseley
2005
Neurology
65:
751‐3
  • 22. www.bodyinmind.com.au Copyright GL Moseley 2009 Acerra
&
Moseley
2005
Neurology
65:
751‐3
  • 23. www.bodyinmind.com.au Copyright GL Moseley 2009 experience normal stimulus Acerra
&
Moseley
2005
Neurology
65:
751‐3
  • 24. www.bodyinmind.com.au Copyright GL Moseley 2009 experience normal stimulus Acerra
&
Moseley
2005
Neurology
65:
751‐3
  • 25. www.bodyinmind.com.au Copyright GL Moseley 2009 experience normal stimulus Acerra
&
Moseley
2005
Neurology
65:
751‐3
  • 26. www.bodyinmind.com.au Copyright GL Moseley 2009 experience stimulus CRPS1 “dysynchiria” Acerra
&
Moseley
2005
Neurology
65:
751‐3
  • 27. www.bodyinmind.com.au Copyright GL Moseley 2009 experience stimulus CRPS1 “dysynchiria” Acerra
&
Moseley
2005
Neurology
65:
751‐3
  • 28. www.bodyinmind.com.au Copyright GL Moseley 2009 pain experience stimulus CRPS1 “dysynchiria” Acerra
&
Moseley
2005
Neurology
65:
751‐3
  • 29. www.bodyinmind.com.au Copyright GL Moseley 2009 Parasthaesia Allodynia Response to light touch on opposite hand while looking x x x in mirror x x x x x x x x x x x x x x x x p = pain x xx x x x x x x xx op x x x x x = ‘odd sensation’ p pp p p p p x pppp pp x 0 =nothing (normal o pp p p response) o o o o o o Acerra
&
Moseley
2005
Neurology
65:
751‐3
  • 30. www.bodyinmind.com.au Copyright GL Moseley 2009 Do imagined movements activate the protective response? Most Functional tasks threatening Movements Reduce speed, range, Explicit motor imagery Implicit motor imagery Least threatening Motor empathy Moseley 2004 Neurology 62: 1644 Moseley et al 2008 Arth Care & Res 59, 623-31
  • 31. www.bodyinmind.com.au Copyright GL Moseley 2009 Do imagined movements activate the protective response? Most Functional tasks threatening Movements Reduce speed, range, Explicit motor imagery Reducing the threat of Implicit motor imagery imagined movements. Least threatening Motor empathy Moseley 2004 Neurology 62: 1644 Moseley et al 2008 Arth Care & Res 59, 623-31
  • 32. www.bodyinmind.com.au Copyright GL Moseley 2009 Graded motor imagery 1. Implicit motor imagery (left/right judgement task) Moseley (2004) Pain; 108: 192-8; Moseley (2005) Pain 114;54-61 Moseley (2006) Neurology 67 2129-34
  • 33. www.bodyinmind.com.au Is this a left or a right hand? Copyright GL Moseley 2009 One image is shown at a time Software is online and via CD “Recognise” www.noigroup.com Objectives: - Equal reaction times for left & right - >80% accuracy
  • 34. www.bodyinmind.com.au Copyright GL Moseley 2009 Graded motor imagery 1. Implicit motor imagery (left/right judgement task) 2. Explicit motor imagery (imagined movements) Moseley (2004) Pain; 108: 192-8; Moseley (2005) Pain 114;54-61 Moseley (2006) Neurology 67 2129-34
  • 35. www.bodyinmind.com.au Imagined limb movements Copyright GL Moseley 2009 One image is shown at a time Software is online and via CD “Recognise” www.noigroup.com “Imagine adopting this posture with your own hand and then returning it to where it is. Imagine a pain-free, smooth movement”. Objectives: - Little or no symptom provocation - Task is easy or boring
  • 36. www.bodyinmind.com.au Copyright GL Moseley 2009 Graded motor imagery 1. Implicit motor imagery (left/right judgement task) 2. Explicit motor imagery (imagined movements) 3. Mirror movements Moseley (2004) Pain; 108: 192-8; Moseley (2005) Pain 114;54-61 Moseley (2006) Neurology 67 2129-34
  • 37. www.bodyinmind.com.au Mirror movements Copyright GL Moseley 2009 “Gently adopt the posture shown with both hands, while watching the mirror image of your good hand”. Objectives: -Little or no symptom provocation -Movement is not dystonic -Movement L & R similar in range and speed - Task is easy or boring
  • 38. www.bodyinmind.com.au Single n Copyright GL Moseley 2009 itio blind d ine gn RCT or ag co irr Im Re M MIP MIP 50 Neuropathic pain scale Crossed over 20 0 2 4 6 12 18 24 Moseley(2004) Pain; 108: 192-8; Time (weeks)
  • 39. www.bodyinmind.com.au Copyright GL Moseley 2009 Single blind • CRPS of arm or leg RCT • 18-75 years old • No other diagnoses Moseley (2006) Neurology 67 2129-34 • English-proficient • Presented to GP, physiotherapy, pain management or neurology
  • 40. www.bodyinmind.com.au Single Copyright GL Moseley 2009 blind RCT Moseley (2006) Neurology 67 2129-34
  • 41. www.bodyinmind.com.au Single Copyright GL Moseley 2009 blind RCT Moseley (2006) Neurology 67 2129-34
  • 42. www.bodyinmind.com.au Single Copyright GL Moseley 2009 blind RCT NNT to get a 50% reduction in pain Post-MIP = 3 (2-6) 6 months = 2 (1-5) NNT to get a 4/10 point increase in function Post-MIP = 4 (2-11) 6 months = 3 (2-4) Moseley (2006) Neurology 67 2129-34
  • 43. www.bodyinmind.com.au Copyright GL Moseley 2009 Why train the brain? Our approach to treating CRPS Go to the Brain changes next set of S1 reorganisation slides: Reorganisation elsewhere? ‘training the brain part 2’