1. Curriculum Vitae
Bryan A. Krantz, Ph.D.
Associate Professor, Department of Microbial Pathogenesis
University of Maryland School of Dentistry
Date March 26, 2015
Contact Information
Business Address: Department of Microbial Pathogenesis
University of Maryland - Baltimore
School of Dentistry
Rm 9207
650 W. Baltimore Street - 8 South
Baltimore, MD 21201
Business Phone Number: (410) 706-1656
Fax: N/A
Email: bkrantz@umaryland.edu
Foreign Languages: N/A
Education
1996 B.S. Chemistry with Highest Honors, B.A. English, Emory University
2002 Ph.D., Biochemistry & Molecular Biology, University of Chicago, Thesis Advisor – Tobin
R. Sosnick
Post Graduate Education and Training
1996-1997 Research Technician, Department of Biochemistry, Emory University School of Medicine,
Advisor – Keith W. Wilkinson
2002-2003 Post-doctoral Fellowship, Biochemistry & Molecular Biology, University of Chicago,
Advisor – Tobin R. Sosnick
2003-2006 Post-doctoral Fellowship, Microbiology and Molecular Genetics, Harvard Medical School,
Advisor – R. John Collier
Certifications
N/A
Medical Licensures
N/A
Employment History
Academic Appointments

2. Krantz, Bryan A
2006-2014 Assistant Professor, Chemistry, University of California, Berkeley
2006-2014 Assistant Professor, Molecular and Cell Biology, University of California, Berkeley
2014-present Associate Professor, Department of Microbial Pathogenesis, University of Maryland
School of Dentistry
Professional Society Membership
2004-present General Member, Biophysical Society
2002-present General Member, Protein Society
2010-present General Member, American Microbiology Society
Honors and Awards
2014 Ron Hites Award, American Society for Mass Spectrometry, distinguished mass
spectrometry article.
2013 Selected Young Investigator Speaker, Protein Society, distinguished meeting abstract for a
young investigator.
2004-2006 National Research Service Award Postdoctoral Fellowship, National Institute of Health,
awarded for distinguished post-doctoral research proposal.
2003 Departmental Dissertation Award in Biochemistry & Molecular Biology, University of
Chicago, award received for distinguished Ph.D. dissertation.
1997-2001 National Institute of Health Training Grant, University of Chicago, distinguished as top
student in biochemistry and molecular biology department.
1996 Highest Honors in Chemistry, Emory University.
1996 Chemistry Departmental Award, Emory University, distinguished as top student in
chemistry department.
1995 Sigma Tau Delta English Honor Society, Emory University.
1995 Howard Hughes Undergraduate Research Fellowship, Emory University.
1995 Phi Βeta Kappa, Emory University.
1992-1996 Dean’s Scholarship, Emory University.
Press Highlights
1. Celia Henry. “Toxin Channeling.” Chemical & Engineering News. 2005; 83: 13.
2. Gunnar von Heijne. Enhanced Perspectives article: “Translocation of Anthrax Toxin: Lord of the
Rings.” Science. 2005; 309: 709.
3. Liz Savage. “Bryan Krantz: From folding to unfolding proteins. Interview by Liz Savage." The
Journal of Cell Biology. 2009; 184: 618.
4. Eva Gordon. “Spotlight: The Tale of Anthrax Unfolds.” ACS Chem. Biol. 2010; 5: 1093.
5. “In this issue: Ratcheting up protein translocation with anthrax toxin.” Protein Sci. 2012; 21: 606.
Clinical Activities
Clinical Expertise
N/A
Scope of Clinical Practice:
N/A
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3. Krantz, Bryan A
Development of any Clinical Programs:
N/A
Administrative Service
Institutional Service
2007-2009 Graduate Student Recruitment Committee, Department of Molecular & Cell Biology,
University of California, Berkeley.
2007-2009 Structural & Quantitative Biology Seminar Coordinator, Department of Chemistry,
University of California, Berkeley.
2010 Graduate Student 1st Year Advisor, Department of Molecular & Cell Biology, University of
California, Berkeley.
2010-2013 Undergraduate Chemical Biology Advisor, Department of Chemistry, University of
California, Berkeley.
2012-2013 Graduate Student 2nd Year Advisor, Department of Molecular & Cell Biology, University
of California, Berkeley.
2012-2013 Graduate Chemical Biology Program Advisor, Department of Chemistry, University of
California, Berkeley.
2012-2013 Coordinator of Ethics Seminar Series for Non-MCB Graduate Students, Department of
Chemistry, University of California, Berkeley.
2014 Ethics Lecturer. Department of Molecular & Cell Biology, University of California,
Berkeley.
2013-2014 Committee on Laboratory & Environmental Biosafety (CLEB), University of California,
Berkeley.
Local and National Service
National Service
2014-Present Editorial Board, Science Open
2012 Ad Hoc Reviewer, NIH Study Section, Partnerships for Development of Therapeutics and
Diagnostics for Biodefense (R01) (RFA: RFA-AI-12-017 )
2006-Present Ad Hoc Reviewer, J. Mol. Biol., PNAS, J. Bacteriology, J. Gen. Phys., Cell, Biophysical Journal,
Protein Science, PLOS ONE, PLOS Pathogens, Molecular Microbiology, and Biochemistry.
Local Service
N/A
Teaching Service
High School Student Teaching
2008 Mentor, Summer Research, University of California, Berkeley
1 undergraduate, Keng Lam from Albany High School, daily contact for the summer.
Undergraduate Student Teaching
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4. Krantz, Bryan A
Undergraduate Coursework
2013 Turing's Brave New Digital World: History, Achievements, and Limits of Interfacing the
Real World with a Digital One (MCB 90A), University of California, Berkeley
5, 1st
and 2nd
year undergraduates – 20 contact hours/semester
2014 General Chemistry Laboratory (CHEM 1AL), University of California, Berkeley
800, 1st
year undergraduates - 100 contact hours/semester
2011-2013 Survey of the Principles of Biochemistry and Molecular Biology (MCB 102), University of
California, Berkeley
400-500, 3rd
, and 4th
year undergraduates (upper-division) – 50 contact hours/semester
2011-2013 Biophysical Chemistry: The Molecules of Life: Physical Principles and Cellular Functions
(CHEM C130 / MCB C100A), University of California, Berkeley
100-200, 2nd
, 3rd
, and 4th
year undergraduates (upper-division) – 75 to 150 contact
hours/semester
2009-2010 General Biochemistry & Molecular Biology Laboratory (MCB 110L), University of
California, Berkeley
70, 4th
year undergraduates (upper-division) – 50 contact hours/semester
2008 Survey of the Principles of Biochemistry and Molecular Biology (MCB 102), University of
California, Berkeley
400-500, 3rd
, and 4th
year undergraduates (upper-division) – 50 contact hours/semester
2007-2008 Biophysical Chemistry: The Molecules of Life: Physical Principles and Cellular Functions
(CHEM C130 / MCB C100A), University of California, Berkeley
100-200, 2nd
, 3rd
, and 4th
year undergraduates (upper-division) – 75 contact hours/semester
Undergraduate Laboratory Mentoring
2014-2013 Undergraduate Research, University of California, Berkeley
2 undergraduates, Vivian LeTran and King Yeung (Justin) Hong, biweekly contact for fall
and spring semesters with daily contact for summer
2013 Amgen summer scholar, University of California, Berkeley
1 undergraduate, Kristin Wucherer, daily contact for summer
2012-2013 Undergraduate Research, University of California, Berkeley
1 undergraduate, Sharyu Barapatrey, biweekly contact for fall and spring semesters
2012 Amgen summer scholar, University of California, Berkeley
1 undergraduate, Naomi Latorraca, daily contact for summer
2009-2012 Undergraduate Research and Paid Technician, University of California, Berkeley
1 undergraduate, Iok I Tang, biweekly and daily contact for fall/ spring and summer
semesters, respectively
2010-2012 Undergraduate Research, University of California, Berkeley
1 undergraduate, Omid Amidi, biweekly and daily contact for fall/ spring and summer
semesters, respectively
2011-2012 Undergraduate Research, University of California, Berkeley
1 undergraduate, Jordana Sandy, biweekly contact for fall and spring semesters
2011-2012 Undergraduate Research with Honors Thesis, University of California, Berkeley
1 undergraduate, Claire Johns, triweekly contact for fall and spring semesters
2010-2011 Undergraduate Research, University of California, Berkeley
4 undergraduates, Seth Garwin, David Gomes, Amir Katz, and Gina Chirichella, biweekly
contact for fall and spring semesters
2008-2009 Amgen summer scholar and Paid summer technician, University of California, Berkeley
1 undergraduate, Evan Worden, daily contact for summers
2006-2009 Undergraduate Research with Honors Thesis, University of California, Berkeley
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5. Krantz, Bryan A
1 undergraduate, Allen Kwong, daily contact for fall, spring, and summer semesters
2009 Undergraduate Research, University of California, Berkeley
1 undergraduates, George Shan, biweekly contact for fall and spring semesters
2006-2008 Undergraduate Research with Honors Thesis, University of California, Berkeley
1 undergraduate, Shoshana Greenberg, daily contact for fall, spring, and summer
semesters
2008-2007 Undergraduate Research, University of California, Berkeley
1 undergraduate, Amy Chang, daily contact for fall, spring, and summer semesters
2008 Undergraduate Research, University of California, Berkeley
2 undergraduates, Sarah Watson and Paulina Bukshpun, weekly contact for fall and spring
semesters
Medical Student Teaching
N/A
Resident and Fellow Teaching
Post-doctoral Research Mentoring
2013-2014 Post-doctoral Fellow Research, University of California, Berkeley
3 fellows, Christopher Agnew, Ph.D. from Bristol University, UK, Fang Wu, Ph.D. from
Brandeis University, and Debasis Das, Ph.D. from University of Calcutta, Calcutta, India,
10-15 contact hours per week
2012 Post-doctoral Fellow Research, University of California, Berkeley
1 fellow, Alexander Kintzer, Ph.D. 2012, from University of California, Berkeley, 10
contact hours per week
2011-2012 Post-doctoral Fellow Research, University of California, Berkeley
Melinda Hanes, Ph.D. 2011-2012, from University of California, Berkeley, 5 contact hours
per week
2009-2011 Post-doctoral Fellow Research, University of California, Berkeley
1 fellow, Sarah Wynia-Smith, Ph.D. 2009-2011, from University of Madison-Wisconsin, 5
contact hours per week
Post-Graduate Teaching
Graduate Coursework
2007 Principles of Cellular Protein Unfolding and Translocation Across Membranes (MCB 290),
University of California, Berkeley
15, 2nd
, 3rd
, and 4th
year graduate students – 30 contact hours/semester
Graduate Research Mentoring
2013-2014 Research Mentor, University of California, Berkeley
1, post-graduate, Alexandra Courtis (Biophysics), 2 hours per week
2012-2014 Research Mentor, University of California, Berkeley
1, post-graduate, Catherine Cassou (Chemistry), 2 hours per week
2008-2013 Research Mentor, University of California, Berkeley
1, post-graduate, Michael Brown (Molecular & Cell Biology), 5 hours per week
2008-2012 Research Mentor, University of California, Berkeley
1, post-graduate, Jen Colby (Molecular Toxicology), 5 hours per week
2007-2012 Research Mentor, University of California, Berkeley
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6. Krantz, Bryan A
1, post-graduate, Alexander Kintzer (Chemistry), 5 hours per week
2007-2012 Research Mentor, University of California, Berkeley
1, post-graduate, Geoffrey Feld (Chemistry), 5 hours per week
2006-2011 Research Mentor, University of California, Berkeley
1, post-graduate, Katie Thoren (Chemistry), 5 hours per week
2008-2010 Research Mentor, University of California, Berkeley
1, post-graduate, Adam Schawel (Chemistry), 5 hours per week
2007-2008 Research Mentor, University of California, Berkeley
1, post-graduate, Samuel Stephenson (Molecular & Cell Biology), 5 hours per week
Graduate Dissertation Committee Mentoring
2008-2013 Member Dissertation Committee, University of California, Berkeley
1, post-graduate, Heather Marie Jensen (Chemistry), Title: “Engineering Escherichia coli
for molecularly defined electron transfer to metal oxides and electrodes”, 2 hours per year
2008-2013 Member Dissertation Committee, University of California, Berkeley
1, post-graduate, Kathryn Ming Hart (Chemistry), Subject: Protein Folding/Protein
Engineering, 4 hours per year
2008-2013 Chairman Dissertation Committee, University of California, Berkeley
1, post-graduate, Michael Brown (Molecular & Cell Biology), Title: “Anthrax lethal toxin
unfolding and translocation via a charge-state ratchet”, 15 hours per year
2008-2012 Chairman Dissertation Committee, University of California, Berkeley
1, post-graduate, Jennifer Colby (Molecular Toxicology), Title: “Investigation of the
hydrophobic/steric ratchet mechanism of the anthrax toxin ϕ clamp”, 15 hours per year
2007-2012 Chairman Dissertation Committee, University of California, Berkeley
1, post-graduate, Alexander Kintzer (Chemistry), Title: “Structure-Function Studies of
Anthrax Protective Antigen Octamer”, 15 hours per year
2007-2012 Chairman Dissertation Committee, University of California, Berkeley
1, post-graduate, Geoffrey Feld (Chemistry), Title: “Molecular Mechanisms of Anthrax
Toxin Assembly and Transport”, 15 hours per year
2008-2012 Member Dissertation Committee, University of California, Berkeley
1, post-graduate, Bryan Schmidt (Molecular & Cell Biology), Title: “Control of strand
scission by type IIA topoisomerases”, 4 hours per year
2007-2011 Member Dissertation Committee, University of California, Berkeley
1, post-graduate, Katherine Miller (Biophysics), Title: “Probing the mechanism of 3D-
domain swapping”, 4 hours per year
2007-2011 Member Dissertation Committee, University of California, Berkeley
1, post-graduate, Christina Baer (Biophysics), Title: “Mechanisms of Mycobacterium
tuberculosis Serine/Threonine Protein Kinase Activation”, 4 hours per year
2007-2011 Member Dissertation Committee, University of California, Berkeley
1, post-graduate, Veronica Zepeda (Molecular & Cell Biology), Title: “Mechanisms and
Regulation of Cellulose Degradation by Clostridia papyrosolvens C7 and Neurospora
crassa”, 4 hours per year
2006-2011 Chairman Dissertation Committee, University of California, Berkeley
1, post-graduate, Katie Thoren (Chemistry), Title: “Mechanisms of translocation-coupled
protein unfolding using anthrax toxin as a model”, 15 hours per year
2006-2009 Member Dissertation Committee, University of California, Berkeley
1, post-graduate, Randall McNally (Chemistry), Title: “Structural and biochemical analysis
of sliding clamps in DNA replication and DNA damage checkpoints”, 4 hours per year
2006-2009 Member Dissertation Committee, University of California, Berkeley
1, post-graduate, Jake Siegel (Biophysics), Title: “Biophysical Characterization of Nucleo-
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7. Krantz, Bryan A
cytoplasmic Transport and Small Length Scale DNA Bending using Integrated Optical
Probes”, 4 hours per year
2006-2009 Member Dissertation Committee, University of California, Berkeley
1, post-graduate, Sebastian Deindl (Comparative Biochemistry), Title: “Structural basis for
the inhibition of tyrosine kinase activity of ZAP-70”, 4 hours per year
Graduate Qualifying Examination Mentoring
2006-2007 Member/Chair Graduate Qualifying Examination Committee, University of California,
Berkeley
4, post-graduates, Susheela Carroll, Katherine Miller, Roseanne Wincek (Chair), and
Christina Baer, 20 contact hours
2007-2008 Member/Chair Graduate Qualifying Examination Committee, University of California,
Berkeley
5, post-graduates, Katelyn Spillane, Sonny Hsiao, William Beeson, Katie Hart, and Jake
Siegel (Chair), 25 contact hours
2008-2009 Member/Chair Graduate Qualifying Examination Committee, University of California,
Berkeley
10, post-graduates, Peter Mustonen, Sara Curtiss, Michael Cianfrocco, Heather Jensen,
Hong-Ngoc Do, Gregory Alushin (Chair), Bryan Schmidt, Brooks Bond-Watts, Chris
Phillips, and Charlie Liu (Chair), 50 contact hours
2009-2010 Member/Chair Graduate Qualifying Examination Committee, University of California,
Berkeley
5, post-graduates, Lissette Andres, Richard Ramirez, Zhijuan Gao, Laura Rosen, and
Charlie Liu (Chair), 25 contact hours
2010-2011 Member/Chair Graduate Qualifying Examination Committee, University of California,
Berkeley
7, post-graduates, Eric Estrin (Chair), Tony Chen, Manchuta (Pim) Dangkulwanich, Chris
Reyes (Chair), Sasha Shekhar, Christian Herold, and Shachi Katira, 35 contact hours
2011-2012 Member/Chair Graduate Qualifying Examination Committee, University of California,
Berkeley
3, post-graduates, Katherine Alfieri, Tristan De Rond, and Douglas Fox, 15 contact hours
2012-2013 Member/Chair Graduate Qualifying Examination Committee, University of California,
Berkeley
6, post-graduates, David Spiciarich, Daniel Mortensen, Yuan-Chi Huang, Kun Zhu, Lin
Yuan, and Caleb Cassidy-Amstutz (Chair), 30 contact hours
2013-2014 Member/Chair Graduate Qualifying Examination Committee, University of California,
Berkeley
3, post-graduates, Andrew Elliott, Mireille Kamariza, and Dawn Lipscomb, 15 contact
hours
Grant Support
Active Grants:
01/10/2013 – 12/31/2017 PI: B. Krantz (100%)
“Physical Principles of bacterial toxin translocation across membranes”
NIH 2R01 AI077703-05
Annual Direct Costs: $337,448
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8. Krantz, Bryan A
Total Direct Costs: $1,687,241
Completed Grants:
2008-2012 PI: B. Krantz (100%)
“Physical Principles of bacterial toxin translocation across membranes”
NIH R01 AI077703
Annual Direct Costs: $363,902
Total Direct Costs: $1,455,606
Publications
Peer-reviewed journal articles
1. Amerik, A, Swaminathan, S, Krantz, BA, Wilkinson, KD, Hochstrasser, M. “In vivo disassembly
of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the
proteasome.” EMBO J. 1997: 16: 4826.
2. Larsen, CN, Krantz, BA, Wilkinson, KD. “Substrate specificity of deubiquitinating enzymes:
ubiquitin C-terminal hydrolases.” Biochemistry. 1998: 37: 3358.
3. Krantz, BA, Moran, LB, Kentsis, A, Sosnick, TR. “D/H amide isotope effects reveal when
hydrogen bonds form during protein folding.” Nature Struct. Biol. 2000: 7: 62.
4. Yin, L, Krantz, B, Russell, NS, Deshpande, S, Wilkinson, KD. “Nonhydrolyzable diubiquitin
analogues are inhibitors of ubiquitin conjugation and deconjugation.” Biochemistry. 2000:
39:10001.
5. Krantz, BA, Sosnick, TR. (2000) “Distinguishing between two-state and three-state models for
ubiquitin folding.” Biochemistry. 2000: 39: 11696.
6. Krantz, BA, Sosnick, TR. “Engineered metal binding sites map the heterogeneous folding
landscape of a coiled coil.” Nature Struct. Biol. 2001: 8: 1042.
7. Shi, Z, Krantz, BA, Kallenbach, N, Sosnick, TR. “Contribution of hydrogen bonding to protein
stability estimated from isotope effects.” Biochemistry. 2002: 41: 2120.
8. Krantz, BA, Srivastava, AK, Nauli, S, Baker, D, Sauer, RT, Sosnick, TR. “Understanding protein
hydrogen bond network formation with kinetic D/H amide isotope effects.” Nature Struct. Biol.
2002: 9: 458.
9. Krantz, BA, Mayne, L, Rumbley, J, Englander, SW, Sosnick, TR. “Fast and slow intermediate
accumulation and the initial barrier mechanism in protein folding.” J. Mol. Biol. 2002: 324: 359.
10. Krantz, BA, Dothager, R, Sosnick, TR. “Discerning the structure and energy of multiple
transition states in protein folding using ψ-analysis.” J. Mol. Biol. 2004: 337: 463.
11. Jacob, J, Krantz, B, Dothager, RS, Thiyagarajan, P, Sosnick, TR. “Early collapse is not an obligate
step in protein folding.” J. Mol. Biol. 2004: 338: 369.
12. Pimental, RL, Christensen, KA, Krantz, BA, Collier, RJ. “Anthrax toxin complexes: heptameric
protective antigen can bind lethal factor and edema factor simultaneously.” Biochem. Biophys.
Res. Comm. 2004: 322: 258.
13. Wigelsworth DJ, Krantz BA*, Christensen KA, Lacy DB, Juris SJ, Collier RJ. “Binding
stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with
protective antigen.” J. Biol. Chem. 2004: 279: 23349. *Contributed equally to this work.
14. Sosnick, TR, Dothager, RS, Krantz, BA. “Differences in the folding transition state of ubiquitin
indicated by ϕ- and ψ-analyses.” Proc. Natl Acad. Sci. 2004: 101: 17377.
15. Krantz, BA, Trivedi, AD, Cunningham, K, Christensen, KA, Collier, RJ. “Anthrax toxin’s lethal
and edema factors unfold under acidic pH conditions.” J. Mol. Biol. 2004: 344: 739.
16. Christensen, KA, Krantz, BA*, Melnyk, RA, Collier, RJ. “Interaction of the 20 kDa and 63 kDa
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9. Krantz, Bryan A
fragments of anthrax protective antigen: kinetics and thermodynamics.” Biochemistry. 2004: 44:
1047. *Contributed equally to this work.
17. Krantz, BA, Melnyk, RA, Zhang, S, Juris, SJ, Lacy, DB, Wu, Z, Finkelstein, A, Collier, RJ. “A
phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore.” Science.
2005: 309: 777.
18. Wolfe JT, Krantz, BA, Rainey, GJA, Young, JAT, Collier, RJ. “Whole-cell voltage clamp
measurements of anthrax protective antigen pores.” J. Biol. Chem. 2005: 280: 39417.
19. Christensen, KA, Krantz, BA, Collier, RJ. “The assembly and disassembly kinetics of anthrax
toxin complexes.” Biochemistry. 2006: 45: 2380.
20. Krantz, BA, Finkelstein, A, Collier, RJ. “Protein translocation through the anthrax toxin
transmembrane pore is driven by a proton gradient.” J. Mol. Biol. 2006: 355: 968.
21. Sosnick, TR, Krantz, BA, Dothager, RS, Baxa, M. “Characterizing the protein folding transition
state using Ψ analysis.” Chem. Rev. 2006: 106: 1862.
22. Kintzer, AF, Thoren, KL, Sterling, HJ, Dong, KC, Feld, GK, Tang, II, Zhang, TT, Williams, ER,
Berger, JM, Krantz, BA. “The protective antigen component of anthrax toxin forms functional
octameric complexes.” J. Mol. Biol. 2009: 292: 614.
23. Thoren, KL, Worden, EJ, Yassif, JM, Krantz, BA. “Lethal factor unfolding is the most force-
dependent step of anthrax toxin translocation.” Proc. Natl Acad. Sci. 2009: 106: 21555.
24. Kintzer, AF, Sterling, HJ, Tang, II, Abdul-Gader, A, Miles, AJ, Wallace, BA, Williams, ER,
Krantz, BA. “Role of the protective antigen octamer in the molecular mechanism of anthrax
lethal toxin stabilization in plasma.” J. Mol. Biol. 2010: 399: 741.
25. Kintzer, AF, Sterling, HJ, Williams, ER, Krantz, BA. “Anthrax toxin receptor drives protective
antigen oligomerization and stabilizes the heptameric and octameric oligomer by a similar
mechanism.” PLoS ONE. 2010: 5(11):e13888.
26. Feld, GF, Thoren, KL, Kintzer, AF, Sterling, HJ, Tang, II, Greenberg, SG, Williams, ER, Krantz,
BA. “Structural basis for the unfolding of anthrax lethal factor by the protective antigen
oligomers.” Nature Struct. Mol. Biol. 2010: 17:1383.
27. Sterling, HJ, Daly, MP, Feld, GK, Thoren, KL, Kintzer, AF, Krantz, BA, Williams, ER. “Effects
of supercharging reagents on noncovalent complex structure in electrospray ionization from
aqueous solutions.” J. Am. Soc. Mass. Spectrom. 2010: 21: 1762.
28. Sterling, HJ, Cassou, CA, Trnka, MJ, Burlingame, AL, Krantz, BA, Williams, ER. “The role of
conformational flexibility on protein supercharging in native electrospray ionization” Phys. Chem.
Chem. Phys. 2011: 13: 18288.
29. Thoren, KL, Krantz, BA. “The unfolding story of anthrax toxin translocation” Mol. Microbiol.
2011: 80: 588.
30. Brown, MJ, Thoren, KL, Krantz, BA. “Charge requirements for proton gradient-driven
translocation of anthrax toxin.” J. Biol. Chem. 2011: 286: 23189.
31. Sterling, HJ, Kintzer, AF, Feld, GK, Cassou, CA, Krantz, BA, Williams, ER. “Supercharging
protein complexes from aqueous solution disrupts their native conformations.” J. Am. Soc. Mass.
Spectrom. 2012: 23: 191.
32. Feld, GK, Kintzer, AF, Tang, II, Thoren, KL, Krantz, BA. “Domain flexibility modulates the
heterogeneous assembly mechanism of anthrax protective antigen.” J. Mol. Biol. 2012: 415: 159.
33. Feld, GK, Brown, MJ, Krantz, BA. “Ratcheting up protein translocation with anthrax toxin.”
Protein Sci. 2012: 21: 606.
34. von Moltke, J, Trinidad, NJ, Moayeri, M, Kintzer, AF, Wang, SM, Rooijen, N, Brown, CR,
Krantz, BA, Leppla, SH, Gronert, K, Vance, RE. “Rapid induction of lipid mediators is a novel
effector function of the inflammasome in vivo” Nature. 2012: 490: 107.
35. Kintzer, AF, Tang, II, Schawel, AK, Brown, MJ, Krantz, BA. “Anthrax toxin protective antigen
integrates poly-γ-D-glutamate and pH signals to sense the optimal environment for channel
formation.” Proc. Natl Acad. Sci. 2012: 109: 18378.
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10. Krantz, Bryan A
36. Wynia-Smith, SL, Brown, MJ, Chirichella, G, Krantz, BA. “Electrostatic ratchet in the protective
antigen channel promotes anthrax toxin translocation.” J. Biol. Chem. 2012: 287: 43753.
37. Abrami, L, Brandi, L, Moayeri, M, Brown, MJ, Krantz, BA, Leppla, SH, van der Goot, FG.
“Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance
Action of Anthrax Toxin.” Cell Rep. 2013: 5: 986.
Non-peer reviewed journal articles
1. Krantz, BA. Protein Folding: New Methods Unveil Rate-limiting Structures. Ph.D. diss., U. of
Chicago. 2002.
2. Pandit, AD, Krantz, BA, Dothager, RS, Sosnick, TR. “Characterizing protein folding transition
States using Ψ-analysis.” Methods Mol. Biol. 2007: 350: 83.
Patents
Krantz BA, Kintzer AF, von Moltke JH. (filed Jan. 10, 2012; recordation Aug. 15, 2012; refiled Jan. 20,
2013) “Poly-Glutamic Acid Anti-Anthrax Composition and Methods for Using the Same” US Application
Serial Nos. 61/585,183 and 13/738,911.
Book Chapters
N/A
Major Invited Speeches
Local
1. Krantz, BA. “When Do Hydrogen Bonds Form? D/H Backbone Amide Isotope Effects in Protein
Folding Kinetics.” University of Chicago. Lake Geneva, WI. Oct 1998.
2. Krantz, BA. “Realizing protein hydrogen bond network formation with kinetic D/H amide
isotope effects.” University of Chicago. Chicago, IL. Dec 2001.
3. Krantz, BA. “Small molecules target protective antigen’s phenylalanine clamp—the site required
to translocate lethal & edema factor into the host cell.” 2nd Annual Retreat of the New England
Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research.
Durham, NH. Sep 2005.
4. Krantz, BA. “Anthrax toxin's protective antigen pore: a protein translocase with a chaperone-like
active site.” Harvard Medical School Dept. of Biological Chemistry & Molecular Pharmacology
Seminar Series. Boston, MA. Oct 2005.
National
5. Krantz, BA. “The protective antigen binding domains of the lethal and edema factors of anthrax
toxin unfold under acidic pH conditions.” 49th Meeting of The Biophysical Society. Long Beach,
CA. Feb 2005.
6. Krantz, BA. “Anthrax toxin translocation.” 50th Meeting of The Biophysical Society. Salt Lake
City, UT. Feb 2006.
7. Krantz, BA. “How the anthrax toxin pore unfolds and then translocates its enzymatic factors
across bilayer membranes.” Biopolymers Gordon Research Conference. Newport, RI. Jun 2006.
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11. Krantz, Bryan A
8. Krantz, BA. “Molecular mechanisms of anthrax toxin translocation” Bay Area Microbial
Pathogenesis Symposium (BAMPS). University of California, San Francisco. 2008-Mar-29.
9. Krantz, BA. “Anthrax toxin assembly & translocation: an interplay of form & function” Gordon
Research Conference. Microbial Toxins & Pathogenicity. Proctor Academy, Andover, NH. 2008-
Jul-13-18.
10. Krantz, BA. “Structural Basis for the Pre-Translocation Unfolding of Proteins by Anthrax Lethal
Toxin.” Children's Hospital Oakland Research Institute (CHORI). Oakland, CA. 2009-Oct-06.
11. Krantz, BA. “Structural basis for the pre-translocation unfolding of proteins by anthrax lethal
toxin” University of California, Davis School of Medicine. Davis, CA. 2009-Dec-07.
12. Krantz, BA. “Structural basis for the unfolding of anthrax lethal factor by protective antigen”
University of Chicago. Chicago, IL. 2010-May-25.
13. Krantz, BA. “Structural basis for the unfolding of anthrax lethal factor by protective antigen”
Albert Einstein College of Medicine. Bronx, NY. 2010-Nov-04.
14. Krantz, BA. “Unfolding story of anthrax toxin protein translocation.” New York University.
2011-Nov-08.
15. Krantz, BA. “Unfolding story of anthrax toxin protein translocation” Brandeis University. 2011-
Nov-09.
16. Krantz, BA. “Insights on the molecular mechanism of transmembrane protein transport using
anthrax toxin as a model system.” Northwestern University. 2011-Dec-08.
17. Krantz, BA. “Insights on the molecular mechanism of transmembrane protein transport using
anthrax toxin as a model system.” University of Madison-Wisconsin. 2011-Dec-15.
18. Krantz, BA. “Insights on the molecular mechanism of transmembrane protein transport using
anthrax toxin as a model system.” University of California, Los Angeles. 2012-Jan-17.
19. Krantz, BA. “Anthrax toxin protein translocation powered by hydrogen+” Biophysical Society.
San Diego, California. 2012-Feb-25.
20. Krantz, BA. “Trafficking and transport: new molecular mechanisms of anthrax toxin regulation.”
Gordon Research Conference. Microbial Toxins & Pathogenicity. Waterville Valley, NH. 2012-Jul-
09.
21. Krantz, BA. “Molecular insights on anthrax toxin translocation and trafficking” Quantitative
Biosciences Seminar. University of California, Berkeley. Berkeley, CA. 2012-Nov-19.
22. Krantz, BA. “Molecular insights on anthrax toxin translocation and trafficking” Biosciences &
Biotechnology Seminar. Lawrence Livermore National Laboratory. Livermore, CA. 2013-Jan-10.
23. Krantz, BA. “Molecular insights on anthrax toxin translocation and trafficking” National
Institutes of Health. Bethesda, MD 2013-Feb-26.
24. Krantz, BA. “Molecular insights on anthrax toxin translocation and trafficking” Tufts Medical
School. Boston, MA. 2013-June-12
25. Krantz, BA. “Anthrax toxin protective antigen promotes lethal factor unfolding and translocation
using an α-helical clamp.” Selected as Young Investigator Speaker. 27th Annual Protein Society
Meeting. Boston, MA. 2013-Jul-21.
26. Krantz, BA. “Anthrax toxin protective antigen promotes lethal factor unfolding and translocation
using an α-helical clamp.” 2013 Madison Molecular Genetics of Bacteria & Phages Meeting.
University of Wisconsin-Madison. Madison, WI. 2013-Aug-06-10.
27. Krantz, BA. “Molecular insights on anthrax toxin translocation and trafficking” University of
Chicago Department of Microbiology. Chicago, IL. 2013-Aug-12.
28. Krantz, BA. “Molecular mechanisms of anthrax toxin translocation and trafficking.” University
of Maryland-Baltimore School of Dentistry. Baltimore, MD. 2013-Sept-30.
29. Krantz, BA. “Molecular mechanisms of anthrax toxin translocation and trafficking.” The United
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12. Krantz, Bryan A
States Army Medical Research Institute for Infectious Diseases (USAMRIID). Frederick, MD.
2013-Oct-1.
30. Krantz, BA. “Molecular mechanisms of anthrax toxin translocation and trafficking.” University
of Maryland-Baltimore School of Medicine. Baltimore, MD. 2013-Nov-11.
31. Krantz, BA. “Molecular mechanisms of anthrax toxin translocation and trafficking.” Worchester
Polytechnic Institute. Worchester, MA. 2013-Dec-9.
32. Krantz, BA. “Molecular mechanisms of anthrax toxin translocation and trafficking.” Purdue
University. West Lafayette, IN. 2014-Jan-25.
33. Krantz, BA. “Molecular mechanisms of anthrax toxin translocation and trafficking.” University
of Massachusetts, Amherst. Amherst, MA. 2014-Sep-25.
34. Krantz, BA. “Anthrax toxin protective antigen promotes lethal factor unfolding and translocation
using an α-helical clamp.” Mid-Atlantic Microbial Pathogenesis Meeting. Wintergreen, VA. 2015-
Jan-27.
35. Krantz, BA. “Molecular insights on anthrax toxin translocation.” Advanced Physics Laboratory.
Laurel, MD. 2015-Feb-27.
36. Krantz, BA. “Detecting a Virulence Factor with Many Disguises: Anthrax Toxin's Heterogeneous
Assembly Mechanism Controls Its Stability.” Gordon Research Conference on Chemical &
Biological Terrorism Defense. Ventura, CA. 2015-Mar-10.
37. Krantz, BA. “Molecular insights on anthrax toxin unfolding & translocation.” Catholic
University. Washington, D.C. 2015-Mar-16.
38. Krantz, BA. “Molecular insights on anthrax toxin unfolding & translocation.” University of
Maryland, College Park. Maryland, MD. 2015-Apr-10.
International
39. Krantz, BA. “Molecular Insights on Anthrax Toxin Unfolding and Translocation across
Membranes” Membrane protein folding meeting. Biophysical Society. Seoul, South Korea. 2013-
May-21.
40. Krantz, BA. “Anthrax toxin protective antigen promotes lethal factor unfolding and translocation
using an α-helical clamp.” European Workshop on Bacterial Protein Toxins (ETOX16).
Universitätsklinikum Freiburg, Albert-Ludwigs-Universität Freiburg. Freiberg, Germany. 2013-
June-25.
41. Krantz, BA. “Molecular insights on anthrax toxin translocation and trafficking” École
Polytechnique Fédérale De Lausanne. Lausanne, Switzerland. 2013-June-27.
42. Krantz, BA. “Molecular insights on anthrax toxin translocation.” Oxford University, UK. 2013-
July-1.
43. Krantz, BA. “Anthrax toxin protective antigen promotes lethal factor unfolding and translocation
using an α-helical clamp.” Southwest structural biology conference (SWSBC). University of
Bristol, UK. 2013-July-2.
44. Krantz, BA. “Anthrax toxin protective antigen promotes lethal factor unfolding and translocation
using an α-helical clamp.” Bacillus ACT 2013. Victoria, British Columbia, Canada. 2013-Sept-1-
5.
45. Krantz, BA. “Allosteric and stereoselective clamps govern protein translocation through the
anthrax toxin protective antigen channel” The 3rd
Prato Conference on Pore Forming Proteins.
Prato, Italy. 2015-May-11-14.
46. Krantz, BA. “Clamp allostery and stereoselectivity govern the molecular mechanism of protein
translocation through the anthrax toxin protective antigen channel” The 6th
Congress of the
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13. Krantz, Bryan A
European Microbiologists. Maastricht, The Netherlands. 2015-Jun-7-11.
Proffered Communications
N/A
Page 13