SlideShare une entreprise Scribd logo
1  sur  24
Using RealTime fMRI Based Neurofeedback
To Probe Default Network Regulation
R. Cameron Craddock, PhD
Director of Imaging, Child Mind Institute
Research Scientist, Nathan Kline Institute
February 25, 2016
Default Network
Task based deactivation
Buckner et al. Ann. N.Y. Acad. Sci. 1124: 1-38 (2008).
Default Network Connectivity
Greicius et. al. 2007 Biol. Psychiatry
DN Dysregulation
Sheline et. al. 2009 PNAS
ICN Competition
Fox MD PNAS 2005
RT Neurofeedback of DMN
• Test hypothesis of DMN dysregulation in
depression, ADHD, aging, etc …
Exp. Design
Class Training
Labels
Training run
Time-Labeled
Scans
Image Recon and SVM
Classification
Image DataData Acquisition
Stimulus Presentation
Stimulus
Conventional FMRI
Test Data Classifier Output
Testing Run
Real-Time Tracking RSNs
LaConte, et al. (2007) Hum Brain Mapp. 28: 1033-1044
Stephen LaConte August 19, 2009
Stimulus seen by volunteer
Updated fMRI
results Motion tracking and correction
Intensity (brightness) of a single voxel, changing
during stimulus conditions
Controller interface for display parameters
Decoding DN Activity
DMN Modulation Task
Modulating the DMN−2−1012
0 100 200 300 400
Best Subject
Worst Subject
TR
Z−scoreDMNActivity
−20246
0 100 200 300 400
TR
Z−scoreDMNActivity
Results
0.00.10.20.30.40.50.6
3 1 7 13 6 9 5 10 11 8 4 2 12
Subject
Accuracy
Feedback
No feedback
FB NOFB
0.10.20.30.40.50.6
1 2 1 2
Scan Number
Accuracy
p = 0.055p = 0.68
Accuracy was measured from Pearson’s correlation between task
paradigm and DMN activity extracted after post-processing.
Behavioral Correlates
Measures that were significantly associated with DN regulation include (p<0.05,
FDR corrected): the affect intensity measure (AIM), ruminative responses scale
(RRS), and the imaginal processes inventory.
RT fMRI Neurofeedback for Children
All data is being prospectively shared
Currently sharing > 10,000 datasets
• 6,422 individuals
– 4 – 90 years old
– 539 ASD
– 383 ADHD
– 72 Schizophrenia
– 29 Cocaine Dependent
– 6 Epilepsy
http://fcon_1000.projects.nitrc.org/
Sharing preprocessed data
• Make data available
to a wider audience
of researchers
• Evaluate
reproducibility of
analysis results
http://preprocessed-connectomes-project.github.io/
Software to enable a new scale of data
analysis
• Very large datasets
– Need to harness high-
performance computing to
expedite processing
• RS fMRI preprocessing is a moving
target
– Many new methods are
proposed all the time
– Need to compare outputs from
different processing strategies
• Many different toolsets have
different strengths
– Need to be able to combine
tools from different packages
http://fcp-indi.github.io/
Principles of Open Neuroscience
Data, tools and ideas should be openly shared
-The Neuro Bureau Manifesto
http://www.neurobureau.org
Acknowledgments
Child Mind Institute
Michael Milham, MD, PhD
Zarrar Shehzad
Nathan Kline Institute
Amalia McDonald
Stan Colcombe, PhD
Bennett Leventhal, MD
NYU – Child Study Center
Adriana DiMartino, MD
F. Xavier Castellanos, MD
VTCRI
Stephen LaConte, PhD
Pearl Chiu, PhD
Jonathan Lisinski, MS
Emory University
Helen Mayberg, MD
This work is funded by: A NARSAD Young
Investigator Award and NIMH R01MH101555
Using RealTime fMRI Based Neurofeedback to Probe Default Network Regulation
Using RealTime fMRI Based Neurofeedback to Probe Default Network Regulation

Contenu connexe

Tendances

Inference of Nonlinear Gene Regulatory Networks through Optimized Ensemble of...
Inference of Nonlinear Gene Regulatory Networks through Optimized Ensemble of...Inference of Nonlinear Gene Regulatory Networks through Optimized Ensemble of...
Inference of Nonlinear Gene Regulatory Networks through Optimized Ensemble of...
Arinze Akutekwe
 
Irina Rish, Researcher, IBM Watson, at MLconf NYC 2017
Irina Rish, Researcher, IBM Watson, at MLconf NYC 2017Irina Rish, Researcher, IBM Watson, at MLconf NYC 2017
Irina Rish, Researcher, IBM Watson, at MLconf NYC 2017
MLconf
 
NeuroPG - Open source software for optical pattern generation and data acquis...
NeuroPG - Open source software for optical pattern generation and data acquis...NeuroPG - Open source software for optical pattern generation and data acquis...
NeuroPG - Open source software for optical pattern generation and data acquis...
Daniel Murphy
 
Comparison of Image Segmentation Algorithms for Brain Tumor Detection
Comparison of Image Segmentation Algorithms for Brain Tumor DetectionComparison of Image Segmentation Algorithms for Brain Tumor Detection
Comparison of Image Segmentation Algorithms for Brain Tumor Detection
IJMTST Journal
 
Task Adaptive Neural Network Search with Meta-Contrastive Learning
Task Adaptive Neural Network Search with Meta-Contrastive LearningTask Adaptive Neural Network Search with Meta-Contrastive Learning
Task Adaptive Neural Network Search with Meta-Contrastive Learning
MLAI2
 
Ijeee 16-19-a novel approach to brain tumor classification using wavelet and ...
Ijeee 16-19-a novel approach to brain tumor classification using wavelet and ...Ijeee 16-19-a novel approach to brain tumor classification using wavelet and ...
Ijeee 16-19-a novel approach to brain tumor classification using wavelet and ...
Kumar Goud
 

Tendances (20)

Inference of Nonlinear Gene Regulatory Networks through Optimized Ensemble of...
Inference of Nonlinear Gene Regulatory Networks through Optimized Ensemble of...Inference of Nonlinear Gene Regulatory Networks through Optimized Ensemble of...
Inference of Nonlinear Gene Regulatory Networks through Optimized Ensemble of...
 
Irina Rish, Researcher, IBM Watson, at MLconf NYC 2017
Irina Rish, Researcher, IBM Watson, at MLconf NYC 2017Irina Rish, Researcher, IBM Watson, at MLconf NYC 2017
Irina Rish, Researcher, IBM Watson, at MLconf NYC 2017
 
Review on classification based on artificial
Review on classification based on artificialReview on classification based on artificial
Review on classification based on artificial
 
A Modified CNN-Based Face Recognition System
A Modified CNN-Based Face Recognition SystemA Modified CNN-Based Face Recognition System
A Modified CNN-Based Face Recognition System
 
Cost-effective Interactive Attention Learning with Neural Attention Process
Cost-effective Interactive Attention Learning with Neural Attention ProcessCost-effective Interactive Attention Learning with Neural Attention Process
Cost-effective Interactive Attention Learning with Neural Attention Process
 
Pattern Recognition using Artificial Neural Network
Pattern Recognition using Artificial Neural NetworkPattern Recognition using Artificial Neural Network
Pattern Recognition using Artificial Neural Network
 
Neural Networks in Data Mining - “An Overview”
Neural Networks  in Data Mining -   “An Overview”Neural Networks  in Data Mining -   “An Overview”
Neural Networks in Data Mining - “An Overview”
 
[Chung il kim] 0829 thesis
[Chung il kim] 0829 thesis[Chung il kim] 0829 thesis
[Chung il kim] 0829 thesis
 
Neural network image recognition
Neural network image recognitionNeural network image recognition
Neural network image recognition
 
IRJET- Prediction of Autism Spectrum Disorder using Deep Learning: A Survey
IRJET- Prediction of Autism Spectrum Disorder using Deep Learning: A SurveyIRJET- Prediction of Autism Spectrum Disorder using Deep Learning: A Survey
IRJET- Prediction of Autism Spectrum Disorder using Deep Learning: A Survey
 
NeuroPG - Open source software for optical pattern generation and data acquis...
NeuroPG - Open source software for optical pattern generation and data acquis...NeuroPG - Open source software for optical pattern generation and data acquis...
NeuroPG - Open source software for optical pattern generation and data acquis...
 
98462-234458-1-PB
98462-234458-1-PB98462-234458-1-PB
98462-234458-1-PB
 
DLD_WeightSharing_Slide
DLD_WeightSharing_SlideDLD_WeightSharing_Slide
DLD_WeightSharing_Slide
 
Hybrid Pixel-Based Method for Multimodal Medical Image Fusion Based on Integr...
Hybrid Pixel-Based Method for Multimodal Medical Image Fusion Based on Integr...Hybrid Pixel-Based Method for Multimodal Medical Image Fusion Based on Integr...
Hybrid Pixel-Based Method for Multimodal Medical Image Fusion Based on Integr...
 
Comparison of Image Segmentation Algorithms for Brain Tumor Detection
Comparison of Image Segmentation Algorithms for Brain Tumor DetectionComparison of Image Segmentation Algorithms for Brain Tumor Detection
Comparison of Image Segmentation Algorithms for Brain Tumor Detection
 
IRJET- Brain Tumor Detection using Hybrid Model of DCT DWT and Thresholding
IRJET- Brain Tumor Detection using Hybrid Model of DCT DWT and ThresholdingIRJET- Brain Tumor Detection using Hybrid Model of DCT DWT and Thresholding
IRJET- Brain Tumor Detection using Hybrid Model of DCT DWT and Thresholding
 
Task Adaptive Neural Network Search with Meta-Contrastive Learning
Task Adaptive Neural Network Search with Meta-Contrastive LearningTask Adaptive Neural Network Search with Meta-Contrastive Learning
Task Adaptive Neural Network Search with Meta-Contrastive Learning
 
Artificial neural network
Artificial neural networkArtificial neural network
Artificial neural network
 
How to create your own artificial neural networks
How to create your own artificial neural networksHow to create your own artificial neural networks
How to create your own artificial neural networks
 
Ijeee 16-19-a novel approach to brain tumor classification using wavelet and ...
Ijeee 16-19-a novel approach to brain tumor classification using wavelet and ...Ijeee 16-19-a novel approach to brain tumor classification using wavelet and ...
Ijeee 16-19-a novel approach to brain tumor classification using wavelet and ...
 

En vedette

Origen del apellido chicote
Origen del apellido chicoteOrigen del apellido chicote
Origen del apellido chicote
bchicote
 

En vedette (20)

David rogers ingles_bloque_5_y_6
David rogers ingles_bloque_5_y_6David rogers ingles_bloque_5_y_6
David rogers ingles_bloque_5_y_6
 
La chimie des couleurs de l'automne
La chimie des couleurs de l'automneLa chimie des couleurs de l'automne
La chimie des couleurs de l'automne
 
Rehasoft MeMotiva Flex
Rehasoft MeMotiva FlexRehasoft MeMotiva Flex
Rehasoft MeMotiva Flex
 
Wouter Blok at Emerce Connect
Wouter Blok at Emerce ConnectWouter Blok at Emerce Connect
Wouter Blok at Emerce Connect
 
Irlanda. diario de viaje
Irlanda. diario de viajeIrlanda. diario de viaje
Irlanda. diario de viaje
 
Io consumatore progetto io sono io vivo
Io consumatore progetto io sono io vivoIo consumatore progetto io sono io vivo
Io consumatore progetto io sono io vivo
 
L'abbandono di rifiuti e il littering
L'abbandono di rifiuti e il litteringL'abbandono di rifiuti e il littering
L'abbandono di rifiuti e il littering
 
E Magazine Num 01 Marzo 2012
E Magazine  Num 01  Marzo 2012E Magazine  Num 01  Marzo 2012
E Magazine Num 01 Marzo 2012
 
Metro count presentation
Metro count presentationMetro count presentation
Metro count presentation
 
ReName | Servicios 2016
ReName | Servicios 2016ReName | Servicios 2016
ReName | Servicios 2016
 
Trivadis TechEvent 2016 Polybase challenges Hive relational access to non-rel...
Trivadis TechEvent 2016 Polybase challenges Hive relational access to non-rel...Trivadis TechEvent 2016 Polybase challenges Hive relational access to non-rel...
Trivadis TechEvent 2016 Polybase challenges Hive relational access to non-rel...
 
CA Sanket Kalyani_CV
CA Sanket Kalyani_CVCA Sanket Kalyani_CV
CA Sanket Kalyani_CV
 
Origen del apellido chicote
Origen del apellido chicoteOrigen del apellido chicote
Origen del apellido chicote
 
The Default Mode Network
The Default Mode NetworkThe Default Mode Network
The Default Mode Network
 
RICS Property Auction Guide
RICS Property Auction GuideRICS Property Auction Guide
RICS Property Auction Guide
 
Datos agrupados
Datos agrupados Datos agrupados
Datos agrupados
 
Mercer Clin Perinatol 2004, Rpm Diagnosis And Management
Mercer Clin Perinatol 2004, Rpm Diagnosis And ManagementMercer Clin Perinatol 2004, Rpm Diagnosis And Management
Mercer Clin Perinatol 2004, Rpm Diagnosis And Management
 
Gerardo moran presentacion richard juma
Gerardo moran presentacion richard jumaGerardo moran presentacion richard juma
Gerardo moran presentacion richard juma
 
Le law destiny calls (2016 gg to african markets)
Le law   destiny calls (2016 gg to african markets)Le law   destiny calls (2016 gg to african markets)
Le law destiny calls (2016 gg to african markets)
 
(24) grupo verde
(24) grupo verde(24) grupo verde
(24) grupo verde
 

Similaire à Using RealTime fMRI Based Neurofeedback to Probe Default Network Regulation

AnLSTMbasedDeeplearningmodelforvoice-baseddetectionofParkinsonsdisease.pdf
AnLSTMbasedDeeplearningmodelforvoice-baseddetectionofParkinsonsdisease.pdfAnLSTMbasedDeeplearningmodelforvoice-baseddetectionofParkinsonsdisease.pdf
AnLSTMbasedDeeplearningmodelforvoice-baseddetectionofParkinsonsdisease.pdf
Danish Raza Rizvi
 
Deep Learning on nVidia GPUs for QSAR, QSPR and QNAR predictions
Deep Learning on nVidia GPUs for QSAR, QSPR and QNAR predictionsDeep Learning on nVidia GPUs for QSAR, QSPR and QNAR predictions
Deep Learning on nVidia GPUs for QSAR, QSPR and QNAR predictions
Valery Tkachenko
 
Prediction of Neurological Disorder using Classification Approach
Prediction of Neurological Disorder using Classification ApproachPrediction of Neurological Disorder using Classification Approach
Prediction of Neurological Disorder using Classification Approach
BRNSSPublicationHubI
 
Reproducibility in human cognitive neuroimaging: a community-­driven data sha...
Reproducibility in human cognitive neuroimaging: a community-­driven data sha...Reproducibility in human cognitive neuroimaging: a community-­driven data sha...
Reproducibility in human cognitive neuroimaging: a community-­driven data sha...
Nolan Nichols
 

Similaire à Using RealTime fMRI Based Neurofeedback to Probe Default Network Regulation (20)

AnLSTMbasedDeeplearningmodelforvoice-baseddetectionofParkinsonsdisease.pdf
AnLSTMbasedDeeplearningmodelforvoice-baseddetectionofParkinsonsdisease.pdfAnLSTMbasedDeeplearningmodelforvoice-baseddetectionofParkinsonsdisease.pdf
AnLSTMbasedDeeplearningmodelforvoice-baseddetectionofParkinsonsdisease.pdf
 
How to mea­sure and improve brain-based out­comes that mat­ter in health care
How to mea­sure and improve brain-based out­comes that mat­ter in health careHow to mea­sure and improve brain-based out­comes that mat­ter in health care
How to mea­sure and improve brain-based out­comes that mat­ter in health care
 
Open repositories for neuroimaging research
Open repositories for neuroimaging researchOpen repositories for neuroimaging research
Open repositories for neuroimaging research
 
Ivy Zhu, Research Scientist, Intel at MLconf SEA - 5/01/15
Ivy Zhu, Research Scientist, Intel at MLconf SEA - 5/01/15Ivy Zhu, Research Scientist, Intel at MLconf SEA - 5/01/15
Ivy Zhu, Research Scientist, Intel at MLconf SEA - 5/01/15
 
Automated Analysis of Microscopy Images using Deep Convolutional Neural Network
Automated Analysis of Microscopy Images using Deep Convolutional Neural NetworkAutomated Analysis of Microscopy Images using Deep Convolutional Neural Network
Automated Analysis of Microscopy Images using Deep Convolutional Neural Network
 
Deep Learning on nVidia GPUs for QSAR, QSPR and QNAR predictions
Deep Learning on nVidia GPUs for QSAR, QSPR and QNAR predictionsDeep Learning on nVidia GPUs for QSAR, QSPR and QNAR predictions
Deep Learning on nVidia GPUs for QSAR, QSPR and QNAR predictions
 
Analogy, Causality, and Discovery in Science: The engines of human thought
Analogy, Causality, and Discovery in Science: The engines of human thoughtAnalogy, Causality, and Discovery in Science: The engines of human thought
Analogy, Causality, and Discovery in Science: The engines of human thought
 
Spatial and Temporal Features of Noise in fMRI
Spatial and Temporal Features of Noise in fMRISpatial and Temporal Features of Noise in fMRI
Spatial and Temporal Features of Noise in fMRI
 
CSU_comp
CSU_compCSU_comp
CSU_comp
 
Prediction of Neurological Disorder using Classification Approach
Prediction of Neurological Disorder using Classification ApproachPrediction of Neurological Disorder using Classification Approach
Prediction of Neurological Disorder using Classification Approach
 
Reproducibility in human cognitive neuroimaging: a community-­driven data sha...
Reproducibility in human cognitive neuroimaging: a community-­driven data sha...Reproducibility in human cognitive neuroimaging: a community-­driven data sha...
Reproducibility in human cognitive neuroimaging: a community-­driven data sha...
 
Ferree Resume
Ferree ResumeFerree Resume
Ferree Resume
 
Share and Reuse: how data sharing can take your research to the next level
Share and Reuse: how data sharing can take your research to the next levelShare and Reuse: how data sharing can take your research to the next level
Share and Reuse: how data sharing can take your research to the next level
 
NERSC, AI and the Superfacility, Debbie Bard
NERSC, AI and the Superfacility, Debbie BardNERSC, AI and the Superfacility, Debbie Bard
NERSC, AI and the Superfacility, Debbie Bard
 
An Evolutionary-based Neural Network for Distinguishing between Genuine and P...
An Evolutionary-based Neural Network for Distinguishing between Genuine and P...An Evolutionary-based Neural Network for Distinguishing between Genuine and P...
An Evolutionary-based Neural Network for Distinguishing between Genuine and P...
 
Deep learning methods applied to physicochemical and toxicological endpoints
Deep learning methods applied to physicochemical and toxicological endpointsDeep learning methods applied to physicochemical and toxicological endpoints
Deep learning methods applied to physicochemical and toxicological endpoints
 
Top Cited Articles in Data Mining - International Journal of Data Mining & Kn...
Top Cited Articles in Data Mining - International Journal of Data Mining & Kn...Top Cited Articles in Data Mining - International Journal of Data Mining & Kn...
Top Cited Articles in Data Mining - International Journal of Data Mining & Kn...
 
Machine Learning in Healthcare Diagnostics
Machine Learning in Healthcare DiagnosticsMachine Learning in Healthcare Diagnostics
Machine Learning in Healthcare Diagnostics
 
Oxford_15-03-22.pptx
Oxford_15-03-22.pptxOxford_15-03-22.pptx
Oxford_15-03-22.pptx
 
C0344023028
C0344023028C0344023028
C0344023028
 

Dernier

Module for Grade 9 for Asynchronous/Distance learning
Module for Grade 9 for Asynchronous/Distance learningModule for Grade 9 for Asynchronous/Distance learning
Module for Grade 9 for Asynchronous/Distance learning
levieagacer
 
Conjugation, transduction and transformation
Conjugation, transduction and transformationConjugation, transduction and transformation
Conjugation, transduction and transformation
Areesha Ahmad
 
Asymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 b
Asymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 bAsymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 b
Asymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 b
Sérgio Sacani
 

Dernier (20)

Module for Grade 9 for Asynchronous/Distance learning
Module for Grade 9 for Asynchronous/Distance learningModule for Grade 9 for Asynchronous/Distance learning
Module for Grade 9 for Asynchronous/Distance learning
 
Zoology 5th semester notes( Sumit_yadav).pdf
Zoology 5th semester notes( Sumit_yadav).pdfZoology 5th semester notes( Sumit_yadav).pdf
Zoology 5th semester notes( Sumit_yadav).pdf
 
Forensic Biology & Its biological significance.pdf
Forensic Biology & Its biological significance.pdfForensic Biology & Its biological significance.pdf
Forensic Biology & Its biological significance.pdf
 
Conjugation, transduction and transformation
Conjugation, transduction and transformationConjugation, transduction and transformation
Conjugation, transduction and transformation
 
❤Jammu Kashmir Call Girls 8617697112 Personal Whatsapp Number 💦✅.
❤Jammu Kashmir Call Girls 8617697112 Personal Whatsapp Number 💦✅.❤Jammu Kashmir Call Girls 8617697112 Personal Whatsapp Number 💦✅.
❤Jammu Kashmir Call Girls 8617697112 Personal Whatsapp Number 💦✅.
 
FAIRSpectra - Enabling the FAIRification of Spectroscopy and Spectrometry
FAIRSpectra - Enabling the FAIRification of Spectroscopy and SpectrometryFAIRSpectra - Enabling the FAIRification of Spectroscopy and Spectrometry
FAIRSpectra - Enabling the FAIRification of Spectroscopy and Spectrometry
 
Clean In Place(CIP).pptx .
Clean In Place(CIP).pptx                 .Clean In Place(CIP).pptx                 .
Clean In Place(CIP).pptx .
 
GBSN - Biochemistry (Unit 1)
GBSN - Biochemistry (Unit 1)GBSN - Biochemistry (Unit 1)
GBSN - Biochemistry (Unit 1)
 
Justdial Call Girls In Indirapuram, Ghaziabad, 8800357707 Escorts Service
Justdial Call Girls In Indirapuram, Ghaziabad, 8800357707 Escorts ServiceJustdial Call Girls In Indirapuram, Ghaziabad, 8800357707 Escorts Service
Justdial Call Girls In Indirapuram, Ghaziabad, 8800357707 Escorts Service
 
Grade 7 - Lesson 1 - Microscope and Its Functions
Grade 7 - Lesson 1 - Microscope and Its FunctionsGrade 7 - Lesson 1 - Microscope and Its Functions
Grade 7 - Lesson 1 - Microscope and Its Functions
 
PSYCHOSOCIAL NEEDS. in nursing II sem pptx
PSYCHOSOCIAL NEEDS. in nursing II sem pptxPSYCHOSOCIAL NEEDS. in nursing II sem pptx
PSYCHOSOCIAL NEEDS. in nursing II sem pptx
 
9654467111 Call Girls In Raj Nagar Delhi Short 1500 Night 6000
9654467111 Call Girls In Raj Nagar Delhi Short 1500 Night 60009654467111 Call Girls In Raj Nagar Delhi Short 1500 Night 6000
9654467111 Call Girls In Raj Nagar Delhi Short 1500 Night 6000
 
Call Girls Ahmedabad +917728919243 call me Independent Escort Service
Call Girls Ahmedabad +917728919243 call me Independent Escort ServiceCall Girls Ahmedabad +917728919243 call me Independent Escort Service
Call Girls Ahmedabad +917728919243 call me Independent Escort Service
 
Site Acceptance Test .
Site Acceptance Test                    .Site Acceptance Test                    .
Site Acceptance Test .
 
GBSN - Microbiology (Unit 1)
GBSN - Microbiology (Unit 1)GBSN - Microbiology (Unit 1)
GBSN - Microbiology (Unit 1)
 
Asymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 b
Asymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 bAsymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 b
Asymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 b
 
GBSN - Microbiology (Unit 3)
GBSN - Microbiology (Unit 3)GBSN - Microbiology (Unit 3)
GBSN - Microbiology (Unit 3)
 
High Class Escorts in Hyderabad ₹7.5k Pick Up & Drop With Cash Payment 969456...
High Class Escorts in Hyderabad ₹7.5k Pick Up & Drop With Cash Payment 969456...High Class Escorts in Hyderabad ₹7.5k Pick Up & Drop With Cash Payment 969456...
High Class Escorts in Hyderabad ₹7.5k Pick Up & Drop With Cash Payment 969456...
 
Human & Veterinary Respiratory Physilogy_DR.E.Muralinath_Associate Professor....
Human & Veterinary Respiratory Physilogy_DR.E.Muralinath_Associate Professor....Human & Veterinary Respiratory Physilogy_DR.E.Muralinath_Associate Professor....
Human & Veterinary Respiratory Physilogy_DR.E.Muralinath_Associate Professor....
 
module for grade 9 for distance learning
module for grade 9 for distance learningmodule for grade 9 for distance learning
module for grade 9 for distance learning
 

Using RealTime fMRI Based Neurofeedback to Probe Default Network Regulation

  • 1.
  • 2. Using RealTime fMRI Based Neurofeedback To Probe Default Network Regulation R. Cameron Craddock, PhD Director of Imaging, Child Mind Institute Research Scientist, Nathan Kline Institute February 25, 2016
  • 3. Default Network Task based deactivation Buckner et al. Ann. N.Y. Acad. Sci. 1124: 1-38 (2008).
  • 4. Default Network Connectivity Greicius et. al. 2007 Biol. Psychiatry
  • 7. RT Neurofeedback of DMN • Test hypothesis of DMN dysregulation in depression, ADHD, aging, etc …
  • 8. Exp. Design Class Training Labels Training run Time-Labeled Scans Image Recon and SVM Classification Image DataData Acquisition Stimulus Presentation Stimulus Conventional FMRI Test Data Classifier Output Testing Run Real-Time Tracking RSNs LaConte, et al. (2007) Hum Brain Mapp. 28: 1033-1044 Stephen LaConte August 19, 2009
  • 9. Stimulus seen by volunteer Updated fMRI results Motion tracking and correction Intensity (brightness) of a single voxel, changing during stimulus conditions Controller interface for display parameters
  • 12. Modulating the DMN−2−1012 0 100 200 300 400 Best Subject Worst Subject TR Z−scoreDMNActivity −20246 0 100 200 300 400 TR Z−scoreDMNActivity
  • 13. Results 0.00.10.20.30.40.50.6 3 1 7 13 6 9 5 10 11 8 4 2 12 Subject Accuracy Feedback No feedback FB NOFB 0.10.20.30.40.50.6 1 2 1 2 Scan Number Accuracy p = 0.055p = 0.68 Accuracy was measured from Pearson’s correlation between task paradigm and DMN activity extracted after post-processing.
  • 14. Behavioral Correlates Measures that were significantly associated with DN regulation include (p<0.05, FDR corrected): the affect intensity measure (AIM), ruminative responses scale (RRS), and the imaginal processes inventory.
  • 15. RT fMRI Neurofeedback for Children
  • 16. All data is being prospectively shared
  • 17. Currently sharing > 10,000 datasets • 6,422 individuals – 4 – 90 years old – 539 ASD – 383 ADHD – 72 Schizophrenia – 29 Cocaine Dependent – 6 Epilepsy http://fcon_1000.projects.nitrc.org/
  • 18. Sharing preprocessed data • Make data available to a wider audience of researchers • Evaluate reproducibility of analysis results http://preprocessed-connectomes-project.github.io/
  • 19. Software to enable a new scale of data analysis • Very large datasets – Need to harness high- performance computing to expedite processing • RS fMRI preprocessing is a moving target – Many new methods are proposed all the time – Need to compare outputs from different processing strategies • Many different toolsets have different strengths – Need to be able to combine tools from different packages http://fcp-indi.github.io/
  • 20. Principles of Open Neuroscience Data, tools and ideas should be openly shared -The Neuro Bureau Manifesto http://www.neurobureau.org
  • 21.
  • 22. Acknowledgments Child Mind Institute Michael Milham, MD, PhD Zarrar Shehzad Nathan Kline Institute Amalia McDonald Stan Colcombe, PhD Bennett Leventhal, MD NYU – Child Study Center Adriana DiMartino, MD F. Xavier Castellanos, MD VTCRI Stephen LaConte, PhD Pearl Chiu, PhD Jonathan Lisinski, MS Emory University Helen Mayberg, MD This work is funded by: A NARSAD Young Investigator Award and NIMH R01MH101555