2. Discovery

3. The Disease
5 Strains

4. Mononegavirales
Filoviridae
Ebolavirus
Marburgvirus
Rhabdoviridae
Bornaviridae
Paramyxoviridae
The Virus
Class V (-ssRNA)
Classification
Order: Mononegavirales
Family: Filoviridae
Genus: Ebolavirus

5. Proteins
º GP
º VP30
º NP
º VP24
º VP40
º VP35
º L
Genome
NP VP35 VP40 GP VP30 VP24 L
18-19 kb
7 genes

6. Proteins
º GP
º VP30
º NP
º VP24
º VP40
º VP35
º L
sGP (isoform glycoprotein)
- A form of glycoprotein
that is secreted into the
extracellular space
- It counteracts antibodies
by absorbing them
VP35
- Has been shown to block
the IFN-β promoter
- Halts the cells defense
mechanism of producing
interferon's
VP30
- A transcription factor
that jump starts the
cell replication
machinery

7. Life Cycle
1. Entry
2. Production
of mRNA
3. Production of
virus proteins
4. Transcription
into positive
sense RNA
5. Replication of
negative sense
RNA
6. Movement of
VP40 to surface
and packaging
7. Maturation
8. Budding

8. Infection
• Transmitted through body fluids
• Often from contact with wild animals
• African practices contribute to outbreak:
– Eating monkeys and bats
– Caressing the dead
Hosts
Reservoir

9. Bats play a big role in the
transmission of Ebola
Hypsignathus monstrosus
Epomops franqueti
Myonycteris torquata

10. Hemorrhagic Fever
By the second week of the infection, the patient
will either experience a full recovery or undergo
systemic multiorgan failure.
-Microbewiki
High fever
Chills
Myalgia
Nausea
Vomiting
Diarrhea
Chest pain
Cough
Headache
Diarrhea
Dark or bloody feces
Vomiting blood
Red eyes
Maculopapular rash
Bleeding from orifices
Seizures and delirium
Early Late
Symptoms
Symptoms are easily mistaken for other
diseases like malaria

11. Sources Cited
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W.-J. Shieh, B. Batten, T. K. Sealy, C. Carrillo, K. E. Moran, A. J. Bracht, G. A. Mayr, M.
Sirios-Cruz, D. P. Catbagan, E. A. Lautner, T. G. Ksiazek, W. R. White, and M. T. McIntosh.
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Chandran, K. "Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for
Infection." Science 308.5728 (2005): 1643-645. Science Magazine. AAAS. Web. 21 Mar.
2013.
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"Ebola Virus." Department of Molecular Virology and Microbiology. Baylor College of Medicine, 31
July 2012. Web. 21 Mar. 2013.
"Ebolavirus." ViralZone. Swiss Institute of Bioinformatics, n.d. Web. 21 Mar. 2013.
Haggmann, Michael. "On the Track of Ebola's Hideout?" Science 286.5440 (1999):
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Apr. 2013.
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