We introduce the all new JChem Web Services platform that allows universal access to ChemAxon’s drug discovery platforms and offers true flexibility with its brand new RESTful API. A fresh take on the existing toolkits allows users to create and integrate applications with high productivity from any programming language, including C/C++, Python and Javascript for any platform including PC, Mac, Android and iOS. We demonstrate the capabilities through examples, including the all new ChemAxon Plexus web application.