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A mid flight correction: setting priorities  David Moher  Canadian Cochrane Centre and Network Cochrane Collaboration’s Bias Methods Group  University of Ottawa’s Evidence based Practice Center CIHR and AHRQ Acknowledge members of the Chalmers Research Group
Outline of talk ,[object Object],[object Object],[object Object],[object Object],[object Object]
Epidemiology and reporting characteristics of systematic reviews ,[object Object],[object Object],[object Object],[object Object],[object Object],Moher D, Tetzlaff J, Tricco AC, Sampson M, Altman DG. Epidemiology and reporting characteristics of systematic reviews. PLoS Medicine 2007; (3):e78.doi:10.1371/journal.pmed.0040078
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Epidemiology and reporting characteristics of systematic reviews
[object Object],[object Object],[object Object],[object Object],Epidemiology and reporting characteristics of systematic reviews
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Epidemiology and reporting characteristics of systematic reviews
More recent data ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Wen J, Ren Y, Wang L, Li Y, Liu Y, Zhou M, Liu P, Ye L, Li Y, Tian W. The reporting quality of meta-analyes improves: a random sampling study. Journal of Clinical Epidemiology 2008;61:770-775
[object Object]
Methodological quality of systematic reviews of animal studies: a survey of reviews of basic research ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Mignini LE, Khan KS. Methodological quality of systematic reviews of animal studies: a survey of basic research. BMC Medical Research Methodology. 2006;
Methodological quality of systematic reviews of animal studies: a survey of reviews of basic research
Push (priority setting) at the expense of quality ,[object Object],[object Object],[object Object],[object Object]
Setting priorities ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
“ Accurate and transparent reporting is like turning on the light before you clean up a room: it doesn’t clean it for you but does tell you where the problems are ” (Frank Davidoff, editor of Annals of Internal Medicine, 2000).
Reporting guidelines ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
EQUATOR:  E nhancing the  QUA lity and  T ransparency  O f health  R esearch   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
EQUATOR Core program ,[object Object],[object Object],[object Object],www.equator-network.org
Improving quality ,[object Object],[object Object],[object Object]
Registering systematic reviews “Moher and colleagues call for the registration of  systematic reviews  in the same manner as is now required for clinical trials: it would then, at least, be possible to track those that are performed.”  The PLoS Medicine Editors. Many reviews are systematic but some are more transparent and completely reported than others. PLoS Medicine 2007; ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],Bagshaw SM, McAlister FA, Manns BJ, Ghali WA. Acetylcysteine in the prevention of contrast-induced nephropathy: a case study of the pitfalls in the evolution of evidence. Arch Intern Med 2006;166:161-166 Biondi-Zoccai GGL, Lotrionte M, Abbate A, Teta L, Remigi E, Burzotta F, Valgimigli M, Romagnoli E, Crea F, Agostoni P. Compliance with QUOROM and quality of reporting of overlapping meta-analyses on the role of acetylcysteine in the prevention of contrast associated nephropathy: case study. BMJ 2006; 332(7535):202-9
Registration and priority setting ,[object Object]
“ It is surely a great criticism of our profession that we have not organised a critical summary, by speciality and subspeciality, adapted periodically, of all relevant randomised controlled trials” It is surely a great criticism that we have not organised a critical summary, by speciality and subspeciality, adapted periodically, of  all relevant systematic reviews
Selective outcome bias ,[object Object],[object Object],[object Object]
Outcomes reporting bias ,[object Object],[object Object],Chan AW, Hrobjartsson A, Haahr MT, Gotzsche PC, Altman DG. Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles. JAMA 2004;291:2457-2465.
Some salient results ,[object Object],[object Object]
Does selective outcome reporting exist within systematic reviews ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Moher D, Tetzlaff J, Tricco AC, Sampson M, Altman DG. Epidemiology and reporting characteristics of systematic reviews. PLoS Medicine 2007; 4(3):e78.doi:10.1371/journal.pmed.0040078
Does systematic review non-publication bias exist? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1 Tricco AC, Pham B, Brehaut J, Tetroe J, Cappelli M, Hopewell S, Lavis J, Berlin JA, Moher D. Systematic review publication bias: an international survey
Does systematic review non-publication bias exist? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What is updating ,[object Object],[object Object],Moher D, Tsertsvadze A. When is an update an update. Lancet 2006 Garritty C, Tsertsvadze A, Tricco AC, Sampson M, Moher D. Updating systematic reviews: an international survey
Why is updating important ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Updating systematic reviews ,[object Object],[object Object],[object Object],[object Object],[object Object],Shojania K,  Sampson M, Ji J, Ansari M, Garritty C, O’Rourke K, Rader, Moher D. Updating Systematic Reviews. Technical Review No. 16. (Prepared by the University of Ottawa Evidence-based Practice Center under Contract No. 290-02-0017). AHRQ Publication No 07-0087 Rockville, MD: Agency for Healthcare Research and Quality. September 2007
Updating systematic reviews ,[object Object],[object Object],[object Object],[object Object],[object Object],Shojania K, Sampson M, Ji J, Ansari MT, Doucette S, Moher D. How quickly do systematic reviews go out of date: A survival analysis .  Annals of Internal Medicine 2007;147:224-233 .
How quickly do systematic reviews become out of date: a survival analysis ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Signals for updating
Structured Search Protocols ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Results
[object Object],[object Object],[object Object],Results
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Results
International survey   ,[object Object],Garritty C, Tsertsvadze A, Tricco AC, Sampson M, Moher D. Updating systematic reviews: an international survey
International survey ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Setting priorities   ,[object Object],[object Object],[object Object],[object Object]
 

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A mid flight correction: setting priorities

  • 1. A mid flight correction: setting priorities David Moher Canadian Cochrane Centre and Network Cochrane Collaboration’s Bias Methods Group University of Ottawa’s Evidence based Practice Center CIHR and AHRQ Acknowledge members of the Chalmers Research Group
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  • 13. “ Accurate and transparent reporting is like turning on the light before you clean up a room: it doesn’t clean it for you but does tell you where the problems are ” (Frank Davidoff, editor of Annals of Internal Medicine, 2000).
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  • 22. “ It is surely a great criticism of our profession that we have not organised a critical summary, by speciality and subspeciality, adapted periodically, of all relevant randomised controlled trials” It is surely a great criticism that we have not organised a critical summary, by speciality and subspeciality, adapted periodically, of all relevant systematic reviews
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