preclinical cardiovascular studies drug discovery pulmonary arterial hypertension echocardiogram drug safety cardiomyopathy physiology rodent heart failure pah cardiovascular safety studies pharmacology contract research thrombosis venous thrombosis carotid and coronary arterial thrombosis ischemia/reperfusion hemodynamics cardiovascular toxicity screen langendorff isolated heart cardiovascular telemetry doxorubicin isoproterenol tac transverse aortic constriction hypoxia sugen hypoxia #2015sot riociguat proarrhythmia cipa oncology drugs create cardiovascular issues qt interval telemetry interrogation qtch putative anti-thrombotics platelet aggregation assessments pulmonary artery pressures anesthetized models electrocardiography myocardial injury cardiac ion channels drug safety services electrophysiology arrhythmias in vivo telemetry acute kidney injury
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