Ce diaporama a bien été signalé.
Nous utilisons votre profil LinkedIn et vos données d’activité pour vous proposer des publicités personnalisées et pertinentes. Vous pouvez changer vos préférences de publicités à tout moment.
CD Creative Diagnostics
®
CD Creative Diagnostics
®
Macrophage
Phenotype
CD Creative Diagnostics
®
Phagocytosis of Macrophage
• Eliminate pathogens
• Remove cellular debris
• Clear apoptotic cell...
CD Creative Diagnostics
®
Phagocytosis of Macrophage
• Clearance of cellular debris result from necrosis
that caused by tr...
CD Creative Diagnostics
®
Concept of Macrophage Activation
1960s Introduce of classic activation: discovery of phagocytic
...
CD Creative Diagnostics
®
M1 (Classic) Polarization of Macrophage
IFNγR
GM-CSF receptor
TLR4
IFNγ
GM-CSF
LPS
STAT1
IRF5
NF...
CD Creative Diagnostics
®
M2 (Alternative) Polarization of Macrophage
IL-4R
IL-10R
IL-4
IL-10
STAT6
Nuclear
translocation
...
CD Creative Diagnostics
®
Function of M1 and M2
M1
• TNF, IL-1, IL-6, iNOS
• Th1 responses, Type I
inflammation, killing o...
CD Creative Diagnostics
®
CD Creative Diagnostics
®
Macrophage polarization│
www.creative-diagnostics.com
45-1 Ramsey Road...
Prochain SlideShare
Chargement dans…5
×

Macrophage phenotype

307 vues

Publié le

A brief introduction of macrophage phenotype including research timelines, the pathways and functional of M1 and M2 phenotype.

Publié dans : Sciences
  • Identifiez-vous pour voir les commentaires

Macrophage phenotype

  1. 1. CD Creative Diagnostics ® CD Creative Diagnostics ® Macrophage Phenotype
  2. 2. CD Creative Diagnostics ® Phagocytosis of Macrophage • Eliminate pathogens • Remove cellular debris • Clear apoptotic cells  This clearance process occurs independently of immune-cell signaling  The removal of apoptotic cells results in little or no production of immune mediators
  3. 3. CD Creative Diagnostics ® Phagocytosis of Macrophage • Clearance of cellular debris result from necrosis that caused by trauma or stress • Markedly dramatic changes in physiology, including alterations in the expression of surface proteins and the production of cytokines and inflammatory mediators
  4. 4. CD Creative Diagnostics ® Concept of Macrophage Activation 1960s Introduce of classic activation: discovery of phagocytic mononuclear cells that adept at bacteria infections 1970s Mechanism and role of lymphocytes were revealed in macrophage microbicidal activation 1980s Discovery of Th1 and Th2 subtypes 2008 Propose of macrophage activation spectrum 2010 Concept of M1 and M2
  5. 5. CD Creative Diagnostics ® M1 (Classic) Polarization of Macrophage IFNγR GM-CSF receptor TLR4 IFNγ GM-CSF LPS STAT1 IRF5 NF-κB AP1 STAT5 ERK AKT
  6. 6. CD Creative Diagnostics ® M2 (Alternative) Polarization of Macrophage IL-4R IL-10R IL-4 IL-10 STAT6 Nuclear translocation STAT3 Glucocorticoids Indirect interaction with transcription factors
  7. 7. CD Creative Diagnostics ® Function of M1 and M2 M1 • TNF, IL-1, IL-6, iNOS • Th1 responses, Type I inflammation, killing of intercellular pathogens and tumor resistance M2 • Fizz1, Arginase 1, Ym1, IL-4, IL-10 and CD206. • Th2 responses, Type II inflammation, allergy, parasite infestation, tissue remodeling and tumor progression
  8. 8. CD Creative Diagnostics ® CD Creative Diagnostics ® Macrophage polarization│ www.creative-diagnostics.com 45-1 Ramsey Road, Shirley, NY 11967, USA info@creative-diagnostics.com

×