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Cytori Therapeutics, Inc.  Nasdaq: CYTX CitiBank Global Healthcare Conference March 2, 2011
Safe Harbor Statement This presentation may contain certain ‘forward-looking statements’. All statements, other than statements of historical fact, that address activities, events or developments that we intend, expect, project, believe or anticipate will or may occur in the future are forward-looking statements. Such statements are based upon certain assumptions and assessments made by our management in light of their experience and their perception of historical trends, current conditions, expected future developments and other factors they believe to be appropriate.  The forward-looking statements included in this presentation are also subject to a number of material risks and uncertainties. We caution investors not to place undue reliance on the forward-looking statements contained in this presentation.  We would advise reading our annual report filed with the United States Securities and Exchange Commission on Form 10-K for a more detailed description of these risks.
Enabling Practice of Regenerative Medicine Real-time Access to a Patient’s Own Regenerative Cells Unique Source Syringe of Cells  Point-of-Care System ≈1 Hour Regenerative Cells Derived from Adipose Tissue (Fat)
Device Process: Frees Cells Trapped in Adipose Liposuction Processing Adipose Tissue Adipose Derived Regenerative Cells ,[object Object]
Multipotent cells
Endothelial cells
Vasc. smooth muscle cells
Tissue resident macrophages
Perivascular cells
Adipocytes
Multipotent cells
Endothelial cells
Vasc. smooth muscle cells
Tissue resident macrophages
Perivascular cells,[object Object]
Goal:  Drive Cartridge Sales for Multiple Apps Cardiovascular Disease Plastic and Reconstructive Surgery 18K potential customers 1 consumable per day  6 mm + consumables/year Cell & Tissue Storage Open Op System: ID new “Apps” and Fuel Pipeline
Strong Partners Supporting Growth Olympus (Japan): Manufacturing Joint Venture ,[object Object]
Hospital-based device
 Reside in OR, cath lab, or cell & tissue bank
 Available for ADVANCE trial
 Manufacturing expertise & service infrastructure
 Invested $55+mmGreen Hospital Supply ,[object Object],GE Healthcare ,[object Object],AstellasPharmaceuticals  ,[object Object]
 Received right-of-first refusal for liver disease partnership,[object Object]
What is the status of the Acute MI Study?
Initiating Pivotal Study in Europe for AMI Intracoronary delivery at point-of-care w/off the shelf catheter Meaningful reduction in infarct size ,[object Object]
Compares to no change in placeboImprovement in other measures  ,[object Object]
3.5 x greater perfusion improvementInitiated pivotal European study (ADVANCE) ,[object Object]
Three arms: 20 MM cells, 30 MM cells, & placebo
Up to 35 centers
Started Jan 2011 (est.18-mo enrollment),[object Object]
Sustained Long Term Functional Benefit Direct injection into heart muscle using JNJ Noga Star catheter MVO2:significant change at 18 months ,[object Object]
MVO2≤ 14 = 47%1 yr survival rateMETS: significant change at 18 months Infarct size: 8.2% change at 6 months Procedure safe and feasible through18-mo Lower cardiac mortality rate ,[object Object],  -  2/6 placebo pts died of cardiac causes    -  1/21 treated pts died of cardiac causes
Seeking Indication for Use in Europe for CMI  Functional data can support indication in “no-option” patients  ,[object Object]

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CYTX CitiBank 2010 Global Healthcare Conference

  • 1. Cytori Therapeutics, Inc. Nasdaq: CYTX CitiBank Global Healthcare Conference March 2, 2011
  • 2. Safe Harbor Statement This presentation may contain certain ‘forward-looking statements’. All statements, other than statements of historical fact, that address activities, events or developments that we intend, expect, project, believe or anticipate will or may occur in the future are forward-looking statements. Such statements are based upon certain assumptions and assessments made by our management in light of their experience and their perception of historical trends, current conditions, expected future developments and other factors they believe to be appropriate. The forward-looking statements included in this presentation are also subject to a number of material risks and uncertainties. We caution investors not to place undue reliance on the forward-looking statements contained in this presentation. We would advise reading our annual report filed with the United States Securities and Exchange Commission on Form 10-K for a more detailed description of these risks.
  • 3. Enabling Practice of Regenerative Medicine Real-time Access to a Patient’s Own Regenerative Cells Unique Source Syringe of Cells Point-of-Care System ≈1 Hour Regenerative Cells Derived from Adipose Tissue (Fat)
  • 4.
  • 15.
  • 16. Goal: Drive Cartridge Sales for Multiple Apps Cardiovascular Disease Plastic and Reconstructive Surgery 18K potential customers 1 consumable per day 6 mm + consumables/year Cell & Tissue Storage Open Op System: ID new “Apps” and Fuel Pipeline
  • 17.
  • 19. Reside in OR, cath lab, or cell & tissue bank
  • 20. Available for ADVANCE trial
  • 21. Manufacturing expertise & service infrastructure
  • 22.
  • 23.
  • 24. What is the status of the Acute MI Study?
  • 25.
  • 26.
  • 27.
  • 28. Three arms: 20 MM cells, 30 MM cells, & placebo
  • 29. Up to 35 centers
  • 30.
  • 31.
  • 32.
  • 33.
  • 35.
  • 37.
  • 38.
  • 39. Currently approx. 40 NOGA Star systems
  • 40.
  • 41. Celution: Discovering New Applications Selling systems to researchers to develop new “apps” Investigator-sponsored trials taking place worldwide Radiation injury SUI Liver Renal Malignant wounds Cardiomyopathy Vocal cord paralysis HIV therapy-induced soft tissue atrophy Others Link: Most indications involve restoring blood flow to damaged tissue Cytori to select most-promising applications to advance or commercialize
  • 42.
  • 43. Moderate to severe Incontinence
  • 45. All improved10 weeks Post-Celution Treatment Dr. Gotoh Nagoya, Japan
  • 46. What is the relevance of the new breast reconstruction developments?
  • 47. RESTORE Procedure for Breast Reconstruction ‘Cell-Enriched Graft’ Treatment not complete until reconstruction Hospital-based procedure and call point Limited options for lumpectomy patients Favorable reimbursement environment Cells: improve “ischemic” state $43 $73 $128 Cells Fat $163 $76 $126 Clinical Clinical Clinical Partner Partner Partner
  • 48.
  • 49. 75% pt satisfaction on (12-mo)
  • 50. Improvement in scar, pigmentation, symmetry and defect index (6-Mo):
  • 51. 2.8 to 3.9 in ptassessment (0-5 scale)
  • 52. 3.1 to 4.1 in phys. assessment (0-5 scale)Binary patient and physician satisfaction with treatment results at 6- and 12-months
  • 53.
  • 54.
  • 56.
  • 57.
  • 58. Support patient awareness/education (www.cellreconstruct.eu)
  • 59.
  • 60. Supplemental Product: PureGraft™ Natural Fill Optimizes fat graft prep Worldwide approval Complements Celution® (EU) Celution lead qualifier (EU) Stand-alone product in US Convert users to Celution® upon U.S. clearance Point-of-Entry: Building out US sales team (6 direct reps) Targets $1.7 bb dermal fill mkt 46K annual fat- grafting procedures in U.S. and growing
  • 61. Supplemental Product: PureGraft™ Natural Fill Fat grafting is growing trend in plastic surgery Ideally suited for low cost consumer awareness campaign TV, print and radio outreach around customers Distributor model Sound Surgical is first in the US Multiple in Europe Minimal training requirements 1000 + shipped from Q2 2010 launch to YE 2010
  • 62. When is the Olympus device available?
  • 63. Celution One: Next Generation Product Commercially available in Europe in 2011 Hospital-based system First system installed for ADVANCE Recon Formula transfer price Cardiac Other Apps Manufacturing JV Commercial rights
  • 64. How strong is the IP?
  • 65.
  • 66.
  • 67.
  • 68. Create customer loyalty with quality product and service
  • 69.
  • 71.
  • 72. Equity Raise (Oct. 10): $19.3 M
  • 73. Strategic Equity (Dec. 10): $10 M investment from AstellasLong-term Debt: $20 million (GE/SVB/Oxford term loan) Shares Outstanding: 53 million as adjusted Revenue Growth 30
  • 74.
  • 75.
  • 76.
  • 77.
  • 78.
  • 79. Know-how, first mover, and $250 mm invested $60 MM (pro forma) in cash as of 9/30/10 Upcoming catalysts to support sales and advance pipeline 32

Notes de l'éditeur

  1. The Celution system is originally being marketed to 2 areas of regenerative medicine: reconstructive and aesthetic.The distinction of these two areas is in the location of the procedure and the general reimbursement of the procedure.