This document summarizes a company called Cadius Health that has developed an app to help manage weight loss through circadian rhythms. The app tracks meal times and analyzes photos of food to gently guide users to a healthier eating window based on their natural metabolic rhythms. Clinical trials showed users lost an average of 3.8% weight in 3 months without calorie counting. The company plans to launch a free consumer app and pursue corporate wellness and healthcare reimbursement models to expand the program.

1. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.01.2015!
!
We have radically simplified effective personal health
management through new circadian science!

2. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.09.2015!
!
2
Americans are grossly overweight. This is the single
largest cause of health problems and costs.
Over 50% of population at
levels of risk for key health
indicators: BMI,
Hypertension, Cholesterol
and Fitness.
60% of the US
population struggles
with weight loss
issues.!
30% are Obese.!
$ 60.9B
39% of overweight
adults seeking
solutions!
Represents a
$60.9 B market!

3. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.09.2015! 3
Calorie Counting
Meal Plans
Paid Coaching
There are NO effective solutions that deliver
sustained weight management

4. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.09.2015! 4
Results are not sustained, as people just simply
fall back into their old HABITS
90% of people who go on a diet,
gain the weight back within 2 years.
90%
gain weight
back

5. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.09.2015! 5
The time we choose to consume calories is the single
easiest thing to change and is now proven to have the
single most significant impact on health
Eat all day, anytime!
Restricted feeding times!
Mice offered a high-fat, high-
sugar diet lose their natural
feeding rhythm and get fat. !
Mice fed this same diet but
forced to maintain their natural
circadian rhythm maintain
normal weight - even with the
same higher caloric intake.!

6. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.09.2015! 6
We now have the science to reverse obesity.
We know which habits to change and how to
change them.
RESEARCH
World-renowned researchers
studying Circadian Rhythm
make a novel discovery.
EVIDENCE
Effects of circadian rhythms in
metabolically important organs can
positively affect physiology and
metabolism.
BREAKTHROUGH
Altering feeding and fasting rhythms
can profoundly change health and
weight, even without altering caloric
intake.
RESULT
Chronic disruption of circadian rhythm can
increase incidences of chronic diseases
like obesity, diabetes, heart disease,
cancer and depression
Our subjects lost 3.8% average weight in 3-month pilot trial, measured after 1 year.

7. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.09.2015! 7
Introducing the Cadius App and Program
AppDemo: ask us for the app demo link
The first diet app driven by circadian rhythm
science. Tracks with time-stamps from the photos
the user takes of the foods and drinks they consume
through the course of the day.
Gradually learns people’s habits and routines and
gently guides them to a healthier eating window that
restores their natural metabolic rhythms.
Almost zero impact on lifestyle
NO calorie counting
NO journaling
NO food restrictions

8. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.09.2015! 8
Consumer Model
The initial free consumer facing application is focussed on meal
schedules, as this will simply deliver tangible results quickly.
Free trial version used as proof of concept and anecdotal efficacy
to drive sales for enterprise health and wellness model. After a 30
day trial period, we will prove our effectiveness and ask for a
subscription to a greatly expanded and accelerated offering:
Paid subscription delivers:
Sleep patterns
tracked and
analyzed
Review of
photos with
professional
analysis
Expert
personalized
advice
Exercise
Options
Advice
Medication
Reminders
Metrics
and device
Integration
BMI BP
BloodSugar
Weight etc.

9. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.09.2015! 9
Enterprise Model
With the results of more extensive clinical trials expanding on the recently
published pilot trial, Cadius will pursue reimbursement from health plans
and payments from large self-insured corporations.
Primary Care MD
125,000 Primary care
Physicians in US
Increasing focus on
preventative care
Adopting mobile apps for
efficient patient interaction
Driven by clinical data
Nutritionists
70,000 Nutritionists in US
Seeking better engagement
tool with clients
Photo storage and feedback
mechanism provides a more
useful and accurate food
consumption tracker versus
food logs and diaries
Corporate Wellness
55 Million Employees with
access to Wellness
programs
Self-insured or covered by
major plans
Employers pushing for
preventative care

10. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.09.2015! 10
Management Team
Satchin Panda, Ph.D.
Co-founder Chief
Science Officer
World renowned
circadian rhythms
researcher.
Associate Professor at
the Salk Institute
Inventor, Cadius
Technology
Shubhroz Gill, Ph.D.
Co-Founder
Ph.D. with Dr. Satchin
Panda
Inventor, Cadius
technology
Thesis work: Circadian
rhythms in humans,
mice and fruit flies
John Barrett
CEO
Extensive leadership
and business-building
experience
Co-founder and CEO of
CoAlign Innovations-
Acquired by Stryker in
2014.
Leadership positions at
Abbott Labs and Baxter
David Shantz
Chief Marketing Officer
Co-Founder and
marketing lead for
multiple funded ventures.
Extensive background in
product development and
marketing for launching
new ventures for
consumer and enterprise
mobile and web
applications

11. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.09.2015! 11
Advisory Board
Dan Zigmond
Ex-VP of Data, Hampton
Creek Foods
Previously head of data
science for Google Maps,
You Tube, etc.
Advising on data science
Tara Wright
Digital Content Manager,
Stanford GSB
Editor, web producer, writer
Founder, Dump Your Frump,
women’s lifestyle blog
Advising on user experience
and social media

12. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.09.2015! 12
Marketing: Customer Acquisition
User Generated Content: My week in food shared
to Social graph
(see shared week in food infograhpic RIGHT)
FRIENDS AND FAMILY: driving referrals where
people can sign up 3 friends with the third group
member free
Channel Marketing with partners and affiliates using
associated products and services.
PR: based on the unique story behind the science

13. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.09.2015! 13
Milestones
2014
2015
2016
2017
Scientific Paper
Application Dev. A B C
!
SALK Mouse Study
Pilot Human Study
Consumer Direct
!
Enterprise Market
!Research App
development and back
end data collection
system completed for
use in clinical trials
Database of 25,000 photos with USDA coding
Build up clinical credibility Sell with evidence based
data. Achieve reimbursement to drive utilization
and revenue $100/month for a 3 month intervention
MVP through two revs of usability optimization
Backend management systems and infrastructure
Expanded Trial
!

14. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.09.2015! 14
Use of Funds
!
!
!
$1M Seed round
Development of consumer app and launch $250K
Pattern recognition process and infrastructure $200k
Support for clinical trials $200K (300 patient trial)
Marketing/PR $200k
Legal $40K
Salk fees $45K
Series A planned in late Q116, early Q216 $5-7M

15. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.09.2015! 15
Media Coverage
We have seen over $300k worth of media coverage in 2015 for the recent paper
authored by Founder Satchin Panda through Salk Institute. See Media Report

16. CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.01.2015!
Appendix Slides!