1. Validated by Peer-reviewed Independent University Studies
Protandim®, the Nrf2 Synergizer®, has been validated by peer-reviewed studies
conducted in the laboratories of respected universities such as The Ohio State
University, LSU and the University of Colorado Denver. The results of these studies
have been published in mainstream medical journals such as “Free Radical Biology
& Medicine”, “Enzyme Research” and “The Multiple Sclerosis Journal.” Many others
can be found on the US National Library of Medicine website. Below are titles and
links to just a few of these peer-reviewed studies:
Antioxidants for the Treatment of Patients with Severe Angioproliferative Pulmonary
Hypertension?
Virginia Commonwealth University
Antioxid Roedox Signal. 2012. Sept 28.
Phytochemical activation of Nrf2 protects human coronary artery endothelial cells
against an oxidative challenge
Colorado State University, Fort Collins, CO
Oxid Med Cell Longev. 2012;2012:132931. Epub 2012 May 22.
Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation.
University of Colorado at Denver
Mol Aspects Med. 2011 Aug;32(4-6):234-46. Epub 2011 Oct 15.
The induction of human superoxide dismutase and catalase in vivo: a fundamentally
new approach to antioxidant therapy
University of Colorado Denver Health Sciences Center
Free Radic Biol Med. 2006 Jan 15;40(2):341-7.
The role of manganese superoxide dismutase in skin cancer
Louisiana State University Health Sciences Center
Enzyme Res. 2011;2011:409295. Epub 2011 Mar 23.
Protandim attenuates intimal hyperplasia in human saphenous veins cultured ex
vivo via a catalase-dependent pathway
The Ohio State University, Columbus, OH
Free Radic Biol Med. 2011 Mar 15;50(6):700-9. Epub 2010 Dec 15.
The Dietary Supplement Protandim Decreases Plasma Osteopontin and Improves
Markers of Oxidative Stress in Muscular Dystrophy Mdx Mice
Texas Tech University Health Sciences Center
J Diet Suppl. 2010 Jun 1;7(2):159-178.
Protandim, a fundamentally new antioxidant approach in chemoprevention using
mouse two-stage skin carcinogenesis as a model
Louisiana State University Health Sciences Center
PLoS One. 2009;4(4):e5284. Epub 2009 Apr 22.

2. Chronic pulmonary artery pressure elevation is insufficient to explain right heart
failure
Virginia Commonwealth University
Circulation. 2009 Nov 17;120(20):1951-60. Epub 2009 Nov 2.
The chemopreventive effects of Protandim: modulation of p53 mitochondrial
translocation and apoptosis during skin carcinogenesis
Louisiana State University Health Sciences Center
PLoS One. 2010 Jul 30;5(7):e11902.
Synergistic induction of heme oxygenase-1 by the components of the antioxidant
supplement Protandim
University of Colorado Denver
Free Radic Biol Med. 2009 Feb 1;46(3):430-40. Epub 2008 Nov 17.
Protandim does not influence alveolar epithelial permeability or intrapulmonary
oxidative stress in human subjects with alcohol use disorders.
Univ. of Colorado School of Medicine
Am J Physiol Lung Cell Mol Physiol. 2012 Apr 1;302(7):L688-99. doi:
10.1152/ajplung.00297.2011. Epub 2012 Jan 20.
Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects
cardiomyocytes against oxidant stress.
Colorado State University, Fort Collins, CO
Free Radic Biol Med. 2012 Nov 30.
These studies and many more can be found online at the US National Library of
Medicine at http://www.ncbi.nlm.nih.gov/pubmed/
Nrf2 activation has been clinically proven through dozens of studies, to enhance our
body’s ability to neutralize free radicals, lower oxidative stress and slow the aging
process at the cellular level.
To find out how you can slow your own aging process at the cellular level, click on
the following link:
david@businesshealthassociates.com
Thank you for your time and review. I look forward to hearing from you soon!
David Tingle
Business Health Associates