A presentation about engineering electronics into body tissues. Bio-Integrated Electronics.

1. Dissolvable films of silk fibroin for
ultrathin conformal bio-integrated
electronics
Dawn John Mullassery
Electrical and Computer Engineering
University of British Columbia
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2. The Paper
John A Rogers 2

3. Overview
• Motivation and Background
• The technology
• Future
3

4. http://www.singularitysymposium.com/moores-law.html
MOORE’s LAW
“The observation made in 1965 by Gordon Moore, co-founder
of Intel, that the number of transistors per square inch on
integrated circuits had doubled every year since the
integrated circuit was invented. Moore predicted that this
trend would continue for the foreseeable future.”
- Webopedia
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5. Bio-Integration
6th International Conference on Intelligent and Advanced Systems 2016 (ICIAS2016), ieeemy.org,
http://www.computerhope.com/jargon/e/edsac.htm, 5

6. Bio-Integration
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7. Existing Technology – Utah
http://www.sci.utah.edu/~gk/abstracts/bisti03/,
Acute human brain responses to intracortical microelectrode arrays: challenges and future prospects - Eduardo et.al , doi: 10.3389/fneng.2014.00024
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8. Electro - Corticography
Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical Mapping
N. Jeremy Hill et.al ; doi: 10.3791/3993 8

9. Two main areas!
• Bio-integrated or Biocompatible
electronics
• Transient electronics or Bioresorbable
electronics
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10. Bio-Integrated Electronics
• Epidermal Electronics
• Non – uniform surfaces inside the body
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11. Bio-Integrated Electronics - Brain
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12. Bio-Integrated Electronics - Brain
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13. http://rogers.matse.illinois.edu/multimedia.php
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14. Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal, Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology: Jonathan Viventi, et.,al;
Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo: Jonathan Viventi, et.al;
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15. Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal, Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology: Jonathan Viventi, et.,al; 15

16. http://rogers.matse.illinois.edu/multimedia.php
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17. Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the
entire epicardium. Lizhi Xu et.al;
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
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18. Bio-Integrated Electronics - Advantages
• High resolution results
• Less complicated process
• Similar process can be used for epidermal
electronics
• Non – invasive method
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19. Transient Electronics
Electronic systems that dissolve, resorb, or
otherwise physically disappear at
programmed rates or specific triggered times.
A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
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20. Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
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21. Water Soluble Silicon
Silicon for Transient
Electronics
• Silicon Thickness - 35
nm
• Dissolution Time – 10
days
• Water – 0.4 ml
Silicon for Regular
Electronics
• Silicon Thickness -
700 µm
• Dissolution Time –
600 to 1000 years
• Water - 8 L
A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
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22. Silk membranes dissolve
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23. Transient Electronic Device
A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
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24. A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
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25. A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
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26. A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
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27. Why a novel approach?
• Biomedical Purposes
• Environmental Sensors
• Consumer Electronics
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28. Biomedical Application – Transient Electronics
A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
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29. Biomedical Application – Surgical Site
Infections
A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
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30. Edible and Good!
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 µg vs ~ 10 mg
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31. Biomedical Applications
• Drug Delivery
• Electronic Aspirin
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32. Environmental sensors & e- waste
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33. http://rogers.matse.illinois.edu/multimedia.php
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34. Next Few Years & Future
• Human body
• Non – biomedical applications
• Further R & D required
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35. Why will this be a classic paper?
• New approach to existing techniques of
biomedical methods
• Any form of biological surface – with minimal
invasion
• Not limited to biomedical
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36. 36