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The Silent Killer
Dr. Bakht Jamal Shaikh
Munich Re. Seminar at Hotel Sheraton Karachi
December 20, 2012.
Diabetes is Chronic Metabolic Syndrome
caused due to absence or resistance to Insulin
hormone, resulting more Glucose in blood.
Dr. BJS
Pancreas
35-50% people do not
know that they are
Diabetic.
•2500 year old disease
•400 BC: Sushruta  Sweet odor/taste
Statue of Sushruta in India
Dr. BJS
•250 BC: Word “Diabetes” was used first time
by Greek Physician Aretaeus, means “Siphon”
or “Drain”.
•Flushing out the muscle
and water from the body.
Aretaeus of Cappadocia
Dr. BJS
•1674 AD: Dr Thomas Willis, Physician of King
Charles-I first used the word “Diabetes
Mellitus”
Mellitus  (Latin)
honey sweet
Dr. Thomas Willis
Dr. BJS
•1869 AD: Berlin Medical student Paul
Langerhans discovered that beta cells of
Pancreas secret Insulin, now known as “Islets of
Langerhans”
Insulin  Island
Paul Langerhans
Dr. BJS
•1889 AD: German Dr. Joseph Von Mering
removed pancreas of dog and it became
Diabetic.
Dr. Joseph Von Mering
Dr. BJS
•1921 AD: Sir Fredrick Banting and his friend
Best of Canada discovered Insulin.
Sir Fredrick Banting
Dr. BJS
It took almost 23 centuries
for effective treatment of
Diabetes Mellitus.
Dr. BJS
Dr. BJS
CELLS
ENERGY
LIVER
GLYCOGENOLYSIS
GLUCOSE
GLYCOGEN
INSULIN
Dr. BJS
Lack of
Insulin
Increased
Blood
Glucose
Less
Energy
Weight loss +
Fatigue
Frequent
urination
Dr. BJS
•Life Long Disease
•Life Style Disease
•Preventable
•Irreversible
•No Cure
•Controllable
•Full of Complications
•Decrease 5-10 years of Life
•40 million DALYs (Disability Adjusted Life Years) wasted annually
•Pakistan average age at onset lower i.e. 33 years
•Hepatitis C virus enhance the chances of early onset
•50% cases lead to Heart Attack
•10-20% to Kidney Failure
•2% to Blindness
•More prevalence in men but more death in women due to lack of attention
Dr. BJS
•Causes more deaths than AIDS + Breast Cancer
•13,000 people die daily
•1 die every 7 seconds (500 die during this session)
•Pre-Diabetes: 281 m or 4% of population
•DM : 558 m or 8% of total population (187 m unknown)
•Top 1 country is Micronesia: 37 %
•Bottom country is Mali: 1.7%
•World Annual Cost US$ 471 B (26 annual Pak Budget)
Source: IDF
Dr. BJS
World
•Death 84,336 p.a. 50% Death below 60.
•8th. Cause of Death
•10.25 m suffer from DM (3.65 m unaware)
• TOP 10th in World in number (#)
• TOP 7th. in World in percentage (%)
i.e. 10.5% of Adult (20-79) Population
•IGT: 7.42 Million
Source: IDF
Dr. BJS
Pakistan
•Middle & Lower Income: 80%
•Males:51% Female: 49%
•Rural:57% Urban: 43%
•Age 40-59: 49%
20-39: 27%
60-79: 24%
Source: IDF
Dr. BJS
Pakistan
1. Age
2. Gender
3. Race
4. Family History
5. Obesity
6. High Blood Pressure
7. Sedentary Life Style
8. High Cholesterol in Blood
9. Stress
Dr. BJS
TYPE 1 (IDDM) Juvenile Onset TYPE 2 (NIDDM) Maturity Onset
 Genetic (a) autoimmunity (b) virus
 Lean
 Children & adolescent < 40 Peak age 14
 White Race & cold weather
 Absence of insulin
 Treatment with Insulin
 Abrupt
 Prevalence 5%
 Environment (strong family history)
 Obese
 Adults > 40
 Black Race and warm weather
 Resistance to insulin
 OHGA + Insulin
 Progressive
 Prevalence 95%
Dr. BJS
New TYPE 1.5 (Latent Autoimmune Adult onset) 
Both parents DM  50% Risk
1 Parent before 50  14% Risk
1 Parent after 50  7% Risk
Dr. BJS
• Polyuria  Frequent Urination
Dr. BJS
• Polydipsia  increased thirst
Dr. BJS
• Polyphagia  increased hunger
Dr. BJS
• Weight loss
• Infection &
Delayed healing
• Fatigue
Dr. BJS
A1C (90 Days)Result Random Blood Sugar
(RBS)
101-126 mg% Impaired 141-200 mg% 5.7 to 6.4 %
Up to 100 mg% Normal Up to 140 mg% Up to 5.6 %
Above 126 mg% Diabetic Above 200 mg% Above 6.4%
Fasting Blood Sugar
(FBS)
Source: ADA
Dr. BJS
•Eyes  loss of vision
Dr. BJS
•Brain  Stroke
Dr. BJS
•Heart  Heart Attack
Dr. BJS
•Kidney  Kidney Failure
Dr. BJS
Diabetic Nephropathy
•Diabetic Keto-Acidosis
Dr. BJS
•Nerves  Peripheral Neuropathy(Numbness)
Dr. BJS
•Diabetic Foot  Amputation
Dr. BJS
Obesity + F/H
Pre-Diabetic
(Candidate)
DIABETIC Complications DEATH
Dr. BJS
Underwriting Approach
 Case of DM Presented as:
1. Family History (see Age, Obesity & Rate)
2. Glycosuria (Postpone till Diagnosis & Rx)
3. I.G.T (see Profile & rate or further invest.)
4. Unaware but suffering Diabetes M.
5. Known Diabetic under control. (Accept +EM)
6. Known Diabetic out of control/comp. (Dec)
Dr BJS
1. Age at onset: Earlier the age more the mortality risk
At age 35: 300%
At age 65: 150%
2. Type: (I or II) I riskier than II.
3. Duration since onset: More duration, more riskier.
Dr. BJS
4. Control (A1c): 6.5%-10% ) Above 10%D.
5. Systolic Blood Pressure: Above 160  D
110 mm Hg = 100% (Standard)
155 = 200% (Twice)
165 = 400% (Four times)
6. Protienuria: Micro/Macro (++++)+ -->D
7. Complication: Heart Attack, Stroke,
Kidney Failure, Blindness, Amputation,
Diabetic Keto-Acidosis.
8. Smoking: Mild or Moderate.
Dr. BJS
Conversion from mg% to mmol/L
 mg% / 18 = mmol/L
180 mg% / 18 = 10 mmol/L
Conversion from A1c% to mg%
 A1c% * 33.3 – 86 = mg%
e.g. 6.5% A1c * 33.3 less 86
= 130 mg%.
Conversion from A1c% to mmol/mol
 (A1c% - 2.15) *10.929
e.g. (A1c 6.5% less 2.15) *10.929
= 4.35 *10.929
= 47.54 say 48 mmol/mol.
Dr. BJS

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Diabetes Mellitus-Killer Disease

  • 1. The Silent Killer Dr. Bakht Jamal Shaikh Munich Re. Seminar at Hotel Sheraton Karachi December 20, 2012.
  • 2. Diabetes is Chronic Metabolic Syndrome caused due to absence or resistance to Insulin hormone, resulting more Glucose in blood. Dr. BJS Pancreas 35-50% people do not know that they are Diabetic.
  • 3. •2500 year old disease •400 BC: Sushruta  Sweet odor/taste Statue of Sushruta in India Dr. BJS
  • 4. •250 BC: Word “Diabetes” was used first time by Greek Physician Aretaeus, means “Siphon” or “Drain”. •Flushing out the muscle and water from the body. Aretaeus of Cappadocia Dr. BJS
  • 5. •1674 AD: Dr Thomas Willis, Physician of King Charles-I first used the word “Diabetes Mellitus” Mellitus  (Latin) honey sweet Dr. Thomas Willis Dr. BJS
  • 6. •1869 AD: Berlin Medical student Paul Langerhans discovered that beta cells of Pancreas secret Insulin, now known as “Islets of Langerhans” Insulin  Island Paul Langerhans Dr. BJS
  • 7. •1889 AD: German Dr. Joseph Von Mering removed pancreas of dog and it became Diabetic. Dr. Joseph Von Mering Dr. BJS
  • 8. •1921 AD: Sir Fredrick Banting and his friend Best of Canada discovered Insulin. Sir Fredrick Banting Dr. BJS It took almost 23 centuries for effective treatment of Diabetes Mellitus.
  • 13. •Life Long Disease •Life Style Disease •Preventable •Irreversible •No Cure •Controllable •Full of Complications •Decrease 5-10 years of Life •40 million DALYs (Disability Adjusted Life Years) wasted annually •Pakistan average age at onset lower i.e. 33 years •Hepatitis C virus enhance the chances of early onset •50% cases lead to Heart Attack •10-20% to Kidney Failure •2% to Blindness •More prevalence in men but more death in women due to lack of attention Dr. BJS
  • 14. •Causes more deaths than AIDS + Breast Cancer •13,000 people die daily •1 die every 7 seconds (500 die during this session) •Pre-Diabetes: 281 m or 4% of population •DM : 558 m or 8% of total population (187 m unknown) •Top 1 country is Micronesia: 37 % •Bottom country is Mali: 1.7% •World Annual Cost US$ 471 B (26 annual Pak Budget) Source: IDF Dr. BJS World
  • 15. •Death 84,336 p.a. 50% Death below 60. •8th. Cause of Death •10.25 m suffer from DM (3.65 m unaware) • TOP 10th in World in number (#) • TOP 7th. in World in percentage (%) i.e. 10.5% of Adult (20-79) Population •IGT: 7.42 Million Source: IDF Dr. BJS Pakistan
  • 16. •Middle & Lower Income: 80% •Males:51% Female: 49% •Rural:57% Urban: 43% •Age 40-59: 49% 20-39: 27% 60-79: 24% Source: IDF Dr. BJS Pakistan
  • 17. 1. Age 2. Gender 3. Race 4. Family History 5. Obesity 6. High Blood Pressure 7. Sedentary Life Style 8. High Cholesterol in Blood 9. Stress
  • 19. TYPE 1 (IDDM) Juvenile Onset TYPE 2 (NIDDM) Maturity Onset  Genetic (a) autoimmunity (b) virus  Lean  Children & adolescent < 40 Peak age 14  White Race & cold weather  Absence of insulin  Treatment with Insulin  Abrupt  Prevalence 5%  Environment (strong family history)  Obese  Adults > 40  Black Race and warm weather  Resistance to insulin  OHGA + Insulin  Progressive  Prevalence 95% Dr. BJS New TYPE 1.5 (Latent Autoimmune Adult onset) 
  • 20. Both parents DM  50% Risk 1 Parent before 50  14% Risk 1 Parent after 50  7% Risk Dr. BJS
  • 21. • Polyuria  Frequent Urination Dr. BJS
  • 22. • Polydipsia  increased thirst Dr. BJS
  • 23. • Polyphagia  increased hunger Dr. BJS
  • 24. • Weight loss • Infection & Delayed healing • Fatigue Dr. BJS
  • 25. A1C (90 Days)Result Random Blood Sugar (RBS) 101-126 mg% Impaired 141-200 mg% 5.7 to 6.4 % Up to 100 mg% Normal Up to 140 mg% Up to 5.6 % Above 126 mg% Diabetic Above 200 mg% Above 6.4% Fasting Blood Sugar (FBS) Source: ADA Dr. BJS
  • 26. •Eyes  loss of vision Dr. BJS
  • 28. •Heart  Heart Attack Dr. BJS
  • 29. •Kidney  Kidney Failure Dr. BJS Diabetic Nephropathy
  • 31. •Nerves  Peripheral Neuropathy(Numbness) Dr. BJS
  • 32. •Diabetic Foot  Amputation Dr. BJS
  • 33. Obesity + F/H Pre-Diabetic (Candidate) DIABETIC Complications DEATH Dr. BJS
  • 34. Underwriting Approach  Case of DM Presented as: 1. Family History (see Age, Obesity & Rate) 2. Glycosuria (Postpone till Diagnosis & Rx) 3. I.G.T (see Profile & rate or further invest.) 4. Unaware but suffering Diabetes M. 5. Known Diabetic under control. (Accept +EM) 6. Known Diabetic out of control/comp. (Dec) Dr BJS
  • 35. 1. Age at onset: Earlier the age more the mortality risk At age 35: 300% At age 65: 150% 2. Type: (I or II) I riskier than II. 3. Duration since onset: More duration, more riskier. Dr. BJS
  • 36. 4. Control (A1c): 6.5%-10% ) Above 10%D. 5. Systolic Blood Pressure: Above 160  D 110 mm Hg = 100% (Standard) 155 = 200% (Twice) 165 = 400% (Four times) 6. Protienuria: Micro/Macro (++++)+ -->D 7. Complication: Heart Attack, Stroke, Kidney Failure, Blindness, Amputation, Diabetic Keto-Acidosis. 8. Smoking: Mild or Moderate. Dr. BJS
  • 37. Conversion from mg% to mmol/L  mg% / 18 = mmol/L 180 mg% / 18 = 10 mmol/L
  • 38. Conversion from A1c% to mg%  A1c% * 33.3 – 86 = mg% e.g. 6.5% A1c * 33.3 less 86 = 130 mg%.
  • 39. Conversion from A1c% to mmol/mol  (A1c% - 2.15) *10.929 e.g. (A1c 6.5% less 2.15) *10.929 = 4.35 *10.929 = 47.54 say 48 mmol/mol.