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Pregnancy Nutrition Growth &
Development of fetus
Dr Nupur Gupta, Consultant & Unit Head
MOTHER’S MILK IS BEST FOR THE BABY
Pregnancy & Lactation: First 4 Trimesters of Growth
Pregnancy – importance of Nutrients
Maternal nutrition-Impact on Fetal health
Lactation – importance of Nutrients
Clinical evidences
Breastfeeding Benefits – Mother & Child
Overview
Proprietary and confidential — do not distribute
Nutrition during pregnancy & lactation
• 2nd trimester to 6 months of lactation is a critical
period for an infant’s growth.
• 70% of brain development happens by birth & an
infant doubles its birth weight during 1st 6months
• Many mothers don’t get the extra nutrients they
need during this period
Proprietary and confidential — do not distribute
The human growth velocity - most rapid during 3rd
trimester & 4-5 months after birth
Nutrition during pregnancy & lactation
It is measured as gains in length,
skull circumference and weight
Proprietary and confidential — do not distribute
Pregnancy & Lactation: Physiology
• Nutrition demand increases
• For normal growth of infants in utero and
during early post-natal life
• The increased need for nutrients cannot always
be met from the maternal diet, however ample
it may be.
Proprietary and confidential — do not distribute
• Indian Mom* needs 31% extra energy & 41% extra protein
during lactation along with incr requirement of Calcium
(100%), Iron (19%), Vit B12 (50%) & Folic acid (50%)
Pregnancy & Lactation: Physiology
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Dietary gaps in India: Birth Outcomes
30% Incidence of IUGR
26% prevalence of LBW
21% prevalence of pre-term
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One of the most vulnerable segments of the
population for micronutrient deficiencies
Pregnant and lactating women
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~27 million pregnancies/year
India contributes about 20% of births worldwide
India has the highest proportion of children < 5 years.
We need to improve maternal nutrition
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Pregnancy- Recommended protein intake
Maximum during 3rd Trimester
For 10 kg gestational wt gain - 1, 7 and 23 g/day in 1st, 2nd,
and 3rd trimesters respectively.
Proprietary and confidential — do not distribute
Nutrients
FOLIC ACID
• Reduces the risk of congenital malformations and increases the birth weight
IRON
• Meet the high demands of erythropoiesis (RBC formation).
CALCIUM
• Proper formation of bones and teeth of the offspring, for secretion of breast-milk rich
in calcium and to prevent osteoporosis in the mother.
IODINE
• Ensures proper mental health of the growing foetus and infant.
VITAMINS
• Vitamin A is required during lactation to improve child survival. Besides these,
nutrients like vitamins B and C need to be taken by the lactating mother
Proprietary and confidential — do not distribute
Pregnancy– Nutrient deficiency
• Increased risk of premature birth and low birth
weight, neurodevelopmental problems and poor
growth outcomes in infants .
• Need in pregnancy
– Protein,
– Vitamin A, B12, C, D
– Folic acid, zinc, iron and choline
Proprietary and confidential — do not distribute
Maternal weight gain & fetal body weight
Gestational weight gain
of 10 to 14 kg,
average 12 kg
Birth weight of 3.1 - 3.6
kg with a desirable birth
weight of 3.3 kg
1kg = 20 to 25 gm
birthweight
Proprietary and confidential — do not distribute
Maternal weight gain & fetal body weight
• Energy + weight gain = protein, fat and water
• Protein - deposited in fetus (42%), uterus (17%),
blood (14%) placenta (10%) and breast (8%)
• Fat – mainly in fetus and maternal tissues &
contributes substantially to overall energy cost of
pregnancy
Proprietary and confidential — do not distribute
Maternal weight gain & fetal body weight
Tissue deposition max during 2nd & 3rd trimester
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Lactation – importance of nutrients
There is growing evidence that optimal dietary
intake of important nutrients, like iodine, DHA,
choline, and folate, is necessary during pregnancy
and lactation
Ziessel et al. Am J Clin Nutr 2009;89(suppl):685S–7S
Proprietary and confidential — do not distribute
Lactation- Recommended protein intake
Proprietary and confidential — do not distribute
Nutrients affecting infant health
• The main nutrients include
– Vitamins A, C, and D
– B vitamins,
– Iodine, and
– Choline
Proprietary and confidential — do not distribute
ESPGHAN COMMITTEE ON NUTRITION
The provision of supplemental food is able to improve
milk production and the duration of exclusive
breastfeeding among undernourished women.
Proprietary and confidential — do not distribute
Maternal nutritional risk factors for SGA
babies in a developed country.
This study has shown that eating more fish and
carbohydrate rich foods and taking folate
supplements around the time of conception is
associated with a reduced risk of having an SGA
baby.
Methods:
Case-control study of 844 cases (SGA) and 870 controls (appropriate size for
gestational age (AGA)). Only term (37+ completed weeks of gestation)
infants were included. Retrospective food frequency questionnaires were
completed at birth on the diet at the time of conception and in the last
month of pregnancy.
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preterm birth (A), low birth weight (B)
Preconception dietary patterns Preterm
Delivery
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The Barker theory (Fetal origin of adult diesase)
Fetal Malnutrition & Adult Metabolic Diseases
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Consequences Of Maternal
Anemia
Foetal
Outcomes
Reduced
Cognitive
Development
LBW &
SGA
Prone to
Infection
after
birth
Maternal Outcomes
Abruptio
Placenta
Prolonged
labour &
PPH
Compro
mised
Physical
capacity
Clinicalevidence Iron supplementation
Proprietary and confidential — do not distribute
Balanced energy Supplementation
WHO & Cochrane review
• Balanced energy and protein supplementation
improves fetal growth, reduces risk of stillbirth, LBW,
SGA infants, especially among undernourished pregnant
women.
• Antenatal nutritional advice - to reduce risk of preterm
birth.
Proprietary and confidential — do not distribute
Benefits of Breastfeeding to Babies
Incidence and severity
of infections
Growth until one
year of age
Incidence of obesity
in adulthood
Improves mental
development
Proprietary and confidential — do not distribute
Not breastfeeding is associated with
health risks for babies
Increased incidence of
Infectious morbidity (otitis media, GE, pneumonia)
Elevated risks of
Childhood obesity,
Type 1 & type 2 diabetes,
Leukemia
Sudden infant death syndrome (SIDS).
Rev Obstet Gynecol. 2009;2(4):222-231
Proprietary and confidential — do not distribute
In India, preferred alternative to Human Milk is:
Bovine Milk
 American Academy of Pediatrics (AAP) states that:
Unmodified cow's milk is not recommended for
infants less than 12mo of age
Proprietary and confidential — do not distribute
g/dl Human milk Cow milk
Total proteins 0.89 3.30
Caseins 0.25 2.60
Whey proteins 0.70 0.67
 -Lactalbumin 0.26 0.12
 ß-Lactoglobulin - 0.30
 Lactoferrin 0.17 trace
 Serum albumin 0.05 0.03
 Lysozyme 0.05 trace
 Immunoglobulin 0.105 0.066
Protein composition of mature HM and cow milk
is very different
(Hambaeus Nutr Abstr Rev, Rev Clin Nutr 1984;54:219-236)
Proprietary and confidential — do not distribute
Psychological benefits
for mother, child
& father
LAM – Contraception
Benefits of Breastfeeding to mother
Weight loss
after
delivery
Proprietary and confidential — do not distribute
If mother is not breastfeeding
• Epidemiologic data suggest that women who do
not breastfeed face higher risk of
– Breast and ovarian cancer,
– Obesity,
– Type 2 diabetes,
– Metabolic syndrome, and
– Cardiovascular disease.
Rev Obstet Gynecol. 2009;2(4):222-231
Proprietary and confidential — do not distribute
Maternal Counseling
Reasons for early breastfeeding discontinuation:
– Lack of confidence in mothers' ability to breastfeed,
– Problems with the infant latching or suckling, breast
pain or soreness,
– Perceptions of insufficient milk supply, and
– Lack of individualized encouragement from their
clinicians in the early post discharge period.
Proprietary and confidential — do not distribute
Summary
 Maternal Nutrition is one of the indicators for
improving Maternal and Child Health Care.
 The last two trimesters of pregnancy and first two
trimesters of lactation are most critical periods for
Infants growth & development.
 The increased need for energy, protein, and
micronutrients cannot always be met from the
maternal diet, however ample it may be.
Proprietary and confidential — do not distribute
Summary
 Inadequate nutrition may affect and lead to adverse
outcomes both in mother as well as fetus.
 In addition to adequate nutrition, maternal counseling
for breastfeeding plays a very important role in
effective lactation.
Proprietary and confidential — do not distribute

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Nutrition in pregnancy

  • 1. Pregnancy Nutrition Growth & Development of fetus Dr Nupur Gupta, Consultant & Unit Head
  • 2. MOTHER’S MILK IS BEST FOR THE BABY
  • 3. Pregnancy & Lactation: First 4 Trimesters of Growth Pregnancy – importance of Nutrients Maternal nutrition-Impact on Fetal health Lactation – importance of Nutrients Clinical evidences Breastfeeding Benefits – Mother & Child Overview
  • 4. Proprietary and confidential — do not distribute Nutrition during pregnancy & lactation • 2nd trimester to 6 months of lactation is a critical period for an infant’s growth. • 70% of brain development happens by birth & an infant doubles its birth weight during 1st 6months • Many mothers don’t get the extra nutrients they need during this period
  • 5. Proprietary and confidential — do not distribute The human growth velocity - most rapid during 3rd trimester & 4-5 months after birth Nutrition during pregnancy & lactation It is measured as gains in length, skull circumference and weight
  • 6. Proprietary and confidential — do not distribute Pregnancy & Lactation: Physiology • Nutrition demand increases • For normal growth of infants in utero and during early post-natal life • The increased need for nutrients cannot always be met from the maternal diet, however ample it may be.
  • 7. Proprietary and confidential — do not distribute • Indian Mom* needs 31% extra energy & 41% extra protein during lactation along with incr requirement of Calcium (100%), Iron (19%), Vit B12 (50%) & Folic acid (50%) Pregnancy & Lactation: Physiology
  • 8. Proprietary and confidential — do not distribute Dietary gaps in India: Birth Outcomes 30% Incidence of IUGR 26% prevalence of LBW 21% prevalence of pre-term
  • 9. Proprietary and confidential — do not distribute One of the most vulnerable segments of the population for micronutrient deficiencies Pregnant and lactating women
  • 10. Proprietary and confidential — do not distribute ~27 million pregnancies/year India contributes about 20% of births worldwide India has the highest proportion of children < 5 years. We need to improve maternal nutrition
  • 11. Proprietary and confidential — do not distribute Pregnancy- Recommended protein intake Maximum during 3rd Trimester For 10 kg gestational wt gain - 1, 7 and 23 g/day in 1st, 2nd, and 3rd trimesters respectively.
  • 12. Proprietary and confidential — do not distribute Nutrients FOLIC ACID • Reduces the risk of congenital malformations and increases the birth weight IRON • Meet the high demands of erythropoiesis (RBC formation). CALCIUM • Proper formation of bones and teeth of the offspring, for secretion of breast-milk rich in calcium and to prevent osteoporosis in the mother. IODINE • Ensures proper mental health of the growing foetus and infant. VITAMINS • Vitamin A is required during lactation to improve child survival. Besides these, nutrients like vitamins B and C need to be taken by the lactating mother
  • 13. Proprietary and confidential — do not distribute Pregnancy– Nutrient deficiency • Increased risk of premature birth and low birth weight, neurodevelopmental problems and poor growth outcomes in infants . • Need in pregnancy – Protein, – Vitamin A, B12, C, D – Folic acid, zinc, iron and choline
  • 14. Proprietary and confidential — do not distribute Maternal weight gain & fetal body weight Gestational weight gain of 10 to 14 kg, average 12 kg Birth weight of 3.1 - 3.6 kg with a desirable birth weight of 3.3 kg 1kg = 20 to 25 gm birthweight
  • 15. Proprietary and confidential — do not distribute Maternal weight gain & fetal body weight • Energy + weight gain = protein, fat and water • Protein - deposited in fetus (42%), uterus (17%), blood (14%) placenta (10%) and breast (8%) • Fat – mainly in fetus and maternal tissues & contributes substantially to overall energy cost of pregnancy
  • 16. Proprietary and confidential — do not distribute Maternal weight gain & fetal body weight Tissue deposition max during 2nd & 3rd trimester
  • 17. Proprietary and confidential — do not distribute Lactation – importance of nutrients There is growing evidence that optimal dietary intake of important nutrients, like iodine, DHA, choline, and folate, is necessary during pregnancy and lactation Ziessel et al. Am J Clin Nutr 2009;89(suppl):685S–7S
  • 18. Proprietary and confidential — do not distribute Lactation- Recommended protein intake
  • 19. Proprietary and confidential — do not distribute Nutrients affecting infant health • The main nutrients include – Vitamins A, C, and D – B vitamins, – Iodine, and – Choline
  • 20. Proprietary and confidential — do not distribute ESPGHAN COMMITTEE ON NUTRITION The provision of supplemental food is able to improve milk production and the duration of exclusive breastfeeding among undernourished women.
  • 21. Proprietary and confidential — do not distribute Maternal nutritional risk factors for SGA babies in a developed country. This study has shown that eating more fish and carbohydrate rich foods and taking folate supplements around the time of conception is associated with a reduced risk of having an SGA baby. Methods: Case-control study of 844 cases (SGA) and 870 controls (appropriate size for gestational age (AGA)). Only term (37+ completed weeks of gestation) infants were included. Retrospective food frequency questionnaires were completed at birth on the diet at the time of conception and in the last month of pregnancy.
  • 22. Proprietary and confidential — do not distribute preterm birth (A), low birth weight (B) Preconception dietary patterns Preterm Delivery
  • 23. Proprietary and confidential — do not distribute The Barker theory (Fetal origin of adult diesase) Fetal Malnutrition & Adult Metabolic Diseases
  • 24. Proprietary and confidential — do not distribute Consequences Of Maternal Anemia Foetal Outcomes Reduced Cognitive Development LBW & SGA Prone to Infection after birth Maternal Outcomes Abruptio Placenta Prolonged labour & PPH Compro mised Physical capacity Clinicalevidence Iron supplementation
  • 25. Proprietary and confidential — do not distribute Balanced energy Supplementation WHO & Cochrane review • Balanced energy and protein supplementation improves fetal growth, reduces risk of stillbirth, LBW, SGA infants, especially among undernourished pregnant women. • Antenatal nutritional advice - to reduce risk of preterm birth.
  • 26. Proprietary and confidential — do not distribute Benefits of Breastfeeding to Babies Incidence and severity of infections Growth until one year of age Incidence of obesity in adulthood Improves mental development
  • 27. Proprietary and confidential — do not distribute Not breastfeeding is associated with health risks for babies Increased incidence of Infectious morbidity (otitis media, GE, pneumonia) Elevated risks of Childhood obesity, Type 1 & type 2 diabetes, Leukemia Sudden infant death syndrome (SIDS). Rev Obstet Gynecol. 2009;2(4):222-231
  • 28. Proprietary and confidential — do not distribute In India, preferred alternative to Human Milk is: Bovine Milk  American Academy of Pediatrics (AAP) states that: Unmodified cow's milk is not recommended for infants less than 12mo of age
  • 29. Proprietary and confidential — do not distribute g/dl Human milk Cow milk Total proteins 0.89 3.30 Caseins 0.25 2.60 Whey proteins 0.70 0.67  -Lactalbumin 0.26 0.12  ß-Lactoglobulin - 0.30  Lactoferrin 0.17 trace  Serum albumin 0.05 0.03  Lysozyme 0.05 trace  Immunoglobulin 0.105 0.066 Protein composition of mature HM and cow milk is very different (Hambaeus Nutr Abstr Rev, Rev Clin Nutr 1984;54:219-236)
  • 30. Proprietary and confidential — do not distribute Psychological benefits for mother, child & father LAM – Contraception Benefits of Breastfeeding to mother Weight loss after delivery
  • 31. Proprietary and confidential — do not distribute If mother is not breastfeeding • Epidemiologic data suggest that women who do not breastfeed face higher risk of – Breast and ovarian cancer, – Obesity, – Type 2 diabetes, – Metabolic syndrome, and – Cardiovascular disease. Rev Obstet Gynecol. 2009;2(4):222-231
  • 32. Proprietary and confidential — do not distribute Maternal Counseling Reasons for early breastfeeding discontinuation: – Lack of confidence in mothers' ability to breastfeed, – Problems with the infant latching or suckling, breast pain or soreness, – Perceptions of insufficient milk supply, and – Lack of individualized encouragement from their clinicians in the early post discharge period.
  • 33. Proprietary and confidential — do not distribute Summary  Maternal Nutrition is one of the indicators for improving Maternal and Child Health Care.  The last two trimesters of pregnancy and first two trimesters of lactation are most critical periods for Infants growth & development.  The increased need for energy, protein, and micronutrients cannot always be met from the maternal diet, however ample it may be.
  • 34. Proprietary and confidential — do not distribute Summary  Inadequate nutrition may affect and lead to adverse outcomes both in mother as well as fetus.  In addition to adequate nutrition, maternal counseling for breastfeeding plays a very important role in effective lactation.
  • 35. Proprietary and confidential — do not distribute