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Dr.Shahida Baloch
 History of Blood Groups and Blood
Transfusions
•Experiments with blood transfusions have
been carried out for hundreds of years. Many
patients have died and it was not
until 1901, when the Austrian Karl Landsteiner
discovered human blood groups, that blood
transfusions became safer.
For this discovery he was awarded the Nobel
Prize in Physiology or Medicine in 1930
 An adult human has about 4–6 litres of blood
circulating in the body.
 Blood consists of several types of cells floating around
in a fluid called plasma.
 The red blood cells (RBCs)
contain haemoglobin, a protein that binds oxygen. RBCs
transport oxygen to, and remove carbon dioxide from
the tissues.
 The white blood cells
fight infection.
 The platelets
help the blood to clot, if you get a wound for example.
 The plasma
contains salts and various kinds of proteins.
 Blood group antigens are actually sugars (not
cheni) attached to the red blood cell.
 Antigens are “built” onto the red cell.
 Individuals inherit a gene which codes for
specific sugar(s) to be added to the red cell.
 The type of sugar added determines the
blood group.
 The differences in human blood are due to
the presence or absence of certain protein
molecules called antigens and antibodies.
 •The antigens are located on the surface of
the RBCs and the antibodies are in the blood
plasma.
 •The blood group you belong to depends on
what you have inherited from your parents.
What are the different blood groups?
Type A Blood
Type A
Antigen
Anti-B
Antibodies
Red Cells Plasma
Type B Blood
Type B
Antigen
Anti-A
Antibodies
Red Cells Plasma
Type AB Blood
Type B
Antigen
Neither Anti-A
or Anti-B
Antibodies
Red Cells Plasma
Type A
Antigen
Type O
Blood
Anti-A and
Anti-B
Antibodies
Red Cells
Plasma
Neither A nor B
Antigens
Blood Typing works by taking the antibodies
for each blood type and mixing them with a
drop of blood. Each drop of blood would be
mixed with a different anti-serum (anti-A,
anti-B and anti-Rh.
Pictures of what
actual slides
would look like
after addition of
the anti-serums
Blood Typing If we mix Anti- A serum with type A
blood there will be clumping of RBC’s as the antibodies
latch on the the antigens.
Type A Cells
Anti-A
serum
antibody
No clumping with Anti-B Antiserum
Type A Red Cell
Anti-B serum
antibody
Anti-A Anti-B Blood Group
NEG NEG O
POS NEG A
NEG POS B
POS POS AB
BLOOD GROUP ANTIGEN IN RBC
SURFACE
ANTIBODIES IN
SERUM
GENOTYPE
A A ANTI-B AA, AO
B B ANTI-A BB, BO
AB A & B NEITHER AB
O NEITHER NEITHER
ANTI-A AND
ANTI-B
OO
According to the ABO blood typing system there are
four different kinds of blood types.
 There are more than 20 genetically
determined blood group systems known
today
 The AB0 and Rhesus (Rh) systems are the
most important ones used for blood
transfusions.
 • Not all blood groups are compatible with
each other. Mixing incompatible blood
groups leads to blood clumping or
agglutination, which is dangerous for
individuals.
Thanks

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Blood groups for ss

  • 2.  History of Blood Groups and Blood Transfusions •Experiments with blood transfusions have been carried out for hundreds of years. Many patients have died and it was not until 1901, when the Austrian Karl Landsteiner discovered human blood groups, that blood transfusions became safer. For this discovery he was awarded the Nobel Prize in Physiology or Medicine in 1930
  • 3.  An adult human has about 4–6 litres of blood circulating in the body.  Blood consists of several types of cells floating around in a fluid called plasma.  The red blood cells (RBCs) contain haemoglobin, a protein that binds oxygen. RBCs transport oxygen to, and remove carbon dioxide from the tissues.  The white blood cells fight infection.  The platelets help the blood to clot, if you get a wound for example.  The plasma contains salts and various kinds of proteins.
  • 4.  Blood group antigens are actually sugars (not cheni) attached to the red blood cell.  Antigens are “built” onto the red cell.  Individuals inherit a gene which codes for specific sugar(s) to be added to the red cell.  The type of sugar added determines the blood group.
  • 5.  The differences in human blood are due to the presence or absence of certain protein molecules called antigens and antibodies.  •The antigens are located on the surface of the RBCs and the antibodies are in the blood plasma.  •The blood group you belong to depends on what you have inherited from your parents. What are the different blood groups?
  • 6. Type A Blood Type A Antigen Anti-B Antibodies Red Cells Plasma
  • 7. Type B Blood Type B Antigen Anti-A Antibodies Red Cells Plasma
  • 8. Type AB Blood Type B Antigen Neither Anti-A or Anti-B Antibodies Red Cells Plasma Type A Antigen
  • 9. Type O Blood Anti-A and Anti-B Antibodies Red Cells Plasma Neither A nor B Antigens
  • 10. Blood Typing works by taking the antibodies for each blood type and mixing them with a drop of blood. Each drop of blood would be mixed with a different anti-serum (anti-A, anti-B and anti-Rh.
  • 11. Pictures of what actual slides would look like after addition of the anti-serums
  • 12. Blood Typing If we mix Anti- A serum with type A blood there will be clumping of RBC’s as the antibodies latch on the the antigens. Type A Cells Anti-A serum antibody
  • 13. No clumping with Anti-B Antiserum Type A Red Cell Anti-B serum antibody
  • 14. Anti-A Anti-B Blood Group NEG NEG O POS NEG A NEG POS B POS POS AB
  • 15. BLOOD GROUP ANTIGEN IN RBC SURFACE ANTIBODIES IN SERUM GENOTYPE A A ANTI-B AA, AO B B ANTI-A BB, BO AB A & B NEITHER AB O NEITHER NEITHER ANTI-A AND ANTI-B OO According to the ABO blood typing system there are four different kinds of blood types.
  • 16.  There are more than 20 genetically determined blood group systems known today  The AB0 and Rhesus (Rh) systems are the most important ones used for blood transfusions.  • Not all blood groups are compatible with each other. Mixing incompatible blood groups leads to blood clumping or agglutination, which is dangerous for individuals.