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Prevention for Everyone
                        Averting America’s epidemic of mental, emotional, mental and related behavioral disorders

                        Dennis D. Embry, Ph.D. • President/Senior Scientist, PAXIS Institute
                        Presentation for ESD #113, Tumwater, WA, August 11, 2011

Friday, August 12, 11                                                                                               1
Welcome
                         introductions and
                           housekeeping




Friday, August 12, 11                        2
What will we pack in
                        our young people’s
                         suitcases for their
                            whole lives?




Friday, August 12, 11                          3
What bricks—heavy objects of pain, injury, illness, or problems
     —do you NOT want in young people’s suitcases for life?




Friday, August 12, 11                                                  4
Ask the suitcase questions of 30 people: some
              republicans, some democrats, some independents
              and some who are apolitical.




Friday, August 12, 11                                          5
What do you want to happen and not happen for our elders?




Friday, August 12, 11                                                   6
Bi-directional Wealth and Wellbeing Transfer




                                5-Year                      65-Year
                                 Olds                        Olds




Friday, August 12, 11                                                  7
Bi-directional Wealth and Wellbeing Transfer




                                5-Year                          65-Year
                                 Olds                            Olds



                                                            Who are living
                                                          longer though get
                                                        progressively sicker…


Friday, August 12, 11                                                           7
Bi-directional Wealth and Wellbeing Transfer



                                         Requiring more wealth transfer


                                5-Year                                            65-Year
                                 Olds                                              Olds



                                                                              Who are living
                                                                            longer though get
                                                                          progressively sicker…


Friday, August 12, 11                                                                             7
Bi-directional Wealth and Wellbeing Transfer



                                                 Requiring more wealth transfer


                                5-Year                                                    65-Year
                                 Olds                                                      Olds



                                                                                      Who are living
                                 Who are less
                                                                                    longer though get
                                and less able…
                                                                                  progressively sicker…


Friday, August 12, 11                                                                                     7
Bi-directional Wealth and Wellbeing Transfer



                                                 Requiring more wealth transfer


                                5-Year                                                        65-Year
                                 Olds            But elders voting to stop funds to kids       Olds



                                                                                          Who are living
                                 Who are less
                                                                                        longer though get
                                and less able…
                                                                                      progressively sicker…


Friday, August 12, 11                                                                                         7
Friday, August 12, 11   8
Our Own Children’s Future




Friday, August 12, 11                               9
Our Own Children’s Future

                                                                                           ADHD

                                          stealing                                                 aggression
                                                                        asthma                            depression
                        learning disabilities
                                                           obesity                    cancer
                                                                                                               bipolar
                          depression
                                                     hi-blood pressure             heart-disease
                                      violence                                                             tobacco
                                                 suicide                diabetes                alcohol
                                                           crime                        drugs
                                                                     dangerous acts




Friday, August 12, 11                                                                                                    10
Friday, August 12, 11   11
Washington State’s Future



                        Children       Children      Children
                        Ages 0-5      Ages 6-18     Ages 0-18
                        457,269       1,129,723     1,586,991




Friday, August 12, 11                                           12
What happens if we
                        pack every Washington
                        state first grader’s life
                        suitcase well?
                                            Universal
                                           Behavioral
                        First Grad       Vaccine Cost       Net Economic
                          Cohort     X    ($150 each)   =   Benefit for All
                         76,211          $11,431,718        $1,094,244,047




Friday, August 12, 11                                                        13
Why prevention for
                        everyone?
                        Shouldn’t we focus
                        on the people at risk?




Friday, August 12, 11                            14
The nation faced
                        a national
                        epidemic of polio.

                        Emergency wards
                        were filled with
                        iron lungs.
                        Children died or
                        crippled. The
                        nation was
                        terrified.
                        Who should be given the
                        vaccine?

                        Only the frail or “at risk”?

                        Or, all children?




Friday, August 12, 11                                  15
The Epidemic Today?
                        Mental, Emotional, Behavioral,
                        and Related Physical Illnesses




Friday, August 12, 11                                    16
The Epidemic Today?
                        Mental, Emotional, Behavioral,
                        and Related Physical Illnesses
                           Do you know a
                            middle class
                            family with a
                            child with a
                               MEB?




Friday, August 12, 11                                    16
Lifetime Prevalence of Disorders in US Adolescents (N=10,123)
        Merikangas et al., 2010   40%

                                  35%

                                  30%

                                  25%

                                  20%

                                  15%

                                  10%

                                  5%

                                  0%
                                        4   5   6   7   8   9   10 11 12       13   14   15   16   17   18
                                                                Age in Years

Friday, August 12, 11                                                                                        17
Lifetime Prevalence of Disorders in US Adolescents (N=10,123)
        Merikangas et al., 2010   40%

                                  35%
                                                                                                             Anxiety
                                  30%

                                  25%

                                  20%

                                  15%

                                  10%

                                  5%

                                  0%
                                        4   5   6   7   8   9   10 11 12       13   14   15   16   17   18
                                                                Age in Years

Friday, August 12, 11                                                                                                  17
Lifetime Prevalence of Disorders in US Adolescents (N=10,123)
        Merikangas et al., 2010   40%

                                  35%
                                                                                                             Anxiety
                                  30%

                                  25%
                                                                                                             Behavior
                                  20%

                                  15%

                                  10%

                                  5%

                                  0%
                                        4   5   6   7   8   9   10 11 12       13   14   15   16   17   18
                                                                Age in Years

Friday, August 12, 11                                                                                                   17
Lifetime Prevalence of Disorders in US Adolescents (N=10,123)
        Merikangas et al., 2010   40%

                                  35%
                                                                                                             Anxiety
                                  30%

                                  25%
                                                                                                             Behavior
                                  20%
                                                                                                             Mood
                                  15%

                                  10%

                                  5%

                                  0%
                                        4   5   6   7   8   9   10 11 12       13   14   15   16   17   18
                                                                Age in Years

Friday, August 12, 11                                                                                                   17
Lifetime Prevalence of Disorders in US Adolescents (N=10,123)
        Merikangas et al., 2010   40%

                                  35%
                                                                                                             Anxiety
                                  30%

                                  25%
                                                                                                             Substance
                                                                                                             Behavior
                                  20%
                                                                                                             Mood
                                  15%

                                  10%

                                  5%

                                  0%
                                        4   5   6   7   8   9   10 11 12       13   14   15   16   17   18
                                                                Age in Years

Friday, August 12, 11                                                                                                    17
Youth MEB Prevalence Rate Comparison



                              4x
                                            2x
                              USA       United Kingdom   OECD




Friday, August 12, 11                                           18
Depression by Jobs




Friday, August 12, 11                        19
Nearly 3 out of 4 of the nation's 17- to 24-year-olds are
                        ineligible for military service for based on national
                        epidemiological data

                                                                                                • Medical/physical problems,
                                                                                                    35 percent.

                                                                                                • Illegal drug use, 18 percent.
                                                                                                • Mental Category V (the
                                                                                                    lowest 10 percent of the
                                                                                                    population), 9 percent.

                                                                                                • Too many dependents under
                                                                                                    age 18, 6 percent.

                                                                                                • Criminal record, 5 percent.

                               Army Times, Nov 5, 2009 • www.missionreadiness.org/PAEE0609.pd


Friday, August 12, 11                                                                                                             20
Cumulative prevalence of psychiatric disorders by
      young adulthood: a prospective cohort analysis from
      the Great Smoky Mountains Study.
      By 21 years of age, 61.1% of
      participants had met criteria for a well-
      specified psychiatric disorder. An
      additional 21.4% had met criteria for a
      not otherwise specified disorder only,
      increasing the total cumulative
      prevalence for any disorder to 82.5%.




Friday, August 12, 11                                       21
The US has 75
            million children
            and teens.
            40.4 million are
            on psychotropic
            medications


                         Wall Street
                          Journal,
                        12-28-2010



Friday, August 12, 11                  22
Friday, August 12, 11   23
Why are these trends happening
                         in Washington State and the
                                United States?




Friday, August 12, 11                                    23
What should the people
                        Why are these trends happening   Washington State do to protect all
                         in Washington State and the     of its children from the epidemic of
                                United States?           mental, emotional, behavioral and
                                                              related physical disorders?




Friday, August 12, 11                                                                           23
Major Ecologic Causes of the Dual Inflammatory Threats to Children & Youth

                        Reinforcement      Antecedents          Physiological        Verbal Relations




Friday, August 12, 11                                                                                   24
Multi-Inflammatory Threat Reaction




                          Major Ecologic Causes of the Dual Inflammatory Threats to Children & Youth

                        Reinforcement      Antecedents           Physiological       Verbal Relations




Friday, August 12, 11                                                                                   24
Mood                              Reward         Executive      Behavioral
                                            Attention
                         Stability                           Delay         Function      Competencies

                                                                                         Immune-
                          Motor                                                           Healing
                          Skills            Multi-Inflammatory Threat Reaction            Functions




                           Major Ecologic Causes of the Dual Inflammatory Threats to Children & Youth

                        Reinforcement       Antecedents           Physiological        Verbal Relations




Friday, August 12, 11                                                                                     24
Substance                         Work         Obesity,
          Early          Mental Illness                   Violence                                   Cancer      School
                                            Abuse                         Problems         etc
          Sex                                                                                                    Failure

                          Mood                              Reward           Executive           Behavioral
                                            Attention
                         Stability                           Delay           Function           Competencies

                                                                                                Immune-
       STD’s              Motor                                                                  Healing          Special
                          Skills            Multi-Inflammatory Threat Reaction                   Functions           Ed




                           Major Ecologic Causes of the Dual Inflammatory Threats to Children & Youth

                        Reinforcement       Antecedents              Physiological            Verbal Relations




Friday, August 12, 11                                                                                                       24
Evolutionary Mismatch
                         How have the changes in modern
                         human ecology for which were were
                         evolved and adapted affected
                          Sleep
                          Eating
                          Mental health
                          Problem behaviors
                          Physical Health
                          Sexual maturity




Friday, August 12, 11                                        25
What are the social rewards for these behaviors?




                        Billy Good      Billy Bad
Friday, August 12, 11                                   26
What are the social rewards for these behaviors?




                        Billy Good      Billy Bad
Friday, August 12, 11                                   26
GGGCCGCCGCATTCGT-3 and 5 -
 AGGGA-3 ; 661-nt product; ref. 20)
 CGTACTGTGCGGCCTCAACGA-
CTGCGTGATGT-3 ; 705-nt product
  r some amplifications of the VNTR,                                                                                                                                                                                                      Fig. 3. Proposed o

 were used (2). The alternative primers                                                                                                                                                                                                   sity. A simplified m
                                                                                                                                                                                                                                          repeat sequence

  e VNTR to minimize out-of-register                                                                                                                                                                                                      with only major re
                                                                                                                                                                                                                                          indicated (Fig. 2). T

  ation. PCRs were conducted in 25- l
                                                                                                                                                                                                                                          7R alleles are show
                                                                                                                                                                                                                                          minor 3R, 5R, and
                                                                                                                                                                                                                                          in gray along with
 f genomic DNA, 200 M dXTPs, 0.5                                                                                                                                                                                                          origins by unequa
                                                                                                                                                                                                                                          arrows). Large red
  buffer (Qiagen, Chatsworth, CA), 1                                                          Text                                                                                                                                        putative multistep
                                                                                                                                                                                                                                          lele. The adjacent p

 .625 units of Taq DNA polymerase                                                                                                                                                                                                         S1), exon 1 (L2 S2)
                                                                                                                                                                                                                                          A-C) polymorphism

 s performed by using Perkin–Elmer                                                                                                                                                                                                        strong linkage of
                                                                                                                                                                                                                                          polymorphisms wit

  c, 96°C hot start was used followed by
                                                                                                                                                                                                                                          is noted.



nd 68°C for 1 min. After a 4-min chase      Fig. 1. Diagrammatic representation of the human DRD4 gene region. Exon              Standard methods of estimating coalescence time for these alleles
                                                                                                                              are not applicable, given the repetitive nature of the region and high
                                                                                                                                                                                                       high fitness if almost everyone is meek but might r
                                                                                                                                                                                                       when very common, because aggressive individua
e eliminated with 0.5 units of shrimp       positions are indicated by blocks (yellow, noncoding; orange, coding). The        recombination frequency. However, calculations of allele age based
                                                                                                                              on the relatively high worldwide population frequency of the DRD4
                                                                                                                                                                                                       penalties of frequent conflict. This type of freq
                                                                                                                                                                                                       selection might be expected to apply to many type
   Amersham Pharmacia), 0.1 unit of         approximate positions of a 120-bp promoter region duplication (blue trian-        4R and 7R alleles suggest that these alleles are ancient ( 300,000
                                                                                                                              years old; refs. 25 and 26; see Methods). On the other hand,
                                                                                                                                                                                                       variation, including those associated with this part
                                            gle), an exon 1 12-bp duplication (blue triangle), an exon 3 VNTR (blue                                                                                    mitter receptor (4–9).
 ham Pharmacia), and 1 SAP buffer                                                                                             calculations of allele age based on the observed intraallelic vari-         Alternative explanations to the proposed posit
                                            triangle), and two intron 3 SNPs are indicated. 2R–11R variants of the VNTR are   ability (refs. 26 and 27; see Methods) suggest that the 7R allele is     as recent random bottlenecks, population expan
 e SAP Exo I reaction was carried out                                                                                         5–10-fold ‘‘younger’’ (30,000–50,000 years old). Such large discrep-     ulation admixture (24) are less likely to account
                                            indicated below exon 3 (blue) along with their worldwide population fre-          ancies between allele ages calculated by these two methods usually
  15-min heat inactivation at 72°C. The     quencies determined by PCR analysis (3, 17).
                                                                                                                              are taken as evidence that selection has increased the frequency of
                                                                                                                                                                                                       results. Bottlenecks certainly have occurred duri
                                                                                                                                                                                                       tion and evolution (33–35) and undoubtedly ha
                                                                                                                              the allele to higher levels than expected by random genetic drift
  reaction was used directly for DNA                                                                                          (26). The absolute values of these estimates are greatly affected by
                                                                                                                                                                                                       current worldwide DRD4 allele frequency. Num
                                                                                                                                                                                                       studies on other genes (24, 33, 35) have shown
                                                                                                                              the assumptions used in their computations, for example the
 uals, the two allelic PCR products first                                                                                     assumed recombination frequency (26). We have used conservative
                                                                                                                                                                                                       Africa’’ constriction of allele diversity (and an incr
                                                                                                                                                                                                       occurred. In the present study, a greater diversit
                                                                                                                              estimates of recombination frequency based on the average ob-
 rose gels. DNA cycle sequencing was        majority of individuals were heterozygotes, and the two allelic PCR               served for the terminal 20 megabases of 11p (31). Given the
                                                                                                                                                                                                       was found for African DRD4 4R alleles in co
                                                                                                                                                                                                       remainder of our population sample, which is co
                                                                                                                              observed high recombination at this locus (Table 1 and Fig. 3), it
niques using ABI 377 and 3700 auto-         products could be separated by gel electrophoresis before sequenc-                is likely that the actual age of the 7R allele is even younger, and
                                                                                                                                                                                                       out-of-Africa hypothesis (24). Although one
                                                                                                                                                                                                       the 7R allele frequency was increased by ch
                                                                                                                              further LD analysis will refine these estimates. The important
                                                                                                                                                                                                       out-of-Africa expansion, this theory does not ex
                                            ing, providing unambiguous haplotypes. Altogether, we screened                    conclusion, however, is that regardless of the parameters assumed,
                                                                                                                              the relative age differences for the 4R and 7R alleles calculated
                                                                                                                                                                                                       lack of diversity in African 7R alleles. The mo
                                                                                                                                                                                                       7R(1-2-6-5-2-5-4)-A-C haplotype (Fig. 3) is fou
                                            over 450,000 bp of genomic DNA and 2,968 48-bp repeats.                           from intraallelic variability remains large, whereas their population
                                                                                                                                                                                                       comparable to those found worldwide ( 85%)
 ions. Ka Ks ratios were calculated by
                                                                                                                              frequency suggests they are both ancient.
                                                                                                                                                                                                       imagine what type of bottleneck could produce
                                              In the 600 chromosomes sequenced, 56 different haplotypes                          The simplest hypothesis to account for (i) the observed bias in
                                                                                                                                                                                                       strong worldwide LD for a single allele (DRD4 7R
 . Putative recombinant haplotypes          were found (Table 1). These haplotypes were composed of 35
                                                                                                                              nucleotide changes (Ka Ks), (ii) the unusual sequence organization
                                                                                                                              of the DRD4 7R allele, and (iii) the strong LD surrounding this          the remaining alleles. A model that is consistent
                                                                                                                                                                                                       results is the ‘‘weak Garden of Eden’’ hypothesis
pendent events. Allele age calcula-         distinct 48-bp variant motifs (Fig. 2), 19 of which were reported
                                                                                                                              allele is that the 7R allele arose as a rare mutational event (or
                                                                                                                              events) that nevertheless increased to high frequency by positive        DRD4 4R allele would be hypothesized to be an
  Friday, August 12, 11                                                                                                       selection. Advantageous alleles usually take a long time to reach a      in indigenous populations, whereas the 7R 27   allele
Reinforcement             Reinforcement                Adult                   Behavior &
                         for “Good”                 for “Bad”                 coercion                the Matching
                         In one hour of school,   In one hour of school,                                  Law
                           how often do peers       how often do peers      How often might adults
  Example               reinforce the “good” in    reinforce the “bad” in      in authority exert
                                                                                                      The probability of human
                                                                                                          behavioral choice
 Evolutionary                   school?                   school?             perceived threats of
                                                                                                      “matches” this saturation
  Mismatch                How often by adults       How often by adults      coercion in school, at
                                                                                                      formula in the classroom,
                               at school?                at school?             home, or in the
                                                                                                        home and community,
                        How often at home or      How often at home or      community in a single
                                                                                                      and Matching Law works
                                                                                     day?
                          community in a day?      community in a day?                                     for all vertebrate
                                                                                                               creatures




Friday, August 12, 11                                                                                                         28
What happens if you change the
                               Matching Law (the Good
                        Behavior Game) in a classroom?




Friday, August 12, 11                                    29
CDC Nurses Office Study


                                                                    60%

                                                                    50%




                                                Percentage Change
                                                                    40%

                                                                    30%

                                                                    20%

                                                                    10%

                                                                     0%

                                                                    -10%

                                                                    -20%
                                                                           All Visits   Injury Viists Non-Injuries   Fighting   Non-Fighting
                                                                                                                     Injuries     Injuries

                                                                                        Control/Wait List   PeaceBuilders




                        What happens if you teach students to praise
                        each other for “peaceability”

Friday, August 12, 11                                                                                                                          30
DRI = Differential       DRO = Differential
                        Reinforcement of         Reinforcement of Other
                        Incompatible Behaviors   Behaviors

Friday, August 12, 11                                                     31
Molecular Psychiatry (2000) 5, 467–475
                                                                                     2000 Macmillan Publishers Ltd All rights reserved 1359-4184/00 $15.00
                                                                                    www.nature.com/mp


                        MILLENNIUM ARTICLE

                        Is there an evolutionary mismatch between the normal
                        physiology of the human dopaminergic system and
                        current environmental conditions in industrialized
                        countries?
                        L Pani
                        CNR Center for Neuropharmacology, ‘BB Brodie’ Department of Neuroscience, University of Cagliari and Neuroscienze
                        Scarl, Cagliari, Italy


                                   A large body of evidence has recently defined a field theory known as ‘evolutionary mismatch’,
                                   which derives its attributes largely from the fact that current environmental conditions are
                                   completely different from those in which the human central nervous system evolved. Current
                                   views on the evolutionary mismatch theory lack, however, any attempts to define which brain
                                   areas or neuronal circuits should be mostly involved in coding such misevolved traits and to
                                   what extent our neurobiological knowledge can be applied to the topographical localization
                                   of a specific psychopathology. In this respect the mesocorticolimbic dopaminergic circuits
                                   have long been misconceptualized as simple reward or reinforcement systems. Instead, they
                                   motivate and coordinate the functions of the higher brain areas that mediate planning and
                                   foresight and direct finalized movement in both animals and humans. These systems make
                                   animals intensely interested in exploring the world around them, but by the same means they
                                   also make them susceptible to the environmental stimuli that have been sought and con-
                                   sumed. It is has been speculated that the cortical dopamine targets that developed most
                                   recently in phylogeny are of particular functional value, and that the mesocorticolimbic dopa-
                                   minergic system is involved in more complex integrative functions than previously assumed.
                                   In the present paper I will argue that some mental disorders may have their deep roots in the
                                   evolutionary mismatch between the normal physiology of the mesocorticolimbic dopami-
                                   nergic system and the current environmental conditions in affluent societies. Molecular Psy-
                                   chiatry (2000) 5, 467–475.
                                   Keywords: evolution; limbic system; dopamine; stress; depression; emotions; Darwinian medicine


Friday, August 12, 11   Introduction                                                Table 1      Steps in brain evolution with increasing environ-
                                                                                                                                                              32
Changes in
                               antecedents of life?

                               TV’s in bedrooms
                        Text   Electronic games
                               Computers, social media




Friday, August 12, 11                                    33
Social Network & Sleep Deprivation
                        Text


                        Social Network & Marijuana Use




Friday, August 12, 11                                        34
Apparent consumption o inoleic acid (% of dietary energy) among
                                                                                                             Australia, Canada, UK and USA for the years 1961–2000


                                                                                                                                                     10        Australia       Canada         UK        USA




                                                                                                             Apparent consumption of linoleic acid
                                                                                                                                                     9

                                                                                                                                                     8

                                                                                                                                                     7




                                                                                                                         (% energy)
                                                                                                                                                     6

                                                                                                                                                     5

                                                                                                                                                     4

                                                                                                                                                     3

                                                                                                                                                     2

                                                                                                                                                     1

                                                                                                                                                     0
                                                                                                                                                          1960 1965   1970   1975 1980 1985    1990   1995 2000




                                                                                                                                                                                                                    “Risky” Beh.
                             Evolution                               Neonates                                                                        Breast Milk
                                                                                                                                                                                                                    & Mismatch
                         In the Rife Valley, the                   Successful human                                                       American infants have
                        human brain evolution                     neonates born with                                                    been getting steadily less                                                     Theory
                        the result of eating fish                    60-day supply of                                                     omega-3 (n3) and more                                                       Almost all adolescent
                                                                                                                                            pro-inflammatory                                                       risky behaviors have now
  Example                high in omega-3 not                          omega-3 in
                                                                                                                                         omega-6 (n6) in breast                                                    been documented to be
                           savannah animals                      subcutaneous fat from
 Evolutionary                                                                                                                                      milk                                                              related to low n3 and
                                                                     mother’s diet                                                                                                                                     high n6 in US diet
 Physiology                See Broadhurst, Cunnane, &                                                                                                                                                               change in last 50 years
  Mismatch
                                                                See HIbbeln et al. (2007).Maternal seafood
                        Crawford (1998). Rift Valley lake fish                                                                        See Ailhaud et al. (2006).Temporal changes
                                                                      consumption in pregnancy and
                                                                                                                                              in dietary fats: Role of n6
                        and shellfish provided brain-specific     neurodevelopmental outcomes in childhood                                                                                                           Hibbeln et al. (2006). Healthy intakes of n-3
                                                                                                                                       polyunsaturated fatty acids in excessive
                                    nutrition for                (ALSPAC study): an observational cohort
                                                                                                                                                    adipose tissue                                                and n-6 fatty acids: estimations considering
                                    early Homo                                     study                                                                                                                                       worldwide diversity.
                                                                                                                                       development and relationship to obesity




Friday, August 12, 11                                                                                                                                                                                                                                        35
30%




                        Percentage with Psychosis at 12 months
                                                                                             27.5%
                                                                 24%


                                                                 18%


                                                                 12%


                                                                 6%
                                                                       4.9%
                                                                 0%
                                                                       Omega-3               Placeo
                                                                                 Psychosis




Friday, August 12, 11                                                                                 36
Evolutionary Mismatch
                        Language of belonging and danger




Friday, August 12, 11                                      37
K                                                                     R R
                              Path                                                                  Path
                                                                                                       Path


                                                       Evolutionary Path
                                                        of a Child’s Life




                        Probability of long-life and                         Probability of short-life and
                          reproductive success                              doubtful reproductive success




Friday, August 12, 11                                                                                         38
K                                                                      R R
                              Path                                                                   Path
                                                                                                        Path


                                                       Evolutionary Path
                                                        of a Child’s Life




                        Probability of long-life and                         Probability of short-life and
                          reproductive success                              doubtful reproductive success
                                                                               R-Path can be triggered by
                                                                            evolutionary mismatch in social or
                                                                                  physical environment.




Friday, August 12, 11                                                                                            38
Human Infectious/Biological Threats   Human Predatory Threats




Friday, August 12, 11                                                                   39
Human Infectious/Biological Threats   Human Predatory Threats


                           Evolutionary Adaptive Responses
                                      (Simplified)




                        Generalized           Localized
                        Inflammatory       Inflammatory
                        Response             Response

                          Anti-Inflammatory Regulators




Friday, August 12, 11                                                                   39
Human Infectious/Biological Threats     Human Predatory Threats


                           Evolutionary Adaptive Responses    Evolutionary Adaptive Responses
                                      (Simplified)                        (Simplified)




                                                               Intra-Group             Threat Attributional
                        Generalized           Localized        Affiliation               Bias (Inflammatory)
                        Inflammatory       Inflammatory          (Anti-Inflammatory)
                                                                                                Out-Group
                        Response             Response
                                                                                    Aggress. (Inflammatory)
                                                               Intra-Group
                                                               Cooperation            Tit-for-Tat Beh. Bias
                          Anti-Inflammatory Regulators          (Anti-Inflammatory)
                                                                                              (Inflammatory)




Friday, August 12, 11                                                                                         39
Human Infectious/Biological Threats                      Human Predatory Threats


                           Evolutionary Adaptive Responses                     Evolutionary Adaptive Responses
                                      (Simplified)             Neuro-Hormones              (Simplified)

                                                                   Mood
                                                                 Modulators


                                                                Reward Delay    Intra-Group             Threat Attributional
                        Generalized           Localized          Modulators
                                                                                Affiliation               Bias (Inflammatory)
                        Inflammatory       Inflammatory                           (Anti-Inflammatory)
                                                                                                                 Out-Group
                        Response             Response             Stress
                                                                                                     Aggress. (Inflammatory)
                                                                 Modulators     Intra-Group
                                                                                Cooperation            Tit-for-Tat Beh. Bias
                          Anti-Inflammatory Regulators           Puberty/Sex     (Anti-Inflammatory)
                                                                Modulators                                     (Inflammatory)




Friday, August 12, 11                                                                                                          39
Human Infectious/Biological Threats                          Human Predatory Threats


                                   Evolutionary Adaptive Responses                       Evolutionary Adaptive Responses
                                              (Simplified)             Neuro-Hormones                (Simplified)

                                                                            Mood
                                                                          Modulators


                                                                         Reward Delay      Intra-Group             Threat Attributional
                               Generalized            Localized           Modulators
                                                                                           Affiliation               Bias (Inflammatory)
                               Inflammatory        Inflammatory                              (Anti-Inflammatory)
                                                                                                                            Out-Group
                               Response              Response              Stress
                                                                                                                Aggress. (Inflammatory)
                                                                          Modulators       Intra-Group
                                                                                           Cooperation            Tit-for-Tat Beh. Bias
                                 Anti-Inflammatory Regulators             Puberty/Sex       (Anti-Inflammatory)
                                                                         Modulators                                       (Inflammatory)


                        Modern culture commonly produces multiple evolutionary mismatches triggering multiple inflammatory responses.

Friday, August 12, 11                                                                                                                     39
Obesity
                         Conduct
                         Disorders


                                                         Homicide &
                                                          Suicide




                                     Depression

                                                                              Oppositional/
                                                  Addictions                    ADHD


                                                                      Aggression

                                                           Self
                                                          harm


                        ANXIETY



                        R PATH = Risky behaviors or health
Friday, August 12, 11                                                                                   40
How many of you know a regular
                American family with a child with…
            a mental, emotional or behavioral disorder?




Friday, August 12, 11                                     41
How many of you know a regular
                American family with a child with…
            a mental, emotional or behavioral disorder?

                                                    Like a more
                Like ADHD or   Like learning or    serious mental     Like a serious
                   behavior    developmental         illness like       addictions
                  problems?       disorder?           bipolar or        problem?
                                                  suicidal actions?

Friday, August 12, 11                                                                  41
Key messages about mental, emotional & behavioral disorders…




Friday, August 12, 11                                                                  42
Key messages about mental, emotional & behavioral disorders…


         MEB’s are
        preventable.




Friday, August 12, 11                                                                  42
Key messages about mental, emotional & behavioral disorders…


         MEB’s are                 Break-even for
        preventable.               MEB prevention
                                    is one year.




Friday, August 12, 11                                                                  42
Key messages about mental, emotional & behavioral disorders…


         MEB’s are                 Break-even for   MEB prevention
        preventable.               MEB prevention     balances
                                    is one year.      budgets.




Friday, August 12, 11                                                                  42
Key messages about mental, emotional & behavioral disorders…


         MEB’s are                 Break-even for   MEB prevention   MEB prevention
        preventable.               MEB prevention     balances        improves US
                                    is one year.      budgets.          business.




Friday, August 12, 11                                                                  42
Key messages about mental, emotional & behavioral disorders…


         MEB’s are                 Break-even for   MEB prevention   MEB prevention
        preventable.               MEB prevention     balances        improves US
                                    is one year.      budgets.          business.



       Effective MEB
      prevention helps
      national security.



Friday, August 12, 11                                                                  42
Key messages about mental, emotional & behavioral disorders…


         MEB’s are                 Break-even for    MEB prevention   MEB prevention
        preventable.               MEB prevention      balances        improves US
                                    is one year.       budgets.          business.



       Effective MEB               MEB prevention
      prevention helps             helps US global
      national security.              success.



Friday, August 12, 11                                                                  42
Key messages about mental, emotional & behavioral disorders…


         MEB’s are                 Break-even for    MEB prevention   MEB prevention
        preventable.               MEB prevention      balances        improves US
                                    is one year.       budgets.          business.


                                                     MEB prevention
       Effective MEB               MEB prevention     saves Social
      prevention helps             helps US global     Security &
      national security.              success.         Medicare.



Friday, August 12, 11                                                                  42
Key messages about mental, emotional & behavioral disorders…


         MEB’s are                 Break-even for    MEB prevention   MEB prevention
        preventable.               MEB prevention      balances        improves US
                                    is one year.       budgets.          business.


                                                     MEB prevention
       Effective MEB               MEB prevention     saves Social    MEB prevention
      prevention helps             helps US global     Security &       heals past
      national security.              success.         Medicare.        inequities.



Friday, August 12, 11                                                                  42
Friday, August 12, 11   43
Mental, emotional, behavioral and health
                         disorders are preventable by our own
                        hands—right here in Washington State.




Friday, August 12, 11                                              44
Increase nurturance of prosociality for
                                                                               persons of all ages
                                                                               This can be individual, family, school and/or community action




                                                                               Reduce toxic influences of all ages
                                                                               This can be at an individual, family, school and/or community level


                                                                               Increase psychological flexibility among
                                                                               people of all ages
                                                                               This can be achieved across settings, as the above.

                        From Biglan, Flay and Embry. Nurturing Environments and the Next Generation of Prevention Research and Practice for the American Psychologist


Friday, August 12, 11                                                                                                                                                   45
Clin Child Fam Psychol Rev
                        DOI 10.1007/s10567-008-0036-x




                        Evidence-based Kernels: Fundamental Units of Behavioral
                        Influence
                                                                                                                                                            Basic understanding of kernels
                                                                                                                                                            Embry, D. D. and A. Biglan (2008). "Evidence-Based Kernels:
                        Dennis D. Embry Æ Anthony Biglan




                                                                                                                                                            Fundamental Units of Behavioral Influence." Clinical Child & Family
                                                                                                                                                            Psychology Review 11(3): 75-113.
                        Ó The Author(s) 2008. This article is published with open access at Springerlink.com


                        Abstract This paper describes evidence-based kernels,                  This paper presents an analysis of fundamental units of
                        fundamental units of behavioral influence that appear to                behavioral influence that underlie effective prevention and
                        underlie effective prevention and treatment for children,              treatment. We call these units kernels. They have two
                        adults, and families. A kernel is a behavior–influence                  defining features. First, in experimental analysis,
                        procedure shown through experimental analysis to affect a              researchers have found them to have a reliable effect on




                                                                                                                                                            Using kernels for population change
                           A R T I C L E


                                           COMMUNITY-BASED
                                           PREVENTION USING SIMPLE,
                                           LOW-COST, EVIDENCE-BASED                                                                                         Embry, D. D. (2004). "Community-Based Prevention Using Simple,
                                           KERNELS AND BEHAVIOR
                                           VACCINES                                                                                                         Low-Cost, Evidence-Based Kernels and Behavior Vaccines."
                                           Dennis D. Embry
                                           PAXIS Institute
                                                                                                                                                            Journal of Community Psychology 32(5): 575.
                                           A paradox exists in community prevention of violence and drugs. Good




                          B e h a v i o r a l Vac c i n e s an d
                          Evidence-Based Kernels:
                          Nonpharmaceutical                                                                                                                 Behavioral vaccines for disease control
                          A p p ro a c h e s f o r th e
                          P re v e n t i o n o f M e n t a l ,                                                                                              Embry, D. D. 2011. Behavioral vaccines and evidence-based kernels:
                          Emotional, and
                          B e h a v i o r a l D i s o rd e r s
                                                                                                                                                            non-pharmaceutical approaches for the prevention of mental, emotional,
                          Dennis D. Embry,               PhD
                                                                                                                                                            and behavioral disorders. Psychiatr Clin North Am 34 (1):1-34.
                            KEYWORDS




Friday, August 12, 11                                                                                                                                                                                                                46
What is a kernel?
                              Is the smallest unit of scientifically proven behavioral
                              influence.

                          •   Is indivisible; that is, removing any part makes it
                              inactive.

                              Produces quick easily measured change that can
                              grow much bigger change over time.

                              Can be be used alone OR combined with other
                              kernels to create new programs, strategies or
                              policies.

                          •   Are the active ingredients of evidence-based
                              programs

                          •   Can be spread by word-of-mouth, by modeling, by
                              non professionals.

                          •   Can address historic disparities without stigma, in
                              part because they are also found in cultural wisdom.




Friday, August 12, 11                                                                   47
Relational
                           Antecedent      Reinforcement             Physiological
                                                                                                  Frame
                             Kernel            Kernel                   Kernel
                                                                                                  Kernel




                                                                       Changes                 Creates verbal
                        Happens BEFORE   Happens AFTER the
                                                                    biochemistry of           relations for the
                          the behavior       behavior
                                                                       behavior                   behavior


                                                               Embry, D. D., & Biglan, A.
                                                                (2008). Evidence-Based

                        Four Types of Kernels
                                                             Kernels: Fundamental Units of
                                                              Behavioral Influence. Clinical
                                                               Child & Family Psychology
                                                                      Review, 39.




Friday, August 12, 11                                                                                             48
Kernel                            Description                                      Behaviors Affected                                                                           References
                                             Combinations of visual, kinesthetic and/or auditory
                            Non-verbal           cues that single shifting attention or task in        Reduces dawdling, increases time on task or                       Rosenkoetter, & Fowler, 1986; Krantz, & Risley, 1977; Abbott et al., 1998;
                          transition cues     patterned way, coupled with praise or occasional       engaged learning; gives more time for instruction                                             Embry et al., 1996
                                                                   rewards.

    Antecedent             Stop lights in     Traffic light signals when behavior is appropriate/
                                                                                                                                                                          (Cox, Cox, & Cox, 2000; Jason & Liotta, 1982; Jason, Neal, & Marinakis,
                                              desirable or inappropriate/undesirable in real time,    Decreases noise, off task behavior, or increases
      Kernel            school settings or
                          traffic settings
                                                 and connected to some kind of occasional                  stopping in dangerous intersections
                                                                                                                                                                         1985; Lawshe, 1940; Medland & Stachnik, 1972; Van Houten & Malenfant,
                                                                                                                                                                                  1992; Van Houten & Retting, 2001; Wasserman, 1977)
                                                                 reinforcement.

                                              These may be lines or other cues such as ropes or        Decreases dangerous behavior; decreases
                        Boundary cues and                                                                                                                                 (Carlsson & Lundkvist, 1992; Erkal & Safak, 2006; Marshall, et al., 2005;
                                              rails that signal where behavior is safe, acceptable   pushing and shoving; increases waiting behavior
                             railings                               or desired                                  in a queue; reduces falls
                                                                                                                                                                                       Nedas, Balcar, & Macy, 1982; Sorock, 1988)



    Happens               Cooperative,       Planned activities happen during children play time
                                                                                                          Decreases aggression and increases social
                                                                                                        competence; also affects body mass index, and                      (Bay-Hinitz, Peterson, & Quilitch, 1994; Leff, Costigan, & Power, 2004;
   BEFORE the            Structured peer
                               play
                                             that involve rules, turn taking, social competencies,
                                             and cooperation with or without “soft competition.”
                                                                                                       appears to reduce ADHD symptoms, and increase
                                                                                                       academics afterwards; reduces social rejection in
                                                                                                                                                                            Mikami, Boucher, & Humphreys, 2005; Murphy, et al., 1983; Ridgway,
                                                                                                                                                                                        Northup, Pellegrin, LaRue, & Hightsoe, 2003)
    behavior                                                                                                            middle school
                                                                                                                                                                              (Barker & Jones, 2006; Ben Shalom, 2000; Bray & Kehle, 2001; Buggey, 2005; Clare,
                                             Drawn, photographic or video model viewer/listener         Increases academic engagement; increases attention;               Jenson, Kehle, & Bray, 2000; Clark, Beck, Sloane, Goldsmith, & et al., 1993; Clark, Kehle,
                                                                                                     increases recall and long term memory; improves behavior;             Jenson, & Beck, 1992; Clement, 1986; R. A. Davis, 1979; Dowrick, 1999; Dowrick, Kim-
                          Self-modeling       engaging targeted behavior, receiving rewards or       reduces dangerous behavior; increases social competence;             Rupnow, & Power, 2006; Elegbeleye, 1994; Hartley, Bray, & Kehle, 1998; Hartley, Kehle, &
                                                               recognition.                            improved sports performance; reduced health problems              Bray, 2002; Hitchcock, Prater, & Dowrick, 2004; Houlihan, Miltenberger, Trench, Larson, & et
                                                                                                                                                                           al., 1995; Kahn, Kehle, Jenson, & Clark, 1990; Kehle, Bray, Margiano, Theodore, & Zhou,
                                                                                                                                                                          2002; Law & Ste-Marie, 2005; Lonnecker, Brady, McPherson, & Hawkins, 1994; Meharg &
                                                                                                                                                                            (Agran, et al., 2005; Blick & & Woltersdorf, 1990; Owusu-Bempah& Frank, 1990; Buggey, 1995;
                                                                                                                                                                              Lipsker, 1991; Meharg Test, 1987; Boyle & Hughes, 1994; Brown & Howitt, 1985; Owusu-
                                                                                                           Reductions in alcohol, tobacco use; reductions in illness      Buggey, Toombs, Gardener, & Cervetti, 1999; Burch, Clegg, & Bailey, 1987; Carr & Punzo, 1993; Cavalier,
                                             Coding target behavior with a relational frame, which   symptoms from diabetes; increased school achievement; changes       Bempah & Hodges, 1983;Clare, et al., 2000;McLoughlin,Kehle, & Truscott, 2001; Dalton, Martella, &
                                                                                                                                                                           Ferretti, &
                                                                                                                                                                                       Howitt, 1997; Possell, Kehle, Clarke, Bray, & Bray, 1999; Ram & McCullagh, 2003;
                                                                                                                                                                         Reamer, Brady, & Hawkins, 1998; Rickards-Schlichting, Kehle, & Bray, 2004; Rickel & Fields,
                         Self-monitoring     is often charted or graphed for public or semi-public     in other social competencies or health behaviors; reductions in       Marchand-Martella, 1999; de Haas-Warner, 1991; R. M. Foxx & Axelroth, 1983; Glasgow, Klesges,
                                                                                                                                                                           Godding, & Gegelman, 1983; Glasgow, Klesges, & Vasey, 1983; Gray & & Simon, 1997; Walker &
                                                                                                                                                                             1983; Schunk & Hanson, 1989; Schwartz, Houlihan, Krueger, Shelton, 1992; Hall & Zentall,
                                                 display, occasioning verbal praise from others         ADHD, Tourettes and other DSM-IV disorder; improvement in        2000; K. R. Harris, Friedlander, 1992; Wedel & Fowler, 1984; Woltersdorf, 1992) 1990; Hitchcock,
                                                                                                                                                                                               Clement, Saddler, Frizzelle, & Graham, 2005; Hertz & McLaughlin,
                                                                                                                            brain injured persons                          et al., 2004; Hughes, et al., 2002; Kern, Dunlap, Childs, & Clarke, 1994; Martella, Leonard, Marchand-
                                                                                                                                                                          Martella, & Agran, 1993; M. Y. Mathes & Bender, 1997; McCarl, Svobodny, & Beare, 1991; McDougall &
                                                                                                                                                                            Brady, 1995; McLaughlin, Krappman, & Welsh, 1985; Nakano, 1990; O'Reilly, et al., 2002; Petscher &
                                                                                                                                                                         Bailey, 2006; Possell, et al., 1999; Rock, 2005; Selznick & Savage, 2000; Shabani, Wilder, & Flood, 2001;
                                             After hearing or seeing some content, person is told                                                                             Shimabukuro, Prater, Jenkins, & Edelen-Smith, 1999; Stecker, Whinnery, & Fuchs, 1996; Thomas,
                            Paragraph                                                                                                                                    Abrams, & Johnson, 1971; Todd, Horner, &G. Mathes, Fuchs, Fuchs, Henley,Winn, Skinner,
                                                                                                                                                                             (Bean & Steenwyk, 1984; P. Sugai, 1999; Trammel, Schloss, & Alper, 1994; & et al.,
                                              to “shrink” meaning to 8-10 words, full sentence;          Improved reading responses and retention                        Allin, & Hawkins, 2004; Wood, Murdock, & Cronin, 2002; Wood, Murdock, Cronin, Dawson, & Kirby, 1998)
                            Shrinking           praise typically happens for good summaries.
                                                                                                                                                                                             1994; Spencer, Scruggs, & Mastropieri, 2003)




Friday, August 12, 11                                                                                                                                                                                                                                                                49
= Public Posting Kernel
      Antecedent
        Kernel




     Happens
    BEFORE the
     behavior

                        = radar




Friday, August 12, 11                               50
Kernel                          Description                                Behaviors Affected                                                                     References
                                                     Person or group receives spoken (or           Examples: Cooperation, social competence, academic         (Leblanc, Ricciardi, & Luiselli, 2005; Lowe & McLaughlin, 1974; Marchant
                                                                                                 engagement, academic achievement, positive-parent child
                                                    signed) recognition for engagement in                                                                        & Young, 2001; Marchant, Young, & West, 2004; Martens, Hiralall, &
                          Verbal Praise            target acts, which may be descriptive or
                                                                                                     interactions, positive marital relations, better sales    Bradley, 1997; Matheson & Shriver, 2005; C. M. Robinson & Robinson,
                                                                                                  performance; reduced disruptive or aggressive behavior;            1979; S. Scott, Spender, Doolan, Jacobs, & Aspland, 2001)
                                                          simple acknowledgements                                reduced DSM-IV symptoms

   Reinforcement         Peer-to-peer written      A pad or display of decorative notes are
                                                                                                   Examples: social competence, academic                      (Cabello & Terrell, 1994; Embry, Flannery, Vazsonyi, Powell, & Atha, 1996;
                        praise--“Tootle” Notes,   posted on a wall, read aloud, or placed in a
       Kernel            compliments books/         photo type album in which behaviors
                                                                                                  achievement, work performance, violence,
                                                                                                                                                                 Farber & Mayer, 1972; Heap & Emerson, 1989; Mayer, Butterworth,
                                                                                                                                                               Nafpaktitis, & Sulzer-Azaroff, 1983; Mayer, Mitchell, Clementi, Clement-
                                                                                                    aggression, physical health, vandalism                         Robertson, & et al., 1993; Skinner, Cashwell, & Skinner, 2000)
                             praise notes              receive written praise from peers
                                                   Tokens or symbolic rewards for positive
                                                   behavior result in random rewards from        Academic achievement, disruptive behavior,                        (Thorpe, Darch, & Drecktrah, 1978; Thorpe,
                        Principal Lottery           status person (e.g., principal, authority                   aggression                                                  Drecktrah, & Darch, 1979)
                                                  figures) such as positive phone calls home

 Happens AFTER              Safety or               Tokens or reward tickets given out for
                                                                                                      Safety behaviors, accident reduction,
                                                                                                                                                              (Geller, Johnson, & Pelton, 1982; Putnam, Handler, Ramirez-
                           Performance            observed safety or performance behavior,                                                                      Platt, & Luiselli, 2003; Roberts & Fanurik, 1986; Saari &
  the behavior               Lottery                    which are entered into lottery
                                                                                                      improved sales or work performance                                              Latham, 1982)


                                                   Music is played or stopped in real time,        Increased weight gain of babies, improved baby              (Allen & Bryant, 1985; Barmann & Croyle-Barmann, 1980; Barmann, Croyle-Barmann, & McLain, 1980;
                                                                                                                                                               Bellamy & Sontag, 1973; Blumenfeld & Eisenfeld, 2006; Cevasco & Grant, 2005; Cook & Freethy, 1973;
                                                                                                 development possibly, work performance, academic
                        Contingent music                                                                                                                      Cotter, 1971; W. B. Davis, Wieseler, & Hanzel, 1980; Dellatan, 2003; Deutsch, Parks, & Aylesworth, 1976;
                                                    based on observed behavior of the            achievement, attention and focus (ADHD symptoms                  Eisenstein, 1974; Harding & Ballard, 1982; Hill, Brantner, & Spreat, 1989; Holloway, 1980; Hume &
                                                                                                                                                               Crossman, 1992; Jorgenson, 1974; Larson & Ayllon, 1990; Madsen, 1982; McCarty, McElfresh, Rice, &
                                                             individual or group.                            down); reduced aggression                             Wilson, 1978; McLaughlin & Helm, 1993; Standley, 1996, 1999; Wilson, 1976; D. E. Wolfe, 1982)


                                                                                                  Improved academic engagement and achievement,                   (Beersma, et al., 2003; Hoigaard, S?fvenbom, &
                            Soft Team                  Groups compete on some task,                  reduced disruptive behavior, increased sales,
                                                                                                 increased funding raising, increased safety; reduced
                                                                                                                                                               Tonnessen, 2006; Kivlighan & Granger, 2006; Koffman,
                           competition                     performance, or game.                 smoking; changed brain chemistry favoring attention            Lee, Hopp, & Emont, 1998; Neave & Wolfson, 2003;
                                                                                                                   and endurance                                   Tingstrom, Sterling-Turner, & Wilczynski, 2006)

                           Peer-to-peer                                                           Increased academic achievement; reduced                       (Allsopp, 1997; Delquadri, Greenwood, Stretton, & Hall, 1983;
                                                  Dyad or triad take turns asking questions,
                                                                                                    ADHD and conduct problems; long-term                      DuPaul, Ervin, Hook, & McGoey, 1998; Fantuzzo & Ginsburg-Block,
                             tutoring               give praise or points and corrective
                                                                                                   effects on school engagement; decreased                      1998; Greenwood, 1991a, 1991b; Maheady, Harper, & Sacca,
                                                                   feedback                                                                                     1988; Maheady, Sacca, & Harper, 1988; Sideridis, et al., 1997)
                                                                                                            special education needs.




Friday, August 12, 11                                                                                                                                                                                                                                                    51
Survival analysis to show long-term advantage of
                        prize bowl kernel




                                    Standard Community Treatment
                                    Prize Bowl for Recovery




Friday, August 12, 11                                                      52
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
Preventing Mental Health Epidemic for All
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Preventing Mental Health Epidemic for All

  • 1. Prevention for Everyone Averting America’s epidemic of mental, emotional, mental and related behavioral disorders Dennis D. Embry, Ph.D. • President/Senior Scientist, PAXIS Institute Presentation for ESD #113, Tumwater, WA, August 11, 2011 Friday, August 12, 11 1
  • 2. Welcome introductions and housekeeping Friday, August 12, 11 2
  • 3. What will we pack in our young people’s suitcases for their whole lives? Friday, August 12, 11 3
  • 4. What bricks—heavy objects of pain, injury, illness, or problems —do you NOT want in young people’s suitcases for life? Friday, August 12, 11 4
  • 5. Ask the suitcase questions of 30 people: some republicans, some democrats, some independents and some who are apolitical. Friday, August 12, 11 5
  • 6. What do you want to happen and not happen for our elders? Friday, August 12, 11 6
  • 7. Bi-directional Wealth and Wellbeing Transfer 5-Year 65-Year Olds Olds Friday, August 12, 11 7
  • 8. Bi-directional Wealth and Wellbeing Transfer 5-Year 65-Year Olds Olds Who are living longer though get progressively sicker… Friday, August 12, 11 7
  • 9. Bi-directional Wealth and Wellbeing Transfer Requiring more wealth transfer 5-Year 65-Year Olds Olds Who are living longer though get progressively sicker… Friday, August 12, 11 7
  • 10. Bi-directional Wealth and Wellbeing Transfer Requiring more wealth transfer 5-Year 65-Year Olds Olds Who are living Who are less longer though get and less able… progressively sicker… Friday, August 12, 11 7
  • 11. Bi-directional Wealth and Wellbeing Transfer Requiring more wealth transfer 5-Year 65-Year Olds But elders voting to stop funds to kids Olds Who are living Who are less longer though get and less able… progressively sicker… Friday, August 12, 11 7
  • 13. Our Own Children’s Future Friday, August 12, 11 9
  • 14. Our Own Children’s Future ADHD stealing aggression asthma depression learning disabilities obesity cancer bipolar depression hi-blood pressure heart-disease violence tobacco suicide diabetes alcohol crime drugs dangerous acts Friday, August 12, 11 10
  • 16. Washington State’s Future Children Children Children Ages 0-5 Ages 6-18 Ages 0-18 457,269 1,129,723 1,586,991 Friday, August 12, 11 12
  • 17. What happens if we pack every Washington state first grader’s life suitcase well? Universal Behavioral First Grad Vaccine Cost Net Economic Cohort X ($150 each) = Benefit for All 76,211 $11,431,718 $1,094,244,047 Friday, August 12, 11 13
  • 18. Why prevention for everyone? Shouldn’t we focus on the people at risk? Friday, August 12, 11 14
  • 19. The nation faced a national epidemic of polio. Emergency wards were filled with iron lungs. Children died or crippled. The nation was terrified. Who should be given the vaccine? Only the frail or “at risk”? Or, all children? Friday, August 12, 11 15
  • 20. The Epidemic Today? Mental, Emotional, Behavioral, and Related Physical Illnesses Friday, August 12, 11 16
  • 21. The Epidemic Today? Mental, Emotional, Behavioral, and Related Physical Illnesses Do you know a middle class family with a child with a MEB? Friday, August 12, 11 16
  • 22. Lifetime Prevalence of Disorders in US Adolescents (N=10,123) Merikangas et al., 2010 40% 35% 30% 25% 20% 15% 10% 5% 0% 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Age in Years Friday, August 12, 11 17
  • 23. Lifetime Prevalence of Disorders in US Adolescents (N=10,123) Merikangas et al., 2010 40% 35% Anxiety 30% 25% 20% 15% 10% 5% 0% 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Age in Years Friday, August 12, 11 17
  • 24. Lifetime Prevalence of Disorders in US Adolescents (N=10,123) Merikangas et al., 2010 40% 35% Anxiety 30% 25% Behavior 20% 15% 10% 5% 0% 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Age in Years Friday, August 12, 11 17
  • 25. Lifetime Prevalence of Disorders in US Adolescents (N=10,123) Merikangas et al., 2010 40% 35% Anxiety 30% 25% Behavior 20% Mood 15% 10% 5% 0% 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Age in Years Friday, August 12, 11 17
  • 26. Lifetime Prevalence of Disorders in US Adolescents (N=10,123) Merikangas et al., 2010 40% 35% Anxiety 30% 25% Substance Behavior 20% Mood 15% 10% 5% 0% 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Age in Years Friday, August 12, 11 17
  • 27. Youth MEB Prevalence Rate Comparison 4x 2x USA United Kingdom OECD Friday, August 12, 11 18
  • 28. Depression by Jobs Friday, August 12, 11 19
  • 29. Nearly 3 out of 4 of the nation's 17- to 24-year-olds are ineligible for military service for based on national epidemiological data • Medical/physical problems, 35 percent. • Illegal drug use, 18 percent. • Mental Category V (the lowest 10 percent of the population), 9 percent. • Too many dependents under age 18, 6 percent. • Criminal record, 5 percent. Army Times, Nov 5, 2009 • www.missionreadiness.org/PAEE0609.pd Friday, August 12, 11 20
  • 30. Cumulative prevalence of psychiatric disorders by young adulthood: a prospective cohort analysis from the Great Smoky Mountains Study. By 21 years of age, 61.1% of participants had met criteria for a well- specified psychiatric disorder. An additional 21.4% had met criteria for a not otherwise specified disorder only, increasing the total cumulative prevalence for any disorder to 82.5%. Friday, August 12, 11 21
  • 31. The US has 75 million children and teens. 40.4 million are on psychotropic medications Wall Street Journal, 12-28-2010 Friday, August 12, 11 22
  • 33. Why are these trends happening in Washington State and the United States? Friday, August 12, 11 23
  • 34. What should the people Why are these trends happening Washington State do to protect all in Washington State and the of its children from the epidemic of United States? mental, emotional, behavioral and related physical disorders? Friday, August 12, 11 23
  • 35. Major Ecologic Causes of the Dual Inflammatory Threats to Children & Youth Reinforcement Antecedents Physiological Verbal Relations Friday, August 12, 11 24
  • 36. Multi-Inflammatory Threat Reaction Major Ecologic Causes of the Dual Inflammatory Threats to Children & Youth Reinforcement Antecedents Physiological Verbal Relations Friday, August 12, 11 24
  • 37. Mood Reward Executive Behavioral Attention Stability Delay Function Competencies Immune- Motor Healing Skills Multi-Inflammatory Threat Reaction Functions Major Ecologic Causes of the Dual Inflammatory Threats to Children & Youth Reinforcement Antecedents Physiological Verbal Relations Friday, August 12, 11 24
  • 38. Substance Work Obesity, Early Mental Illness Violence Cancer School Abuse Problems etc Sex Failure Mood Reward Executive Behavioral Attention Stability Delay Function Competencies Immune- STD’s Motor Healing Special Skills Multi-Inflammatory Threat Reaction Functions Ed Major Ecologic Causes of the Dual Inflammatory Threats to Children & Youth Reinforcement Antecedents Physiological Verbal Relations Friday, August 12, 11 24
  • 39. Evolutionary Mismatch How have the changes in modern human ecology for which were were evolved and adapted affected Sleep Eating Mental health Problem behaviors Physical Health Sexual maturity Friday, August 12, 11 25
  • 40. What are the social rewards for these behaviors? Billy Good Billy Bad Friday, August 12, 11 26
  • 41. What are the social rewards for these behaviors? Billy Good Billy Bad Friday, August 12, 11 26
  • 42. GGGCCGCCGCATTCGT-3 and 5 - AGGGA-3 ; 661-nt product; ref. 20) CGTACTGTGCGGCCTCAACGA- CTGCGTGATGT-3 ; 705-nt product r some amplifications of the VNTR, Fig. 3. Proposed o were used (2). The alternative primers sity. A simplified m repeat sequence e VNTR to minimize out-of-register with only major re indicated (Fig. 2). T ation. PCRs were conducted in 25- l 7R alleles are show minor 3R, 5R, and in gray along with f genomic DNA, 200 M dXTPs, 0.5 origins by unequa arrows). Large red buffer (Qiagen, Chatsworth, CA), 1 Text putative multistep lele. The adjacent p .625 units of Taq DNA polymerase S1), exon 1 (L2 S2) A-C) polymorphism s performed by using Perkin–Elmer strong linkage of polymorphisms wit c, 96°C hot start was used followed by is noted. nd 68°C for 1 min. After a 4-min chase Fig. 1. Diagrammatic representation of the human DRD4 gene region. Exon Standard methods of estimating coalescence time for these alleles are not applicable, given the repetitive nature of the region and high high fitness if almost everyone is meek but might r when very common, because aggressive individua e eliminated with 0.5 units of shrimp positions are indicated by blocks (yellow, noncoding; orange, coding). The recombination frequency. However, calculations of allele age based on the relatively high worldwide population frequency of the DRD4 penalties of frequent conflict. This type of freq selection might be expected to apply to many type Amersham Pharmacia), 0.1 unit of approximate positions of a 120-bp promoter region duplication (blue trian- 4R and 7R alleles suggest that these alleles are ancient ( 300,000 years old; refs. 25 and 26; see Methods). On the other hand, variation, including those associated with this part gle), an exon 1 12-bp duplication (blue triangle), an exon 3 VNTR (blue mitter receptor (4–9). ham Pharmacia), and 1 SAP buffer calculations of allele age based on the observed intraallelic vari- Alternative explanations to the proposed posit triangle), and two intron 3 SNPs are indicated. 2R–11R variants of the VNTR are ability (refs. 26 and 27; see Methods) suggest that the 7R allele is as recent random bottlenecks, population expan e SAP Exo I reaction was carried out 5–10-fold ‘‘younger’’ (30,000–50,000 years old). Such large discrep- ulation admixture (24) are less likely to account indicated below exon 3 (blue) along with their worldwide population fre- ancies between allele ages calculated by these two methods usually 15-min heat inactivation at 72°C. The quencies determined by PCR analysis (3, 17). are taken as evidence that selection has increased the frequency of results. Bottlenecks certainly have occurred duri tion and evolution (33–35) and undoubtedly ha the allele to higher levels than expected by random genetic drift reaction was used directly for DNA (26). The absolute values of these estimates are greatly affected by current worldwide DRD4 allele frequency. Num studies on other genes (24, 33, 35) have shown the assumptions used in their computations, for example the uals, the two allelic PCR products first assumed recombination frequency (26). We have used conservative Africa’’ constriction of allele diversity (and an incr occurred. In the present study, a greater diversit estimates of recombination frequency based on the average ob- rose gels. DNA cycle sequencing was majority of individuals were heterozygotes, and the two allelic PCR served for the terminal 20 megabases of 11p (31). Given the was found for African DRD4 4R alleles in co remainder of our population sample, which is co observed high recombination at this locus (Table 1 and Fig. 3), it niques using ABI 377 and 3700 auto- products could be separated by gel electrophoresis before sequenc- is likely that the actual age of the 7R allele is even younger, and out-of-Africa hypothesis (24). Although one the 7R allele frequency was increased by ch further LD analysis will refine these estimates. The important out-of-Africa expansion, this theory does not ex ing, providing unambiguous haplotypes. Altogether, we screened conclusion, however, is that regardless of the parameters assumed, the relative age differences for the 4R and 7R alleles calculated lack of diversity in African 7R alleles. The mo 7R(1-2-6-5-2-5-4)-A-C haplotype (Fig. 3) is fou over 450,000 bp of genomic DNA and 2,968 48-bp repeats. from intraallelic variability remains large, whereas their population comparable to those found worldwide ( 85%) ions. Ka Ks ratios were calculated by frequency suggests they are both ancient. imagine what type of bottleneck could produce In the 600 chromosomes sequenced, 56 different haplotypes The simplest hypothesis to account for (i) the observed bias in strong worldwide LD for a single allele (DRD4 7R . Putative recombinant haplotypes were found (Table 1). These haplotypes were composed of 35 nucleotide changes (Ka Ks), (ii) the unusual sequence organization of the DRD4 7R allele, and (iii) the strong LD surrounding this the remaining alleles. A model that is consistent results is the ‘‘weak Garden of Eden’’ hypothesis pendent events. Allele age calcula- distinct 48-bp variant motifs (Fig. 2), 19 of which were reported allele is that the 7R allele arose as a rare mutational event (or events) that nevertheless increased to high frequency by positive DRD4 4R allele would be hypothesized to be an Friday, August 12, 11 selection. Advantageous alleles usually take a long time to reach a in indigenous populations, whereas the 7R 27 allele
  • 43. Reinforcement Reinforcement Adult Behavior & for “Good” for “Bad” coercion the Matching In one hour of school, In one hour of school, Law how often do peers how often do peers How often might adults Example reinforce the “good” in reinforce the “bad” in in authority exert The probability of human behavioral choice Evolutionary school? school? perceived threats of “matches” this saturation Mismatch How often by adults How often by adults coercion in school, at formula in the classroom, at school? at school? home, or in the home and community, How often at home or How often at home or community in a single and Matching Law works day? community in a day? community in a day? for all vertebrate creatures Friday, August 12, 11 28
  • 44. What happens if you change the Matching Law (the Good Behavior Game) in a classroom? Friday, August 12, 11 29
  • 45. CDC Nurses Office Study 60% 50% Percentage Change 40% 30% 20% 10% 0% -10% -20% All Visits Injury Viists Non-Injuries Fighting Non-Fighting Injuries Injuries Control/Wait List PeaceBuilders What happens if you teach students to praise each other for “peaceability” Friday, August 12, 11 30
  • 46. DRI = Differential DRO = Differential Reinforcement of Reinforcement of Other Incompatible Behaviors Behaviors Friday, August 12, 11 31
  • 47. Molecular Psychiatry (2000) 5, 467–475  2000 Macmillan Publishers Ltd All rights reserved 1359-4184/00 $15.00 www.nature.com/mp MILLENNIUM ARTICLE Is there an evolutionary mismatch between the normal physiology of the human dopaminergic system and current environmental conditions in industrialized countries? L Pani CNR Center for Neuropharmacology, ‘BB Brodie’ Department of Neuroscience, University of Cagliari and Neuroscienze Scarl, Cagliari, Italy A large body of evidence has recently defined a field theory known as ‘evolutionary mismatch’, which derives its attributes largely from the fact that current environmental conditions are completely different from those in which the human central nervous system evolved. Current views on the evolutionary mismatch theory lack, however, any attempts to define which brain areas or neuronal circuits should be mostly involved in coding such misevolved traits and to what extent our neurobiological knowledge can be applied to the topographical localization of a specific psychopathology. In this respect the mesocorticolimbic dopaminergic circuits have long been misconceptualized as simple reward or reinforcement systems. Instead, they motivate and coordinate the functions of the higher brain areas that mediate planning and foresight and direct finalized movement in both animals and humans. These systems make animals intensely interested in exploring the world around them, but by the same means they also make them susceptible to the environmental stimuli that have been sought and con- sumed. It is has been speculated that the cortical dopamine targets that developed most recently in phylogeny are of particular functional value, and that the mesocorticolimbic dopa- minergic system is involved in more complex integrative functions than previously assumed. In the present paper I will argue that some mental disorders may have their deep roots in the evolutionary mismatch between the normal physiology of the mesocorticolimbic dopami- nergic system and the current environmental conditions in affluent societies. Molecular Psy- chiatry (2000) 5, 467–475. Keywords: evolution; limbic system; dopamine; stress; depression; emotions; Darwinian medicine Friday, August 12, 11 Introduction Table 1 Steps in brain evolution with increasing environ- 32
  • 48. Changes in antecedents of life? TV’s in bedrooms Text Electronic games Computers, social media Friday, August 12, 11 33
  • 49. Social Network & Sleep Deprivation Text Social Network & Marijuana Use Friday, August 12, 11 34
  • 50. Apparent consumption o inoleic acid (% of dietary energy) among Australia, Canada, UK and USA for the years 1961–2000 10 Australia Canada UK USA Apparent consumption of linoleic acid 9 8 7 (% energy) 6 5 4 3 2 1 0 1960 1965 1970 1975 1980 1985 1990 1995 2000 “Risky” Beh. Evolution Neonates Breast Milk & Mismatch In the Rife Valley, the Successful human American infants have human brain evolution neonates born with been getting steadily less Theory the result of eating fish 60-day supply of omega-3 (n3) and more Almost all adolescent pro-inflammatory risky behaviors have now Example high in omega-3 not omega-3 in omega-6 (n6) in breast been documented to be savannah animals subcutaneous fat from Evolutionary milk related to low n3 and mother’s diet high n6 in US diet Physiology See Broadhurst, Cunnane, & change in last 50 years Mismatch See HIbbeln et al. (2007).Maternal seafood Crawford (1998). Rift Valley lake fish See Ailhaud et al. (2006).Temporal changes consumption in pregnancy and in dietary fats: Role of n6 and shellfish provided brain-specific neurodevelopmental outcomes in childhood Hibbeln et al. (2006). Healthy intakes of n-3 polyunsaturated fatty acids in excessive nutrition for (ALSPAC study): an observational cohort adipose tissue and n-6 fatty acids: estimations considering early Homo study worldwide diversity. development and relationship to obesity Friday, August 12, 11 35
  • 51. 30% Percentage with Psychosis at 12 months 27.5% 24% 18% 12% 6% 4.9% 0% Omega-3 Placeo Psychosis Friday, August 12, 11 36
  • 52. Evolutionary Mismatch Language of belonging and danger Friday, August 12, 11 37
  • 53. K R R Path Path Path Evolutionary Path of a Child’s Life Probability of long-life and Probability of short-life and reproductive success doubtful reproductive success Friday, August 12, 11 38
  • 54. K R R Path Path Path Evolutionary Path of a Child’s Life Probability of long-life and Probability of short-life and reproductive success doubtful reproductive success R-Path can be triggered by evolutionary mismatch in social or physical environment. Friday, August 12, 11 38
  • 55. Human Infectious/Biological Threats Human Predatory Threats Friday, August 12, 11 39
  • 56. Human Infectious/Biological Threats Human Predatory Threats Evolutionary Adaptive Responses (Simplified) Generalized Localized Inflammatory Inflammatory Response Response Anti-Inflammatory Regulators Friday, August 12, 11 39
  • 57. Human Infectious/Biological Threats Human Predatory Threats Evolutionary Adaptive Responses Evolutionary Adaptive Responses (Simplified) (Simplified) Intra-Group Threat Attributional Generalized Localized Affiliation Bias (Inflammatory) Inflammatory Inflammatory (Anti-Inflammatory) Out-Group Response Response Aggress. (Inflammatory) Intra-Group Cooperation Tit-for-Tat Beh. Bias Anti-Inflammatory Regulators (Anti-Inflammatory) (Inflammatory) Friday, August 12, 11 39
  • 58. Human Infectious/Biological Threats Human Predatory Threats Evolutionary Adaptive Responses Evolutionary Adaptive Responses (Simplified) Neuro-Hormones (Simplified) Mood Modulators Reward Delay Intra-Group Threat Attributional Generalized Localized Modulators Affiliation Bias (Inflammatory) Inflammatory Inflammatory (Anti-Inflammatory) Out-Group Response Response Stress Aggress. (Inflammatory) Modulators Intra-Group Cooperation Tit-for-Tat Beh. Bias Anti-Inflammatory Regulators Puberty/Sex (Anti-Inflammatory) Modulators (Inflammatory) Friday, August 12, 11 39
  • 59. Human Infectious/Biological Threats Human Predatory Threats Evolutionary Adaptive Responses Evolutionary Adaptive Responses (Simplified) Neuro-Hormones (Simplified) Mood Modulators Reward Delay Intra-Group Threat Attributional Generalized Localized Modulators Affiliation Bias (Inflammatory) Inflammatory Inflammatory (Anti-Inflammatory) Out-Group Response Response Stress Aggress. (Inflammatory) Modulators Intra-Group Cooperation Tit-for-Tat Beh. Bias Anti-Inflammatory Regulators Puberty/Sex (Anti-Inflammatory) Modulators (Inflammatory) Modern culture commonly produces multiple evolutionary mismatches triggering multiple inflammatory responses. Friday, August 12, 11 39
  • 60. Obesity Conduct Disorders Homicide & Suicide Depression Oppositional/ Addictions ADHD Aggression Self harm ANXIETY R PATH = Risky behaviors or health Friday, August 12, 11 40
  • 61. How many of you know a regular American family with a child with… a mental, emotional or behavioral disorder? Friday, August 12, 11 41
  • 62. How many of you know a regular American family with a child with… a mental, emotional or behavioral disorder? Like a more Like ADHD or Like learning or serious mental Like a serious behavior developmental illness like addictions problems? disorder? bipolar or problem? suicidal actions? Friday, August 12, 11 41
  • 63. Key messages about mental, emotional & behavioral disorders… Friday, August 12, 11 42
  • 64. Key messages about mental, emotional & behavioral disorders… MEB’s are preventable. Friday, August 12, 11 42
  • 65. Key messages about mental, emotional & behavioral disorders… MEB’s are Break-even for preventable. MEB prevention is one year. Friday, August 12, 11 42
  • 66. Key messages about mental, emotional & behavioral disorders… MEB’s are Break-even for MEB prevention preventable. MEB prevention balances is one year. budgets. Friday, August 12, 11 42
  • 67. Key messages about mental, emotional & behavioral disorders… MEB’s are Break-even for MEB prevention MEB prevention preventable. MEB prevention balances improves US is one year. budgets. business. Friday, August 12, 11 42
  • 68. Key messages about mental, emotional & behavioral disorders… MEB’s are Break-even for MEB prevention MEB prevention preventable. MEB prevention balances improves US is one year. budgets. business. Effective MEB prevention helps national security. Friday, August 12, 11 42
  • 69. Key messages about mental, emotional & behavioral disorders… MEB’s are Break-even for MEB prevention MEB prevention preventable. MEB prevention balances improves US is one year. budgets. business. Effective MEB MEB prevention prevention helps helps US global national security. success. Friday, August 12, 11 42
  • 70. Key messages about mental, emotional & behavioral disorders… MEB’s are Break-even for MEB prevention MEB prevention preventable. MEB prevention balances improves US is one year. budgets. business. MEB prevention Effective MEB MEB prevention saves Social prevention helps helps US global Security & national security. success. Medicare. Friday, August 12, 11 42
  • 71. Key messages about mental, emotional & behavioral disorders… MEB’s are Break-even for MEB prevention MEB prevention preventable. MEB prevention balances improves US is one year. budgets. business. MEB prevention Effective MEB MEB prevention saves Social MEB prevention prevention helps helps US global Security & heals past national security. success. Medicare. inequities. Friday, August 12, 11 42
  • 73. Mental, emotional, behavioral and health disorders are preventable by our own hands—right here in Washington State. Friday, August 12, 11 44
  • 74. Increase nurturance of prosociality for persons of all ages This can be individual, family, school and/or community action Reduce toxic influences of all ages This can be at an individual, family, school and/or community level Increase psychological flexibility among people of all ages This can be achieved across settings, as the above. From Biglan, Flay and Embry. Nurturing Environments and the Next Generation of Prevention Research and Practice for the American Psychologist Friday, August 12, 11 45
  • 75. Clin Child Fam Psychol Rev DOI 10.1007/s10567-008-0036-x Evidence-based Kernels: Fundamental Units of Behavioral Influence Basic understanding of kernels Embry, D. D. and A. Biglan (2008). "Evidence-Based Kernels: Dennis D. Embry Æ Anthony Biglan Fundamental Units of Behavioral Influence." Clinical Child & Family Psychology Review 11(3): 75-113. Ó The Author(s) 2008. This article is published with open access at Springerlink.com Abstract This paper describes evidence-based kernels, This paper presents an analysis of fundamental units of fundamental units of behavioral influence that appear to behavioral influence that underlie effective prevention and underlie effective prevention and treatment for children, treatment. We call these units kernels. They have two adults, and families. A kernel is a behavior–influence defining features. First, in experimental analysis, procedure shown through experimental analysis to affect a researchers have found them to have a reliable effect on Using kernels for population change A R T I C L E COMMUNITY-BASED PREVENTION USING SIMPLE, LOW-COST, EVIDENCE-BASED Embry, D. D. (2004). "Community-Based Prevention Using Simple, KERNELS AND BEHAVIOR VACCINES Low-Cost, Evidence-Based Kernels and Behavior Vaccines." Dennis D. Embry PAXIS Institute Journal of Community Psychology 32(5): 575. A paradox exists in community prevention of violence and drugs. Good B e h a v i o r a l Vac c i n e s an d Evidence-Based Kernels: Nonpharmaceutical Behavioral vaccines for disease control A p p ro a c h e s f o r th e P re v e n t i o n o f M e n t a l , Embry, D. D. 2011. Behavioral vaccines and evidence-based kernels: Emotional, and B e h a v i o r a l D i s o rd e r s non-pharmaceutical approaches for the prevention of mental, emotional, Dennis D. Embry, PhD and behavioral disorders. Psychiatr Clin North Am 34 (1):1-34. KEYWORDS Friday, August 12, 11 46
  • 76. What is a kernel? Is the smallest unit of scientifically proven behavioral influence. • Is indivisible; that is, removing any part makes it inactive. Produces quick easily measured change that can grow much bigger change over time. Can be be used alone OR combined with other kernels to create new programs, strategies or policies. • Are the active ingredients of evidence-based programs • Can be spread by word-of-mouth, by modeling, by non professionals. • Can address historic disparities without stigma, in part because they are also found in cultural wisdom. Friday, August 12, 11 47
  • 77. Relational Antecedent Reinforcement Physiological Frame Kernel Kernel Kernel Kernel Changes Creates verbal Happens BEFORE Happens AFTER the biochemistry of relations for the the behavior behavior behavior behavior Embry, D. D., & Biglan, A. (2008). Evidence-Based Four Types of Kernels Kernels: Fundamental Units of Behavioral Influence. Clinical Child & Family Psychology Review, 39. Friday, August 12, 11 48
  • 78. Kernel Description Behaviors Affected References Combinations of visual, kinesthetic and/or auditory Non-verbal cues that single shifting attention or task in Reduces dawdling, increases time on task or Rosenkoetter, & Fowler, 1986; Krantz, & Risley, 1977; Abbott et al., 1998; transition cues patterned way, coupled with praise or occasional engaged learning; gives more time for instruction Embry et al., 1996 rewards. Antecedent Stop lights in Traffic light signals when behavior is appropriate/ (Cox, Cox, & Cox, 2000; Jason & Liotta, 1982; Jason, Neal, & Marinakis, desirable or inappropriate/undesirable in real time, Decreases noise, off task behavior, or increases Kernel school settings or traffic settings and connected to some kind of occasional stopping in dangerous intersections 1985; Lawshe, 1940; Medland & Stachnik, 1972; Van Houten & Malenfant, 1992; Van Houten & Retting, 2001; Wasserman, 1977) reinforcement. These may be lines or other cues such as ropes or Decreases dangerous behavior; decreases Boundary cues and (Carlsson & Lundkvist, 1992; Erkal & Safak, 2006; Marshall, et al., 2005; rails that signal where behavior is safe, acceptable pushing and shoving; increases waiting behavior railings or desired in a queue; reduces falls Nedas, Balcar, & Macy, 1982; Sorock, 1988) Happens Cooperative, Planned activities happen during children play time Decreases aggression and increases social competence; also affects body mass index, and (Bay-Hinitz, Peterson, & Quilitch, 1994; Leff, Costigan, & Power, 2004; BEFORE the Structured peer play that involve rules, turn taking, social competencies, and cooperation with or without “soft competition.” appears to reduce ADHD symptoms, and increase academics afterwards; reduces social rejection in Mikami, Boucher, & Humphreys, 2005; Murphy, et al., 1983; Ridgway, Northup, Pellegrin, LaRue, & Hightsoe, 2003) behavior middle school (Barker & Jones, 2006; Ben Shalom, 2000; Bray & Kehle, 2001; Buggey, 2005; Clare, Drawn, photographic or video model viewer/listener Increases academic engagement; increases attention; Jenson, Kehle, & Bray, 2000; Clark, Beck, Sloane, Goldsmith, & et al., 1993; Clark, Kehle, increases recall and long term memory; improves behavior; Jenson, & Beck, 1992; Clement, 1986; R. A. Davis, 1979; Dowrick, 1999; Dowrick, Kim- Self-modeling engaging targeted behavior, receiving rewards or reduces dangerous behavior; increases social competence; Rupnow, & Power, 2006; Elegbeleye, 1994; Hartley, Bray, & Kehle, 1998; Hartley, Kehle, & recognition. improved sports performance; reduced health problems Bray, 2002; Hitchcock, Prater, & Dowrick, 2004; Houlihan, Miltenberger, Trench, Larson, & et al., 1995; Kahn, Kehle, Jenson, & Clark, 1990; Kehle, Bray, Margiano, Theodore, & Zhou, 2002; Law & Ste-Marie, 2005; Lonnecker, Brady, McPherson, & Hawkins, 1994; Meharg & (Agran, et al., 2005; Blick & & Woltersdorf, 1990; Owusu-Bempah& Frank, 1990; Buggey, 1995; Lipsker, 1991; Meharg Test, 1987; Boyle & Hughes, 1994; Brown & Howitt, 1985; Owusu- Reductions in alcohol, tobacco use; reductions in illness Buggey, Toombs, Gardener, & Cervetti, 1999; Burch, Clegg, & Bailey, 1987; Carr & Punzo, 1993; Cavalier, Coding target behavior with a relational frame, which symptoms from diabetes; increased school achievement; changes Bempah & Hodges, 1983;Clare, et al., 2000;McLoughlin,Kehle, & Truscott, 2001; Dalton, Martella, & Ferretti, & Howitt, 1997; Possell, Kehle, Clarke, Bray, & Bray, 1999; Ram & McCullagh, 2003; Reamer, Brady, & Hawkins, 1998; Rickards-Schlichting, Kehle, & Bray, 2004; Rickel & Fields, Self-monitoring is often charted or graphed for public or semi-public in other social competencies or health behaviors; reductions in Marchand-Martella, 1999; de Haas-Warner, 1991; R. M. Foxx & Axelroth, 1983; Glasgow, Klesges, Godding, & Gegelman, 1983; Glasgow, Klesges, & Vasey, 1983; Gray & & Simon, 1997; Walker & 1983; Schunk & Hanson, 1989; Schwartz, Houlihan, Krueger, Shelton, 1992; Hall & Zentall, display, occasioning verbal praise from others ADHD, Tourettes and other DSM-IV disorder; improvement in 2000; K. R. Harris, Friedlander, 1992; Wedel & Fowler, 1984; Woltersdorf, 1992) 1990; Hitchcock, Clement, Saddler, Frizzelle, & Graham, 2005; Hertz & McLaughlin, brain injured persons et al., 2004; Hughes, et al., 2002; Kern, Dunlap, Childs, & Clarke, 1994; Martella, Leonard, Marchand- Martella, & Agran, 1993; M. Y. Mathes & Bender, 1997; McCarl, Svobodny, & Beare, 1991; McDougall & Brady, 1995; McLaughlin, Krappman, & Welsh, 1985; Nakano, 1990; O'Reilly, et al., 2002; Petscher & Bailey, 2006; Possell, et al., 1999; Rock, 2005; Selznick & Savage, 2000; Shabani, Wilder, & Flood, 2001; After hearing or seeing some content, person is told Shimabukuro, Prater, Jenkins, & Edelen-Smith, 1999; Stecker, Whinnery, & Fuchs, 1996; Thomas, Paragraph Abrams, & Johnson, 1971; Todd, Horner, &G. Mathes, Fuchs, Fuchs, Henley,Winn, Skinner, (Bean & Steenwyk, 1984; P. Sugai, 1999; Trammel, Schloss, & Alper, 1994; & et al., to “shrink” meaning to 8-10 words, full sentence; Improved reading responses and retention Allin, & Hawkins, 2004; Wood, Murdock, & Cronin, 2002; Wood, Murdock, Cronin, Dawson, & Kirby, 1998) Shrinking praise typically happens for good summaries. 1994; Spencer, Scruggs, & Mastropieri, 2003) Friday, August 12, 11 49
  • 79. = Public Posting Kernel Antecedent Kernel Happens BEFORE the behavior = radar Friday, August 12, 11 50
  • 80. Kernel Description Behaviors Affected References Person or group receives spoken (or Examples: Cooperation, social competence, academic (Leblanc, Ricciardi, & Luiselli, 2005; Lowe & McLaughlin, 1974; Marchant engagement, academic achievement, positive-parent child signed) recognition for engagement in & Young, 2001; Marchant, Young, & West, 2004; Martens, Hiralall, & Verbal Praise target acts, which may be descriptive or interactions, positive marital relations, better sales Bradley, 1997; Matheson & Shriver, 2005; C. M. Robinson & Robinson, performance; reduced disruptive or aggressive behavior; 1979; S. Scott, Spender, Doolan, Jacobs, & Aspland, 2001) simple acknowledgements reduced DSM-IV symptoms Reinforcement Peer-to-peer written A pad or display of decorative notes are Examples: social competence, academic (Cabello & Terrell, 1994; Embry, Flannery, Vazsonyi, Powell, & Atha, 1996; praise--“Tootle” Notes, posted on a wall, read aloud, or placed in a Kernel compliments books/ photo type album in which behaviors achievement, work performance, violence, Farber & Mayer, 1972; Heap & Emerson, 1989; Mayer, Butterworth, Nafpaktitis, & Sulzer-Azaroff, 1983; Mayer, Mitchell, Clementi, Clement- aggression, physical health, vandalism Robertson, & et al., 1993; Skinner, Cashwell, & Skinner, 2000) praise notes receive written praise from peers Tokens or symbolic rewards for positive behavior result in random rewards from Academic achievement, disruptive behavior, (Thorpe, Darch, & Drecktrah, 1978; Thorpe, Principal Lottery status person (e.g., principal, authority aggression Drecktrah, & Darch, 1979) figures) such as positive phone calls home Happens AFTER Safety or Tokens or reward tickets given out for Safety behaviors, accident reduction, (Geller, Johnson, & Pelton, 1982; Putnam, Handler, Ramirez- Performance observed safety or performance behavior, Platt, & Luiselli, 2003; Roberts & Fanurik, 1986; Saari & the behavior Lottery which are entered into lottery improved sales or work performance Latham, 1982) Music is played or stopped in real time, Increased weight gain of babies, improved baby (Allen & Bryant, 1985; Barmann & Croyle-Barmann, 1980; Barmann, Croyle-Barmann, & McLain, 1980; Bellamy & Sontag, 1973; Blumenfeld & Eisenfeld, 2006; Cevasco & Grant, 2005; Cook & Freethy, 1973; development possibly, work performance, academic Contingent music Cotter, 1971; W. B. Davis, Wieseler, & Hanzel, 1980; Dellatan, 2003; Deutsch, Parks, & Aylesworth, 1976; based on observed behavior of the achievement, attention and focus (ADHD symptoms Eisenstein, 1974; Harding & Ballard, 1982; Hill, Brantner, & Spreat, 1989; Holloway, 1980; Hume & Crossman, 1992; Jorgenson, 1974; Larson & Ayllon, 1990; Madsen, 1982; McCarty, McElfresh, Rice, & individual or group. down); reduced aggression Wilson, 1978; McLaughlin & Helm, 1993; Standley, 1996, 1999; Wilson, 1976; D. E. Wolfe, 1982) Improved academic engagement and achievement, (Beersma, et al., 2003; Hoigaard, S?fvenbom, & Soft Team Groups compete on some task, reduced disruptive behavior, increased sales, increased funding raising, increased safety; reduced Tonnessen, 2006; Kivlighan & Granger, 2006; Koffman, competition performance, or game. smoking; changed brain chemistry favoring attention Lee, Hopp, & Emont, 1998; Neave & Wolfson, 2003; and endurance Tingstrom, Sterling-Turner, & Wilczynski, 2006) Peer-to-peer Increased academic achievement; reduced (Allsopp, 1997; Delquadri, Greenwood, Stretton, & Hall, 1983; Dyad or triad take turns asking questions, ADHD and conduct problems; long-term DuPaul, Ervin, Hook, & McGoey, 1998; Fantuzzo & Ginsburg-Block, tutoring give praise or points and corrective effects on school engagement; decreased 1998; Greenwood, 1991a, 1991b; Maheady, Harper, & Sacca, feedback 1988; Maheady, Sacca, & Harper, 1988; Sideridis, et al., 1997) special education needs. Friday, August 12, 11 51
  • 81. Survival analysis to show long-term advantage of prize bowl kernel Standard Community Treatment Prize Bowl for Recovery Friday, August 12, 11 52