16. Multiplex RT-PCR 1: 4 FUS F primers and 2 R primers CREB3L2/L1 exon 5 2: 4 FUS F primers and 2 R primers CREB3L2/L1 exon 6 3: 1 beta actin F and 1 beta actin R primers FUS exon 6-CREB3L2 exon 5 FUS exon 6-CREB3L1 exon 6 Case A Case B Case B Case B Case A Case A NC NC NC 1 2 3
In 2000 Bejarano et al: t(7;16) in a case of HSCTGR Mezzelani et al: ring chromosome derived from chr 7 and 16 in a lung met (HSCTGR) In 2003 Reid et al: t(7;16)(q34;p11) in both LGMS and HSCTGR Storlazzi et al: FUS-BBF2H7 (CREB3L2) In 2004 Panagopoulos et al: t(7;16) is specific In 2005 Mertens et al: t (11;16)(p11;p11) with FUS-CREB3L1 Guillou 2007: Specificity 45/52 sarcomas: absence of FUS-CREB3L2 7/52 sarcomas: FUS-CREB3L2 (4 SEF, 1MFS, 1MPNST, 1 perineurioma ) Hypothesis: SEF belong to the same spectrum