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Big Questions,
Small Particles and
the Optimism of Curiosity




                    EPS EDISON VOLTA PRIZE
                          Como, April 13, 2013
                             Sergio Bertolucci
                                        CERN
The Mission of CERN

 Push forward the frontiers of knowledge
  E.g. the secrets of the Big Bang …what was the matter like
  within the first moments of the Universe‟s existence?


 Develop new technologies for
  accelerators and detectors
  Information technology - the Web and the GRID
  Medicine - diagnosis and therapy
Paradigm shifts …..




“I have no special talent. I am only passionately curious.” A. Einstein
The Mission of CERN

 Push forward the frontiers of knowledge
  E.g. the secrets of the Big Bang …what was the matter like
  within the first moments of the Universe‟s existence?


 Develop new technologies for
  accelerators and detectors
  Information technology - the Web and the GRID
  Medicine - diagnosis and therapy


 Train scientists and engineers of
  tomorrow

 Unite people from different countries and
  cultures
Next challenge: to understand
the first moments of our Universe




          13.7 Billion Years
                                    Today
               1028   cm
Big Bang


                          Proton
                              Atom


                                             Radius of Earth
                                                      Earth to Sun


                                                                            Radius of Galaxies
                                                                                   Universe
                        LHC

Super-Microscope


 Study physics laws of first moments after Big Bang       Hubble     WMAP
                                                                                      ALMA
   increasing Symbiosis between Particle Physics,
   Astrophysics and Cosmology
                                                                      VLT
The Standard Model




                     Weak   7
How does the Higgs mechanism work ? An over-simplified picture …

At the time of the Big Bang particles were all massless ( were moving at
speed of light) and Higgs field was there as an “non-interacting ether”
(minimum of Higgs potential = 0).




                         10-11 s after Big Bang:
                         phase transition




About 10-11 s after the Big Bang  temperature became low enough for phase
transition ( minimum of Higgs potential became negative)  ether becomes
“molasses”  particles interacting with ”molasses” acquire a mass and are
slowed down                                                               8
Enter a New Era in Fundamental Science
                                         LHCb




         CMS
                                                          ATLAS




  Since March 2010 exploration of a new energy frontier
              in p-p and Pb-Pb collisions
                                                      ALICE

                        LHC ring:
                   27 km circumference
Unprecedented energy: 4 TeV per beam particle               collision energy = 8 TeV
                                                                    (1 TeV= 10-7 Joule)
2014  collision energy to 14 TeV
Note: huge amount of energy concentrated in the collision point
      (14 TeV corresponds to 20 1-Volt batteries for each star of our galaxy and
      to 1014 times the temperature in this room)
      However: small energy on macroscopic scale (1 Joule is just enough to swat a mosquito)



The most challenging components
of the LHC are 1232 high-tech
superconducting magnets, providing
a field of 8.3 T (needed to bend
7 TeV beams inside a 27 km ring).
7600 km of NbTi superconducting cable
Work at 1.9K (-270 degrees)




 Energy stored in the beams: 350 MJoule
 (can melt 500 kg of Cu)
 Electrical Melbourne, 10/7/2012 LHC (from French EDF): ~200 MW
  F. Gianotti, power to run the
                                                                                          10
Lucio Rossi   LHC status - INFN Roma1   11
Detectors for particle physics

Cover the whole angular range around the
collision point to detect as many particles
produced in the collision as possible.




                            e


                                      p


                     Transverse
 F. Gianotti, Melbourne, 10/7/2012   slice through CMS
                                                         12
The LHC experiments:
      about 100 million “sensors” each
      [think your 6MP digital camera...
   ...taking 40 million pictures a second]
                       ATLAS    CMS
five-storey building
ATLAS: Installation of Barrel Toroid




14
                    ATLAS cavern (-100 m) in June 2003
F. Gianotti, Melbourne, 10/7/2012                        14
October 2005: Barrel toroid magnet system in place
The CMS experiment
Balloon

                   The LHC data                             (30 km)


• 40 million events (pictures) per second               DVD stack with
                                                        1 year LHC data!
• Select (on the fly) the ~500 interesting events       (~ 20 km)

  per second to write on tape
• “Reconstruct” data and convert for analysis:
• “physics data” [ the grid...]
                                                    Concorde
                                                    (15 km)


 (x4 experiments x15 years) Per event
                                      Per
                                      year
 Raw data                    1.6 MB 30 PB
 Reconstructed data          1.0 MB 20 PB           Mt. Blanc
                                                    (4.8 km)
 Physics data                0.1 MB    2 PB
Astronomy & Astrophysics
                                                                     Civil Protection
                           Enabling Grids for E-sciencE
                                                           Computational Chemistry
                                                              Comp. Fluid Dynamics
                                                            Computer Science/Tools
                                                          Condensed Matter Physics
                                                                      Earth Sciences
                                                                             Finance
                                                                              Fusion
                                                                High Energy Physics
                                                                         Humanities
                                                                       Life Sciences
                                                                   Material Sciences
                                                                     Social Sciences




~285 sites
48 countries
>350,000 CPU cores
>300 PetaBytes disk, >200PB tape
>13,000 users
>12 Million jobs/month

EGEE-III INFSO-RI-222667
Comparison: 2010, 2011 & 2012
                                 2010: 0.04 fb-1
                                    7 TeV CoM
                                    Machine commissioning
                                 2011: 6.1 fb-1
                                    7 TeV CoM
                                    … Production & exploration
                                 2012: 21 fb-1 so far
                                      Higher energy, 8 TeV
                                      Smaller *
                                      Increased bunch current


  75% of Design
Luminosity @ Half
design Energy and
Half the number of
     bunches!!
The BIG challenge in 2012: PILE-UP



                                                                               Experiment‟s
                                                                               design value
                                                                               (expected to be
                                                                               reached at L=1034 !)




                            Z μμ event from 2012 data with 25 reconstructed vertices




                     Z μμ



ATLAS Higgs searches, F. Gianotti, HEPAP meeting, 27/8/2012                                      20
4 July 2012: “CERN experiments observe particle
    consistent with long-sought Higgs boson”
It has the properties of a Higgs boson
Is this new particle the Higgs boson ?

It looks like it, but it‟s too early to tell whether it is the Standard
Model Higgs or another type of Higgs boson … We will need to
measure its properties in detail in the months to come.



Even if it is the Higgs boson, this is just the beginning,
as this particle raises many other questions !




                                                                          24
A considerable number of key questions…




origin of mass/matter       or
origin of electroweak symmetry breaking
unification of forces
fundamental symmetry of forces and
matter
unification of quantum physics and
general relativity
number of space/time dimensions
what is dark matter?
what is dark energy?
But What is Wrong with this Picture?
Cosmic problems......
                            Standard Model
THE ENERGY DENSITY BUDGET



         BARYONS
  B

  CDM COLD DARK MATTER

         NEUTRINOS

  DE     DARK ENERGY

  TOT
   BCDM
      DE
Solutions?
                                                                                                       Technicolor
                                                                                             New (strong) interactions produce EWSB

                                                                                               Extensions of the SM gauge group :

                                                     Salam Glashow Weinberg                    Little Higgs / GUTs / …
                          Politzer Wilczek   Gross                              Veltman „t Hooft

                Reines



                                   For all proposed solutions:
                                  new particles should appear
                                                                                                   Friedman
       Perl                          at TeV scale or below van der
                                                     Rubbia   Higgs
                         Schwartz Lederman Ting                        Meer       Fitch   Cronin
Hofstadter Steinberger
    Schwinger                                                                                                    Selected NP
                                                                                                    Kendall      since 1957
                                             Richter Gell-Mann Alvarez Taylor                                    Except P. Higgs
                                  Feynman                                          Yang     Lee




        Supersymmetry                                                                          Extra Dimensions
New particles at ≈ TeV scale, light Higgs                                                    New dimensions introduced
          Unification of forces                                                           mGravity ≈ melw Hierarchy problem
        Higgs mass stabilized                                                                               solved
        No new interactions                                                                 New particles at ≈ TeV scale
Further ahead: present LHC upgrade plans                             ATLAS




                                                              New Pixel B-layer
                                                              + consolidation




                                                                  New Muon small wheels
                                                                  FTK, LVL1 Trigger



                                                               New tracker




ATLAS Higgs searches, F. Gianotti, HEPAP meeting, 27/8/2012                               31
Only abstract speculations???
Cutting edge Research Infrastructures play a key role in a
               knowledge driven society
Medical Application as an Example of Particle Physics Spin-off
              Combining Physics, ICT, Biology and Medicine to fight cancer



                                  Hadron Therapy
                                               Tumour                                      Leadership in Ion
                                                Target                                     Beam Therapy now
                                                                                           in Europe and
                                  Protons                                                  Japan
                                  light ions
Accelerating particle beams                                          X-ray       protons
 ~30‟000 accelerators worldwide   >70‟000 patients treated worldwide (30 facilities)
   ~17‟000 used for medicine      >21‟000 patients treated in Europe (9 facilities)




                                   Imaging                         PET Scanner
                                      Clinical trial in Portugal
                                      for new breast imaging
                                        system (ClearPEM)



    Detecting particles
CNAO in Pavia
ClearPEM-Sonic a collaborative
                    project between physicians and
                               physicists
                                   ClearPEM   METABOLIC information




            Ultrasound Probe MORPHOLOGIC and STRUCTURAL information
 Objective: Detect 1 to 2mm tumors and define their cancerous status
June 2011                                                  P. Lecoq CERN   36
Derenzo phantom
            Excellent resolution (< 1.5mm)
            compared to
            5mm for the best commercial PET scanners

                                         OSEM 3D

                                                   2.0 mm
                                2.5 mm




                                                    1.5 mm
                                3.0 mm


                                          1.2 mm




June 2011                                                    P. Lecoq CERN   37
ClearPET-XPAD X-ray tube
                               RTW
                                                Mo target, 50 µm spot size, 50 W
                                                Nb/Mo additional filter
                                                Threshold 3-35 keV

                                            XPAD3/Si Hybrid pixel
                                             camera
                                                X-ray photon counting mode
                                                500 µm silicon sensor thickness
                                                78 x 75 mm² detector
                                                130 x 130 µm² pixel size

                                            PET FOV
 ClearPET/XPAD                                  55mm axial
                                                111mm transverse

 Simultaneous                              35 mm transverse FOV
  hybrid PET/CT                                 59mm axial
                    Courtesy of C. Morel        38mm transverse
  imaging system    CPPM/CERIMED
June 2011                                                         P. Lecoq CERN   38
Why grids for e-Health?
                           Enabling Grids for E-sciencE

   • Sharing computing resources and algorithms
      – Research (populations studies, models
        design, validation, statistics)
      – Complex analysis (compute intensive image processing, time
        constraints...)
                                           •Data




                                                                              •Procedures

                                   •Seq1                   >
                                   dcscdssdcsdcdsc
                                   bscdsbcbjbfvbfvbvfbvbvbhvb
                                   hsvbhdvbhfdbvfd



                                   •Seq2                   >

                 •Algorithms
                                   bvdfvfdvhbdfvb
                                   bhvdsvbhvbhdvrefghefgdscg
                                   dfgcsdycgdkcsqkc



                                   •…

                                   •Seqn                   >
                                   bvdfvfdvhbdfvb
                                   bhvdsvbhvbhdvrefghefgdscg
                                   dfgcsdycgdkcsqkchdsqhfduh
                                   dhdhqedezhhezldhezhfehfle
                                   zfzejfv




                                                                            •Computing power
EGEE-III INFSO-RI-222667                                                                       •39
ThIS: Therapeutic Irradiation
                           Enabling Grids for E-sciencE                      Simulator

                                                          •Cancer treatment by irradiation
                                                          of patient with beams of
                                                          photons, protons or carbons
                                                          •CT image (482x360x141)
                                                          •3D dose distribution, 700h CPU


    • Offer an open platform to researchers for Monte Carlo
      simulations optimisation
    • Offer a fast and reliable simulation tool for researchers
      in medical physics and medical imaging for treatment
      control
    • Produce a reference dataset for non-conventional
      therapies (hadrontherapy).
EGEE-III INFSO-RI-222667                            Grid usage for eHealth, EGEE life sciences activity, January 2010   40
Health-e-Child Network

      4 paediatric hospitals
                                              • 7 technical sites
          IGG - Gaslini, Genoa, Italy
                                              • 4 clinical sites
          GOSH, London, UK
          NECKER, Paris, France                  (+1 clinical site in the US:
          OPBG, Rome, Italy                          Johns Hopkins)
      Strong interdisciplinary team across
          Countries and languages
          Technical and clinical fields

      Research on three paediatric areas
          Arthritis
          Cardiac Disorders
          Brain Tumours




41                   Health-e-Child
Decision Support




                         Virtual
                      Physiological
                         Child

42   Health-e-Child
Cern as the central hub of a network
                    CERN is our laboratory:
how can we maximize its benefits for the member states?

 Create/maintain at the national level research infrastructures
 and integrate them in a network, enabling:
      Brain circulation
      Knowledge and Technology Transfer
      Industrial applications
      Training
      Cross fertilization
How Do We Manage This?
Contrary to popular belief, our community is rather elementary:
    It has simple rules, honed by centuries of practice
    It shares a common vision and a common set of values
    It is based on collaboration AND competition

 Science is intrinsically not democratic (can‟t decide who is
 right by vote!) and therefore it has to be performed with the
 most democratic tools:
    Freedom of expression
    Peer reviewing
    Independency from political orientation, religion, social
     status, etc…
A peculiar ant colony, probably worth of a closer look
The scientists/engineers
Despite the usual cinematographic representation, in general
we DO NOT
    Wear white lab coats
    Live in ivory towers
    Find a revolutionary result every second day (scientist=genius)

 We are a pragmatic community capable to address in a
 very material way grand and (apparently) immaterial
 questions, knowing that for every answer we might find, we
 will open more and unpredicted questions.
 (we definitely prefer to be Ministers of Doubt than Kings of
 Truth: ubi dubium, ibi libertas)
How can you manage such a community?
Need individualized, enabling and integrated structures
within supporting infrastructure to:
    Allow everybody to keep his/her 5% of dream (i.e. the own
     original contribution to the advancement of Science), while
     operating in a very large symphony orchestra.
    Encourage the emergence of gifted performers/soloists
    Foster a leadership based on credibility and consensus more
     than on authority
In conclusion

 The historic observation of a new particle compatible
  with the Higgs boson opens a new era in the
  understanding of nature.

 We are just at the beginning of a long journey into
  uncharted territories.

 CERN is a paradigmatic example of the powerful
  synergy of “pure” and “applied” science.

 The exploitation of this synergy is possibly the only way
  to enable a sustainable future.
To conclude….

 The relationship between basic research and
  sustainable progress is fundamental (contrary to
  common belief, technology does not sustain itself on
  the long term)

 In a globalized world, knowledge is becoming the
  most important asset.

 Developed countries are about to make a major
  strategic error by underestimating the value of
  fundamental research ( whereas emerging countries
  are doing the opposite and catching up fast)
Paradigm shifts are a necessity!




                          Refining candles
                         would not have led
                         candles into electric
                              bulbs …
THANK YOU!

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Eps edison volta

  • 1. Big Questions, Small Particles and the Optimism of Curiosity EPS EDISON VOLTA PRIZE Como, April 13, 2013 Sergio Bertolucci CERN
  • 2. The Mission of CERN  Push forward the frontiers of knowledge E.g. the secrets of the Big Bang …what was the matter like within the first moments of the Universe‟s existence?  Develop new technologies for accelerators and detectors Information technology - the Web and the GRID Medicine - diagnosis and therapy
  • 3. Paradigm shifts ….. “I have no special talent. I am only passionately curious.” A. Einstein
  • 4. The Mission of CERN  Push forward the frontiers of knowledge E.g. the secrets of the Big Bang …what was the matter like within the first moments of the Universe‟s existence?  Develop new technologies for accelerators and detectors Information technology - the Web and the GRID Medicine - diagnosis and therapy  Train scientists and engineers of tomorrow  Unite people from different countries and cultures
  • 5. Next challenge: to understand the first moments of our Universe 13.7 Billion Years Today 1028 cm
  • 6. Big Bang Proton Atom Radius of Earth Earth to Sun Radius of Galaxies Universe LHC Super-Microscope Study physics laws of first moments after Big Bang Hubble WMAP ALMA increasing Symbiosis between Particle Physics, Astrophysics and Cosmology VLT
  • 8. How does the Higgs mechanism work ? An over-simplified picture … At the time of the Big Bang particles were all massless ( were moving at speed of light) and Higgs field was there as an “non-interacting ether” (minimum of Higgs potential = 0). 10-11 s after Big Bang: phase transition About 10-11 s after the Big Bang  temperature became low enough for phase transition ( minimum of Higgs potential became negative)  ether becomes “molasses”  particles interacting with ”molasses” acquire a mass and are slowed down 8
  • 9. Enter a New Era in Fundamental Science LHCb CMS ATLAS Since March 2010 exploration of a new energy frontier in p-p and Pb-Pb collisions ALICE LHC ring: 27 km circumference
  • 10. Unprecedented energy: 4 TeV per beam particle collision energy = 8 TeV (1 TeV= 10-7 Joule) 2014  collision energy to 14 TeV Note: huge amount of energy concentrated in the collision point (14 TeV corresponds to 20 1-Volt batteries for each star of our galaxy and to 1014 times the temperature in this room) However: small energy on macroscopic scale (1 Joule is just enough to swat a mosquito) The most challenging components of the LHC are 1232 high-tech superconducting magnets, providing a field of 8.3 T (needed to bend 7 TeV beams inside a 27 km ring). 7600 km of NbTi superconducting cable Work at 1.9K (-270 degrees) Energy stored in the beams: 350 MJoule (can melt 500 kg of Cu) Electrical Melbourne, 10/7/2012 LHC (from French EDF): ~200 MW F. Gianotti, power to run the 10
  • 11. Lucio Rossi LHC status - INFN Roma1 11
  • 12. Detectors for particle physics Cover the whole angular range around the collision point to detect as many particles produced in the collision as possible. e p Transverse F. Gianotti, Melbourne, 10/7/2012 slice through CMS 12
  • 13. The LHC experiments: about 100 million “sensors” each [think your 6MP digital camera... ...taking 40 million pictures a second] ATLAS CMS five-storey building
  • 14. ATLAS: Installation of Barrel Toroid 14 ATLAS cavern (-100 m) in June 2003 F. Gianotti, Melbourne, 10/7/2012 14
  • 15. October 2005: Barrel toroid magnet system in place
  • 17. Balloon The LHC data (30 km) • 40 million events (pictures) per second DVD stack with 1 year LHC data! • Select (on the fly) the ~500 interesting events (~ 20 km) per second to write on tape • “Reconstruct” data and convert for analysis: • “physics data” [ the grid...] Concorde (15 km) (x4 experiments x15 years) Per event Per year Raw data 1.6 MB 30 PB Reconstructed data 1.0 MB 20 PB Mt. Blanc (4.8 km) Physics data 0.1 MB 2 PB
  • 18. Astronomy & Astrophysics Civil Protection Enabling Grids for E-sciencE Computational Chemistry Comp. Fluid Dynamics Computer Science/Tools Condensed Matter Physics Earth Sciences Finance Fusion High Energy Physics Humanities Life Sciences Material Sciences Social Sciences ~285 sites 48 countries >350,000 CPU cores >300 PetaBytes disk, >200PB tape >13,000 users >12 Million jobs/month EGEE-III INFSO-RI-222667
  • 19. Comparison: 2010, 2011 & 2012  2010: 0.04 fb-1  7 TeV CoM  Machine commissioning  2011: 6.1 fb-1  7 TeV CoM  … Production & exploration  2012: 21 fb-1 so far  Higher energy, 8 TeV  Smaller *  Increased bunch current 75% of Design Luminosity @ Half design Energy and Half the number of bunches!!
  • 20. The BIG challenge in 2012: PILE-UP Experiment‟s design value (expected to be reached at L=1034 !) Z μμ event from 2012 data with 25 reconstructed vertices Z μμ ATLAS Higgs searches, F. Gianotti, HEPAP meeting, 27/8/2012 20
  • 21. 4 July 2012: “CERN experiments observe particle consistent with long-sought Higgs boson”
  • 22.
  • 23. It has the properties of a Higgs boson
  • 24. Is this new particle the Higgs boson ? It looks like it, but it‟s too early to tell whether it is the Standard Model Higgs or another type of Higgs boson … We will need to measure its properties in detail in the months to come. Even if it is the Higgs boson, this is just the beginning, as this particle raises many other questions ! 24
  • 25. A considerable number of key questions… origin of mass/matter or origin of electroweak symmetry breaking unification of forces fundamental symmetry of forces and matter unification of quantum physics and general relativity number of space/time dimensions what is dark matter? what is dark energy?
  • 26. But What is Wrong with this Picture?
  • 27. Cosmic problems...... Standard Model THE ENERGY DENSITY BUDGET BARYONS B CDM COLD DARK MATTER NEUTRINOS DE DARK ENERGY TOT BCDM DE
  • 28. Solutions? Technicolor New (strong) interactions produce EWSB Extensions of the SM gauge group : Salam Glashow Weinberg Little Higgs / GUTs / … Politzer Wilczek Gross Veltman „t Hooft Reines For all proposed solutions: new particles should appear Friedman Perl at TeV scale or below van der Rubbia Higgs Schwartz Lederman Ting Meer Fitch Cronin Hofstadter Steinberger Schwinger Selected NP Kendall since 1957 Richter Gell-Mann Alvarez Taylor Except P. Higgs Feynman Yang Lee Supersymmetry Extra Dimensions New particles at ≈ TeV scale, light Higgs New dimensions introduced Unification of forces mGravity ≈ melw Hierarchy problem Higgs mass stabilized solved No new interactions New particles at ≈ TeV scale
  • 29.
  • 30.
  • 31. Further ahead: present LHC upgrade plans ATLAS New Pixel B-layer + consolidation New Muon small wheels FTK, LVL1 Trigger New tracker ATLAS Higgs searches, F. Gianotti, HEPAP meeting, 27/8/2012 31
  • 32. Only abstract speculations??? Cutting edge Research Infrastructures play a key role in a knowledge driven society
  • 33. Medical Application as an Example of Particle Physics Spin-off Combining Physics, ICT, Biology and Medicine to fight cancer Hadron Therapy Tumour Leadership in Ion Target Beam Therapy now in Europe and Protons Japan light ions Accelerating particle beams X-ray protons ~30‟000 accelerators worldwide >70‟000 patients treated worldwide (30 facilities) ~17‟000 used for medicine >21‟000 patients treated in Europe (9 facilities) Imaging PET Scanner Clinical trial in Portugal for new breast imaging system (ClearPEM) Detecting particles
  • 35.
  • 36. ClearPEM-Sonic a collaborative project between physicians and physicists ClearPEM METABOLIC information Ultrasound Probe MORPHOLOGIC and STRUCTURAL information Objective: Detect 1 to 2mm tumors and define their cancerous status June 2011 P. Lecoq CERN 36
  • 37. Derenzo phantom Excellent resolution (< 1.5mm) compared to 5mm for the best commercial PET scanners OSEM 3D 2.0 mm 2.5 mm 1.5 mm 3.0 mm 1.2 mm June 2011 P. Lecoq CERN 37
  • 38. ClearPET-XPAD X-ray tube  RTW Mo target, 50 µm spot size, 50 W Nb/Mo additional filter Threshold 3-35 keV  XPAD3/Si Hybrid pixel camera X-ray photon counting mode 500 µm silicon sensor thickness 78 x 75 mm² detector 130 x 130 µm² pixel size  PET FOV ClearPET/XPAD 55mm axial 111mm transverse Simultaneous  35 mm transverse FOV hybrid PET/CT 59mm axial Courtesy of C. Morel 38mm transverse imaging system CPPM/CERIMED June 2011 P. Lecoq CERN 38
  • 39. Why grids for e-Health? Enabling Grids for E-sciencE • Sharing computing resources and algorithms – Research (populations studies, models design, validation, statistics) – Complex analysis (compute intensive image processing, time constraints...) •Data •Procedures •Seq1 > dcscdssdcsdcdsc bscdsbcbjbfvbfvbvfbvbvbhvb hsvbhdvbhfdbvfd •Seq2 > •Algorithms bvdfvfdvhbdfvb bhvdsvbhvbhdvrefghefgdscg dfgcsdycgdkcsqkc •… •Seqn > bvdfvfdvhbdfvb bhvdsvbhvbhdvrefghefgdscg dfgcsdycgdkcsqkchdsqhfduh dhdhqedezhhezldhezhfehfle zfzejfv •Computing power EGEE-III INFSO-RI-222667 •39
  • 40. ThIS: Therapeutic Irradiation Enabling Grids for E-sciencE Simulator •Cancer treatment by irradiation of patient with beams of photons, protons or carbons •CT image (482x360x141) •3D dose distribution, 700h CPU • Offer an open platform to researchers for Monte Carlo simulations optimisation • Offer a fast and reliable simulation tool for researchers in medical physics and medical imaging for treatment control • Produce a reference dataset for non-conventional therapies (hadrontherapy). EGEE-III INFSO-RI-222667 Grid usage for eHealth, EGEE life sciences activity, January 2010 40
  • 41. Health-e-Child Network  4 paediatric hospitals • 7 technical sites  IGG - Gaslini, Genoa, Italy • 4 clinical sites  GOSH, London, UK  NECKER, Paris, France (+1 clinical site in the US:  OPBG, Rome, Italy Johns Hopkins)  Strong interdisciplinary team across  Countries and languages  Technical and clinical fields  Research on three paediatric areas  Arthritis  Cardiac Disorders  Brain Tumours 41 Health-e-Child
  • 42. Decision Support Virtual Physiological Child 42 Health-e-Child
  • 43. Cern as the central hub of a network CERN is our laboratory: how can we maximize its benefits for the member states? Create/maintain at the national level research infrastructures and integrate them in a network, enabling:  Brain circulation  Knowledge and Technology Transfer  Industrial applications  Training  Cross fertilization
  • 44. How Do We Manage This? Contrary to popular belief, our community is rather elementary:  It has simple rules, honed by centuries of practice  It shares a common vision and a common set of values  It is based on collaboration AND competition Science is intrinsically not democratic (can‟t decide who is right by vote!) and therefore it has to be performed with the most democratic tools:  Freedom of expression  Peer reviewing  Independency from political orientation, religion, social status, etc…
  • 45. A peculiar ant colony, probably worth of a closer look
  • 46. The scientists/engineers Despite the usual cinematographic representation, in general we DO NOT  Wear white lab coats  Live in ivory towers  Find a revolutionary result every second day (scientist=genius) We are a pragmatic community capable to address in a very material way grand and (apparently) immaterial questions, knowing that for every answer we might find, we will open more and unpredicted questions. (we definitely prefer to be Ministers of Doubt than Kings of Truth: ubi dubium, ibi libertas)
  • 47. How can you manage such a community? Need individualized, enabling and integrated structures within supporting infrastructure to:  Allow everybody to keep his/her 5% of dream (i.e. the own original contribution to the advancement of Science), while operating in a very large symphony orchestra.  Encourage the emergence of gifted performers/soloists  Foster a leadership based on credibility and consensus more than on authority
  • 48. In conclusion  The historic observation of a new particle compatible with the Higgs boson opens a new era in the understanding of nature.  We are just at the beginning of a long journey into uncharted territories.  CERN is a paradigmatic example of the powerful synergy of “pure” and “applied” science.  The exploitation of this synergy is possibly the only way to enable a sustainable future.
  • 49. To conclude….  The relationship between basic research and sustainable progress is fundamental (contrary to common belief, technology does not sustain itself on the long term)  In a globalized world, knowledge is becoming the most important asset.  Developed countries are about to make a major strategic error by underestimating the value of fundamental research ( whereas emerging countries are doing the opposite and catching up fast)
  • 50. Paradigm shifts are a necessity! Refining candles would not have led candles into electric bulbs …