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Covid 19 MindMap
1.
COVID-19 EPIDEMIOLOGY Globally, more than four million confirmed cases of COVID-19 have been reported. The number is increasing daily TRANSMISSION 1. Person to person:Via respiratory droplets typically within the distance of 6 feet while coughing, sneezing or talking. 2. Airborne: Through the particles smaller than droplet that remain in air over time and distance. 3. Virus has been found in non respiratory droplets such as stool, blood, occular secretions and semen, but the role of these sites in transmission is uncertain TAXONOMY Category: Coronaviruses Kingdom: Riboviria Order: Nidovirales Sub-Order: Cornidovirineae Family: Coronaviridae Sub- Family: Orthocoronaviridae Genus: Betacoronavirus Sub-Genus: Sarbecovirus Species: SARS-r Coronavirus Individuum: SARS-CoV2 CLINICAL FEATURES Incubation period: 14 days following exposure Spectrum of Illness severity 1. Mild: No or mild Pneumonia 2. Severe: With dyspnea, hypoxia or >50% Lung involvement on imaging within 24-48 hours 3. Critical: With respiratory failure, shock or multi-organ dysfunction Overall case fatality rate: 2.3% RISK FACTORS FOR SEVERE ILLNESS Cardiovascular disease Diabetes mellitus Hypertension Chronic lung disease Cancer (in particular hematologic malignancies, lung cancer, and metastatic disease) Chronic kidney disease Obesity Smoking LAB FEATURES with worse outcomes Lymphopenia Elevated liver enzymes Elevated lactate dehydrogenase (LDH) Elevated inflammatory markers ( eg, C-reactive protein [CRP], ferritin) Elevated D-dimer (>1 mcg/mL) Elevated prothrombin time (PT) Elevated troponin Elevated creatine phosphokinase (CPK) Acute kidney injury Fever in 99 percent (note that fever on presentation is not this common in all studies Fatigue in 70 percent Dry cough in 59 percent Anorexia in 40 percent Myalgias in 35 percent Dyspnea in 31 percent Sputum production in 27 percent DIAGNOSIS NAAT (RT-PCR) to diagnose current infection SPECIMEN COLLECTION One of the following Nasopharyngeal swab specimen, collected by a health care professional Oropharyngeal swab specimen, collected by a health care professional Nasal swab specimen from the anterior nares, collected by a health care professional or by the patient on-site or at home Nasal or nasopharyngeal wash/ aspirate, collected by a health care professional MANAGEMENT Symptomatic and Supportive Antiviral drugs are under study to reduce the course of the disease such as Fapilavir, Remdesivir. Furthe studies are required PREVENTION Infection control in health care setting Personal Preventive measures: Social distancing Diligent hand washing, particularly after touching surfaces in public. Use of hand sanitizer that contains at least 60 percent alcohol is a reasonable alternative if the hands are not visibly dirty. Respiratory hygiene (eg, covering the cough or sneeze). Avoiding touching the face (in particular eyes, nose, and mouth). Cleaning and disinfecting objects and surfaces that are frequently touched.
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