The document summarizes the BioMedReg project, which aims to concentrate, evaluate, and develop national chemical knowledge through collaboration between the Institute of Organic Chemistry and Biochemistry (IOCB), Palacky University in Olomouc (UPOL), and the Institute of Chemical Technologies Prague (ICT). It establishes the Institute of Molecular and Translational Medicine (IMTM) at UPOL to facilitate joint projects on drug development through high-throughput screening, clinical trials, and biomarker analysis. The IMTM has 120 scientists and students working across 4700 square meters of research facilities focused on areas like immunomodulation, antivirals, and cancer therapies.

1. INSTITUTE OF MOLECULAR
AND TRANSLATIONAL MEDICINE
Presentation of The BioMedReg Project
Marian Hajduch, MD, PhD
Laboratory of Experimental Medicine,
Institute of Molecular and Translational Medicine,
Faculty of Medicine and Dentistry,
Palacky University in Olomouc
Czech Republic

2. INSTITUTE OF MOLECULAR
AND TRANSLATIONAL MEDICINE
Palacký University in Olomouc
• Established in 1573
•The second oldest university after the Charles Universty in Prague
•Olomouc Archibishop – center of Moravian religion and education – alumni or region associated
scientists: John Amos Comenius, Vincenz Priessnitz, Johann Gregor Mendel, Sigmund Freund, Konrad
Zirm, Otto Wichterle, Frantisek Santavy, Jiri Bartek
•Currently 25.000 students, approx. 10% of Czech university students and 2.800 employees
OLOMOUC
Gregor Johann Mendel
BRNO (July 20th, 1822
- Jan. 6th, 1884)
"Father of genetics"

3. INSTITUTE OF MOLECULAR
AND TRANSLATIONAL MEDICINE
Long-lasting tradition of chemistry in the country
Main medicinal chemistry, drug development and chemical biology centers in the
Czech Republic
Institute of Inorganic Chemistry and Biochemistry, ASCR
Institute of Organic Chemistry and Biochemistry, ASCR
Institute of Chemical Technologies Prague
Institute of Macromolecular Chemistry ASCR
Charles University
PRAGUE
Palacký University in Olomouc
OLOMOUC
Masaryk University
BRNO

4. Infrastructural project for chemical biology and translational medicine (BIOMEDREG) –
concentrating, evaluating and developing the national chemical knowledge
Clinical
High throughput trials
screening Communication with
partners
IOCHB ASCR
ICT
Palacký University Olomouc
Universtiy Hospital Olomouc
Data collection for
national &
Biomarkers international
databases
Presentation of Therapeutic
results standards

5. INSTITUTE OF MOLECULAR
AND TRANSLATIONAL MEDICINE
Institute of Molecular and Translational Medicine - Management

6. INSTITUTE OF MOLECULAR
AND TRANSLATIONAL MEDICINE

7. INSTITUTE OF MOLECULAR
AND TRANSLATIONAL MEDICINE
Current joined projects (IOCB/UPOL/ICT)
•MDP analogues – immunomodulatory molecules, vaccine adjuvants, anticancer agents
•Carboranes – antiviral, antibacterial and anticancer properties
•Nucleotide and nucleoside analogues – anticancer and antiviral activities
•Terpenoid compounds – antiviral, immunomodulatory and anticancer activities
•Antimicrobial peptides
•Targeted biological therapies – transport systems
•New biomarkers – cancer, infection

8. INSTITUTE OF MOLECULAR
AND TRANSLATIONAL MEDICINE
BIOMEDREG/IMTM – Major Milestones
• Start of the Project: January 1, 2008
•Preparatory Phase: January 1, 2008 – March 31, 2010
•Construction Phase: April 1, 2010 – March 31, 2012
•Start-Up Phase: April 1 2012 – March 31, 2013
•Full Operation: Since April 1, 2013
120 scientists and PhD. students, 4700 m2 of research space, uHTS facility, BL3 laboratories
including animal facility, genomics&proteomics&metabolomics unit, tissue bank, clinical
trial unit, GLP, GMP, GCP certified units