Introduction to one of the most common symptoms that can represent a wide range of diseases, from benign to life-threatening, covering number of systems including gastrointestinal, cardiovascular, pulmonary, musculoskeletal and psychiatric.
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6. Definition
×Dyspnea is an uncomfortable sensation or
awareness of breathing.
× The term is used interchangeably with:
• Shortness of breath
• Difficulty in breathing
• Breathlessness
7. “Dyspnea is a term used to describe
subjective experience of breathing
discomfort that consists of qualitatively
distinct sensations that vary in intensity.
- American Thoracic Society
8. “×These distinct sensations include:
• increased effort for breathing
• chest tightness
• air hunger (feeling of not enough oxygen)
- American Thoracic Society
10. Etiology
× Dyspnea is a normal symptom of heavy exertion.
× Dyspnea becomes pathological if it occurs in unexpected
situations, on light exertion, or at rest.
× It is a symptom of many organ systems, especially
cardiovascular and respiratory causes.
11. Etiology
×In 85% of the cases it is due to:
• Asthma
• Pneumonia
• Ischemic heart disease
• Interstitial lung disease
• Congestive heart failure
• COPD
• Psychogenic causes
16. Tachypnea
× Tachypnea is rapid breathing (respiratory rate is > 20 breaths per minute)
• Causes: exercise, labor in pregnancy, CO poisoning, pneumonia in children
• Children have higher resting resp. rate that decline rapidly by first 3 yrs of life
× Hyperpnea is breathing that is more rapid and deeper, than at rest
• Physiologic - after heavy exertion, high altitude
• Pathologic - anemia, sepsis, metabolic acidosis
× Hyperventilation (over-breathing) so that PCO2 is decreased
• Hypocapnia leads to respiratory alkalosis (tingling, dizziness, weakness,
tetany, nausea, vomiting)
× Kussmaul breathing is rapid, deep, laboured breathing seen with
worsening metabolic acidosis i.e. diabetic ketoacidosis, kidney failure
17. Bradypnea
× Apnea is cessation of breathing
• Sleep apnea – pauses in breathing 20-30 times per hour during sleep
• Apnea of prematurity – pauses in breathing in premature infants for >20 sec
× Bradypnea is breathing that is more rapid and deeper, than at rest
• A rate of < 12 breaths for age >12 years
× Hypopnea is bradypnea with overly shallow breathing than at rest
• Causes – sedatives, alcoholism, adenoiditis, aging, obesity, hypo-thyroidism,
hypokalemia, neuromuscular diseases (GB syndrome, myasthenia, ALS)
× Hypoventilation (under-breathing) so that PCO2 is increased
• Hypercapnia leads to respiratory acidosis (headache, anxiety, confusion,
blurred vision). Hypoventilation can lead to hypoxia.
18. Respiratory Distress
× Respiratory distress
• Physical presentation of respiratory distress is “labored breathing”
• Subjective sensation or awareness of respiratory distress is “dyspnea”
× Examples:
• Adults – Acute Respiratory Distress Syndrome (ARDS)
• Premature infants – Infant Respiratory Distress Syndrome (IRDS)
also called Hyaline Membrane Disease
due to surfactant deficiency
19. Paraoxysmal Nocturnal Dyspnea
× Paraoxysmal nocturnal dyspnea (PND)
• attacks of severe dyspnea that occur suddenly during sleep hours,
• causing the person to wake and sit up,
• associated with cough and wheeze
× Pathophysiology of PND
• In horizontal position, there is redistribution of blood from lower
extremities into the pulmonary circulation
• In patients who have already reduced pulmonary compliance and left
ventricular dysfunction, will develop pulmonary congestion
• Congestion decreases when patient assumes a more erect position
28. History Evaluation
× Chronicity
× Onset
× Positionality
× Severity
× Associated symptoms
× Past medical and surgical history
× Past gynecological and obstetric history
× Family history
× Occupational history
× Drug use / abuse history
× Social history (smoking, alcoholism)
29. acute
(in matter of minutes)
sub-acute
(over hours to days)
chronic
(over weeks to months)
History - Chronicity
31. History - Onset
× Dyspnea on exertion
• i.e. IHD, CHF, valvular insufficiency, interstitial lung disease etc
× Dyspnea on rest
• i.e. ACS, severe anxiety, acute asthma exacerbation etc
× Any triggers
• i.e. recent trauma, emotional stress, cold, wind, dust, mould, drugs, any new
pets or plants, smoke inhalation, any phobias
× Any diurnal variation
• i.e. PND is seen in CHF
× Any seasonal variation
• i.e. seasonal variant asthma
32. History - Positionality
× Orthopnea – dyspnea which occurs when lying supine
Seen with pulmonary edema i.e. due to left ventricular failure
× Platypnea – dyspnea that is relieved by lying down
× Orthodeoxia – low oxygen saturation in upright position
× Platypnea – Orthodeoxia syndrome
Seen in postional right-to-left shunt (ASD, PFO), constrictive pericarditis,
severe V/Q mismatch (mutliple pulmonary emboli), hepatopulmonary synd.
× Trepopnea – dyspnea sensed while lying on one side but not the other
Seen in heart failure, or due to disease of one lung / bronchus / pleura
(i.e. unilateral pleural effusion)
33. History - Severity
× Severity of dyspnea is subjective to the perception of the patient.
× It is important to establish degree of severity of dyspnea in patients
with chronic causes like heart failure, COPD or interstitial lung disease,
as these can affect the quality of life.
× We can use the following scales:
• New York Heart Association (NYHA) functional classification
- used mainly for patients with heart failure
• Medical Research Council (MRC) scale
- used mainly for patients with COPD
• Veterans Specific Activity Questionnaire (VSAQ)
- estimates aerobic capacity in meters
37. History – Misc.
× Past medical history
• any medical conditions, past admissions, recent trauma or immobilization etc
× Past surgical history
• any major operations, history of difficult intubation or catheterization etc
× Past gynecological and obstetric history
• menstrual history, current or recent pregnancy and related complications etc
× Family history
• IHD, sudden cardiac death, TB, asthma, cancer, hematologic disorders etc
× Occupational history
• long standing/sitting hours, pneumoconiosis, carcinogen exposure etc
× Drug use and abuse history
• sedatives (narcotics, benzodiazepines), beta blockers, contraceptives etc
× Personal history - diet, exercise, smoking, alcohol consumption
46. PERC Rule
× Low clinical pre-test probability
× Plus:
• Age < 50 years
• Pulse < 100 b/m
• SpO2 > 94%
• No leg swelling
• No hemoptysis
• No recent trauma / surgery
• No prior PE / DVT
• No hormone use
8,138 patients
Sensitivity 97.4 %
False negative 0.9 %
48. D-dimer
× A fibrin degrataion product (FDP)
- released after a blood clot undergoes fibrinolysis
× Its blood levels are raised in
- thromboembolic conditions
- pro-thrombotic conditions
× A negative test is useful in ruling out the following:
- Deep venous thrombosis (DVT)
- Pulmonary embolism (P.E)
- Ischemic stroke
- Disseminated intravascular coagulation (DIC)
× A positive test warrants further investigation for underlying causes
ELISA D-dimer
Sensitivity 96 %
Specificity 45 %
49. Brain natriuretic peptide
× BNP is secreted by heart ventricles in repsonse
to excessive stretching of cardiomyocytes
× PreproBNP ProBNP BNP + NT-proBNP
× Physiologic actions of BNP are:
- vasodilation (decrease systemic vascular resistance)
- natriuresis and diuresis (reduction in blood volume)
× Net effect – decrease cardiac output and blood pressure
× Useful in differentiating heart failure from other causes of dyspnea
- Normal BNP levels ( < 100 pg/ml ) rule out acute heart failure
- Raised levels ( > 500 pg/ml ) are not useful in diagnosis of acute HF
- Raised levels are useful in prognosis in heart failure
Sensitivity 100 %
Specificity 85 %
Half life 20 m