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www.gavi.org
IMMUNISATION: THE GATEWAY
TO HEALTH AND ECONOMIC
DEVELOPMENT
Dr. Seth Berkley,
CEO Gavi, the Vaccine Alliance
April 2016, UNECA meeting
Gavi/2012/DounePorter
 Immunisation landscape
 Return on investment
 Affording immunisation
 Cost of inaction
 Taking action
IMMUNISATION LANDSCAPE
2
Traditional
vaccines
Gavi-
supported new
vaccines
Pre-school
education
Community
health workers
RETURN ON INVESTMENT
Public
infrastructure
Immunisation
3x
7x 9x
16x
(cost of illness)
44x
(full income
approach)
Income
growth
Value of
life years
gained in
that period
Change in
country's
full income
over time
period
The Economic Benefits of Public
Infrastructure Spending in Canada.
The Centre for Spatial Economics,
September 2015
The rate of return to the HighScope
Perry Preschool Program.
Department of Economics, University
of Chicago, April 2009
Strengthening primary health care
through community health workers…
Dessalegn H, Chambers R, Clinton
C, Phumaphi J, Sirleaf J, Evans T, et
al. 2015
Return on investment from childhood
immunizations in low- and middle-income
countries, 2011-20.
Health Affairs. 35(2):199-207. Ozawa S, Clark S,
Portnoy A, Grewal S, Brenzel L, Walker D. 2016
BEHIND IMMUNISATION’S ROI
4
Immunisation
investment
Reduced
sickness
Improved
learning
Reduced
caretaker
burden
Increased
productivity
Healthcare
savings
GNI
increase
ONE VACCINE-PREVENTABLE DEATH
EVERY TEN SECONDS
5
• People in remote locations
• Inadequate monitoring
• Limited resources
• Competing health priorities
• Political will
WHY?
WHO RECOMMENDED ANTIGENS
• BCG (1 dose)
• DTP (3 doses)
• Hepatitis B (3 doses)
• Hib (3 doses)
• Pneumococcal (3 doses)
• Polio (OPV, 3 doses)
• Rotavirus (2 or 3 doses)
• Measles (2 doses)
• Rubella (1 dose with Measles)
• HPV (2 doses)
6
• HPV (2 doses)
WHO RECOMMENDED ANTIGENS: HPV
7
Annual causes of
death in women
Cervical
cancer
266,000
Child birth
289,000
HPV vaccines
prevent against of
cervical
cancer70%
• BCG
• DTP
• Hepatitis B
• Hib
• Pneumococcal
• Polio
• Rotavirus
• Measles
• Rubella
• HPV
VACCINE PORTFOLIO: COST
8
Approx.
USA price
$950
Purchasing for 60% of
world’s birth cohort
THE GAVI MODEL: CO-FINANCING
9
$35
Gavi price
Co-financing vaccine
purchase
GaviCountry
0.1%
0.2%
0.3%
0.4%
0.5%VACCINES
AS % OF GENERAL
GOVERNMENT
SPENDING
0.0%
SHARING THE INVESTMENT
10
GNI
0.42% Gavi contribution
< US $1,000
0.08% Country contribution
0.1%
0.2%
0.3%
0.4%
0.5%VACCINES
AS % OF GENERAL
GOVERNMENT
SPENDING
0.0%
GNI
SHARING THE INVESTMENT
11
= US $1,000-2,000
0.12% Gavi contribution
0.03% Country contribution
Gavi 0.42%
Country 0.08%
GNI < $1k
0.1%
0.2%
0.3%
0.4%
0.5%VACCINES
AS % OF GENERAL
GOVERNMENT
SPENDING
0.0%
SHARING THE INVESTMENT
12
GNI > US $3,000
0.01%
Gavi contribution
0.01% Country contribution
Gavi 0.42% 0.12%
Country 0.08% 0.03%
GNI < $1k $1-2k
0.1%
0.2%
0.3%
0.4%
0.5%VACCINES
AS % OF GENERAL
GOVERNMENT
SPENDING
0.0%
Access to
Gavi vaccine
tenders for
5 years
SHARING THE INVESTMENT
13
Self-financing
Gavi 0.42% 0.12% 0.01%
Country 0.08% 0.03% 0.01%
GNI < $1k $1-2k > $3k
GNI > US $3,000
0.01%
0.01% Country contribution
Gavi contribution
0.02%*
* 0.03% for all self-financing countries
including with GNI < US $3,000
ONGOING
AFFORDABILITY
Note: Vaccines for routine immunisation only. Cuba, Djibouti, India, DPR Korea, Somalia and Zimbabwe excluded from analysis.
Sources: World Bank GNI pc data as published 1 July 2015, IMF, WHO National Health Accounts/Gavi Adjusted Demand Forecast v12
THE COST OF INACTION
14
Ebola
$2.2 billion
Estimated GDP
losses for Guinea,
Liberia & Sierra
Leone in 2015
SARS
$50 billion
Estimated damage to the
global economy 2003
Sources:
SARS: The Economist, Aug 2014
EBOLA: WHO Pandemic Emergency Facility: FAQ, Jan 2016
GLOBAL HEALTH SECURITY
15
Detect
Prevent
Respond
GAVI SUPPORT BRINGS SUCCESS
16
million children
immunised
500
million future
deaths averted
7
vaccine
introductions
& campaigns
300
GRAND HEALTH CONVERGENCE
17
Under-5mortality(deathsper1,000livebirths)
50
300
1991 2010 2020 2030 2040 2050
Countries with the
lowest child mortality
Countries with the
highest child mortality
CONVERGENCE
TARGET
2063
TAKING ACTION
1. Prioritise investment in immunisation
2. Ensure vaccine line-item in
health budgets
3. Focus on equity by investing in
health to fully immunise every child
4. Act now to achieve the 2030 SDG's
and be on track for Agenda 2063
5. Become an immunisation champion
18

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Gavi UNECA Seth Berkley 040416

  • 1. www.gavi.org IMMUNISATION: THE GATEWAY TO HEALTH AND ECONOMIC DEVELOPMENT Dr. Seth Berkley, CEO Gavi, the Vaccine Alliance April 2016, UNECA meeting Gavi/2012/DounePorter  Immunisation landscape  Return on investment  Affording immunisation  Cost of inaction  Taking action
  • 3. Pre-school education Community health workers RETURN ON INVESTMENT Public infrastructure Immunisation 3x 7x 9x 16x (cost of illness) 44x (full income approach) Income growth Value of life years gained in that period Change in country's full income over time period The Economic Benefits of Public Infrastructure Spending in Canada. The Centre for Spatial Economics, September 2015 The rate of return to the HighScope Perry Preschool Program. Department of Economics, University of Chicago, April 2009 Strengthening primary health care through community health workers… Dessalegn H, Chambers R, Clinton C, Phumaphi J, Sirleaf J, Evans T, et al. 2015 Return on investment from childhood immunizations in low- and middle-income countries, 2011-20. Health Affairs. 35(2):199-207. Ozawa S, Clark S, Portnoy A, Grewal S, Brenzel L, Walker D. 2016
  • 5. ONE VACCINE-PREVENTABLE DEATH EVERY TEN SECONDS 5 • People in remote locations • Inadequate monitoring • Limited resources • Competing health priorities • Political will WHY?
  • 6. WHO RECOMMENDED ANTIGENS • BCG (1 dose) • DTP (3 doses) • Hepatitis B (3 doses) • Hib (3 doses) • Pneumococcal (3 doses) • Polio (OPV, 3 doses) • Rotavirus (2 or 3 doses) • Measles (2 doses) • Rubella (1 dose with Measles) • HPV (2 doses) 6
  • 7. • HPV (2 doses) WHO RECOMMENDED ANTIGENS: HPV 7 Annual causes of death in women Cervical cancer 266,000 Child birth 289,000 HPV vaccines prevent against of cervical cancer70%
  • 8. • BCG • DTP • Hepatitis B • Hib • Pneumococcal • Polio • Rotavirus • Measles • Rubella • HPV VACCINE PORTFOLIO: COST 8 Approx. USA price $950
  • 9. Purchasing for 60% of world’s birth cohort THE GAVI MODEL: CO-FINANCING 9 $35 Gavi price Co-financing vaccine purchase GaviCountry
  • 10. 0.1% 0.2% 0.3% 0.4% 0.5%VACCINES AS % OF GENERAL GOVERNMENT SPENDING 0.0% SHARING THE INVESTMENT 10 GNI 0.42% Gavi contribution < US $1,000 0.08% Country contribution
  • 11. 0.1% 0.2% 0.3% 0.4% 0.5%VACCINES AS % OF GENERAL GOVERNMENT SPENDING 0.0% GNI SHARING THE INVESTMENT 11 = US $1,000-2,000 0.12% Gavi contribution 0.03% Country contribution Gavi 0.42% Country 0.08% GNI < $1k
  • 12. 0.1% 0.2% 0.3% 0.4% 0.5%VACCINES AS % OF GENERAL GOVERNMENT SPENDING 0.0% SHARING THE INVESTMENT 12 GNI > US $3,000 0.01% Gavi contribution 0.01% Country contribution Gavi 0.42% 0.12% Country 0.08% 0.03% GNI < $1k $1-2k
  • 13. 0.1% 0.2% 0.3% 0.4% 0.5%VACCINES AS % OF GENERAL GOVERNMENT SPENDING 0.0% Access to Gavi vaccine tenders for 5 years SHARING THE INVESTMENT 13 Self-financing Gavi 0.42% 0.12% 0.01% Country 0.08% 0.03% 0.01% GNI < $1k $1-2k > $3k GNI > US $3,000 0.01% 0.01% Country contribution Gavi contribution 0.02%* * 0.03% for all self-financing countries including with GNI < US $3,000 ONGOING AFFORDABILITY Note: Vaccines for routine immunisation only. Cuba, Djibouti, India, DPR Korea, Somalia and Zimbabwe excluded from analysis. Sources: World Bank GNI pc data as published 1 July 2015, IMF, WHO National Health Accounts/Gavi Adjusted Demand Forecast v12
  • 14. THE COST OF INACTION 14 Ebola $2.2 billion Estimated GDP losses for Guinea, Liberia & Sierra Leone in 2015 SARS $50 billion Estimated damage to the global economy 2003 Sources: SARS: The Economist, Aug 2014 EBOLA: WHO Pandemic Emergency Facility: FAQ, Jan 2016
  • 16. GAVI SUPPORT BRINGS SUCCESS 16 million children immunised 500 million future deaths averted 7 vaccine introductions & campaigns 300
  • 17. GRAND HEALTH CONVERGENCE 17 Under-5mortality(deathsper1,000livebirths) 50 300 1991 2010 2020 2030 2040 2050 Countries with the lowest child mortality Countries with the highest child mortality CONVERGENCE TARGET 2063
  • 18. TAKING ACTION 1. Prioritise investment in immunisation 2. Ensure vaccine line-item in health budgets 3. Focus on equity by investing in health to fully immunise every child 4. Act now to achieve the 2030 SDG's and be on track for Agenda 2063 5. Become an immunisation champion 18