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Acute ppendicitis case
1. Differential Diagnosis: Appendicitis
RULE IN RULE OUT
Initial Periumbilical pain Cannot be ruled out
Progression to RLQ pain
Anorexia
Vomitting
Loose stool
Rebound tenderness
Progression to muscle guarding
Leukocytosis
The Appendix: Anatomy
The appendix is derived from the midgut just like the ileum and ascending colon. It first appears
at the 8th week of gestation as an outpouching of the cecum and gradually rotates to a more medial
location as the gut rotates and the cecum becomes fixed in the right lower quadrant. Its length varies
from 2 to 20 cm, and the average length is 9 cm in adults. Its base is located at the convergence of the
taeniae along the inferior aspect of the cecum, and this anatomic relationship facilitates identification of
the appendix at operation. The tip of the appendix may lie in a variety of locations. The most common
location is retrocecal but within the peritoneal cavity. It is pelvic in 30% and retroperitoneal in 7% of the
population. The varying location of the tip of the appendix likely explains the myriad of symptoms that
are attributable to the inflamed appendix. The appendiceal artery, a branch of the ileocolic artery,
supplies the appendix. The lymphatics drain into the anterior ileocolic lymph nodes. In adults, the
appendix has no known function.
Appendicitis
Appendicitis is swelling (inflammation) of the appendix. The appendix is a normal true
diverticulum of the cecum that is prone to acute and chronic inflammation. Acute appendicitis is most
common in adolescents and young adults, but may occur in any age group. The lifetime rate of
appendectomy is 12% for men and 25% for women, with approximately 7% of all people undergoing
appendectomy for acute appendicitis during their lifetime
Etiology and Pathogenesis
Appendicitis is believed to occur as a result of appendiceal luminal obstruction in 50% to 80% of
cases.It is thought to initiateprogressive increase in intraluminal pressure that compromise venous
outflow. This may be due to inspissated stool (fecalith or appendicolith), lymphoid hyperplasia,
vegetable matter or seeds, parasites, or a neoplasm.
2. The lumen of the appendix is small in relation to its length, and this configuration may
predispose to closed-loop obstruction. Obstruction of the appendiceal lumen contributes to bacterial
overgrowth, and continued secretion of mucus leads to intraluminal distention and increased wall
pressure. Subsequent impairment of lymphatic and venous drainage leads to mucosal ischemia.
Ischemic injury and stasis of luminal contents, which favor bacterial proliferation, trigger inflammatory
responses including tissue edema and neutrophilic infiltration of the lumen, muscular wall, and
periappendiceal soft tissues. If the process evolves slowly, adjacent organs such as the terminal ileum,
cecum, and omentum may wall off the appendiceal area so that a localized abscess will develop,
whereas rapid progression of vascular impairment may cause perforation with free access to the
peritoneal cavity. Subsequent rupture of primary appendiceal abscesses may produce fistulas between
the appendix and bladder, small intestine, sigmoid, or cecum.
Clinical Manifestations
Abdominal pain is the prime symptom of acute appendicitis. The pain is described as being
located in the periumbilical region initially after a period varying from 1 to 12 hours, but usually within 4
to 6 hours, the pain localizes to the right lower quadrant.. This classic sequence of symptoms occurs in
only 66% of patients.Luminal distention of the appendix produces the visceral pain sensation
experienced by the patient as periumbilical pain. Inflammation of the adjacent peritoneum gives rise to
localized pain in the right lower quadrant. This classic pattern of migratory pain is the most reliable
symptom of acute appendicitis. Fever ensues, followed by the development of leukocytosis.Although
moderate leukocytosis of 10,000–18,000 cells/uL is frequent (with a concomitant left shift), the absence
of leukocytosis does not rule out acute appendicitis. Leukocytosis of >20,000 cells/uL suggests probable