Inflammation

1. Professor of Pathophysiology Department
Vlasova Tatyana Ivanovna
v.t.i@bk.ru

2.  It is local protective response of an organism
to injury in which the blood, connective
tissue cells, and local nerve elements are
involved.
Definition of inflammation

3. The pathogenetic basis of an inflammation is
made by three components
alteration,
exudation,
proliferation,
closely interconnected among themselves.

5. EXTRINSIC INTRINSIC
NON-INFECTIOUS
INFECTIOUS
malignant cells
aggressive gastric juice
immune
complexes

6. VASCULAR REACTIONS
AND CHANGES OF
MICROCIRCULATION
EMIGRATION OF
LEUCOCYTES

PHAGOCYTOSIS
ALTERATION
Complex of
structural
functional
changes
PROLIFERATION
Involution of a
connecting
tissue (cicatrix)
Reproduction of
local tissue
elements,
connective tissue
cells
Complex of
metabolic
changes
Complex of
physical and
chemical
changes
Pathogenetic basis (components) of an
inflammation
EXUDATION
WITH
EDEMATIZATION
The damaging
factor

8. spasm of the small vessels,
short-termed
active hyperemia
congestion
stasis

12. 

16. MEDIATORS OF INFLAMMATION

17.  Imitate as vasoactive substances (increase small
vessels permeability, modulate the diameter of
these vessels, and number of acting capillaries)
 attract the phagocytes, accumulating them in
site of inflammation
 kill and degrade the pathogens
 take part in reparation of the injured tissue

18. Histamine
vasodilation
spasmogenic and
algesiogenic
effects
biogenic
amines

19. serotonin
biogenic
amines
Veinules
spasm
increases the
vessels
permeability
pain
Thrombus
formation

21. Role of PAF in an acute inflammation
 Increases the vessels permeability
 Provokes leukocyte aggregation and adhesion to the vessels
wall through molecules adhesion expression on both the
leukocytes and endothelium,
 Activates platelets that makes them more sticky to the vessels
wall and active in the primary and secondary hemostasis,
 Plays role of chemoattractant for the phagocytes,
 Stimulates release and formation not only inflammatory
mediators, but synthesized “de novo” mediators of an acute
phase response (IL-1, IL-6 and TNF) by the cells of
inflammation

25. Thank you for your
attention!
To your success!
Send me your question
v.t.i@bk.ru