The document provides information about computational toxicology data resources available from the EPA's Office of Research and Development including the Aggregated Computational Toxicology Resource (ACToR), DSSTox Database, ExpoCast Database, ToxCast Database, ToxRefDB, and Tox21 Collaboration. It also lists exposure data resources such as the Consolidated Human Activity Database (CHAD), Consumer Product Chemical Profiles Database, ExpoCast, and Stochastic Human Exposure and Dose Simulation Model (SHEDS). Finally, it mentions toxicological data shared via the Comparative Toxicogenomics Database (CTD) from the NIEHS.

1. Office of Research and Development
National Health and Environmental Effects Research Laboratory
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June 25, 2013
EPA Data from the Office of
Research and Development
Stephen W. Edwards
Edwards.stephen@epa.gov
This talk does not necessarily reflect the views of the Environmental
Protection Agency.

2. Office of Research and Development
National Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology Division
One Stop Shopping for EPA Data
http://epa.gov/datafinder/

3. Office of Research and Development
National Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology Division
Computational Toxicology Data
• Aggregated Computational Toxicology Resource (ACToR)
–http://www.epa.gov/actor/
• Distributed Structure-Searchable Toxicity (DSSTox) Database
–http://actor.epa.gov/actor/faces/DSSTox/Home.jsp
• Exposure foreCaster (ExpoCastTM) Database
–http://www.epa.gov/ncct/expocast/
• Toxicity foreCaster (ToxCastTM) Database
–http://www.epa.gov/ncct/toxcast/
• Toxicity Reference Database (ToxRefDB)
–http://actor.epa.gov/toxrefdb/faces/Home.jsp
• Tox21 Collaboration (NIH, FDA)
–http://www.epa.gov/ncct/Tox21/
http://epa.gov/ncct/index.html

4. Office of Research and Development
National Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology Division
Exposure Data
• Consolidated Human Activity Database - CHAD
–http://www.epa.gov/heasd/chad.html
• Consumer Product Chemical Profiles Database – CPCPDB
–Coming soon to ACToR: http://www.epa.gov/actor/
• ExpoCast
–http://www.epa.gov/ncct/expocast/
• Stochastic Human Exposure and Dose Simulation Model (SHEDS)
– http://www.epa.gov/heasd/research/sheds.html

5. Office of Research and Development
National Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology Division
DSS Tox
ToxCast
ExpoCast
SHEDS
Virtual Tissue,
Biomarker, and
Adverse Outcome Pathway
Knowledgebases
ToxRefDB
WikiLIMS
Tox21 Data Housed at EPA

6. Office of Research and Development
National Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology Division
Toxicological Data Shared via CEBS (NIEHS)
Proteomics Core
2D Gel
Mass Spec
Metabolomics /
Anal Chem Core
NMR
Mass Spec
ToxicoGenomics Core
Microarray
qPCR
Sequencing
WikiLIMS
Many different investigators
Experimental Design
Human, Animal, Culture
Treatment Schedule
Stressor (Compound)
Assay descriptions
Timeline
Animal Care
Cell Culture Conditions
Sample Preparation
Laboratory/Field Data
Histopathology
Clinical Chemistry
In Life Observations
Behavioral Obs
Developmental Obs
Necropsy Obs
Exposure biomarkers
Exit
http://cebs.niehs.nih.gov/