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1 | Harvard Club | Jeff George | September 24, 2014
Accelerating Innovation in Ophthalmology
OIS@AAO Keynote, October 16, ...
2 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
Innovation requires a three...
3 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
Ophthalmology has tremendou...
4 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
Alcon’s mission is built on...
5 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
Three key factors underscor...
6 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
However innovation is not c...
7 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
Organization
Building a suc...
8 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
Alcon optimizes its investm...
9 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
Innovation requires making ...
10 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
Cataract innovation
Surgic...
11 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
Laser &
Trabeculoplasty
Mi...
12 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
Vitreoretinal innovation
H...
13 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
Retina Pharma innovation
F...
14 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
Portable, low cost
refract...
15 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
•  Strengthens Alcon’s lea...
16 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
Alcon Phaco Development Pr...
17 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
What can we do to further ...
18 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only
Think what’s possible!
Foc...
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Alcon's "Accelerating Innovation in Ophthalmology" Presentation from OIS@AAO 2014

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  1. 1. 1 | Harvard Club | Jeff George | September 24, 2014 Accelerating Innovation in Ophthalmology OIS@AAO Keynote, October 16, 2014 Jeff George
  2. 2. 2 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only Innovation requires a three-pronged approach Focus on patient and customer needs Organize for success Make thoughtful choices
  3. 3. 3 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only Ophthalmology has tremendous unmet need 1.7BILLION with Presbyopia with Glaucoma 20MILLION Blind from Treatable Cataracts 25MILLION with AMD 67MILLION Patients and Customers
  4. 4. 4 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only Alcon’s mission is built on patient needs “To provide innovative products that enhance quality of life by helping people see better” Patients and Customers
  5. 5. 5 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only Three key factors underscore the growth potential in eye care High unmet need in emerging markets Aging population Exciting scientific and technological innovation Patients and Customers
  6. 6. 6 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only However innovation is not cheap— especially in eye care Cost per patient for clinical trials USD, thousands 10 CNS Transplant Pain 14 19 11 Endo/Metab 16 Inf Dis Derm 10 22 12 CVBlood 16 8 Ophtha Onco *Costs per patient includes all costs related to a single patient such as procedures, personnel costs, travel reimbursement. Site costs are not included. Source: PAREXEL Biopharmaceutical R&D Statistical Sourcebook, 2011/2012 Patients and Customers
  7. 7. 7 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only Organization Building a successful innovation organization requires several key ingredients •  Passion for results •  Will to win and ‘can-do’ mindset Performance drive •  Clear vision of where to go … •  . . . and how to get there Vision •  Strong technical and scientific capabilities Capabilities •  Fast pipeline decisions •  Clean processes •  Cross-functional alignment Culture and org model
  8. 8. 8 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only Alcon optimizes its investment structure to support continuous innovation Key tenets of Alcon’s investment approach Focus on therapeutic area, not a specific technology $1Bn R&D spend per year, agnostic to internal or external innovation Wide array of partnerships Organization
  9. 9. 9 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only Innovation requires making thoughtful choices Delivery Model Product Innovation Disruptive Platforms Thoughtful Choices
  10. 10. 10 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only Cataract innovation Surgical Planning Femtosecond Laser Clinical Plan Treatment Intra-operative Aberrometry Operate The transaction is subject to closing conditions, including anti-trust approval. Product Innovation
  11. 11. 11 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only Laser & Trabeculoplasty Minimally Invasive Glaucoma Surgery (MIGS) Filtration Procedures Shunt/ Valve Procedures MicroPulse® Laser Therapy Ahmed™ Valve Surgical Glaucoma innovation Improved laser technologies Greater reproducibility/ faster recovery Less invasive/ earlier intervention Standard of care for advanced disease Product Innovation
  12. 12. 12 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only Vitreoretinal innovation High Speed Vitrectors MIVS Instrumentation Digital Screening Systems Intraoperative Diagnostics 1. Rizzo S, et al. Comparative study of the standard 25-gauge vitrectomy system and a new ultrahigh-speed 25-gauge system with duty cycle control in the treatment of various vitreoretinal diseases. RETINA 31:2007-2013, 2011. Membrane Peeling Planning Treatment Product Innovation
  13. 13. 13 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only Retina Pharma innovation Fovista® Wet AMD/ DME/ RVO Geographic Atrophy Intravitreal Injection Topical Vitreomacular Adhesion Wet AMD Wet AMD Wet AMD Current treatments Potential future treatments Product Innovation
  14. 14. 14 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only Portable, low cost refractor Virtual reality headset for Amblyopia Telescopic contact lens for AMD Accommodating lens Refractive innovation Product Innovation
  15. 15. 15 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only •  Strengthens Alcon’s leadership in contact lenses and intraocular lenses •  Involves non-invasive sensors, microchips, and other miniaturized electronics •  Focuses currently on diabetes and presbyopia Alcon’s collaboration with Google could transform presbyopia and diabetes care Disruptive Platforms
  16. 16. 16 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only Alcon Phaco Development Program creates access to latest technology Comprehensive and sustainable cataract care •  Promoting use of phacoemulsification (gold standard) •  Investing in organizational resources and innovation •  Introducing standardized training Results to date •  Launched in China, India, Vietnam, and Russia •  Over 1,400 doctors trained •  Over 500,000 phaco procedures Delivery Model
  17. 17. 17 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only What can we do to further accelerate innovation? 3D Printing Computer Simulations
  18. 18. 18 | OIS@AAO Keynote Speech | Jeff George | October 16, 2014 | Confidential - Business Use Only Think what’s possible! Focus on patient and customer needs Organize for success Make thoughtful choices

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