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A Brisardik Pharmaceuticals Product


  Presentation by: David Brinser, Tiana Harris
              and Michele Hladik
About Brisardik
 Established in 1987

 Based in Columbus, Ohio

 More than 500 physicians,
  chemists, and lab assistants

 Known for popular ADHD medications
  and anti depressants

 Creator of Intelliboost
Intelliboost
 Taken once daily

 Prescription

 Gradually builds up

 Strengthen and develops decision
  making and processing functions

 Could be sold in a variety of sizes

 Study to determine if medication
  works and is ready for sale
Study Participants
 Randomly selected 60 adults

 Customers and research volunteers

 Intelligence testing

 30 given Intelliboost, 30 placebos

 Intelligence retesting
Data Collection
 Participant IDs

 Test scores recorded

 Data sorted in several ways including:
        All participants
        Intelliboost recipients
        Placebo recipients
        Gender
        Age
        Improvements made
Patients Taking Intelliboost
  Participant                              Participant
      ID.     Before    After                  ID.     Before   After
     1001      140       143                  1031      117      117
     1002      110       110                  1034       95       96
     1006      138       135                  1035      147      148
     1007      141       142                  1037       96      105
     1010       70       74                   1043       74       74
     1011      119       122                  1045       97      105
     1014      113       125                  1046      129      135
     1015       78       78                   1047      149      149
     1018      143       144                  1048       94      105
     1019      125       130                  1050      130      128
     1022       86       87                   1051       99      110
     1023      126       127                  1054       95      100
     1026       76       80                   1055      112      112
     1027      127       128                  1057      114      120
     1030       92       95                   1060       96      106


                                 Before                After
              Average           110.9333             114.3333
Patients Taking Placebo
  Participant                              Participant
      ID.       Before    After                ID.        Before   After
     1003         80        82                1032          84      84
     1004         97       103                1033          71      72
     1005         92        92                1036          79      79
     1008         90        95                1038         135      130
     1009        123       123                1040         116      116
     1012        142       138                1041         148      148
     1013         77        77                1044         110      112
     1016        134       132                1042          89      89
     1017         99       100                1039          93      93
     1020         81        85                1049          85      86
     1021         91        93                1052         111      111
     1024        144       142                1053         120      121
     1025        112       112                1056          90      94
     1028         98        98                1058          75      75
     1029        145       145                1059         121      121


                                  Before         After
                Average           104.4        104.9333
Data by Age
                                                                         58 and
                   18-27           28-37   38-47         48-57            older
Intelliboost         6               9       8             5                2
Placebo              5               8       9             6                2



 Increased IQ with Intelliboost              Increased IQ with Placebo
              January      March                            January      March
 18-27           3           1               18-27              2         1
 28-37           4           2               28-37              4         2
 38-47           5           3               38-47              4         2
 48-57           4           1               48-57              2         1
 58 & Older      1           0               58 & Older         0         0
Summary Output
                   All Data
 The independent variable                          medicine/placebo

 The dependent variable                            the IQ score

 Scatter diagram

                                  All Participants Before/After
           160

           140

           120

           100
       After




               80

               60

               40

               20

                0
                    0   20   40     60      80      100    120    140   160
                                           Before
Linear Correlation
                   All Data
 Coefficient of correlation-r=0.9911        r = 0.991146
                                             p = 0.000000
 Strong positive correlation
                                             y=a+bx
 Represents a good model                    a=7.663276883
                                             b=.9473999051
 The line fits the points well              n=60
                                             7.663276883+.94739990
 r suggests there is a linear correlation   51(60)=64.5073
  between IQ scores and the use of a
  placebo or new medication                  slope = 1.03691245
All Data Continued…
 A few outliers based on the scatter diagram are (94,105),
  (96,106), (97,103), (75,75), and (129, 135)

 Using (129,135) and entering it into the regression line the
  solution would be: 7.6633+.9474(129)=130

 This predicted answer is close to the observed answer of 135.

 This is not too far beyond the scope of available data.

 The point with the largest residual is (94,105).

 7.6633+.9474(94)=97

 105-97=8 equaling the largest residual.

This point does not accurately represent the regression line.
Summary Output-Intelliboost
  The independent variable                            the medicine

  The dependent variable                              the IQ score

  Scatter diagram

                               Patients Taking Intelliboost

                160
                140
                120
                100
        After




                 80                                                   Series1
                 60                                                   Linear (Series1)
                 40
                 20
                  0
                      0   50           100           150      200

                                      Before
Correlation - Intelliboost

 Coefficient of correlation r=.9847                 slope=1.02528284
                                                     5
 Strong positive correlation                        p=0.0000
                                                     r=0.9847
 This represents a good model                       r square=0.9696
                                                     y=a+bx
 The line fits the points well                      a=9.4258
                                                     b=0.9457
 r suggests there is a linear correlation between   n=30
  IQ scores and the use of the new medication        9.4258+.9457x
Intelliboost Continued…
 A few outliers based on the scatter diagram are (113,125) and (99,110).

 Using point (140,143) and entering it into the regression line:
  y=9.4258+0.9457(140)=142 with a residual of 1.

 The predicted answer is close to the observed answer of 143. This is not
   too far beyond the scope of available data.

 97% of participants saw a change in their IQ after taking the new medicine

 y=9.4258+.9457(99)=103 with a residual difference of 7.

 y=9.4258+.9457(113)=116 with a residual difference of 9.

 This point has the largest residual value and does not accurately
  represent the regression line.
Summary Output-Placebo
   The independent variable                              the placebo

   The dependent variable                                the IQ score

   Scatter diagram


                            Patients Taking New Placebo

             160
             140
             120
             100
     After




              80                                                 Series1
              60                                                 Linear (Series1)
              40
              20
              0
                   0   50         100          150         200

                                 Before
Correlation - Placebo

 Coefficient of correlation r=0.9963
                                                     slope=1.04585667
 Strong positive correlation                        p=0.0000
                                                     r=0.9963
 This represents a good model                       r square=0.9926
                                                     y=a+bx
 The line fits the points well                      a=5.8513
                                                     b=0.9491
 r suggests there is a linear correlation between   n=30
  the IQ scores and the use of the placebo           5.8513+0.9491
Placebo Continued…
 There are no outliers on the placebo scatter diagram

 Using point (80,82) and entering it into the regression line:
  y=5.8513+0.9491(80)=82

 It has a residual of 0.

 The predicted answer is exactly the same as the observed answer of
  82. This is exactly within the scope of available data.

 Using the point (97,103) and entering it into the regression line:
  y=5.8513+.9491(97)=98 with a residual of 5.

 This point has the largest residual value and does not accurately
  represent the regression line.
ANOVA
                           Intelliboost
 Test criteria              ANOVA
                             f= .33425
                              p=.5654
 Test results
                            Placebo
 Importance of the mean    ANOVA
                             f=.00809
                             p=.9286
Paired Test

 Breakdown of test   Intelliboost                     Placebo
                      Paired Test                     Paired Test
                      t= 4.55279                     t= 1.2867
 Analyzing results   p=.00004387                    p= .10418
                      x= 3.4                         x= -.5333
                      Sx=4.09035                     Sx= 2.2702
 Validity of test    n=30                           n= 30

                      Critical value for 29 deg of freedom is : 2.045
Final Recommendations
 Move forward with Intelliboost.

 Seek final approval from the United States
  Food and Drug Administration

 Begin marketing Intelliboost

 Begin production and pharmaceutical
  distribution of Intelliboost
Closing
 Thank you!

 Questions
Footnote
Note: Brisardik Pharmaceuticals and Intelliboost
were invented for the sake of this project. All data
was created for the project purposes only. Data
collection methods are designed to show how the
data would have been collected if the company,
drug and study were real.

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Brisardik Pharmaceuticals Intelliboost Study Results

  • 1. A Brisardik Pharmaceuticals Product Presentation by: David Brinser, Tiana Harris and Michele Hladik
  • 2. About Brisardik  Established in 1987  Based in Columbus, Ohio  More than 500 physicians, chemists, and lab assistants  Known for popular ADHD medications and anti depressants  Creator of Intelliboost
  • 3. Intelliboost  Taken once daily  Prescription  Gradually builds up  Strengthen and develops decision making and processing functions  Could be sold in a variety of sizes  Study to determine if medication works and is ready for sale
  • 4. Study Participants  Randomly selected 60 adults  Customers and research volunteers  Intelligence testing  30 given Intelliboost, 30 placebos  Intelligence retesting
  • 5. Data Collection  Participant IDs  Test scores recorded  Data sorted in several ways including:  All participants  Intelliboost recipients  Placebo recipients  Gender  Age  Improvements made
  • 6. Patients Taking Intelliboost Participant Participant ID. Before After ID. Before After 1001 140 143 1031 117 117 1002 110 110 1034 95 96 1006 138 135 1035 147 148 1007 141 142 1037 96 105 1010 70 74 1043 74 74 1011 119 122 1045 97 105 1014 113 125 1046 129 135 1015 78 78 1047 149 149 1018 143 144 1048 94 105 1019 125 130 1050 130 128 1022 86 87 1051 99 110 1023 126 127 1054 95 100 1026 76 80 1055 112 112 1027 127 128 1057 114 120 1030 92 95 1060 96 106 Before After Average 110.9333 114.3333
  • 7. Patients Taking Placebo Participant Participant ID. Before After ID. Before After 1003 80 82 1032 84 84 1004 97 103 1033 71 72 1005 92 92 1036 79 79 1008 90 95 1038 135 130 1009 123 123 1040 116 116 1012 142 138 1041 148 148 1013 77 77 1044 110 112 1016 134 132 1042 89 89 1017 99 100 1039 93 93 1020 81 85 1049 85 86 1021 91 93 1052 111 111 1024 144 142 1053 120 121 1025 112 112 1056 90 94 1028 98 98 1058 75 75 1029 145 145 1059 121 121 Before After Average 104.4 104.9333
  • 8. Data by Age 58 and 18-27 28-37 38-47 48-57 older Intelliboost 6 9 8 5 2 Placebo 5 8 9 6 2 Increased IQ with Intelliboost Increased IQ with Placebo January March January March 18-27 3 1 18-27 2 1 28-37 4 2 28-37 4 2 38-47 5 3 38-47 4 2 48-57 4 1 48-57 2 1 58 & Older 1 0 58 & Older 0 0
  • 9. Summary Output All Data  The independent variable medicine/placebo  The dependent variable the IQ score  Scatter diagram All Participants Before/After 160 140 120 100 After 80 60 40 20 0 0 20 40 60 80 100 120 140 160 Before
  • 10. Linear Correlation All Data  Coefficient of correlation-r=0.9911 r = 0.991146 p = 0.000000  Strong positive correlation y=a+bx  Represents a good model a=7.663276883 b=.9473999051  The line fits the points well n=60 7.663276883+.94739990  r suggests there is a linear correlation 51(60)=64.5073 between IQ scores and the use of a placebo or new medication slope = 1.03691245
  • 11. All Data Continued…  A few outliers based on the scatter diagram are (94,105), (96,106), (97,103), (75,75), and (129, 135)  Using (129,135) and entering it into the regression line the solution would be: 7.6633+.9474(129)=130  This predicted answer is close to the observed answer of 135.  This is not too far beyond the scope of available data.  The point with the largest residual is (94,105).  7.6633+.9474(94)=97  105-97=8 equaling the largest residual. This point does not accurately represent the regression line.
  • 12. Summary Output-Intelliboost  The independent variable the medicine  The dependent variable the IQ score  Scatter diagram Patients Taking Intelliboost 160 140 120 100 After 80 Series1 60 Linear (Series1) 40 20 0 0 50 100 150 200 Before
  • 13. Correlation - Intelliboost  Coefficient of correlation r=.9847 slope=1.02528284 5  Strong positive correlation p=0.0000 r=0.9847  This represents a good model r square=0.9696 y=a+bx  The line fits the points well a=9.4258 b=0.9457  r suggests there is a linear correlation between n=30 IQ scores and the use of the new medication 9.4258+.9457x
  • 14. Intelliboost Continued…  A few outliers based on the scatter diagram are (113,125) and (99,110).  Using point (140,143) and entering it into the regression line: y=9.4258+0.9457(140)=142 with a residual of 1.  The predicted answer is close to the observed answer of 143. This is not too far beyond the scope of available data.  97% of participants saw a change in their IQ after taking the new medicine  y=9.4258+.9457(99)=103 with a residual difference of 7.  y=9.4258+.9457(113)=116 with a residual difference of 9.  This point has the largest residual value and does not accurately represent the regression line.
  • 15. Summary Output-Placebo  The independent variable the placebo  The dependent variable the IQ score  Scatter diagram Patients Taking New Placebo 160 140 120 100 After 80 Series1 60 Linear (Series1) 40 20 0 0 50 100 150 200 Before
  • 16. Correlation - Placebo  Coefficient of correlation r=0.9963 slope=1.04585667  Strong positive correlation p=0.0000 r=0.9963  This represents a good model r square=0.9926 y=a+bx  The line fits the points well a=5.8513 b=0.9491  r suggests there is a linear correlation between n=30 the IQ scores and the use of the placebo 5.8513+0.9491
  • 17. Placebo Continued…  There are no outliers on the placebo scatter diagram  Using point (80,82) and entering it into the regression line: y=5.8513+0.9491(80)=82  It has a residual of 0.  The predicted answer is exactly the same as the observed answer of 82. This is exactly within the scope of available data.  Using the point (97,103) and entering it into the regression line: y=5.8513+.9491(97)=98 with a residual of 5.  This point has the largest residual value and does not accurately represent the regression line.
  • 18. ANOVA Intelliboost  Test criteria ANOVA f= .33425 p=.5654  Test results Placebo  Importance of the mean ANOVA f=.00809 p=.9286
  • 19. Paired Test  Breakdown of test Intelliboost Placebo Paired Test Paired Test t= 4.55279 t= 1.2867  Analyzing results p=.00004387 p= .10418 x= 3.4 x= -.5333 Sx=4.09035 Sx= 2.2702  Validity of test n=30 n= 30 Critical value for 29 deg of freedom is : 2.045
  • 20. Final Recommendations  Move forward with Intelliboost.  Seek final approval from the United States Food and Drug Administration  Begin marketing Intelliboost  Begin production and pharmaceutical distribution of Intelliboost
  • 22. Footnote Note: Brisardik Pharmaceuticals and Intelliboost were invented for the sake of this project. All data was created for the project purposes only. Data collection methods are designed to show how the data would have been collected if the company, drug and study were real.