Healthy people through excellent research and applied knowledge

1. Clinical Research Summit
Dr Graham Love
Chief Executive
Health Research Board
Radisson Blu, Athlone, 14 Oct 2015
Healthy people through excellent research and applied knowledge

2. 2

3. 3
Conclusions
……..Research active Trusts had lower risk-adjusted mortality for acute
admissions, which persisted after adjustment for staffing and other
structural factors.

4. Sample R&D Intensities
4
• Healthcare is a KNOWLEDGE industry!
• Expectations & costs are rising out of sync with resources. This is not sustainable.
• We need a much smarter use of our resources, people, processes & technology to meet
healthcare needs/expectations.
• Our healthcare system needs a much greater self-learning capacity: an ability to research &
develop people/processes/technology both in Ireland and to absorb them from abroad.
• That capacity is not strong in our healthcare system at present.
€13,000,000,000
€150,000,000
1.1%
£109,000,000,000
£2,400,000,000
2.20%
$53,000,000,000
$2,800,000,000
5.28%
Total spend
R&D spend
R&D as % of total
However, recently we have made important progress 

21. A ~€100million jigsaw that is now clicking together…..

22. The Groups & the
CRFs/infrastructure are aligning...
22
Dublin North East
Dublin Midlands
Ireland East
South/South West
Saolta
(Mid-West)
(Children’s)

23. 23
-15%
-10%
-5%
0%
5%
10%
15%
1Underpinning
2Aetiology
3Prevention
4DetectionandDiagnosis
5TreatmentDevelopment
6TreatmentEvaluation
7DiseaseManagement
8HealthServices
PercentageProfile of HRB spend 2010-2014
(~€200m)

24. 24
0.04%
0.14%
0.90%
0.93%
1.21%
1.68%
1.96%
2.21%
2.32%
2.48%
3.28%
3.83%
4.28%
4.45%
5.11%
5.77%
7.41%
9.72%
19.41%
22.86%
0% 5% 10% 15% 20% 25%
Percentage
HealthCategory Percentage of spending attributed to all health categories:
2010-2014 (~€200m)

25. So what next? A preview
l
2016-2020: ~€235 million plan (~50% already committed)
25
Enabler B
Build a strong enabling enviornment
Build a strong enabling environment
for health research in Ireland.
Enabler A
Support exceptional researchers
and leaders
Support the exceptional researchers,
talent and leadership we need to
undertake high-quality research and
generate evidence.
Focus 1
Address major
health
challenges
Support innovative,
investigator- led
and internationally
competitive
research to address
major health
challenges in
society.
Focus 2
Support
healthcare
interventions
Support the design,
conduct and
evaluation of
healthcare
intervention
studies in order to
improve health
outcomes and
health service
delivery.
Focus 3
Address the
research needs
of the Irish
health system
Support
partnership-driven
research,
information and
evidence that meet
the needs of the
Irish health and
social care system.
Underpinning Support
Organisational performance
Achieve & sustain organisational excellence, foster transparency and accountability, and demonstrate impact.

26. What specific actions can we take to
improve our system now?
Hospital (Group) CEOs
• Speed up Hospital
approvals for
studies/trials
• ‘Encourage’ research in
member hospitals to go
via CRF
• Mainstream research
into your upcoming
Group Strategies
Pharma
• Drive feasibility studies
for multi-site trials into
the infrastructure, via
HRB CRCI
• (based on credibility of
above) secure full multi-
site studies to Ireland
26