Recent research suggests that old blood may have a negative impact on the body by damaging organs and increasing the effects of aging. A newly developed compound shows promise in protecting against this, by preventing aging in the brains of mice. A slideshow presentation by Dr. Jenson Mak
2. Recent research suggests that
old blood may have a negative
impact on the body by
damaging organs and
increasing the effects of aging.
A newly developed compound
shows promise in protecting
against this, by preventing
aging in the brains of mice.
3. Initial Studies
The link between blood and aging was first
discovered during experiments that
connected young and old mice so that
circulating blood was shared between them.
The older mice showed improvements,
including developing healthier organs and
gaining protection from age-related
diseases. However, the younger mice
showed signs of premature aging.
Experiments like this suggest that young
blood has restorative properties, but
something in older blood causes harm.
Hanadie Yousef at Stanford University
appears to have isolated a protein
responsible for some of the damage
caused by older blood, and developed a
potential way to prevent it.
4. The VCAM1 Protein
Yousef discovered that a protein called VCAM1
increases in the blood as the body ages. The
levels of VCAM1 are 30 percent higher in
individuals over 65 compared to those under 25.
Yousef tested the effects of the protein by
injecting blood plasma from older mice into
young mice; as expected, the young mice
showed signs of aging. She then repeated the
experiments using blood plasma from humans in
their late 60s. Again, the young mice showed
signs of premature aging after injections of older
blood.
The effects of aging were prevented
during experiments where Yousef also
injected a compound to block VCAM1.
Young mice given the antibody at the
same time or before an injection of older
blood were protected from the negative
effects. Yousef hopes that this research
will contribute to an understanding of the
way mechanisms that cause aging work
and how to reverse them in order to
encourage healthy aging.
5. Surprising Results
Other researchers are impressed with the
findings, but interested in seeing more data
and replicated results. Jonathan Godbout at
Ohio State University expressed cautious
optimism about the work leading to a
possible treatment to protect aging brains.
Some teams have started giving plasma
donated by young people to older adults,
to find out if it will impact their health or
possibly lessen the effect of Alzheimer’s
disease. Although this is a start,
neutralizing the effects of the older blood
is likely to give the best chance for
success.
6. Protect Against Old Blood
Yousef says a drug to protect people from the damaging
effects of old blood would be more effective than plasma
injections. It would be safer, less expensive, and easier to
produce on a wide scale than transfusions. She is in the
process of patenting her compound and hopes to develop an
effective treatment against the effects old blood on aging.