An overview to Insitu Vaccination

1. In-Situ Vaccination
Manahil Khanum Durrani

2. • “Instead of engineering cells in lab scientist used radiation
or injections of special viruses that kills some of cancer cells
and stimulate the tumor to release the antigens hidden
inside essentially creating a personalize vaccine within the
body, termed as In-situ vaccination”

4. First scientific Report of Cancer therapy
Dr. William Coley (1890) Used
microorganisms to treat infection of a tumor
surgical site
Treated about 900 inoperable cancer
patients with bacteria, named “Coley's
Toxin
Achieved
• Cure rate 20%
• Regression rate 60%

5. A paper published in 1957
Carcinogen- induced fibro sarcomas that could
be transferred between inbred mice were
rejected by mice that had previously been
growing the same tumor and had it removed
surgically.
This study demonstrated that tumors can
be recognized by the immune system
Tumor immunotherapy research
properly started

7. In-Situ vaccination therapy for treating
cancer

8. Anti-tumor Immune Responses Mediated
By In-situ Vaccination

9. •Strengths of in situ vaccination as compared to
more complex therapeutic vaccination strategies

10. Approaches for combination with In-Situ
vaccination
• The combinations of adjuvant administration by ISV with other physical
treatments that stimulate immunogenic death of tumor cells is likely to
provide the optimal local control and systemic antitumor immune
responses. Simplicity and safety of ISV also support the potential for ISV
to synergize with systemic immunotherapy, it includes
• Radiation
• Hyperthermia
• Nano particles for in situ vaccination delivery
• Potential synergy for in situ vaccination combined with
systemic immunotherapy