Dr. K.Ferrini 21-02-2017 Doctoral Degree in Psychology, Health and Statistical Science- Presentation

1. Doctoral Degree in
Psychology, Health and
Statistical Science
Dott.ssa Krizia Ferrini RD, MS
Supervisor Prof. Luisa Bernardinelli

2. New insights into the
mechanisms of bioactive
food components
INTEGRATIVE NUTRITION AND HEALTH PROMOTION IN CLINICAL
TRIALS
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3. INDEX
 INTRODUCTION
 PREVENTIVE NUTRITION AND
BIOACTIVE FOOD COMPONENTS
 GERMAN INSTITUTE OF HUMAN
NUTRITION
 HEALTH PROMOTION: mHEALTH
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4. PREVENTIVE
NUTRITION AND
BIOACTIVE FOOD
COMPONENTS
Anthocyanins
Department of Experimental Oncology of
IEO in collaboration with the Department
of Internal Medicine of the University of
Catania demonstrated that the juice of
Moro exerts metabolic hepatoprotective
effects due to changes in the expression
of several enzymes involved in lipid
homeostasis (Titta et al., 2010; Salamone
et al., 2012b).
Thus, the dietary administration of this
food may be effective in preventing liver
steatosis, and may be considered as a
nutritional approach for the prevention
of Non-alcoholic fatty liver disease
(Salamone et al., 2012a).
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Diet and Aging Oxidative Medicine and Cellular Longevity, Volume 2012

5. SmartTrial Arancia Rossa (STAR): Study Design
MORO JUICE
NUTRITION COUSELLINGNUTRITION COUSELLING
MORO JUICE
G1 = 34
G2 = 34
T0 T1 T2 T3 T4 T5 T6 T7
------------ 3 MONTHS------------ ------------ 3 MONTHS------------
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1 MONTH

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7. RESULTS
RESULTS ABOUT BLOOD LIPID PROFILE IN 12
WEEKS
ESTIMATED EFFECT BY CROSSOVER MODEL FOR
TREATMENT, PERIOD AND SEQUENCE (N=64)
Variable
Treatment
Coeff
(95% CI)
P*
Period
Coeff
(95% CI)
P*
Sequence
Coeff
(95% CI)
P*
Cholesterol (mg/dl)
3.83
(-3.88;11.54)
0.324 -6.53
(-14.24;1.18)
0.095 -1.02
(-9.33;7.29)
0.807
Cholesterol HDL (mg/dl)
-1.38
(-4.34;1.57)
0.353 0.34
(-2.62;3.29)
0.820 1.11
(-1.31;3.54)
0.362
Cholesterol LDL (mg/dl)
5.85
(-0.98;12.67)
0.092 -6.85
(-13.68;-0.03)
0.049 -3.89
(-11.37;3.6)
0.303
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8. SmartTrial Arancia Rossa (STAR): CONCLUSION
Moro orange juice (500 mL/d) failed to improve blood lipid profiles in
hypercholesterolemic breast cancer survivor
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9. TRIMETHYLAMINE N-OXIDE
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0
1
2
3
4
5
6
7
A B
umol/L
T1
T7
Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early
Atherosclerosis in Humans, Scientific Reports | 6:26745 | DOI: 10.1038/srep26745
SmartTrial Arancia Rossa (STAR): TMAO-d9

10. GERMAN INSTITUTE
OF HUMAN
NUTRITION
CLINICAL AND EPIDEMIOLOGICAL
NUTRITION RESEARCH
EPIC Germany: Target Metabolomics
Approach
Multiple Source Method (MSM) for
estimating usual dietary intake from
short-term measurement data
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11. EPIC: European Prospective Investigation
into Cancer and Nutrition
Sex Breast Colorectal Lung Prostate Stomach Total Cancer
M 0 4907 4152 10 771 1198 32 334
F 24 899 7669 3852 0 1010 64 242
Total 24 899 12 576 8004 10 771 2208 96 576
Fonte: WHO
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12. HEALTH
PROMOTION:
NUTRITION
SCIENTIST
From Nutritional Counselling to
Personalized Nutrition
Mobile Health
Alimendiary App
Reference: Natural and therapy-induced immunosurveillance in
breast cancer Nature Medicine 21, 1128–1138 (2015)
doi:10.1038/nm.3944PAVIA – 21/02/17

13. eHealth technology assessment:
mHealth
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16. ALIMENDIARY
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https://play.google.com/store/apps/details?id=it.alimendiary&hl=it

17. ALIMENDIARY
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18. Personalized Health Prevention
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19. SCIENTIFIC DISSEMINATION:
COLLABORATIONS
NUTRITION SCIENCE AND GENETICS
HOW COOKING AFFECTS THE NUTRIENT
CONTENT OF FOODS
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20. NEXT?
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21. Thanks for your attention