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An Introduction to Pharmacogenomics for Behavioral Health Nurses This program has been approved for one contact hour for nurses by the Really Important Contact Hour Approver This course is valid for two years and expires 8/31/2013
Objectives ,[object Object],[object Object],[object Object]
Background ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Source:  The Human Genome Project Information,  http://www.ornl.gov/sci/techresources/Human_Genome/project/info.shtml
Background ,[object Object],[object Object],[object Object],[object Object],[object Object],Source:  The Human Genome Project Information,  http://www.ornl.gov/sci/techresources/Human_Genome/project/info.shtml
The Human Genome Project ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Source:  The Human Genome Project Information,  http://www.ornl.gov/sci/techresources/Human_Genome/project/about.shtml
SNPs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Source:  The Human Genome Project Information,  http://www.ornl.gov/sci/techresources/Human_Genome/faq/snps.shtml
SNPs and Pharmacogenomics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Source:  The Human Genome Project Information,  http://www.ornl.gov/sci/techresources/Human_Genome/medicine/pharma.shtml
Drugs that undergo metabolism by CYP2D6 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Source:  Mayo Clinic Laboratories,  http://www.mayomedicallaboratories.com/test-catalog/ Clinical+and+Interpretive/83180
SNPs and Pharmacogenomics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Source:  National Human Genome Research Institute,  http://www.genome.gov/27530645
Pharmacogenomics in Prescribing ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Source:  The Human Genome Project Information,  http://www.ornl.gov/sci/techresources/Human_Genome/medicine/pharma.shtml
Pharmacogenomics and Venlafaxine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pharmacogenomics and Venlafaxine ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pharmacogenomics and Venlafaxine ,[object Object],[object Object],[object Object],[object Object]
Pharmacogenomics and Venlafaxine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pharmacogenomics and Venlafaxine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What conclusions can we draw? ,[object Object],[object Object],[object Object]
What conclusions can we draw? ,[object Object],[object Object],[object Object]
Implications for clinicians ,[object Object],[object Object],[object Object],[object Object],[object Object]
References –  Understanding Pharmacogenomics ,[object Object],[object Object],[object Object]
References –  Understanding Pharmacogenomics ,[object Object],[object Object],[object Object],[object Object]
References – Venlafaxine Studies ,[object Object],[object Object],[object Object]
References – Venlafaxine Studies ,[object Object],[object Object]

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Pharmacogenomics Dissemination of Information

  • 1. An Introduction to Pharmacogenomics for Behavioral Health Nurses This program has been approved for one contact hour for nurses by the Really Important Contact Hour Approver This course is valid for two years and expires 8/31/2013
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Notes de l'éditeur

  1. Chromosome 1 has the most genes (2968), and the Y chromosome has the fewest (231).
  2. As a matter of fact, one of the two cytochrome variations that influence the body’s response to warfarin, or coumadin, is a Cytochrome P450 enzyme. If you’d like more information about pharmacogenomics and coumadin, please see the reference list for a national Institutes of Health report on this subject. Introduce Macy’s analogy
  3. Mayo Clinic lists 57 drugs metabolized by this pathway
  4. Higher number of deaths in proportion to consumption
  5. Higher number of deaths in proportion to consumption