CannMed 2018: Controlling Terpenes and Cannabinoids in Flower and Extract

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Markus Roggen

Research update on what effects terpenes and cannabinoids and how to control it.

Sciences

Controlling Terpenes and
Cannabinoids in Flower and
Extract
Dr. Markus Roggen
CannMed Conference
Oct. 24th 2018
slideshare.net/MarkusRoggen

Cannabis Processing Pipeline
• Cultivation
• Drying and curing
• Extraction
• Post processing
• Formulation
CBDA
CBD THCA
THC

Cannabis Processing Pipeline
• Cultivation
• Drying and curing
• Extraction
• Post processing
• Formulation (except…)
Myrcene
a-Pinene
b-Pinene
Limonene
b-Caryophyllene

Cannabis Flower and Medicine
• Cannabinoid ratios and concentrations show little variability
• Terpene ratios and concentrations show strong variability
Cannabinoid Chemotaxonomy: DOI:10.1038/s41598-018-31120-2
Terpene Chemovars: DOI: 10.1089/can.2016.0040
Gorilla Glue Sour Diesel
Cookies
Sour Tangie
Lemonade Haze

Drying and Curing
• Drying room conditions influence on terpenes
30%
Drying
Conditions
Slower
Faster
Air
Vacuum
N2
Ar
Long Term
Storage
20%
CO2
Storage
Atmosphere

Drying and Curing
• Drying room conditions influence on terpenes
• Storage time influences on cannabinoids
• Drying room conditions influence on terpenes
• Storage time influences on cannabinoids
• Curing Gases influence on terpene ratios
30%
Drying
Conditions
Slower
Faster
Air
Vacuum
N2
Ar
Long Term
Storage
20%
CO2
Storage
Atmosphere

Drying and Curing
• Drying room conditions influence on terpenes
• Storage time influences on cannabinoids
• Curing Gases influence on terpene ratios
30%
Drying
Conditions
Slower
Faster
Air
Vacuum
N2
Ar
Long Term
Storage
20%
CO2
Storage
Atmosphere

Extraction
• Particle size effects yield and precision
2mm
Milling
Method
Whole
Flower
Food
Blender
Extraction
Method
Terpenes
THC
THCA
CBDA

Extraction
• Particle size effects yield and precision
2mm
Terpenes
THC
THCA
CBDA
Whole
Flower
Food
Blender
Milling Method

$Extraction • Particle size effects yield and precision • SFE can extract terpene fractions • SFE can extract either THCA or THC 2mm Whole Flower Food Blender Terpenes THC THCA Milling Method Extraction Method$

$Extraction • Particle size effects yield and precision • SFE can extract terpene fractions • SFE can extract either THCA or THC • SFE can change the THC to CBD ratio 2mm Milling Method Extraction Method Terpenes THC THCA CBDA Whole Flower Food Blender$

Post-Processing
• Decarboxylation under CO2 vs air
Air
CO2
Decarboxylation
Method
Distillation
Method

Post-Processing
• Decarboxylation under CO2 vs air
• Distillation to purify THC
Air
CO2
Decarboxylation
Method
Distillation
Method

Final Product: The Blind Side
• Patient: Male, mid-30, 8 seizures per day

Final Product: The Blind Side
• Patient: Male, mid-30, 8 seizures per day
• CBD/THC 3:1 tincture, 40 mg/mL, no terpenes, MCT oil:
• seizure-free for 9 weeks

Final Product: The Blind Side
• Patient: Male, mid-30, 8 seizures per day
• CBD/THC 3:1 tincture, 40 mg/mL, no terpenes, MCT oil:
• seizure-free for 9 weeks
• Next batch of 3:1 oil:
• seizures re-start immediately

Research Collaborations
complexbiotech.com
slideshare.net/MarkusRoggen email: markus@complexbiotech.com

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CannMed 2018: Controlling Terpenes and Cannabinoids in Flower and Extract

1. Controlling Terpenes and Cannabinoids in Flower and Extract Dr. Markus Roggen CannMed Conference Oct. 24th 2018 slideshare.net/MarkusRoggen

2. Cannabis Processing Pipeline • Cultivation • Drying and curing • Extraction • Post processing • Formulation CBDA CBD THCA THC

3. Cannabis Processing Pipeline • Cultivation • Drying and curing • Extraction • Post processing • Formulation (except…) Myrcene a-Pinene b-Pinene Limonene b-Caryophyllene

4. Cannabis Flower and Medicine • Cannabinoid ratios and concentrations show little variability • Terpene ratios and concentrations show strong variability Cannabinoid Chemotaxonomy: DOI:10.1038/s41598-018-31120-2 Terpene Chemovars: DOI: 10.1089/can.2016.0040 Gorilla Glue Sour Diesel Cookies Sour Tangie Lemonade Haze

5. Drying and Curing • Drying room conditions influence on terpenes 30% Drying Conditions Slower Faster Air Vacuum N2 Ar Long Term Storage 20% CO2 Storage Atmosphere

6. Drying and Curing • Drying room conditions influence on terpenes • Storage time influences on cannabinoids • Drying room conditions influence on terpenes • Storage time influences on cannabinoids • Curing Gases influence on terpene ratios 30% Drying Conditions Slower Faster Air Vacuum N2 Ar Long Term Storage 20% CO2 Storage Atmosphere

7. Drying and Curing • Drying room conditions influence on terpenes • Storage time influences on cannabinoids • Curing Gases influence on terpene ratios 30% Drying Conditions Slower Faster Air Vacuum N2 Ar Long Term Storage 20% CO2 Storage Atmosphere

8. Extraction • Particle size effects yield and precision 2mm Milling Method Whole Flower Food Blender Extraction Method Terpenes THC THCA CBDA

9. Extraction • Particle size effects yield and precision 2mm Terpenes THC THCA CBDA Whole Flower Food Blender Milling Method

10. Extraction • Particle size effects yield and precision • SFE can extract terpene fractions • SFE can extract either THCA or THC 2mm Whole Flower Food Blender Terpenes THC THCA Milling Method Extraction Method

11. Extraction • Particle size effects yield and precision • SFE can extract terpene fractions • SFE can extract either THCA or THC • SFE can change the THC to CBD ratio 2mm Milling Method Extraction Method Terpenes THC THCA CBDA Whole Flower Food Blender

12. Post-Processing • Decarboxylation under CO2 vs air Air CO2 Decarboxylation Method Distillation Method

13. Post-Processing • Decarboxylation under CO2 vs air • Distillation to purify THC Air CO2 Decarboxylation Method Distillation Method

14. Final Product: The Blind Side • Patient: Male, mid-30, 8 seizures per day

15. Final Product: The Blind Side • Patient: Male, mid-30, 8 seizures per day • CBD/THC 3:1 tincture, 40 mg/mL, no terpenes, MCT oil: • seizure-free for 9 weeks

16. Final Product: The Blind Side • Patient: Male, mid-30, 8 seizures per day • CBD/THC 3:1 tincture, 40 mg/mL, no terpenes, MCT oil: • seizure-free for 9 weeks • Next batch of 3:1 oil: • seizures re-start immediately

17. Final Product: The Blind Side • Patient: Male, mid-30, 8 seizures per day • CBD/THC 3:1 tincture, 40 mg/mL, no terpenes, MCT oil: • seizure-free for 9 weeks • Next batch of 3:1 oil: • seizures re-start immediately • THC came from two different cultivars: Diamond OG and Lemonade Haze

18. Final Product: The Blind Side • Patient: Male, mid-30, 8 seizures per day • CBD/THC 3:1 tincture, 40 mg/mL, no terpenes, MCT oil: • seizure-free for 9 weeks • Next batch of 3:1 oil: • seizures re-start immediately • THC came from two different cultivars: Diamond OG and Lemonade Haze CBD THC THCA CBDA CBN CBG THCV CBGA CBC Diamond OG 300 100 15.3 0.00 0.66 1.76 0.73 0.99 0.00 Lemonade Haze 300 100 15.6 0.00 0.45 1.62 1.19 0.00 1.06

19. Final Product: The Blind Side • Patient: Male, mid-30, 8 seizures per day • CBD/THC 3:1 tincture, 40 mg/mL, no terpenes, MCT oil: • seizure-free for 9 weeks • Next batch of 3:1 oil: • seizures re-start immediately • THC came from two different cultivars: Diamond OG and Lemonade Haze CBD THC THCA CBDA CBN CBG THCV CBGA CBC Diamond OG 300 100 15.3 0.00 0.66 1.76 0.73 0.99 0.00 Lemonade Haze 300 100 15.6 0.00 0.45 1.62 1.19 0.00 1.06

20. Final Product: The Blind Side • Patient: Male, mid-30, 8 seizures per day • CBD/THC 3:1 tincture, 40 mg/mL, no terpenes, MCT oil: • seizure-free for 9 weeks • Next batch of 3:1 oil: • seizures re-start immediately • THC came from two different cultivars: Diamond OG and Lemonade Haze CBD THC THCA CBDA CBN CBG THCV CBGA CBC Diamond OG 300 100 15.3 0.00 0.66 1.76 0.73 0.99 0.00 Lemonade Haze 300 100 15.6 0.00 0.45 1.62 1.19 0.00 1.06

21. Final Product: The Blind Side • Patient: Male, mid-30, 8 seizures per day • CBD/THC 3:1 tincture, 40 mg/mL, no terpenes, MCT oil: • seizure-free for 9 weeks • Next batch of 3:1 oil: • seizures re-start immediately • THC came from two different cultivars: Diamond OG and Lemonade Haze CBD THC THCA CBDA CBN CBG THCV CBGA CBC Diamond OG 300 100 15.3 0.00 0.66 1.76 0.73 0.99 0.00 Lemonade Haze 300 100 15.6 0.00 0.45 1.62 1.19 0.00 1.06

22. Research Collaborations complexbiotech.com slideshare.net/MarkusRoggen email: markus@complexbiotech.com

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