1. RTD
Research & Technology Development
Nanocomposites: present and
future challenges for
sustainable and safe industrial
solutions.
Nanoforum 2012
Rome, 26 th September 2012
2. Summary
» Albelissa Approach to RTD
» Nanocomposites for sustainable
solutions
» Nanotech trends & market
» Functionalities & solutions
» Envi & human impact
» Conclusions and question time
10. Categories of Innovation
An Innovation that cannot be used by customers in
Disruptive mainstream markets – introduces new dimensions of
performances
Application Takes existing technologies into new markets to serve new
purposes
Improves established offering in markets,… performances,
Product cost, usability, etc.
Process Optimise industrial processes for existing offerings in
established markets more efficient or effective
Experiential Modifications that improve the customers’ overall experience
with established offering
Marketing Improvements to customer-touching processes, such as
communications or transactions
Business Changes the way you make money and the corresponding
Model value proposition to customers
Structural Capitalizes on changes that restructure an industry
12. RTD integration and support
» Act as RTD outsource partner:
extension/integration of Customers’ R&D facilities
and infrastructure
» Flexible staffing of RTD groups or selected and
targeted applied research specialists to be allocated
on identified development tasks/programmes
» RTD Fund rasing:
• Participation to EU projects
• Proposals preparation
• Submission
• Consortium set up
14. Nanomedicine
Nanomedicine is the application of
nanotechnology to achieve breakthroughs
in healthcare.
• It exploits the improved and often novel
physical, chemical and biological properties of
materials at the nanometer scale.
• Nanomedicine has the potential to enable
early detection and prevention, and to
essentially improve diagnosis, treatment and
follow-up of diseases.
16. Nanomedical mkt figures
The global nanomedicine market reached:
$63.8 billion in 2010
and $72.8 billion in 2011.
The market is expected to grow to
$130.9 billion by 2016
at a compound annual growth rate (CAGR) of
12.5% between years 2011 and 2016.
Press Release published in January 2012 by Global Information Inc. (GII) to
announce the new market research report "Nanotechnology in Medical
Applications: The Global Market" by BCC Research.
17. Point of Care Treatment
(POCT) market
• Blood Glucose
• Blood gas/Electrolytes
• Hematology
• Pregnancy/Fertility
• Tumor markers
• Cardiology
• Coagulation
• Infectious diseases
• Drugs of Abuse
• Clinical
• Chemistry/Urinalysis
18. Nanotech for Osteogenesis
and osteointegration
Some figures displaying market potential:
The clinical burden with fractures alone costs 17€
billion to EU, $20billion to US annually.
8 million bone fractures in US nd 5-10% delayed
healing/re-union
Osteoporosis 75million people in EU, US, JP; increase
of hip fracture of 310% (men) and 240% (women) by
2050
20. Laser / inkjet -patterning
(A) Laser-Guided Direct
Write (LGDW) laser focused
into a suspension of particles
particles trapped by the light
are pulled through the fluid
and deposited on a target
surface;
(B) MAPLE DW a laser pulse
focusing on the absorbing
layer evaporates the matrix
containing biological material
on the lower side of the
substrate due to localized
heating and thus pushes the
material towards the
substrate;
(C) Inkjet technology ejects
material piezoelectric,
thermally actuated or
printed cell patterns with electrostatically actuated after
2 different cell types receiving a signal
21. Nanostructured fibres
SEM (secondary
electrons):
adherent cells
murine fibroblasts
gold on carbon based
nanostructured fibres
[CRYSTAL project
onCryo-banking of
stem cells for human
therapeutic
application]
120 m
22. Nanoparticles
Magnetofection technology
(Magnetic target delivery) to
carry by magnetovectors in
vivo and in vitro to
vehiculate compounds able
to modulate ENaC expression
by RNA interference to cure
Cystic fibrosis
novel magnetic
nanoparticles
formulations based on
Magnetofection, industrial
products: SilenceMag,
ViroMag and ViroMag R/L,
by OZ Biosciences
24. Magnetic nanovectors
Magnetically enhanced nucleic acid delivery. Ten years of magnetofection—
Progress and prospects, Christian Planka, Olivier Zelphatib, Olga Mykhaylyka,
Advanced Drug Delivery Reviews Volume 63, Issues 14–15, November 2011,
Pages 1300–1331, Hybrid nanostructures for diagnostics and therapeutics
25. Theragnostics through nano-
biomarkers/carriers
New diagnostic based on nanotechnology
to quantify disease-related biomarkers
earlier and more personalised risk
assessment before symptoms show up
Nanotechnology improve in vitro
diagnostic tests by providing more
sensitive detection technologies by
binding nano-labels to disease-specific
molecules (surface functionalisation)
SiNWsand CNTs are capable of detecting
molecules at ultra low concentrations
26. Theragnostics and imaging
• Therapy- targeted delivery, nanovectors
• Nano-assisted regenerative medicine
treatments of osteoarthritis could include
disease modifying therapies
• In vitro, in vivo imaging: nanoparticle
coating, to improve its efficiency of targeting
and biocompatibility.
28. Bio Sensors
Screen-printed Electrochemical Sensors and
Biosensors for Monitoring Metal Pollutants
SPCEs modified with carbon nanoparticles ->
amperometric based sensor capable of determining
Hg2+ levels as low as 1 ng/mL [1]
Arduini F., Majorani C., Amine A., Moscone D., Palleschi G., Hg2+ detection by
measuring thiol groups with a highly sensitive screen-printed electrode
modified with a nanostructured carbon black film. Electrochim. Acta, 2011,
56, 4209–4215.
29. CNT integration in ICs for
bio-sensing applications
• Deposition platform on
waferscale based on
dielectrophoresis (DEP)
• CNT-metal contact
engineering
• Fabrication of CNT-FET
structures for
characterization and tuning
• Integration in process lines
30. Electrostatically actuated
NEMS Switch (CNT, SiNW)
Three-state NEMS
switches. (a) Device
array design. (b-d)
Top-view of a few
devices.
The labeling of terminals
T2 and T3 is shown in
panel b. Panel c
illustrates the labeling
of terminal T1, which
represents the two
device contacts held at
an identical potential.
33. Nanotech for Osteogenesis
and osteointegration
nanotopography and biomaterials for
skeletal stem cells based bone repair
Osteoblasts enhanced adhesion to nanoscale
(1-100nm) alumina, titania, hydroxy
hapatite, Titanium Alloy (Ti6AL4V) w.r.t
micro-scaled patterning of ceramic materials
Electron beam litography for
nanotopographic surface patterns
34. Nano patterning
Square arrangements of nanopits maintain the
stem cells state for multiple passages (SEM)
In vitro differentiation of skeletal stem cells
35. Synthetic eye prosthesis:
Nanomodified surfaces
Synthetic eye prosthesis
(cornea implant):
Layer-by-layer technique
(nanoscaled ionic
polymers)
For modification of
haptic and edge
36. Abrasion resistance
Riblet-structure based
on embossed UV-curable
nanocomposite
containing nanosilica
(resistant to abrasion)
imitating shark skin
surface
(Fraunhofer IFAM Bremen)
37. HRSEM of ZnO coated
fabric
Fibers after sonication are homogeneously coated with
nanoparticles. The distribution of the particles is quite
narrow primary particles are in a very low nanometric range
(~ 30 nm)
39. Mechanism of nano-coating
» The after-effects of the cavitation are several
hundred times greater in heterogeneous systems
than in homogeneous systems.
» In the SONO process, the ultrasonic waves
promote the fast migration of the newly-formed NPs
to the fabric's surface
» Mechanical interaction may cause a local melting
of the fibers at the contact sites, which may be the
reason why the particles strongly adhere to the
fabric's.
43. RTD Domains & solutions
Material and material surface functionalisation;
nanotechnologies:
» Hard Coatings
» Polymers functionalisation
» Flat surfaces- continuous process
» 3D shaped surfaces- batch process
» Vacuum treatment
» Atmospheric pressure treatment
» Plasma / sol-gel / thermal treatment
44. Typical solutions
» Enhancing wear and scratch resistance
» Balistic properties
» Provide chemical inertness
» Adhesion control (hydro-/oil- phylic repellence)
» Surface self cleaning/anti-fingerprint
» Appearance (color)
» Electrical and thermal properties
(insulating/conducting layers)
» Biocompatibility
» Encapsulation of substrate
45. Nanostructured Coatings
Show structural changes in the range of 10 nm
Nanolayer-Struktur
50 nm
100 nm
Nanogradient Nanolayer Nanocomposite Interface structure
on the grain boundary
46. Tensile and mechanical properties
-advantage-6: Multilayer Depositon
Multilayer Im proves Coating Toughness
Source: A. Matthews, University of Hull, UK
Scale:
500 nm
47. Micro-scale functional coatings
Top
Top coating, coating
different
stoichiometry,
thickness =
Coating 0,5 T
structure Multilayer
step A
Total coating Multilayer
thickness = T step B
Gradient layer
Multilayer, n.5 Adhesion layer
alternate A+B
layers, fixed
stoichiometry,
thickness = Metal
substrate
0,5 T
54. Integral Eco-design perspective
Sistemic approach
Target to:
» Functional performance
» Cost effectiveness
» Environmental sustainability
» Human Safety
Through:
» RTD on materials, products and processes
» Life Cycle Costing
» Life cycle assessment ISO 14040, nano-toxicology
55. Environ. sustainabilty LCA
Final product: functionalised
surface
Inputs (energy, raw Process
materials) (Traditional or
innovative) Outputs (air emissions, water
emissions, solids,…)
LCA CODE
(Computation)
Total Total raw
GER GWP Acid POPC EU emissions materials
56. LCA according to ISO 14040
Global Warming
Potential (GWP) ISO 14041
LIFE CYCLE FRAMEWORK
Acidification Goal I
Potential (AP)
N
definition
T
E
R
P
Life Cycle R
Eutrophication Inventory E
T
Potential (EP) A
T
I
Impact O
Assessment N
Photochemical
Ozone Creation
Potential (POCP) ISO 14042 ISO 14043
58. Nanotoxicity assessment
• Preparation protocols
• 1) for well defined test systems
• 2) For hazard assessment, i.e. in test media
idealised vs. realistic conditinos
• Establisch, validate and harmonize stanards
operation protocols
60. EU prjs & initiatives
NANOGenotox Prj on safety evaluation of
manufactured NMs by characterisation of potential
genotoxic hazard
Characterisation of NMs (CNTs, TiO2, SiO2):
- Characterisation
- Genotoxixcity
- Toxicokinetics
Testing of JRC repository using also NAPHIRA NMs DB
& OECD hamonised templates, Synergies with ISO
TC229. In vivo and in vitro testing.
61. Nanodevice Prj.
Novel concept, methoods and technologies for the
productioon of Portable Easy-to-use devices for
measurementand Analysis of Airborne Engineered
Nanoparticles in Workspace Air
65. Determinants of CNT toxicity
What are the causes of the assessed CNTs toxicity:
• Presence of metallic contaminants?
• Surface defecs playing a role?
• Crystallinity?
• ...?
68. Conclusions
• Nanomaterials and NP based composites paved the
way to new components and system enhanced
functionalities in conventional and cutting edge
industrial sectors due bulk and surface properties
• Development of innovative solutions based on
nanomaterials display a huge potential especially in
fast growing marktets such as biomedical for
medical assays, diagnosis, therapy
• Manufacture, commercialisation and use of NM-
based devices and products addresses important
issues of sustainability and safety: specific
environmental and toxicity assessment has to be
carreid out on a case to case basis through LCA and
nanotoxicity assessment to support applicability.
69. ...any question?
massimo.perucca@albelissa.com
www.albelissa.com
Quality at Work for You
