1. ALZHEIMERS AND DEMENTIA UPDATE TOMA 2006 G. BARRY ROBBINS, D.O., FACN Associate Professor and Chair Department of Neurobehavioral Sciences KCOM a college of ATSU

4. Number of People Age 65 and Over, by Age Group, Selected Years 1990-2000 and Projected 2010-2050 Federal Interagency Forum on Aging-Related Statistics 2004 , Older Americans

17. Pathogenesis of Mild Cognitive Impairment

22. Differential Diagnosis of Dementia 5% 10% 65% 5% 7% 8% Dementia with Lewy bodies Parkinson’s disease Diffuse Lewy body disease Lewy body variant of AD Vascular dementias and AD Other dementias Frontal lobe dementia Creutzfeldt-Jakob disease Corticobasal degeneration Progressive supranuclear palsy Many others AD and dementia with Lewy bodies Vascular dementias Multi-infarct dementia Binswanger’s disease AD Small et al, 1997; APA, 1997; Morris, 1994.

23. Genetics of Alzheimer’s Disease

31. Alzheimer’s Disease Spect Scan

35. Vascular Dementia

36. Vascular Dementia Spect Scan

41. Progressive Supranuclear Palsy Facial appearance “ Poker face”

42. Progressive Supranuclear Palsy Retrocollis (neck extension)

43. Progressive Supranuclear Palsy Paresis of vertical gaze (Downward paresis)

47. Fronto-Temporal Dementia Spect scan

58. Diagnosing AD in primary care cognitive assessment The Clock Draw Test Cognitive Assessment Time: 5.00 Score: 7 (normal) Time: 'no real time' Score: 2 (demented) Thalmann et al 1996. Time: .10.30 Score: 3 (demented) Time: 1/4 past 25 Score: 3 (demented)

60. Hierarchical Approach to Diagnosing Dementia

63. Functional Features of the Cholinergic System

65. Alzheimer’s Disease Senile Plaque

66. Plaques and Tangles In Alzheimer’s Disease

68. Reduction of A  burden in entorhinal cortex In PDAPP mice following A  injection

70. Cardiovascular Disease: Heart Disease and Stroke The Human Value Death Rates for Coronary Heart Disease, 1950-1998 National Center for Chronic Disease Prevention and Health Promotion 2003, The Burden of Chronic Disease and the Future of Public Health