kras-variant inherited gene mutation inherited cancer risk miradx microrna triple negative breast cancer prevention cancer research biomarker infertility endometriosis genetic marker joanne weidhaas germline cancer studies breast cancer lung cancer mirakind hboc weidhaas weidhaas jb double primary breast and ovarian cancer ovarian cancer gene mutation brca1 cancer germline variant endometrial cancer yale school of medicine platinum resistance yale university
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