Momordica charantia - Bitter melon/gourd which has been used widely as a meal in different cuisines all over the world specially in Asia, Africa, and the Caribbean, but it has many many more Medicinal uses. Its Anti-diabetic, Hypocholesterolemic, Anti-oxidant, Antiviral, Laxative, Antibacterial and Anthelmintic property is well known. Here in this presentation I summarizes the Mechanisms of Action of its Chief Chemical Components i.e; "Charantin,Lectin,Momordicine II and P-Insulin" through which it treats Diabetes.

4. Introduction01
02
03
04
Agenda
05
Chemical Constituents
Pharmacological Actions
Mechanism of Action
Others

5. Introduction
Cucurbitaceae
Momordica charantia
Bitter melon; Bitter apple; Bitter gourd;
Bitter squash; Balsam-pear
‫کریال‬
Family Name
Botanical Name
English Name
Urdu Name

6. Some Interesting Facts
1
4
2
3
Origin -> KERELA 14th century1
Flowering during June & July and fruiting
during September - November
2
Used in beer for flavoring3
Cooked for the Tết holiday in Vietnam4
Water melon, Colocynth and Cucumber
also belongs to Cucurbitaceae

8. A Vegetable or a Fruit?
You Should Know
Who I am..

17. Momordica charantia
Momordica charantia
Carica papaya
Ricinus communis

19. Temprament
Hot
&
Dry
In 1st / 2nd / 3rd Order

20. Content Here
Parts Used
Seeds, Leaves, Fruit, Juice

21. Chemical Components
Charantin
Mixed steroid
Hypoglycemic
Lectin
A bioactive compound
Insulin like
activity
P-Insulin
A polypeptide
Rapidly decrease
blood glucose
(can be
demonstrated
Subcutaneous)
Momordicine II
A Saponin
Significant
insulin releasing
activity in MIN6 β-
cells
Momordica charantia contains bitter chemicals like, vicine, charantin, glycosides and
karavilosides along with polypeptide-p plant insulin etc.

22. Pharmacological Actions with
Medicinal Uses
Respiratory Sys. GI and Abdomen Renal Sys. Musculoskeletal Sys.
Pneumonia Antidiabetic Kidney Stone Gout
Anti bilious Rheumatism
Anti H.Pilori
Purgative
Laxative
Piles

23. Pharmacological Actions with
Medicinal Uses
Urogenital Sys. Other Other Other
Abortifacient Anthelmintic Eczema Prostatic cancer
Contraceptive Antimalarial Leprosy Breast cancer
Galactagogue Antibacterial Psoriasis Lymphoid leukemia
Emmenagogue Antiviral Fever
Dysmenorrhea Anti lymphoma Scabies
Leucorrhea Anti melanoma Cataract

24. THE MECHANISM OF ACTION
Let’s See what can I do for
your Blood Glucose …
(By the Command of ALLAH SWW)

25. Momordica
charantia

27. Dosage
Joshanda of leaves- 1 to 2 tola
Powder - 1 gm
Juice - 10-20 ml
Seeds - 1-2 gm

28. The
Market
Products

31. Tenedium
Cinnamon
(Anti diabetic – PPAR stimulator)
Aloe Vera
(Laxative)

32. Corrigent
Filfil Siyah
Sikanjibin
Roghniat

33. Adverse Effects
Causes
Dysentery
(In excessive use)
• To individuals of
hot temperament
• Cause dryness

34. Contraindication
Pregnancy
Hypoglycemic
Diarrhea
Pancreatitis

35. REFRENCES • Joseph B, Jini D. Insight into the hypoglycaemic effect of traditional Indian herbs
used in the treatment of diabetes. Res J Med Plant 2011a; 5(4): 352-376.
• Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for
2010 and 2030. Diabetes Res Clin Pract 2010; 87: 4-14.
• Patel DK, Prasad SK, Kumar R, Hemelatha S. An overview on antidiabetic medicinal
plants having insulin mimetic property. Asian Pac J Trop Biomed 2012; 2: 320-330.
• Ogbonnia SO, Odimegu JI, Enwuru VN. Evaluation of hypoglycemic and
hypolipidemic effects of ethanolic extracts of Treculia africana Decne and Bryopyllum
pinnatum Lam. and their mixture on streptozotocin (STZ)- induced diabetic rats. Afr J
Biotech 2008; 7(15): 2535-2539.
• Sharma AK, Aggarwal A, Singhal VK. Treatment of diabetes mellitus with indian
herbal Drugs. IJARPB 2012; 1(2): 145-153.
• Raman BV, Krishna NV, Rao NB, Saradhi PM, Rao BMV. Plants with antidiabetic
activities and their medicinal values. Int Res J Pharm 2012; 3(3): 11-15.

36. TheEnd
Thank You for your tolerance :D
Hope you learn something fruitful…