5. The drugs which increase the force of muscle
contraction of heart without increasing its
oxygen consumption are called cardiotonic
drugs.
6.
7. These drugs on hydrolysis give a sugar
portion and aglycone portion (genin)
Cardiotonic drugs = sugar + aglycone part
The sugar part is linked glycosidically with
aglycone part.
They contain a steroidal nucleus.
14. It is obtained from suitable species of digitalis.
Properties
It occurs as white crystalline powder,
odourless, insoluble in water and slightly
soluble in alcohol.
Its hydrolysis gives aglycone (digitoxigenin) ad
sugar part (digitoxose)
15. Stability Storage
It is affected by atmosphere and light. Hence
stored in tightly closed light resistant
container.
Uses
1. cardiotonic, for congestive cardiac failure,
to treat atrial fibrillation.
2. To cause diuresis.
17. It is a cradiac glycoside obtained from leaves
of digitalis lanata.
Properties
Occurs as colourless crystals or white
crystalline powder, odourless, insoluble in
water and slightly soluble in alcohol.
Its hydrolysis gives aglycone (digitoxigenin) ad
sugar part (digitoxose)
18. Stability Storage and uses : same as Digitoxin
Dosage forms :
Injection, tablets, elixir, oral suspension
Brand names :
Lanacardin, cardiogoxin
19. When cold water extract of digitalis purpurea
is purified and evaporated to dryness, the
residue is called getalin. It consists of
gitoxin, digitoxin and gitoloxin.
Properties
It is white to pale buff amorphous powder.
soluble in water and free soluble in alcohol.
20. Stability Storage and uses : same as Digitoxin
Dosage forms :
tablets
Brand names :
Dynocard
21. It is obtained from the seeds of strophantus
gratus or from wood of Acokanthera
schimperi or A. ouabaio
Properties
Occurs as colourless crystals or white
crystalline powder. Odourless.
Storage : store in well closed light resistant
containers
22. uses : same as Digitoxin
Dosage forms :
injection
Brand names :
Strodival
