Core course lecture - Rheumatoid Arthritis

Rheumatoid Arthritis Carole Callaghan Principal Pharmacist NHS Lothian

Aim ,[object Object],[object Object],[object Object],[object Object],[object Object]

Objectives ,[object Object],[object Object],[object Object],[object Object]

Rheumatoid Arthritis ,[object Object]

Epidemiology ,[object Object],[object Object],[object Object],[object Object]

Pathogenesis ,[object Object],[object Object],[object Object],[object Object],[object Object]

Pathology ,[object Object],[object Object],[object Object]

Symptoms ,[object Object],[object Object],[object Object]

Signs ,[object Object],[object Object],[object Object],[object Object],[object Object]

Joint involvement ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Investigation ,[object Object],[object Object],[object Object]

Management (1st stage) ,[object Object],[object Object],[object Object],[object Object],[object Object]

Management (2nd stage) ,[object Object]

NSAIDs ,[object Object],[object Object],[object Object],[object Object]

NSAID toxicity ,[object Object],[object Object],[object Object],[object Object]

GI toxicity ,[object Object],[object Object],[object Object]

NSAID summary ,[object Object],[object Object],[object Object]

COX-2 Inhibitors ,[object Object],[object Object],[object Object],[object Object]

Management (3rd stage) ,[object Object]

Early DMARD ,[object Object],[object Object],[object Object]

DMARDs ,[object Object],[object Object],[object Object],[object Object]

DMARDs (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Systemic corticosteroids ,[object Object],[object Object],[object Object]

Intra-articular corticosteroids ,[object Object],[object Object],[object Object],[object Object]

TNF  -  Mode of Action Activated Macrophage TNF Target Cell Signal sTNFR

Anti-TNF Biologics - Mode of Action Activated Activated Macrophage Target Target Cell Cell Signal Signal sTNFR sTNFR TNF TNF TNFR TNFR

TNF  ,[object Object],[object Object],[object Object],[object Object],[object Object]

Effects of Blocking TNF  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

B Cell Involvement in the Pathogenesis of RA

Nomenclature ,[object Object],[object Object],[object Object],[object Object]

Eligibility Criteria for Biologic Therapy (BSR) ,[object Object],[object Object],[object Object],[object Object]

Infection ,[object Object],[object Object],[object Object],[object Object]

Tuberculosis ,[object Object],[object Object],[object Object],[object Object],[object Object]

Other Infections ,[object Object],[object Object],[object Object],[object Object]

Vaccination ,[object Object],[object Object],[object Object],[object Object]

Malignancy ,[object Object],[object Object],[object Object],[object Object],[object Object]

Rituximab ,[object Object],[object Object],[object Object],[object Object]

Safety with Rituximab ,[object Object],[object Object],[object Object],[object Object],[object Object]

Abatacept (contd) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Tocilizumab (contd) ,[object Object],[object Object],[object Object],[object Object],[object Object]

Certolizumab ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Summary ,[object Object],[object Object],[object Object]

Core course lecture - Rheumatoid Arthritis

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Core course lecture - Rheumatoid Arthritis