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Stakeholders in
infection prevention
and control
Keys to Evidence-Based Infection Prevention
in the Healthcare Setting
Learning Objectives
 Analyze the principles, practices and regulations
associated with infection prevention in a health care
setting
 Analyze the route of infection in the health care setting
from its source to the susceptible host
 Discuss the evidence based methods to break the chain
of infection and prevent transmission in the health care
setting
 Clarify the role of point of care instrument disinfection
to prevent the spread of infection
 Develop creative strategies to adapt infection
prevention processes to a variety of settings
Infection Control Preventionist ICP
 The trained, competent ICP shall be able to establish an
active, effective, facility-wide program to help prevent the
development and spread of infections and infectious
diseases
 Prevent infection, not just control
Infection Prevention and Control Functions
 Surveillance
 Outbreak Control
 Isolation and Precautions
 Education
 Mandatory State Reporting
 Fiscal Responsibility
 Employee Health
 Antibiotic Stewardship
 Patient Safety Programs
 Hand Hygiene
Surveillance
Collecting data
 Review lab results
 Review charts
 Talk to stakeholders
 Tracking antibiotic usage
Data collection results in
 Outcome measures - # of infections
 Process measures- is equipment and supplies clean
Outbreak Control
 Most infections are sporadic
 A cluster (outbreak) implies the excess of the expected
number
 Each disease has a different threshold:
• One case of flu
• One case of TB
• Three cases of MRSA
Antibiotic Stewardship
 Signs and symptoms of infection
 No cultures, start prophylactic treatment
 Virus but continue antimicrobials
 Results in:
• Antibiotic resistance
• No new drugs in development
• MRSA, VRE, MDRO, CRE
Regulatory Standards
Federal
Occupational
Safety and
Health
Administration
CDC FDA
State Department of
Health
State
Education
Department
Department of
Sanitation
Others TJC APIC, SHEA AHA AORN CLIS
Professional Responsibility
Responsibility to adhere to scientifically
accepted principles and practices of infection
prevention and control
Responsibility to monitor those for whom the
professional is responsible
Pathogen
Biological agent
capable
of causing disease
Reservoir
where infectious agent
normally
lives and multiplies
Portal of Exit
mechanisms by
which
pathogen can
leave reservoir
Mode of
Transmission
contact, droplet,
airborne,
common vehicle,
vector-borne
Portal of Entry
entry sites,
mechanisms of
introduction
Susceptible Host
lacks effective
resistance
to pathogen
The Chain of Infection
Breaking The Chain of Infection
Pathogen
Biological agent
capable
of causing disease
X
Reservoir
where infectious agent
normally
lives and multiplies
Portal of Exit
mechanisms by
which
pathogen can
leave reservoir
Mode of
Transmission
contact, droplet,
airborne,
common vehicle,
vector-borne
Portal of Entry
entry sites,
mechanisms of
introduction
X
X
X
X
Susceptible Host
lacks effective
resistance
to pathogen
X
Healthcare-Associated Infections HAIs
One HAI costs between Rs.80000-100000per infection
Increases the average length of stay by 19 days
CMS and VBP will not pay for HAIs
Commitment to transforming the quality of healthcare by
realigning the healthcare facility’s financial incentives to do so.
Controlling The Route of Transmission By
Breaking the Chain of Infection
Basic Infection Control Practices
• Hand Hygiene
• Standard Precautions
• Transmission - Based Precautions
• Engineering Controls
• Disinfection of Patient Care Equipment
• Work Practice Controls
Indirect Contact Transmission
Transfer of an infectious agent through a contaminated
intermediate object or person
 Hands of healthcare personnel
 Patient care devices (e.g., glucose meters)
 Instruments (e.g., endoscopes) that are not adequately
reprocessed
 Medications and injection equipment
http://www.cdc.gov/ncidod/dhqp/pdf/guidelines/Isolation2007.pdf
Importance of Hand Hygiene
Hand contamination is a major cause of transmission of infection in healthcare
facilities.
Improved hand hygiene is associated with lower rates of healthcare –associated
infections
According to the CDC, National adherence to recommended hand hygiene
procedures is POOR, from 5 –81% with an overall average of 40%
Hand hygiene is the most important infection prevention intervention.CDC
TJC National Patient Safety Goal
The Joint Commission
National Infection Control Standards
Standard IC.02.02.01
The hospital reduces the risk of infections associated with medical
equipment, devices, and supplies (Most cited standard in 2011= 36%)
EP 1. Cleaning and disinfecting medical equipment, devices, and
supplies
EP2. Sterilizing medical equipment, devices, and supplies. (See also
EC.02.04.03, EP 4)
EP3. Disposing of medical equipment, devices, and supplies
Semi-Critical Items
Touches mucous
membranes or broken skin
Non-Critical Items
Touches intact skin
Examples:
Arthroscopes, surgical
instruments, vascular devices,
cardiac & urinary catheters,
implants, dental instruments
Examples:
Endoscopes, laryngoscopes,
diaphragm fitting rings, respiratory
and anesthesia equipment, vaginal
ultrasound probes
Examples:
Stethoscopes, blood pressure
cuffs, tabletops, bedpans, floors
and furniture
Sterilization
Autoclave / Liquid Sterilants
(Cycle / Exposure time per
manufacturer)
High-Level Disinfection
OPA
(exposure time >12 minutes)
Low-Level
Disinfection
PDI super Sani-Cloth
(exposure time = 2 minutes)
Clorox Wipes
(exposure time = 5 minutes)
Cleaning Patient Care Equipment
Critical Items
Enters sterile tissue or
vascular system
Antiseptics vs. Disinfectants
Antiseptics are used on living tissues to protect the
spreading of germs and infection to humans.
Disinfectants are used on surfaces to disinfect items
which can potentially transmit germs.
Contact Times for Surface Disinfectants
EPA-registered disinfectants
Long contact time is not practical for disinfection
of environmental surfaces
Most health-care facilities utilize a disinfectant
with a contact times of one to three minutes
CDC Guideline for Disinfection and Sterilization
in Healthcare Facilities, 2008
WHAT GOES WHERE?
Dirty (examples)
 Waste receptacles
 Patient specimens
 Sharps containers
 Used linen
 Recycling
 Used instruments
 Dirty items should never be in
clean storage areas
Clean (examples)
 Sterile packs
 Supplies of PPE
 Linen
 IV pumps/poles (clean)
 Other clean medical equipment
and supplies
 Clean items should
 never be in dirty utility rooms
CLEAN AND DIRTY CAN NEVER MIX!
Glucometer
Management
 HBV can survive for at least
one week in dried blood on
environmental surfaces or on
contaminated instruments
and supplies.
Hepatitis B Virus Infection
RisksamongDiabetic Patients
Residingin Long-Term Care
Facilities:
 30acute HBV infections and
2 deaths
 shared equipment and lapses
in aseptic technique or
infection control practices.
Clin Infect Dis. (2005) 41 (5): 760-761.doi:
10.1086/432624
Hepatitis B Vaccine
HBV vaccination is a safe, effective means of prevention.
Key criteria for HBV vaccination recommendation:
Advisory Committee on Immunization Practices (ACIP) recommend adults aged < 60years w/
diabetes be vaccinated for HBV.1
Benefit of routine vaccination for adults aged >60 years is reduced as vaccine immunogenicity
appears to decrease w/ increasing age.2
1.Centers for Disease Control and Prevention. Use of hepatitis B vaccination for adults with diabetes mellitus: Recommendations of the
Advisory Committee on Immunization Practices (ACIP). MMWR 2011;60:1709-11.
2.Zimmerman RK, Middleton DB, Burns IT, Clover RD, Kimmel SR. Routine vaccines across the life span, 2007. J Fam Pract 2007;56:S18-37.
CDC Blood Glucose Meters
 Sharing of blood glucose metersshould be avoided, if
possible. If shared, the device must be cleaned and
disinfected after every use according to manufacturer’s
instructions.
 If there are no manufacturer’s instructions, the device
must not be shared.1
FDA: Disinfection
Blood glucose meters should be cleaned and disinfected
per manufacturer’s instructions after each and every
use, unless assigned to a single patient and protected by
specific precautions
FDA guidance for manufacturers:
“The disinfection solvent you choose should beeffective
against HIV, Hepatitis C, and Hepatitis B viruses ... Please
note that 70% ethanol solutions arenot effective against viral
blood borne pathogens and the use of 10% bleach
solutions may lead to physical degradation of your
device.”1
Glucometer Management
Clean glucometer surface when visible blood or bloody fluids are present by
wiping with a cloth dampened with soap and water to remove any visible
organic material.
If no visible organic material is present, disinfect after each use the exterior
surfaces following the manufacturer’s directions using a cloth/wipe with
either an EPA-registered detergent/germicide with a HBV/HIV label claim.
Remember the contact time needed for disinfection.
Test Strips
 Test strips packaged in vials can become contaminated with
bacteria during routine use in the hospital
 Studies confirm that bacterial contamination of test strips from
open vials is common, and suggest that these vials can serve as
reservoirs for patient- to-patient transmission of potentially
pathogenic bacteria
CDC Recommendation
C D C recommends:
“Unused supplies and medications taken to a patient’s
bedside during finger stick monitoring or insulin
administration should not be used for another
patient because of possible inadvertent
contamination.”1
.
Clinical Laboratory Standards Institute
“ It is recommended that unused supplies taken to a
patient’s bedside during fingerstick monitoring
should not used for another patient because of
possible inadvertent contamination.”
Single-Use Supplies
Spaulding Classification
SUMMARY
We can help reduce the risk of cross-contamination by:
• Using only single-use skin puncture/lancet devices
• Advocating for restricting point-of-care meter use to a single
patient, when possible
• Properly cleaning and disinfecting meters according to
manufacturer’s recommendation
• Changing gloves and perform hand hygiene between patients for
each testing event
• Employ single-use packaging of glucose test strips
• Be an advocate and encourage others to break the chain of
infection
Patient Safety
“It may seem a strange
principle to enunciate
as the very first
requirement in a
hospital that it should
do the sick no harm”.
FlorenceNightingale

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  • 2. Keys to Evidence-Based Infection Prevention in the Healthcare Setting
  • 3. Learning Objectives  Analyze the principles, practices and regulations associated with infection prevention in a health care setting  Analyze the route of infection in the health care setting from its source to the susceptible host  Discuss the evidence based methods to break the chain of infection and prevent transmission in the health care setting  Clarify the role of point of care instrument disinfection to prevent the spread of infection  Develop creative strategies to adapt infection prevention processes to a variety of settings
  • 4. Infection Control Preventionist ICP  The trained, competent ICP shall be able to establish an active, effective, facility-wide program to help prevent the development and spread of infections and infectious diseases  Prevent infection, not just control
  • 5. Infection Prevention and Control Functions  Surveillance  Outbreak Control  Isolation and Precautions  Education  Mandatory State Reporting  Fiscal Responsibility  Employee Health  Antibiotic Stewardship  Patient Safety Programs  Hand Hygiene
  • 6. Surveillance Collecting data  Review lab results  Review charts  Talk to stakeholders  Tracking antibiotic usage Data collection results in  Outcome measures - # of infections  Process measures- is equipment and supplies clean
  • 7. Outbreak Control  Most infections are sporadic  A cluster (outbreak) implies the excess of the expected number  Each disease has a different threshold: • One case of flu • One case of TB • Three cases of MRSA
  • 8. Antibiotic Stewardship  Signs and symptoms of infection  No cultures, start prophylactic treatment  Virus but continue antimicrobials  Results in: • Antibiotic resistance • No new drugs in development • MRSA, VRE, MDRO, CRE
  • 9. Regulatory Standards Federal Occupational Safety and Health Administration CDC FDA State Department of Health State Education Department Department of Sanitation Others TJC APIC, SHEA AHA AORN CLIS
  • 10. Professional Responsibility Responsibility to adhere to scientifically accepted principles and practices of infection prevention and control Responsibility to monitor those for whom the professional is responsible
  • 11. Pathogen Biological agent capable of causing disease Reservoir where infectious agent normally lives and multiplies Portal of Exit mechanisms by which pathogen can leave reservoir Mode of Transmission contact, droplet, airborne, common vehicle, vector-borne Portal of Entry entry sites, mechanisms of introduction Susceptible Host lacks effective resistance to pathogen The Chain of Infection
  • 12. Breaking The Chain of Infection Pathogen Biological agent capable of causing disease X Reservoir where infectious agent normally lives and multiplies Portal of Exit mechanisms by which pathogen can leave reservoir Mode of Transmission contact, droplet, airborne, common vehicle, vector-borne Portal of Entry entry sites, mechanisms of introduction X X X X Susceptible Host lacks effective resistance to pathogen X
  • 13. Healthcare-Associated Infections HAIs One HAI costs between Rs.80000-100000per infection Increases the average length of stay by 19 days CMS and VBP will not pay for HAIs Commitment to transforming the quality of healthcare by realigning the healthcare facility’s financial incentives to do so.
  • 14. Controlling The Route of Transmission By Breaking the Chain of Infection Basic Infection Control Practices • Hand Hygiene • Standard Precautions • Transmission - Based Precautions • Engineering Controls • Disinfection of Patient Care Equipment • Work Practice Controls
  • 15. Indirect Contact Transmission Transfer of an infectious agent through a contaminated intermediate object or person  Hands of healthcare personnel  Patient care devices (e.g., glucose meters)  Instruments (e.g., endoscopes) that are not adequately reprocessed  Medications and injection equipment http://www.cdc.gov/ncidod/dhqp/pdf/guidelines/Isolation2007.pdf
  • 16. Importance of Hand Hygiene Hand contamination is a major cause of transmission of infection in healthcare facilities. Improved hand hygiene is associated with lower rates of healthcare –associated infections According to the CDC, National adherence to recommended hand hygiene procedures is POOR, from 5 –81% with an overall average of 40% Hand hygiene is the most important infection prevention intervention.CDC TJC National Patient Safety Goal
  • 17. The Joint Commission National Infection Control Standards Standard IC.02.02.01 The hospital reduces the risk of infections associated with medical equipment, devices, and supplies (Most cited standard in 2011= 36%) EP 1. Cleaning and disinfecting medical equipment, devices, and supplies EP2. Sterilizing medical equipment, devices, and supplies. (See also EC.02.04.03, EP 4) EP3. Disposing of medical equipment, devices, and supplies
  • 18. Semi-Critical Items Touches mucous membranes or broken skin Non-Critical Items Touches intact skin Examples: Arthroscopes, surgical instruments, vascular devices, cardiac & urinary catheters, implants, dental instruments Examples: Endoscopes, laryngoscopes, diaphragm fitting rings, respiratory and anesthesia equipment, vaginal ultrasound probes Examples: Stethoscopes, blood pressure cuffs, tabletops, bedpans, floors and furniture Sterilization Autoclave / Liquid Sterilants (Cycle / Exposure time per manufacturer) High-Level Disinfection OPA (exposure time >12 minutes) Low-Level Disinfection PDI super Sani-Cloth (exposure time = 2 minutes) Clorox Wipes (exposure time = 5 minutes) Cleaning Patient Care Equipment Critical Items Enters sterile tissue or vascular system
  • 19. Antiseptics vs. Disinfectants Antiseptics are used on living tissues to protect the spreading of germs and infection to humans. Disinfectants are used on surfaces to disinfect items which can potentially transmit germs.
  • 20. Contact Times for Surface Disinfectants EPA-registered disinfectants Long contact time is not practical for disinfection of environmental surfaces Most health-care facilities utilize a disinfectant with a contact times of one to three minutes CDC Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008
  • 21. WHAT GOES WHERE? Dirty (examples)  Waste receptacles  Patient specimens  Sharps containers  Used linen  Recycling  Used instruments  Dirty items should never be in clean storage areas Clean (examples)  Sterile packs  Supplies of PPE  Linen  IV pumps/poles (clean)  Other clean medical equipment and supplies  Clean items should  never be in dirty utility rooms CLEAN AND DIRTY CAN NEVER MIX!
  • 22. Glucometer Management  HBV can survive for at least one week in dried blood on environmental surfaces or on contaminated instruments and supplies. Hepatitis B Virus Infection RisksamongDiabetic Patients Residingin Long-Term Care Facilities:  30acute HBV infections and 2 deaths  shared equipment and lapses in aseptic technique or infection control practices. Clin Infect Dis. (2005) 41 (5): 760-761.doi: 10.1086/432624
  • 23. Hepatitis B Vaccine HBV vaccination is a safe, effective means of prevention. Key criteria for HBV vaccination recommendation: Advisory Committee on Immunization Practices (ACIP) recommend adults aged < 60years w/ diabetes be vaccinated for HBV.1 Benefit of routine vaccination for adults aged >60 years is reduced as vaccine immunogenicity appears to decrease w/ increasing age.2 1.Centers for Disease Control and Prevention. Use of hepatitis B vaccination for adults with diabetes mellitus: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 2011;60:1709-11. 2.Zimmerman RK, Middleton DB, Burns IT, Clover RD, Kimmel SR. Routine vaccines across the life span, 2007. J Fam Pract 2007;56:S18-37.
  • 24. CDC Blood Glucose Meters  Sharing of blood glucose metersshould be avoided, if possible. If shared, the device must be cleaned and disinfected after every use according to manufacturer’s instructions.  If there are no manufacturer’s instructions, the device must not be shared.1
  • 25. FDA: Disinfection Blood glucose meters should be cleaned and disinfected per manufacturer’s instructions after each and every use, unless assigned to a single patient and protected by specific precautions FDA guidance for manufacturers: “The disinfection solvent you choose should beeffective against HIV, Hepatitis C, and Hepatitis B viruses ... Please note that 70% ethanol solutions arenot effective against viral blood borne pathogens and the use of 10% bleach solutions may lead to physical degradation of your device.”1
  • 26. Glucometer Management Clean glucometer surface when visible blood or bloody fluids are present by wiping with a cloth dampened with soap and water to remove any visible organic material. If no visible organic material is present, disinfect after each use the exterior surfaces following the manufacturer’s directions using a cloth/wipe with either an EPA-registered detergent/germicide with a HBV/HIV label claim. Remember the contact time needed for disinfection.
  • 27. Test Strips  Test strips packaged in vials can become contaminated with bacteria during routine use in the hospital  Studies confirm that bacterial contamination of test strips from open vials is common, and suggest that these vials can serve as reservoirs for patient- to-patient transmission of potentially pathogenic bacteria
  • 28. CDC Recommendation C D C recommends: “Unused supplies and medications taken to a patient’s bedside during finger stick monitoring or insulin administration should not be used for another patient because of possible inadvertent contamination.”1 .
  • 29. Clinical Laboratory Standards Institute “ It is recommended that unused supplies taken to a patient’s bedside during fingerstick monitoring should not used for another patient because of possible inadvertent contamination.”
  • 32. SUMMARY We can help reduce the risk of cross-contamination by: • Using only single-use skin puncture/lancet devices • Advocating for restricting point-of-care meter use to a single patient, when possible • Properly cleaning and disinfecting meters according to manufacturer’s recommendation • Changing gloves and perform hand hygiene between patients for each testing event • Employ single-use packaging of glucose test strips • Be an advocate and encourage others to break the chain of infection
  • 33. Patient Safety “It may seem a strange principle to enunciate as the very first requirement in a hospital that it should do the sick no harm”. FlorenceNightingale