Presentation form ORPHEUS conference 2017 in Klaipeda

1. Fostering Translational Doctoral
Programmes in Health Sciences
Opportunities and Challenges at Nova Medical School, Lisbon
PAULO PEREIRA
ppereira@nms.unl.pt

2. Prevention
Diagnosis
Treatment
The Cycle of Biomedical Research
Transla0onal Research
Individual
Popula>on
Genes &
environment
Cell
Animal

3. Strategy
Educa>on
products
Mechanisms
Drugs
Devices
T1 T2
Transla0onal Research
19 years
Basic
Science
Cells &
molecules
Clinical
Research
Humans/ trials
Health
community
& popula0on
“Transla)onal research fosters the mul)direc)onal and mul)disciplinary integra)on of
basic research, pa)ent-oriented research, and popula)on-based research,
with the long-term aim of improving the health of the public”.
Rubio et al. Acad Med. 2010 - Evalua0on CommiDee of the Associa0on for Clinical Research Training (ACRT)

4. The “valley of death”
Tomorrow’s Medicine, 2015
Facts & Figures
• 800.000 medical Res papers, 2008
• 21 new drugs approved by FDA, 2011
• Time to market: 10-15 Yrs
• Average Cost: 1000 M€
• Failure Rate: 90%

5. Changes to Portuguese scientific production by scientific area
The Landscape
FCT, 2013

6. The Landscape:
Medical and Health
FCT, 2013

7. A PhD programme in medical sciences @
NOVA MEDICAL SCHOOL
CEDOC IBET
IPOLF4
Research center
for Chronic
Diseases
Nova Medical School
Private non
for profit SME
in Biotechnology
Ins0tute for Chemical
and Biological .
Technology .
Portuguese
Oncology
Ins0tute
ITQB
iNOVA 4
Health

8. The research and teaching ecosystem for PhD training
Pa)ent
Applica)on
Student
Molecules & cells
Theory
principles
Prac)ce
industry
TRANSLATIONAL BASIC
TRANSLATIONAL
POLICIES
CLINICAL
IPO/ ITQB
Hospitals
IBET/ITQB
CEDOC
Toxomics
CEDOC
Popula0on studies
Funding to compe00ve transla0onal projects

9. Admission
Degree
Core courses
CSRT*
Elec0ve courses
CP1: Project Defense
Research Work
Elec0ve courses
CP2: Mee>ng with
thesis commiQee
Research Work
Elec0ve courses
CP2: Mee>ng with
thesis commiQee
Research Work
Submit PhD thesis
Viva Voce
*CSRT: Clinical Scholars Research Training Program – Designed and implemented in collabora0on with Harvard Medical School
Curricular Structure and Milestones

10. Programs and Speciali0es
New policies
for funding
From PhD programs to individual studentship
Programmes
Ageing and
Chronic Diseases
Bioengineering
and Cell Therapies
Regenera0ng
Medicine
Medicine
PhD in Medical Sciences
All students
All areas
Degree in Medical Sciences
Chronic
diseases Oncobiology Neurobiology Regenera0ve
Medicine
Speciali>es:
Transla0onal
• Clinical oriented
Medical
speciali0es

11. The way forward: form discovery to delivery
Ins0tu0onal strategies & Public Policies
¤ Facilitate communica0on: Forum basic, transla0onal, clinical
¤ Facilitate access to resources and facili0es
¤ Nurture people and groups – do not punish failure
¤ Train new genera0on of clinicians in Research
¤ Mo0vate basic researchers
¤ Develop Infrastructures (e.g. Clinical Trials, Biobanks)
¤ Iden0fy Research navigators & Sherpa
¤ Implement Incubator Programs and Accelerators

12. The way forward
Trainning a new genera0on of scien0sts that can “walk the walk”
From discovery to delivery
The goal is becoming competent to interpret, evaluate,
and discuss different types of research, rather than
conduc)ng it all yourself D. Rubio, 2011