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Presented by
Dr. Sudhakar Kokate
Director PPRC, India
Asthma
 Ancient time known as “Shwasa” meaning
disease pertaining to breathing or respiration
 Asthma is a lung disease
 Elaborate description available from the earliest
times

PPRC/INDIA 01
Asthma
 Classification according to Ayurveda:
1. Kshudra shwasa
2. Maha shwasa
3. Urdhva shwasa
4. Chhinna shwasa
5. Tamak shwasa
PPRC/INDIA 02
Kshudra shwasa
 Because of vititation of air in the alimentary tract
 Not much pain involved & Easily curable
 Doesn’t interfere in food course or breathing
 Doesn’t disturb the sensory organs
 Not much harmful to the body as compared to other
types
 In allopath such conditions are grouped under
exertional dyspnoea

PPRC/INDIA 03
Maha shwasa
 Caused by disturbance in respiratory movement
of air
 Patient feels great obstruction in respiration
 Breathes without break with a very loud and
long stertore
 Voluntary control disappears, wheezing audible
sounds called as major dyspnoea in Ayurveda
PPRC/INDIA 04
Maha shwasa
 Patient looses all senses of understanding and
knowledge. Restless look in eyes, distorted voice
going into semi-comatose condition
 According to allopathy the wheezing sound is
similar to that of the heart, kidney and brain
disorders

PPRC/INDIA 05
Urdhva shwasa
 Expiration prolonged, insignificant inspiration
 Mouth and respiratory tract get obstructed with
cough
 Eyes turn upwards and restless
 Severe pain and person suffers from delusions
and senselessness
PPRC/INDIA 06
Urdhva shwasa
 According to Ayurveda this condition is harmful
 According to Allopathy, such condition is found
in pneumonia, lung abcesses, gangrene, acute
inflammation in lungs, epilepsy.

PPRC/INDIA 07
Chhinna shwasa
 Depressed breathing system
 Person breathes with great difficulty and full force with
interruption
 Person suffers from constipation, excessive sweating,
repeated fainting, burning and retention of urine, eyes
full of tears, unconsciousness, dry mouth
 According to allopathy this is interrupted respiratory
dyspnoea

PPRC/INDIA 08
Tamaka shwasa
 Two types: Pratamaka and Santamaka
 Febrile dyspnoea appears in a person with fever and
fainting
 Santamaka, cardiac asthma greatly aggravates during
night
 Person feels submerged in a sea of darkness
PPRC/INDIA 09
Asthma
 Chronic disease
 Long term disease that has no cure
 Asthma – Greek word “Panting” common
inflammatory disease
 Cause: Genetic and environmental factors
 2011…..235-330 million people suffered from
asthma world wide

PPRC/INDIA 10
Asthma
 250,000 – 345,000 people die every year
 Adult women suffer more than men
 Asthma affects:
 7% population in U.S.
 5% population in U.K., Canada, Australia
 14 – 15% population in New Zealand
PPRC/INDIA 11
History of Asthma
 Ancient Egypt – Asthma treated by drinking incense
mixture called ‘Kyphi’
 Hippocrates circa 450 B.C. – Greek word ‘Panting’
for this specific respiratory problem
 1873 – Pathophysiology of disease known
 1880 – Use of intravenous doses of ‘Pilocarpin’ for
treatment

PPRC/INDIA 12
History of Asthma
 1886 – Dr. F. H. Bosworth theorized relation
between asthma and hay fever
 1905 – Use of epinephrine for treatment
 1950 – Use of oral corticosteroids in treatment
 1960 – Wide use of inhaled corticosteroids

PPRC/INDIA 13
Practice parameters
 Allergy testing
 Anaphylaxis
 Drug allergy
 Food allergy
 Immunodeficiency
 Skin allergy
PPRC/INDIA 14
Asthma triggers
 Organic compounds
 Formaldehyde exposure
 Dust mites cockroaches
 Animal dander
 Mold
 Certain viral respiratory infections
 Respiratory syncytial

PPRC/INDIA 15
Asthma triggers
 Virus and rhinovirus
 Cigarette smoke, Pets, Aspirin
 Smoking during pregnancy
 Environmental chemicals
 Environmental pollution
 Traffic pollution
 High ozone levels

PPRC/INDIA 16
Symptoms
 Wheezing, shortness of breath
 Chest tightness, coughing
 Symptoms worse at night, early mornings
 Also exposure to cold air or triggers

PPRC/INDIA 17
Associated diseases
 Gastro oesophageal reflex disc
 Rhino sinusitis
 Obstructive sleep apnea

PPRC/INDIA 18
Medicines for Asthma
Two types:
 Long term and quick relief
 Quick relief or rescue device nebulize 1-2
times / mouth

PPRC/INDIA 19
Long term medicine
 Cromolyn
 Omalizumab (anti-Ig E)
 Beta 2 agonists
 Leukotriene modifiers
 Theophylline

PPRC/INDIA 20
Rescue medicine
 Beta 2 agonists
 Inhaled short acting
Rule: Quick relief medicines shouldn’t be used /
prescribed in place of long term control
medicines or medicines that doesn’t reduce
inflammation
PPRC/INDIA 21
PPRC/INDIA 22
Classification of drugs
Based on Mechanism of action
1

Bronchodilatory activity

2

Mast cell stabilizing activity

3

Anti-allergic activity

4

Anti-inflammatory activity

5

Inhibiting interleukins (ILs) biosynthesis

6

Inhibiting leukotrienes (LTs) biosynthesis

7

Inhibiting platelet activating factor

8

Ability to inhibit lipoxygenase
PPRC/INDIA 23
1

Plants
having

Bronchodilatory activity
PPRC/INDIA 24
Adhatoda vasica
PPRC/INDIA 25
Albizzia lebbeck
PPRC/INDIA 26
Ammi visnaga
PPRC/INDIA 27
Artemisia caerulescens
PPRC/INDIA 28
Belamcanda chinensis
PPRC/INDIA 29
Benincasa hispida
PPRC/INDIA 30
Cissampelos sympodialis
PPRC/INDIA 31
Clerodendron serratum
PPRC/INDIA 32
Coleus forskohlii
PPRC/INDIA 33
Elaeocarpus sphaericus
PPRC/INDIA 34
Galphimia glauca
PPRC/INDIA 35
Ocimum sanctum
PPRC/INDIA 36
Picrorhiza kurroa
PPRC/INDIA 37
Tylophora asthmatica
PPRC/INDIA 38
Vitex negundo
PPRC/INDIA 39
Rosmarinus officinalis
PPRC/INDIA 40
Curcuma longa
PPRC/INDIA 41
Drimys winteri
PPRC/INDIA 42
Ephedra sinica
PPRC/INDIA 43
Gleditsia sinensis Lam.
PPRC/INDIA 44
Caesalpinia bonduc
PPRC/INDIA 45
2

Plants
having

Mast cell stabilizing
activity
PPRC/INDIA 46
Achyranthes aspera
PPRC/INDIA 47
Azadirachta indica
PPRC/INDIA 48
Bacopa monnieri
PPRC/INDIA 49
Drymaria cordata
PPRC/INDIA 50
Cassia alata
PPRC/INDIA 51
Citrus unshiu
PPRC/INDIA 52
Hi-chum s. glabrescence
PPRC/INDIA 53
3

Plants
having

Anti-allergic activity
PPRC/INDIA 54
Desmodium adscendens
PPRC/INDIA 55
Solanum melongena
PPRC/INDIA 56
4

Plants
having

Anti-inflammatory activity
PPRC/INDIA 57
Asystasia gangetica
PPRC/INDIA 58
Calotropis procera
PPRC/INDIA 59
Ocimum sanctum
PPRC/INDIA 60
Cinnamonum zelanicum
PPRC/INDIA 61
Ixora coccinea
PPRC/INDIA 62
Allium sativum
PPRC/INDIA 63
Glycyrrhiza glabra
PPRC/INDIA 64
Anacardium occidentale
PPRC/INDIA 65
Caesalpiniaceae bonducella
PPRC/INDIA 66
Morus indica
PPRC/INDIA 67
Curcuma amada
PPRC/INDIA 68
Cassia fistula
PPRC/INDIA 69
5

Plants
inhibiting

Interleukins (ILs)
biosynthesis
PPRC/INDIA 70
Ganoderma tsugae
PPRC/INDIA 71
6

Plants
inhibiting

Leukotrienes (LTs)
Biosynthesis
PPRC/INDIA 72
Nigella sativa
PPRC/INDIA 73
7

Plants
inhibiting

Platelet-activating factor
PPRC/INDIA 74
Gingko biloba
PPRC/INDIA 75
8

Plants
having ability to inhibit

Lipoxygenase
PPRC/INDIA 76
Allium cepa
PPRC/INDIA 77
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