Recent investigations of Phytodrugs curing tuberculosis are essential for further Research & Development. Tuberculosis is mostly a latent and asymptomatic infection, typically attacks lungs and other parts of the body.

1. Recent Investigations
of
Phyto-drugs curing
TUBERCULOSIS
Presented by
Dr. Sudhakar Kokate
Director PPRC, India

2. Tuberculosis (TB)
1. Globally TB continues to be a major cause of disability
and death
2. 1/3 of world’s population is affected by Mycobacterium
tuberculosis (MBT)
PPRC/INDIA 01

3. Tuberculosis (TB)
3. 2 million deaths are caused / year in the world
4. TB is responsible for more human deaths than any
other single infectious agent
5. 26% of all preventable deaths, 7% all deaths
PPRC/INDIA 02

4. Tuberculosis (TB)
6. WHO 1993 declared TB – a global emergency
7. In developing countries the impact of TB has intensified
with the spread of HIV infection
8. Earlier therapy was costlier and longer duration
treatment
PPRC/INDIA 03

5. Tuberculosis (TB)
9. Multi-drug resistant TB evolved that’s why documented
in many countries
10. Herbs are rich sources of therapeutic agents for
Prevention and treatment of TB
PPRC/INDIA 04

6. Plant extracts exhibiting anti-TB activity
PLANT
PART
TYPE OF EXTRACT
MIN. CONC AT WHICH
NO GROWTH
Punica granatum
Fruit peelings
Methanolic
5 mg / ml
Punica granatum
Fruit peelings
Ethanolic
3 mg / ml
Fruits
Ethanolic
2 mg / ml
Fruits
Ethanolic
3 mg / ml
Buds
Methanolic
1.5 mg / ml
Rhizome
Ethanolic
1.5 mg / ml
Coriandrum
sativum
Myristica fragrans
Syzygium
aromaticum
Zingiber officinale
PPRC/INDIA 05

7. Punica granatum
PPRC/INDIA 06

8. Punica granatum
 A shrub or small tree native of Iran, Afghanistan and
Baluchistan
 Cultivated throughout India
 Seeds along with the fleshy portions are dried and
commercially marketed as Anar dana
 Edible portion 68% contain 78% moisture, protein 4.6, fat
0.1, fibre 5.1, carbohydrate 14.5 and minerals
PPRC/INDIA 07

9. Punica granatum
 Fruit: good source of sugars, Vitamin C and iron
 Fresh rind of fruit contains: ___%
Wax 0.8
Inulin 1.0
Resins 4.5
Mucilage 0.6
Mannitol 1.8
Rannin 10.4
Gums 3.2
Gallic acid 4.0
Non-crystallized sugars 2.7
Pectin 2-4
Calcium oxalate 4.0
Tannin upto 26% in dried rind
Dr. Thorpe 1958
PPRC/INDIA 08

10. Punica granatum
 Rind of pomegranate….source of a dye (yellowish, brown shades)
 Fruit peelings used for diarrhoea & respiratory infections
 Extracts of fruits effective against:
 Micrococcus pyogenes
 Escherichia coli
 Pseudomonas aeruginosa
 Intestinal pathogenic bacilli
PPRC/INDIA 09

11. Coriandrum sativum
PPRC/INDIA 10

12. Coriandrum sativum
 Annual herb from Apiaceae family
 Native to south-western Asia to North Africa
 Medicinal plant is used as domestic remedy
 Culinary properties and used in preparations of Indian food
items
PPRC/INDIA 11

13. Coriandrum sativum
It has several pharmacological effects such as anti-fertility,
anti-hyperglycaemic, anti-oxidant, anti-proliferative and
hypo-tensive activities
 Chemicals: quercetin-3-glucuronide, linalool, camphor,
geranyl acetate, geraniol and coumarins
PPRC/INDIA 12

14. Myristica fragrans
PPRC/INDIA 13

15. Myristica fragrans
Family: Myristicaceae
 Evergreen, aromatic tree
 Fruit is yellow, broadly pyriform orglobose, 6.9 cm long,
often drooping pericarp, fleshy, splitting into 2 halves at
maturity
PPRC/INDIA 14

16. Myristica fragrans
Imported from South-east Asian countries & consumed in
India for culinary and medical purpose
 Traditionally Myristica fragnans is used as anti-
inflammatory, hypolipidemic, hypocholesterolemic agent
 Anti-cancer, anti-diabetic activities are also known
PPRC/INDIA 15

17. Syzygium aromaticum
PPRC/INDIA 16

18. Syzygium aromaticum
Family: Myrtaceae
Buds of Syzygium aromaticum are used as spice and
flavouring agents.
 It’s oil (clove oil) is traditionally used in toothache, mouth
sores, rheumatism and arthritis
PPRC/INDIA 17

19. Syzygium aromaticum
Used as carminative, to increase hydrochloric acid and
improve peristalsis
 Said to be natural anthelmintic
 Used in aromatherapy where stimulation and warming is
needed, especially for digestive tract
PPRC/INDIA 18

20. Zingiber officinale
PPRC/INDIA 19

21. Zingiber officinale
10-gingerol is the main component of Ethanolic extract of
dried rhizome of ginger
 Exhibits anti-bacterial, anti-fungal activity, anti-oxidant,
anti-inflammatory activity
 Used as a stimulant & carminative for curing gastrointestinal disorders
PPRC/INDIA 20

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