Guilt free sugary treats in the offing

1. Guilt-free sugary treats in
the offing
Scientists Discover Enzyme That Reverses Toxic Effects Of Sugar In
Body
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2. Contd…
Guilt-free sugary treats may be on the horizon after scientists, including one of
Indian-origin, have discovered an enzyme that can stop the toxic effects of sugar in
various organs of the body. The finding could lead to the development of
therapeutics for obesity and type 2 diabetes, researchers said. The enzyme, named
glycerol 3-phosphate phosphatase (G3PP), plays a central role in controlling glucose
and fat utilisation.
Led by doctors Marc Prentki and Murthy Madiraju, the research team has
demonstrated that G3PP is able to detoxify excess sugar from the cells. “When
glucose is abnormally elevated in the body, glucose-derived glycerol-3 phosphate
reaches excessive levels in cells, and exaggerated G3PP metabolism can damage
various tissues,“ said Prentki. “G3PP is able to breakdown a great proportion of this
excess glycerol phosphate to glycerol and divert it outside the cell, thus protecting
the insulin producing beta cells of pancreas and various organs from toxic effects of
high glucose levels,“ he added. Brought to you by
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3. Contd…
Mammalian cells use glucose and fatty acids as the main nutrients, which
governs many physiological processes such as insulin secretion by beta cells,
production of glucose in liver, storage of fat in adipose tissue and breakdown
of nutrients for energy production. Derangement of these processes leads to
obesity, type 2 diabetes and car diovascular diseases. The beta cells sense
changes in blood glucose levels and produce insulin according to body
demand.
However, when beta cells are presented with excess glucose and fatty acids,
the same nutrients become toxic and damage them, leading to their
dysfunction and diabetes.
“By diverting glucose as glycerol, G3PP prevents excessive formation and
storage of fat and it also lowers excessive production of glucose in liver, “
said Madiraju. “It is extremely rare since the 1960s that a novel enzyme is
discovered at the heart of metabolism of nutrients,“ he said.
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