Macromolecules and about fulids

1. BY
K.PRASHANTH RAJ
B182746

2. CONTENTS
INTRODUCTION
THE ROLE OF MICROFLUIDICS
 MICROFABRICATION
 PUMPING,VALVING&MIXING
 ADVANTAGES OF MICROFLUIDICS
 USES
 MODEL &INVENTED OF MICROFLUIDICS
 FUTURE OF MICROFLUIDIES
 APPLICATIONS
 CONCLUSION
 REFERENCES

3. INTRODUCTION
The micro fluidics involves the use of micro structured
device.
Featuring dimensions typically on the order of tens to hundreds
of micro meters that allow the precise handling of low volumes
(usually nano liters or less)of fluids within them.
First micro fluidic device was developed in 1970’s,it not until the
early 1990’s that micro fluidic came to “LAB-ON-A-CHIP”.
 Devices originally focoused on aspects of analytical chemistry but micro
fluidics has since expanded into many areas ,particularly in chemistry&
biology.
Flow within micro fluidics devices is almost always laminar.

4. FIGURES
LAB-ON-CHIP
A GLASS OF MICROFLUIDIC DEVICE

5. THE ROLE OF MICROFLUIDICS
Microfluidic technology has the potential to be used
as a platform to investigate interactions between drug
carriers and cells.
And also treatment effects of active compounds and
drugs.
The platform can be helpful for filling gap between
animal studies and human clinical trials.

6. MICRO FABRICATION
 Microfluidic devices can be fabricated from a range
different method
 In research lab now-a-days the most common chip
material is flexible elastomer ,
poly(dimethylsiloxane)(PDMS),which is well suited to
rapid prototyping.
 And also developed the
paper microfluidic devices.
paper microfluidic

7. PUMPING,VALVING &MIXING
 Two methods are available for pumping solutions.
Hydrodynamic pumping &
electro osmotic flow(EOF).
Hydrodynamic pumping:
 It involves the application of pressure ,for example via a
syringe pump &centrifugal forces and characterized by a
parabolic flow profile.
EOF –based pumping:
pumping occurs when a voltage difference is applied
across a micro channel that features charged surface
&the flow profile being almost completely flat.

8. ADVANTAGES
 The low cost savings .
 Increased precision .
 Shortened time of experiments.
 Flexible application.
 Use less volume of samples in chemical reagents.
 Micro fluidics allow the analysis the use of less volume
of samples , chemicals &reagents reducing the global
fees of applications.

9. USES
 Micro fluidic systems are used in procedures such
as
 sample injection in mass spectrometry.
PCR amplification.
DNA analysis.
Separation &manipulation of cells &cell patterning.

10. MODEL OF MICROFLUIDICS
 Micro fluidic models allow including all the main
elements involved in the process of extravasation.
Ex: geometry of the blood vessel, presence of a 3D
environment ,etc.
INVENTED MICROFLUIDICS
 Frederick stanley kipping, the british chemist
considered the father of silicon chemistry. The first
microfluidic devices were usually made of silicon from
micro electronics.

11. FUTURE OF MICROFLUIDICS
The future of microfluidic devices is likely to involve
their direct integration with human body.
It poses some challenges , not incompatibility between
electrial components &the flexible,dynamic nature of
tissue.
DEVELOPED BY
 In late 1990’s the george white sides group of harvard
university introduced a new concept of low-cost micro
fluidics.

12. APPLICATIONS
“LAB-ON-CHIP” Technology can be applied to a wide
variety of chemical and biological process.
Micro fluidic devices can be employed for the
monitoring of every day concerns such as
enverinomental &food analysis, as well as in forensic
science. Where only small amount of samples may be
available.
Microfluidics has becomes of particular important for
clinical dignostics & DNA analysis.
Microfluidic technology has been developing more
and more towards integrated systems.

13. CONCLUSION
 I concluded that the Microfluidics are easy to use in
laboratory ,
Also it give the type of flow .
And also used in DNA analysis.

14. REFERENCES
o Haeberle , S.; Zengerle , R. Lab Chip 2007, 7(9), 1094–1110; (b) Livak-Dahl, E.;
Sinn, I.; Burns, M. Ann. Rev. Chem. Biomol . Eng. 2011, 2(1), 325–353; (c) Nge, P.
o Rogers, C. I.; Woolley, A. T. Chem. Rev. 2013, 113(4), 2550–2583; (d) Mark, D.;
Haeberle , S.; Roth, G.; von Stetten , F.; Zengerle , R. Chem. Soc. Rev. 2010,
39(3), 1153–1182.
o Ohla, S.; Belder, D. Curr. Opin. Chem. Biol. 2012, 16(3–4), 453–459.

15. THANK YOU