Latest Advances in Clinical Senology and Oncology

1. Senology Newsletter Page 1 of 4
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International Senologic and Oncologic Scientific Community
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Editor-in-Chief: Gian Paolo Andreoletti, MD
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Literature Selection
Hubbard RA et al.: "Cumulative probability of false-positive recall or biopsy recommendation after 10
years of screening mammography: a cohort study", Ann Intern Med. 2011 Oct 18;155(8):481-92
Takeshita T et al.: "Clinical Implications of Occult Metastases and Isolated Tumor Cells in Sentinel and
Non-Sentinel Lymph Nodes in Early Breast Cancer Patients: Serial Step Section Analysis with Long-
Term Follow-Up", Ann Surg Oncol. 2011 Oct 12. [Epub ahead of print]
Han Y et al.: "Prognostic value of chemotherapy-induced neutropenia in early-stage breast cancer",
Breast Cancer Res Treat. 2011 Oct 5. [Epub ahead of print]
Arun B et al.: "Response to Neoadjuvant Systemic Therapy for Breast Cancer in BRCA Mutation
Carriers and Noncarriers: A Single-Institution Experience", J Clin Oncol. 2011 Oct 1;29(28):3739-46
Mohammadianpanah M et al.: "The efficacy and safety of neoadjuvant chemotherapy +/- letrozole in
postmenopausal women with locally advanced breast cancer: a randomized phase III clinical trial",
Breast Cancer Res Treat. 2011 Oct 16. [Epub ahead of print]
Stearns V et al.: "Preclinical and clinical evaluation of intraductally administered agents in early
breast cancer", Sci Transl Med. 2011 Oct 26;3(106):106ra108
Regan MM et al.: "Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal
women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at
8·1 years median follow-up", Lancet Oncol. 2011 Oct 20. [Epub ahead of print]
Slamon D et al.: "Adjuvant trastuzumab in HER2-positive breast cancer", N Engl J Med. 2011 Oct 6;365
(14):1273-83
Brufsky AM et al.: "Final 5-year results of Z-FAST trial: Adjuvant Zoledronic Acid Maintains Bone Mass
in Postmenopausal Breast Cancer Patients Receiving Letrozole", Cancer. 2011 Oct 10 [Epub ahead of
print]
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2. Senology Newsletter Page 2 of 4
Adkins FC et al.: "Triple-negative breast cancer is not a contraindication for breast conservation",
Ann Surg Oncol. 2011 Oct;18(11):3164-73
Early Breast Cancer Trialists' Collaborative Group (EBCTCG): "Effect of radiotherapy after breast-
conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of
individual patient data for 10 801 women in 17 randomised trials", Lancet. 2011 Oct 19. [Epub ahead of
print]
Miao H et al.: "Incidence and Outcome of Male Breast Cancer: An International Population-Based
Study", J Clin Oncol. 2011 Oct 3. [Epub ahead of print]
Comment
"Patients with small, node-negative HER2-positive breast carcinoma may benefit from trastuzumab
therapy" - Ana Kiess, Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New
York, NY, USA
""Our study shows that women with small, node-negative HER2-positive breast cancer may benefit from
trastuzumab
therapy. These
women actually have a significant risk of local recurrence in the breast after breast conservation therapy
(~10%), but trastuzumab may reduce their risk to about 1%"
(Comment on: Kiess AP et al.: "Adjuvant trastuzumab reduces locoregional recurrence in women who
receive breast-conservation therapy for lymph node-negative, human epidermal growth factor
receptor 2-positive breast cancer", Cancer. 2011 Sep 1. doi: 10.1002/cncr.26484. [Epub ahead of print])
Discussion
Welch HG et al.: "Likelihood That a Woman With Screen-Detected Breast Cancer Has Had Her "Life
Saved" by That Screening", Arch Intern Med. Published online October 24, 2011,
doi:10.1001/archinternmed.2011.476
- What do you think about the conclusions of this study? Share your opinion on LinkedIn®
Healthcare Companies News
Oncotype DX Newsletter - Genomic Health
Calendar of Events
1st Advanced Breast Cancer International Consensus Conference, November 3-5, 2011, Lisbon,
Portugal
IX Madrid Breast Cancer Conference, November 16 - 17, 2011, Madrid, Spain
AORTIC (African Organisation for Research and Training in Cancer) - 8th International Conference,
November 28 - December 2, 2011, Cairo, Egypt
The 2011 CTRC-AACR San Antonio Breast Cancer Symposium, December 6-10, 2011, San Antonio,
TX
The World Cancer Immunotherapy Conference, January 25-26, 2012, San Diego, CA
Fragments of History
William S Halsted (New York, 1852-1922), "The Results of Operations for the Cure of Cancer of the
Breast Performed at the Johns Hopkins Hospital from June, 1889, to January, 1894, Ann Surg. 1894
November; 20(5): 497–555: “Now we can state positively that cancer of the breast is a curable disease if
operated upon properly and in time. I cannot emphasize too strongly the fact that internal metastases occur
very early in cancer of the breast, and this is an additional reason for not losing a day in discussing the
propriety of an operation"
Literature Selection
Gillgren P et al.: "2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma
thicker than 2 mm: a randomised, multicentre trial", Lancet. 2011 Oct 21. [Epub ahead of print]
Chaturvedi AK et al.: "Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the
United States", J Clin Oncol. 2011 Oct 3. [Epub ahead of print]
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3. Senology Newsletter Page 3 of 4
Palefsky JM et al.: "HPV Vaccine against Anal HPV Infection and Anal Intraepithelial Neoplasia", N
Engl J Med. 2011 Oct 27;365(17):1576-1585
Hvid-Jensen F et al.: "Incidence of Adenocarcinoma among Patients with Barrett's Esophagus", N
Engl J Med. 2011 Oct 13;365(15):1375-83
Herbrik M et al.: "Diagnostic Accuracy of Virtual 18F-FDG PET/CT Bronchoscopy for the Detection of
Lymph Node Metastases in Non-Small Cell Lung Cancer Patients", J Nucl Med. 2011 Oct;52(10):1520-5
Oken MM et al.: "Screening by Chest Radiograph and Lung Cancer Mortality: The Prostate, Lung,
Colorectal, and Ovarian (PLCO) Randomized Trial", JAMA. 2011 Oct 26. [Epub ahead of print]
Quoix E et al.: "Therapeutic vaccination with TG4010 and first-line chemotherapy in advanced non-
small-cell lung cancer: a controlled phase 2B trial", Lancet Oncol. 2011 Oct 21. [Epub ahead of print]
Ruge M et al.: "Stereotactic Brachytherapy With Iodine-125 Seeds for the Treatment of Inoperable
Low-Grade Gliomas in Children: Long-Term Outcome", J Clin Oncol. 2011 Oct 3. [Epub ahead of print]
Yang D et al.: "Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity,
and gene mutator phenotype in patients with ovarian cancer", JAMA. 2011 Oct 12;306(14):1557-65
Klein EA et al.: "Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer
Prevention Trial (SELECT)", JAMA. 2011 Oct 12;306(14):1549-56
Miyatake H et al.: "Effect of Previous Interferon Treatment on Outcome After Curative Treatment for
Hepatitis C Virus-Related Hepatocellular Carcinoma", Dig Dis Sci. 2011 Oct 12. [Epub ahead of print]
Garcia-Donas J et al.: "Single nucleotide polymorphism associations with response and toxic effects
in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre,
observational, prospective study", Lancet Oncol. 2011 Oct 17. [Epub ahead of print]
Discussion
"Screening for Prostate Cancer - A Review of the Evidence for the U.S. Preventive Services Task
Force"
- "Prostate cancer screening guidelines called into question", Dana-Farber Cancer Institute
- Share your opinion on LinkedIn®
Literature Selection
Vesco KK et al.: "Risk Factors and Other Epidemiologic Considerations for Cervical Cancer
Screening: A Narrative Review for the U.S. Preventive Services Task Force", Ann Intern Med. 2011 Oct
17. [Epub ahead of print]
Whitlock EP et al.: "Liquid-Based Cytology and Human Papillomavirus Testing to Screen for Cervical
Cancer: A Systematic Review for the U.S. Preventive Services Task Force", Ann Intern Med. 2011 Oct
17. [Epub ahead of print]
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Recent Advances in Clinical Medicine
O'Connor P et al.: "Randomized trial of oral teriflunomide for relapsing multiple sclerosis", N Engl J
Med. 2011 Oct 6;365(14):1293-303
http://www.senology.org/newsletter/Newsl_Nov2011.htm 03/11/2011

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