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Multi-drug resistant Mtb is a major worldwide health problem. Therefore, it is need to develop new antibiotics with novel modes of action to overcome this emerging resistance problem.
FtsZ (Filamentous temperature-sensitive protein Z ) Drug Target for Tuberculosis
FtsZ is the key protein of bacterial cell division, filament-forming GTPase and a structural homologue of eukaryotic tubulin.
It interacts with membrane-associated proteins FtsA and ZipA and assembles into a ring like structure at the midcell, this ring is known as Z-ring.
The formation of the Z-ring is facilitated by the ability of FtsZ to bind to GTP, which enables polymerization of FtsZ, resulting in the creation of straight protofilaments.
It is the first protein to move to the division site, and is essential for recruiting other proteins that produce a new cell wall between the dividing cells. So it is an emergent target for new antibiotics.