Strategy for GPAT. Tips n tricks to crack gpat.pptx
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This ppt describes the importance of GPAT AND NIPER,IMp topics to be discussed
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Strategy for GPAT. Tips n tricks to crack gpat.pptx
- 1. Strategy for GPAT By Payaam Vohra
- 2. Best Pharmacy tips and tricks All cology classification All medchem class All cognosy class All anaylsis titrations and IMA All ceutics formulations (IP ,PP) All POC name reactions Imp terminologies Microbiology and biotech Biopharmaceutics. APP Jurisprudence Inorganic chem Biochemistry Miscellaneous topics Things that will be covered during the sessions
- 3. No 3D Model? No Problem! Microsoft makes it easy to insert a 3D Model! Simply go to the Insert Ribbon and click on the 3D Models option. Choose the option for online sources gallery (shown at the right). Select the model you wish to insert. 3D Models is a subscription-only feature. If you have a subscription, the next slide shows you how it works in a new presentation. Parameters Tablets Capsules Parenterals Aerosols Evaluation Hardness Uniformity of wt, Uniformity of content Dissolution Wt variation Disintegration Friability Morphological,Bloom strength,Iron content-(15PPm), Viscosity(25-45 mp),Base adsorption, MC,Content uniformi ,Wt variation Sterility Pyrogenicity Leakage (1% Methyelene blue),Clarity,Particulate matter Particle size distrbituion,Identifciati on,MC,Flash point Flame ,Vap pree,foam stability ,Spray pattern,Density Method Dry Wet Direct slugging Chilsonator roller compa Aseptic area Clean area Cold,Pressure Vaccum filling Excipients Binder 10-20% glidant diluents disintegrants 5% Super disintegrant adherants antiadherant Lubricants Colouring ,flavouring sweetening Gelatin , HPMC, Opacifying, Diluents, Plasticizer, Absorbents vehicles/solvents, tonicity agents, buffers, solubilizing agents (such co-solvents, surfactants, complexing agents), bulking agents,osmotic agent antimicrobials/preservatives, Viscosity modfifer, antioxidants, chelating agents Cryoprotectans Lyoprotectants Propellant,Wetting,Hu mectant, Antifoaming Equipments Multipunch rotary die press Zanasi Eli lily, Rotosort Rotofill,Accogel, Accogil Dip tube Actuator Canister Gasket Miscellaneous Tablet defects,Sugar and Enteric coated polymer Type a and b gelatin , Glcyerin :gelatin Preformulation consideration 140-180 psi pressure at 130 F/ 70 degree
- 4. Capping Lamination Blushing ,Mottlling Blooming Type A TYPE B Pork skin Bovine bones Acidic Basic 9 4.7 Capsule Ratio HGC 0.4/1 Intermediate 0.6/1 Soft 0.8/1
- 5. Cascae impactor-Particle szie Gas crgayp-Mositure content Hygrometer-density Tag open cup appratus- - 25 f Propellant- Ir spectrsocopy Rotosort-Unfilled capsules Accogel-Powder in SGC Accofill-Powder in HGC Nacl-0.9 % w/v Dextrose- 5% w/v Antioxidants BHT, BHA,Tocopherols
- 6. Monsanto Erweka Strong cobb Schrolonguier Pftizer 20 tablets - potency 30 tablets-Content of unifromity 10 mesh size 37+ 2 - Disintegration 20 mesh size 37+ 0.5- Dissolution Roche friabolotr- 1% Propellant 11-Trichloromonoflurourmethane Propellant 12-dicholor difluroormethan prope 114-dichloro tetrafluror ethane
- 7. FTM- aerobic and anaerboic 30-35 degree 7 days SCDM-Aerobic fingi-20-25 degree -14 days Base adsotption Capsule size Less filling capacity Density
- 8. Anti fungal, bacterial, Viral ,protozoal, Parasitic, Amoebic, Helminthic, Malarial, Cancer, Gout, Rheumatism, Parkinson, Alzheimer, Depressant, Thyroid, Diabetic ,Anticoagulant Mania Bipolar, Anxiety, Sedative Hypnotic, Local anesthetic, General anesthetic, erectile dysfunction, Pre anesthetic, Coagulants, Fibrinolytics , Antithrombotic, Leprotic Anti-inflammatory ,pyretic , analgesic, Cholinergic ,AC , adrenergic, AA, Myasthenia gravis , Alcohols, Skeletal muscle relaxants, Glaucoma, Tubercular Antiulcer, Anti arrhythmic ,Anginals,Hyperlipidaemics,CHF,DiureticsHypertension,Antibiotics ,Anabolic steroids, Insulin analogues,UTI Antiasthma, Hormones ,(Estrogen progesterone Testosterone) ,oral contraceptives, Corticosteroids, Tranquilizers (Schizophrenia),Protein target drugs Laxative, Immunosuppressants and stimulants, Tocolytics, Oxytociosis, Hormones (ACTH STH MSH prolactin),STD,Mab ,Biosmilars Antiemetic, Drugs of abuse, Hallucinogens, Nootropics Hematinic, Shock, Calcium level, Antipsychotics,Appetite regulators, Autocoids(Histamine serotonin PG ),Nasal decongestant ,Expectorant ,Respiratory stimulnts,Digestants,Posioning (Lead arsenic Mercury) Pharmacology MedChem
- 9. ADR DRUG interactions SAR MOA Tafts stearic, hammets Electronic, Hanstch analysis
- 10. Iodo Iodi Bromato Cerio Permangano Dichrom Iodato Mohr Volhard Fajan Gay lussac T IMA Titrations Acid base(Neutralization) SA-SB WA-WB SA-WB WA-SB Redox Precipitation Complexometric Gravimetric Indicators Primary and seconday Colour change
- 11. For acidic Ph=7.9 pka =6.9 PH-PKA For basic Ph=7.9 pka=8.9 PKA -PH
- 12. Solubility Complexation Preformulation Kinetics States of Matter Incompatibliets Thermodynamics Acids and bases buffer Antidotes PP and Ip
- 13. Krebs glycolysis ETS Acetate mevalonate Proteins Amino acids Carbohydrates Lipids Identification tests classification uses Urea cycle Vitamins Enzymes Few disorder( Black urine) Acid saponification Iodine values Synthesis and metbaolism of ACH adrenaline Biochemistry
- 14. Potentiometry Conductomtery Polarography(Ilkovic majorly) Differnce between indicator and Ref Nephelturbidometry Fluorimetry UV IR NMR FLAME AAS MASS spectroscopy Chromatography Electrophoresis Analysis TLC paper Gc hplc gel affinity ion exchange gel eclect paper elecet capillar y elec principle detector detrctor principle ligand types zone types mb procedu re injector injector gel permati on spacer arm iec epm eof devlop tech colum oven pump tev types injecting injecting carrier gas mp rese temp progra
- 16. Param eters IR FLAME AAS AES Nephel o- turbido FLuo rimtr y UV NMR MASS Detecto r Sample holder Source Graph Sample Ref stand
- 17. Suspension Emulsion Micromeretics Rheology Solublity Complexation Interfacial tension Ceutics α (alpha)-cyclodextrin: 6 glucose subunits. β (beta)-cyclodextrin: 7 glucose subunits. γ (gamma)-cyclodextrin: 8 glucose subunits.
- 19. Steroids proteins Carbs Tropane Alkaloids Antraquinoin glcyoi Pale catechu Flavanoids Tannins Sudan red 3 Volatile oil Cuoaxam Cellulose Ruthenium red Mucilage Phloroglucinol con hcl Lignin Extraction techniques(Soxhlation , Craigs, Infusion Decotion maceration Shikimic acid Cognosy
- 20. Category Name Therapeutic activity Miscellaneous Subcategory B.S Active consituent Family Alkaloids Vinca Anti cancer Indole Leaf Vincristin Apocynacae Glycosides Digitalis CHF leaf Digoxin Tannins Catechu catechutannic Resins Benzoin Flavanoids Rutin Capillary per Volatile oils Fennel Cognsoy
- 21. Radioactive Hematinic Dentifrices (Fluoride) Heat transfer (Fouriers and Kirchoffs law) Limit tests Packagings Buffer Few Ophthalmic concepts Inorganic chemistry Alcohol Phenol aldehyde Ketone Amine acid Ester Lucas Fecl3 Sodi nitorpru Carbylamine Na2CO3 Fruity smell Victor mayer Bromine water Iodoform Nitrous acid Fluroesein Picric acid Hinsberg Esterification
- 22. ELISA, Western, Southern blotting Sterilization Gram acid fast staining Sterility testing IMVIC Vaccines Fermentation Enzyme immobilization Immunity -MHC Blood products Analytical Validation Microbiology and Biotech
- 23. •Fscher Indole Synthesis •Walden Inversion •Perkin Reaction Mechanism •Diels-Alder Reaction Mechanism •Michael Addition Mechanism •Heck Reaction •Mannich Reaction Mechanism •Hydroboration oxidation reaction •Claisen condensation •Lindlar Catalyst •Maillard Reaction •Robinson Annulation •Woodward Reaction •Oppenauer Oxidation POC name reactions
- 24. L Lossen rearrangement Marknoikov, Peterson Pechmann Kharash mayo effect Coulson moffit, Rosenumund Sasche moh,Paal knorr ,Haworth ,knoor pyrrole,, Skraup synthesis PIncole pinacolone Bayers strain, Saythzeff A Aldol Arndt-Eistert Synthesis B Baeyer-Villiger oxidation Bartoli indole synthesis Beckmann rearrangement Birch reduction Bamford steven C Cannizzaro reaction Claisen condensation Claisen rearrangement Clemmensen reduction Cope rearrangement Corey House synthesis Curtius rearrangement D Dakin-West reaction Doebner miller synthesis Dieckmann condensation Diels-Alder reaction Darzen reaction F Finkelstein reaction Fischer esterification Fischer indole synthesis Friedel-Crafts acylation and alkylation Fries rearrangement Favosrki Fittig Friendlander
- 25. Hybridization Acidity and basicity OP directing activating and deactivating SN1 SN2 E1 E2 Isomerism BCS class
- 26. HAP Reference books and which topic to refer from which book Images adopted from Solution pharmacy
- 27. Compartment modelling Linear and causes on non linearity Reynolds number Bernoullis theorem Receptor types ADME BPPK and PE Name Principle Uses Type Disadvantage Miscellaneous Ball mill Size reduction Fractional Distillation Perforated Centrifugation Falling film Evaporation Plate and frame Filtration Elutriation tank Size sepration Sigma blade Mixing crystallization Fluidized Bed Drying Venturimeter Flow of fluid
- 28. D AND C MTP ICH NDPS IPR( GI,CCOPYRIGHT TRADEMARK,PATENT PHARMACY ACT DRUG AND MAGIC REMEDIES TOILET PREPRATIONS IP Publciations Hatch Waxmann act Drug discovery and developemtn phasses clinical trials Jurisprudence
- 30. 1) GLASS 2) PLASTIC 3) RUBBER